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Virchows Archiv

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16.06.2020 | Commentary

Mixed germ cell sex cord-stromal tumors, collision or inclusion?

verfasst von: J. Wolter Oosterhuis

Erschienen in: Virchows Archiv | Ausgabe 5/2020

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Excerpt

Michalova et al. [1] address the question whether mixed germ cell sex cord-stromal tumors (MGSCT) of the testis do indeed exist. This extremely rare entity, originally described by Dr. Aleksander Talerman, consists of a sex cord-stromal component resembling the adult granulosa cell tumor and interspersed germ cells [2]. …

Michalova KMJ, Kristiansen G, Steiner P, Grossmann P, Putzova M, Martinek P, Chottova-Dvorakova M, Michal M, Hes O, Michal M (2020) Novel insights into the mixed germ cell-sex cord stromal tumor of the testis: detection of chromosomal aneuploidy and further morphological evidence supporting the neoplastic nature of the germ cell component. Virchows Arch

Talerman A (1979) Gonadal tumours composed of germ cells and sex cord stroma derivatives. Patol Pol 30(2):221–228PubMed

Michal M, Vanecek T, Sima R, Mukensnabl P, Hes O, Kazakov DV, Matoska J, Zuntova A, Dvorak V, Talerman A (2006) Mixed germ cell sex cord-stromal tumors of the testis and ovary. Morphological, immunohistochemical, and molecular genetic study of seven cases. Virchows Arch 448(5):612–622CrossRef

Michal M, Hes O, Mukensnabl P, Kazakov DV (2007) Mixed germ cell sex cord-stromal tumours of the testis. Virchows Arch 451(6):1095–1096

Ulbright TM, Srigley JR, Reuter VE, Wojno K, Roth LM, Young RH (2000) Sex cord-stromal tumors of the testis with entrapped germ cells: a lesion mimicking unclassified mixed germ cell sex cord-stromal tumors. Am J Surg Pathol 24(4):535–542CrossRef

Ulbright TM, Young RH (2007) Reply: mixed germ cell sex cord-stromal tumors of the testis and ovary. Virchows Arch 450(1):131–132CrossRef

Ulbright TM (2016) Germ cell tumours. In: Moch H (ed) WHO Classification of tumours of the urinary system and male genital organs. IARC Press, Lyon, pp 189–226

Looijenga LH et al (2006) Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene. Cancer Res 66(1):290–302CrossRef

Giannoulatou E, Maher GJ, Ding Z, Gillis AJM, Dorssers LCJ, Hoischen A, Rajpert-de Meyts E, WGS500 Consortium, McVean G, Wilkie AOM, Looijenga LHJ, Goriely A (2017) Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline. PLoS One 12(5):e0178169CrossRef

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Oosterhuis JW, Looijenga LHJ (2019) Human germ cell tumours from a developmental perspective. Nat Rev Cancer 19(9):522–537CrossRef

Titel: Mixed germ cell sex cord-stromal tumors, collision or inclusion?
verfasst von: J. Wolter Oosterhuis
Publikationsdatum: 16.06.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 5/2020
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-020-02866-w

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Mixed germ cell sex cord-stromal tumors, collision or inclusion?

Excerpt

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Excerpt

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