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Virchows Archiv

Erschienen in:

01.02.2010 | Review and Perspective

Gastrointestinal stromal tumors

verfasst von: Bernadette Liegl-Atzwanger, Jonathan A. Fletcher, Christopher D. M. Fletcher

Erschienen in: Virchows Archiv | Ausgabe 2/2010

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Abstract

Gastrointestinal stromal tumors (GISTs) have emerged from being poorly defined, treatment-resistant tumors to a well-recognized, well-understood, and treatable tumor entity within only one decade. The understanding of GIST biology has made this tumor a paradigm for molecularly targeted therapy in solid tumors and provides informative insights into the advantages and limitations of so-called targeted therapeutics. Approximately 85% of GISTs harbor activating mutations in KIT or the homologous receptor tyrosine kinase PDGFRA gene. These mutations are an early event in GIST development and the oncoproteins serve as a target for the small molecule tyrosine kinase inhibitors imatinib and sunitinib. The existing and emerging treatment options demand exact morphologic classification and risk assessment. Although, KIT (CD117) immunohistochemistry is a reliable diagnostic tool in the diagnosis of GIST, KIT-negative GISTs, GISTs showing unusual morphology as well as GISTs which progress during or after treatment with imatinib/sunitinib can be a challenge for pathologists and clinicians. This review focuses on GIST pathogenesis, morphologic evaluation, promising new immunohistochemical markers, risk assessment, the role of molecular analysis, and the increasing problem of secondary imatinib resistance and its mechanisms.

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Titel: Gastrointestinal stromal tumors
verfasst von: Bernadette Liegl-Atzwanger
Jonathan A. Fletcher
Christopher D. M. Fletcher
Publikationsdatum: 01.02.2010
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 2/2010
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-010-0891-y

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Gastrointestinal stromal tumors

Abstract

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Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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