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Erschienen in: Pediatric Nephrology 12/2007

01.12.2007 | Original Article

NGAL is an early predictive biomarker of contrast-induced nephropathy in children

verfasst von: Russel Hirsch, Catherine Dent, Holly Pfriem, Janene Allen, Robert H. Beekman III, Qing Ma, Sudha Dastrala, Michael Bennett, Mark Mitsnefes, Prasad Devarajan

Erschienen in: Pediatric Nephrology | Ausgabe 12/2007

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Abstract

We hypothesized that neutrophil gelatinase-associated lipocalin (NGAL) is an early predictive biomarker of contrast-induced nephropathy (CIN). We prospectively enrolled 91 children (age 0–18 years) with congenital heart disease undergoing elective cardiac catheterization and angiography with contrast administration (CC; Ioversol). Serial urine and plasma samples were analyzed in a double-blind fashion by NGAL enzyme-linked immunosorbent assay (ELISA). CIN, defined as a 50% increase in serum creatinine from baseline, was found in 11 subjects (12%), but detection using increase in serum creatinine was only possible 6–24 h after CC. In contrast, significant elevation of NGAL concentrations in urine (135 ± 32 vs. 11.6 ± 2 ng/ml without CIN, p < 0.001) and plasma (151 ± 34 vs. 36 ± 4 without CIN, p < 0.001) were noted within 2 h after CC in those subjects. Using a cutoff value of 100 ng/ml, sensitivity, specificity, and area under the receiver-operating characteristic (ROC) curve for prediction of CIN were excellent for the 2-h urine NGAL (73%, 100%, and 0.92, respectively) and 2-h plasma NGAL (73%, 100%, and 0.91, respectively). By multivariate analysis, the 2-h NGAL concentrations in the urine (R 2 = 0.52, p < 0.0001) and plasma (R 2 = 0.72, p < 0.0001) were found to be powerful independent predictors of CIN. Patient demographics and contrast volume were not predictive of CIN.
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Metadaten
Titel
NGAL is an early predictive biomarker of contrast-induced nephropathy in children
verfasst von
Russel Hirsch
Catherine Dent
Holly Pfriem
Janene Allen
Robert H. Beekman III
Qing Ma
Sudha Dastrala
Michael Bennett
Mark Mitsnefes
Prasad Devarajan
Publikationsdatum
01.12.2007
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 12/2007
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-007-0601-4

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