Erschienen in:
26.03.2018 | Editorial
Optimizing animal models for HIV-associated CNS dysfunction and CNS reservoir research
verfasst von:
Jeymohan Joseph
Erschienen in:
Journal of NeuroVirology
|
Ausgabe 2/2018
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Excerpt
Understanding the mechanisms of HIV-associated CNS dysfunction and establishment of CNS viral reservoirs are priority research areas for the NeuroHIV field. Over the past decade, both the clinical and pathophysiological characteristics of HIV-induced central nervous system (CNS) dysfunction have changed. Early in the pandemic, dementia and encephalitis dominated the clinical and pathological picture; and macrophage-derived mediators and HIV-1 proteins were the key pathogenic mechanisms implicated in causing CNS dysfunction. However, with the advent of combination antiretroviral therapy (cART), the spectrum of CNS disorders has transformed. While, HIV-associated CNS dysfunction still affects a considerable proportion of people living with HIV (PLHIV), the signs and symptoms are generally mild, and do not correlate with the classical findings of HIV-related neuropathology. …