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Pediatric Nephrology

Erschienen in:

01.06.2003 | Original Article

Metabolic status in diabetes mellitus affects markers for glomerular filtration rate

verfasst von: Peter Holmquist, Ole Torffvit, Sture Sjöblad

Erschienen in: Pediatric Nephrology | Ausgabe 6/2003

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Abstract.

The present study was performed in newly diagnosed diabetic children to evaluate the effect of metabolic derangement on routine tests for glomerular filtration rate (GFR). Children with (n=16) and without (n=10) ketonuria at diagnosis of diabetes followed a routine clinical treatment program. Serum creatinine, creatinine clearance, serum cystatin C, and iohexol clearance were analyzed at diagnosis and after 20 days of treatment. Iohexol clearance was used as the "true GFR". Serum creatinine and iohexol clearances were not affected by the acute metabolic status or ketonuria. In contrast, serum cystatin C was significantly influenced by ketonuria. Creatinine clearance was an unreliable marker for GFR both in the more deranged and in the balanced metabolic situation.

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Titel: Metabolic status in diabetes mellitus affects markers for glomerular filtration rate
verfasst von: Peter Holmquist
Ole Torffvit
Sture Sjöblad
Publikationsdatum: 01.06.2003
Verlag: Springer-Verlag
Erschienen in: Pediatric Nephrology / Ausgabe 6/2003
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-003-1086-4

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