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02.01.2020 | Review Article

Recent progress in neuronal intranuclear inclusion disease: a review of the literature

verfasst von: Hafiz Khuram Raza, Sandeep Singh, Pabitra Rai, Thitsavanh Chansysouphanthong, Arooj Amir, Guiyun Cui, Wenjing Song, Lei Bao, Su Zhou, Hongjuan Shi, Hao Chen

Erschienen in: Neurological Sciences | Ausgabe 5/2020

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Abstract

Objective

To summarize the current understanding of neuronal intranuclear inclusion disease (NIID) and improve the understanding of the physician about this condition.

Methods

We searched PubMed with keywords related to NIID and selected publications which seemed appropriate. We analyzed its clinical features, pathogenesis, evaluation methods, treatment options, and research prospectives.

Results

NIID is a degenerative condition which can affect multiple organ systems especially central nervous system. Its clinical features greatly vary, and making the exact diagnosis is often difficult. There are several genes which have been associated with this disorder. Some specific signs on diffusion-weighted-imaging (DWI) sequence of magnetic resonance (MR) imaging are characteristics to NIID.

Conclusion

Intranuclear inclusions have been found in various nonneural cells of the body; therefore, the term systemic intranuclear inclusion disease is, perhaps, better suited to explain this disorder. There are several disorders which need to be ruled out before making the diagnosis, and neuroimaging and biopsy analysis should be combined to support the diagnosis.

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Titel: Recent progress in neuronal intranuclear inclusion disease: a review of the literature
verfasst von: Hafiz Khuram Raza
Sandeep Singh
Pabitra Rai
Thitsavanh Chansysouphanthong
Arooj Amir
Guiyun Cui
Wenjing Song
Lei Bao
Su Zhou
Hongjuan Shi
Hao Chen
Publikationsdatum: 02.01.2020
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 5/2020
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-04195-6

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