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27.11.2015 | Review and Perspectives

Tumour budding in colorectal cancer: what do we know and what can we do?

verfasst von: Linde De Smedt, Sofie Palmans, Xavier Sagaert

Erschienen in: Virchows Archiv | Ausgabe 4/2016

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Abstract

Budding is a process during which individual or small clusters of up to five tumour cells detach from the main tumour mass and invade into the surrounding stroma. In colorectal cancer, this feature is observed in 20–40 % of cases and is associated with lymphovascular invasion, lymph node and distant metastases, and poor prognosis. A variety of scoring systems for budding have been proposed but so far a gold standard is lacking, hampering implementation of a budding score in guidelines for pathological examination of colorectal cancer. Furthermore, little is known about the mechanisms which cause tumour cells to detach from the main tumour mass and obtain increased invasive potential. In this review, we present an overview of tumour budding including its definition, scoring systems, prognostic relevance and biological mechanisms involved.

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Titel: Tumour budding in colorectal cancer: what do we know and what can we do?
verfasst von: Linde De Smedt
Sofie Palmans
Xavier Sagaert
Publikationsdatum: 27.11.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 4/2016
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-015-1886-5

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Tumour budding in colorectal cancer: what do we know and what can we do?

Abstract

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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