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Cellular Oncology

Erschienen in:

29.07.2019 | Review

The emerging role of noncoding RNAs in colorectal cancer chemoresistance

verfasst von: Ling Wei, Xingwu Wang, Liyan Lv, Yan Zheng, Nasha Zhang, Ming Yang

Erschienen in: Cellular Oncology | Ausgabe 6/2019

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Abstract

Background

Colorectal cancer (CRC) is the third most prevalent cancer in the world and one of the most lethal human malignancies. Chemotherapy with 5-fluorouracil, platinum, hydroxycamptothecin, vincristine, methotrexate, irinotecan, paclitaxel and/or cetuximab has significantly improved the survival of CRC patients. However, most CRC patients eventually develop chemoresistance, resulting in a poor prognosis. The mechanisms involved in CRC chemoresistance are complex and, as yet, inconclusive. Noncoding RNAs (ncRNAs), such as small nucleolar RNAs (snoRNAs), microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), represent transcripts without protein-coding potential. Accumulating evidence indicates that multiple deregulated ncRNAs, including miRNAs and lncRNAs, play pivotal roles in the development of chemoresistance in CRC. This notion has potential clinical implications.

Conclusions

In this review, we highlight the emerging roles and the regulatory mechanisms by which miRNAs and lncRNAs affect CRC chemoresistance. Tumor-specific miRNAs and lncRNAs may serve as novel therapeutic targets and prognostic biomarkers for CRC.

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Titel: The emerging role of noncoding RNAs in colorectal cancer chemoresistance
verfasst von: Ling Wei
Xingwu Wang
Liyan Lv
Yan Zheng
Nasha Zhang
Ming Yang
Publikationsdatum: 29.07.2019
Verlag: Springer Netherlands
Erschienen in: Cellular Oncology / Ausgabe 6/2019
Print ISSN: 2211-3428
Elektronische ISSN: 2211-3436
DOI: https://doi.org/10.1007/s13402-019-00466-8

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The emerging role of noncoding RNAs in colorectal cancer chemoresistance

Abstract

Background

Conclusions

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Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

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Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Background

Conclusions

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