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Current Addiction Reports
Erschienen in: Current Addiction Reports 2/2015

01.06.2015 | Adolescent Substance Abuse (TA Chung, Section Editor)

Genetic and Environmental Interplay in Adolescent Substance Use Disorders

verfasst von: Lindsey A. Hines, Katherine I. Morley, Clare Mackie, Michael Lynskey

Erschienen in: Current Addiction Reports | Ausgabe 2/2015

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Abstract

Adolescent substance use is of considerable public health importance. This narrative review provides a brief background to genetically informative research methodologies and highlights key recent literature examining the interplay between genetic and environmental influences in the etiology of substance use. Twin studies have quantified the magnitude of genetic and environmental influences, and more recently, co-relative and Children of Twin designs have shown environments can moderate heritability. Studies have identified a number of specific gene variants (e.g. OPRM1, DRD4, 5HTTLPR) that interact with parenting and peer influence, and the effectiveness of interventions may vary by genotype. However, little research has taken into account the stage-sequential nature of substance use. This may obscure important differences in the genetic and environmental influences, and their interplay, at the stages of escalation to problem use. Future research needs to build on existing methodologies to disentangle the complexities of progression in adolescent substance use.
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Metadaten
Titel
Genetic and Environmental Interplay in Adolescent Substance Use Disorders
verfasst von
Lindsey A. Hines
Katherine I. Morley
Clare Mackie
Michael Lynskey
Publikationsdatum
01.06.2015
Verlag
Springer International Publishing
Erschienen in
Current Addiction Reports / Ausgabe 2/2015
Elektronische ISSN: 2196-2952
DOI
https://doi.org/10.1007/s40429-015-0049-8

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