Erschienen in:
24.08.2018 | Editorial
‘Lumping or splitting’ in paediatric acute respiratory distress syndrome (PARDS)
verfasst von:
Daniele De Luca, David A. Harrison, Mark J. Peters
Erschienen in:
Intensive Care Medicine
|
Ausgabe 9/2018
Einloggen, um Zugang zu erhalten
Excerpt
Improvements in acute respiratory distress syndrome (ARDS) outcomes in adults have been achieved alongside demonstration of the superiority of low-tidal volume ventilation [
1], the relative advantage of a restrictive fluid strategy [
2] and the characterisation of the main effectors of ventilator-induced lung injury [
3]. The heterogeneity of the group of patients defined as ‘ARDS’ on pragmatic criteria is widely recognized. ‘Lumping’ together patients with different ages, aetiologies, time courses, co-morbidities and broad categories of severity has so far been the norm in clinical trials. This undoubtedly assists in patient recruitment, and any positive trial results in such mixed populations are very likely to be robust and generalisable [
4]. …