Diagnostic performance of 320-slice multidetector computed tomography coronary angiography in patients after coronary artery bypass grafting
verfasst von:
Fleur R. de Graaf, Joëlla E. van Velzen, Agnieszka J. Witkowska, Joanne D. Schuijf, Noortje van der Bijl, Lucia J. Kroft, Albert de Roos, Johan H. C. Reiber, Jeroen J. Bax, Greetje J. de Grooth, J. Wouter Jukema, Ernst E. van der Wall
To evaluate the diagnostic performance of 320-slice computed tomography coronary angiography (CTA) in the evaluation of patients with prior coronary artery bypass grafting (CABG). Invasive coronary angiography (ICA) served as the standard of reference, using a quantitative approach.
Methods
CTA studies were performed using CT equipment with 320 detector-rows, each 0.5 mm wide, and a gantry rotation time of 0.35 s. All grafts, recipient and nongrafted vessels were deemed interpretable or uninterpretable. The presence of significant (≥50%) stenosis and occlusion were determined on vessel and patient basis. Results were compared to ICA using quantitative coronary angiography.
Results
A total of 40 patients (28 men, 76 ± 15 years), with 89 grafts, were included in the study. On a graft analysis, the sensitivity, specificity, positive and negative predictive values in the evaluation of significant stenosis were 96%, 92%, 83% and 98% respectively. The diagnostic accuracy for the assessment of recipient and nongrafted vessels was 89% and 80%, respectively. The diagnostic accuracy for the assessment of graft, recipient and nongrafted vessel occlusion was 96%, 92% and 100%, respectively.
Conclusions
320-slice CTA allows accurate non-invasive assessment of significant graft, recipient vessel and nongrafted vessel stenosis in patients with prior CABG.
Abkürzungen
CABG
coronary artery bypass grafting
CAD
coronary artery disease
CI
confidence interval
CTA
computed tomography coronary angiography
ICA
invasive coronary angiography
LAD
left anterior descending coronary artery
LCx
left circumflex coronary artery
NPV
negative predictive value
PCI
percutaneous coronary intervention
PPV
positive predictive value
RCA
right coronary artery
Introduction
Coronary artery bypass grafting (CABG) is frequently performed in order to restore myocardial perfusion in patients with severe three-vessel disease or left main coronary artery stenosis [1]. At present, invasive coronary angiography (ICA) is the standard of reference for the detection of stenotic coronary artery disease (CAD) in patients with prior CABG. However, ICA is associated with a small but non-negligible risk of complications, patient discomfort, and costs of hospital stay [2]. As a result, a non-invasive investigation to assess patients after CABG may be of clinical benefit in selected patients.
Over the past decade multidetector computed tomography coronary angiography (CTA) has become an important imaging modality for the non-invasive assessment of CAD [3‐6]. This technique enables the non-invasive visualization of cardiac anatomy, coronary arteries, stents and grafts with good spatial resolution [7‐9]. The diagnostic performance of CTA for the evaluation of patients with prior CABG has increased with each new generation of CT equipment [10]. Using older generations such as 16-slice CTA, high diagnostic accuracy was reported in the assessment of graft patency and significant stenosis [11‐13], while the assessment of significant stenosis in native coronary arteries remained suboptimal [14‐16]. Using 64-slice CTA, the efficacy of CTA in the detection of significant stenosis in native coronary arteries and grafts improved, with fair diagnostic accuracy in the detection of graft and native vessel stenosis, but still at the cost of high radiation and contrast doses [17, 18].
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Recently, 320-slice CT systems were introduced, with a maximum of 16 cm volumetric coverage in a single gantry rotation. With the simultaneous acquisition of 320 slices per rotation, a volumetric CT data acquisition approach is used, thereby reducing radiation burden, time of breath-hold and contrast load [19]. Good diagnostic performance of 320-slice CTA has been previously demonstrated in the assessment of CAD [20‐22]. The assessment of patients with prior CABG, however, has not been formerly reported. The purpose of the present study, therefore, was to assess the diagnostic performance of 320-slice CTA in patients with previous CABG, in the evaluation of significant stenosis and occlusion in grafts, recipient vessels and nongrafted vessels.
Materials and methods
Patient population
The patient population consisted of 40 consecutive patients with a history of CABG (mean 16.3 years). A total of 35 patients were scheduled for both CTA and ICA for visualization of coronary anatomy and cardiac structures [23, 24]. Specifically, 32 patients were referred for CTA for preprocedural evaluation prior to transcatheter aortic valve implantation [23, 25] and 3 patients undergoing catheter ablation for atrial fibrillation were referred for CTA [24, 26]. In addition, 5 patients were referred for ICA following CTA based on CTA findings and clinical presentation. All patients were symptomatic. In total, 34 patients presented with angina pectoris, and in 17 patients dyspnoea was present. This evaluation was conducted according to the clinical protocol of the institution. All patients provided informed consent for the procedures. Patients were entered prospectively into the departmental Cardiology Information System (EPD-Vision®, Leiden University Medical Center) and were retrospectively analysed. Table 1 shows an overview of the baseline clinical characteristics of the patient population. Exclusion criteria for CTA investigation were: (supra)ventricular arrhythmias, known allergy to iodine contrast material, renal failure (glomerular filtration rate <30 ml/min), severe claustrophobia, pregnancy and high heart rate in the presence of contraindications to beta-blocking medication. ICA served as the standard of reference. Both examinations were performed within 3 months of each other. No interventions or changes in the clinical condition of the patients occurred between the examinations.
Table 1
Patient characteristics (n = 40)
Men/women
28/12
Age (years)
76 ± 15
Time after CABG (years)
16.3 ± 7.6
BMI (kg/m²)
25 ± 3
Family history of CADa
9 (23%)
Diabetes
11 (28%)
Hypertensionb
35 (88%)
Hypercholesterolemiac
30 (75%)
Current smoker
3 (8%)
Previous myocardial infarction
12 (30%)
Previous PCI
22 (55%)
Pacemaker or ICD
2 (5%)
Values in parentheses are percentages
aDefined as presence of coronary artery disease in first degree family members at <55 years in men and <65 years in women
bDefined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg and/or the use of antihypertensive medication
cSerum total cholesterol ≥230 mg/dl and/or serum triglycerides ≥200 mg/dl or treatment with lipid lowering drugs
CTA investigations were performed using 320-row multidetector CT (Aquilion ONE, Toshiba Medical Systems, Otawara, Japan) with 320 detector rows each 0.5 mm wide and a gantry rotation time of 0.35 s. If the patient’s heart rate exceeded 65 beats/min, oral beta-blocking medication (50 or 100 mg metoprolol) was administered 1 h before examination, unless contraindicated. In addition, sublingual nitroglycerin (0.4 or 0.8 mg) was administered 5 min before the CTA investigation, if tolerated. A tri-phasic protocol for the administration intravenous contrast medium was used. The total amount of non-ionic contrast agent (Iomeron 400; Bracco, Milan, Italy) injected into the antecubital vein was 60–80 ml (depending on body weight). Patients examined using the venous graft protocol (in the presence of only venous grafts, n = 14) received 50–70 ml of contrast media at a flow rate of 5.0 or 6.0 ml/s, followed by 20 ml of 50% contrast/saline. Patients examined using an arterial graft protocol (in the presence of at least one arterial graft, n = 26) received 60–80 ml of contrast media at a flow rate of 5.0 or 6.0 ml/s, followed by 30 ml of 50% contrast/saline. Subsequently, a saline flush of 25–30 ml was administered at a flow rate of 3.0 ml/s. An automated peak enhancement detection technique was used to determine arrival of contrast agent in the left ventricle (LV) to synchronize the arrival of the contrast media and the CT data acquisition, using a threshold of +180 Hounsfield Units.
CTA images were acquired during an inspiratory breath-hold of approximately 5 s. During the CT data acquisition, the ECG was registered simultaneously for prospective triggering of the data. The phase window was set at 30–80% of the R-R interval in patients with a stable heart rate ≤65 beats/min. In patients with a heart rate >65 beats/min, CTA acquisition was performed during multiple heart beats (typically two). In patients requiring LV function measurements, image acquisition was performed during an entire R-R interval using tube current modulation. Tube voltage and current were adapted to body mass index (BMI) and thoracic anatomy as described [20]. Tube voltage ranged from 100–135 kV and maximal tube current was 400–580 mA.
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In both venous and arterial graft protocols, the heart and ascending aorta were examined in a single volume with a cranio-caudal anatomical range of 16 cm. Additionally, in patients examined using an arterial graft protocol, a second, untriggered volume was acquired, with the upper limit set at the proximal origin of the (internal mammary) arterial graft from the subclavian artery and the lower limit equal to the upper limit of the triggered volume.
An initial data set was reconstructed at 75% of R-R interval. A slice thickness of 0.50 mm was obtained and the reconstruction interval was set to 0.25 mm. If multiple phases were obtained, the cardiac phase with the least motion artifacts was used [7]. For processing and assessment, images were transferred to a remote workstation with dedicated CTA analysis software (Vitrea FX 1.0, Vital Images, Minnetonka, MN, USA). During the CTA examination the average heart rate was 62 ± 14 beats/min (range 44–99 beats/min).
Radiation dose was quantified with a dose-length product conversion factor of 0.014 mSv/(mGy × cm) as described [27]. In patients in whom the heart was examined in a single cardiac cycle, estimated mean radiation doses were 7.8 ± 3.3 mSv when LV function measurements were not performed and 11.2 ± 4.1 mSv when LV function measurements were performed.
CTA data analysis
CTA image analysis was performed by 2 observers in consensus, experienced in the evaluation of CTA and blinded to the results of ICA. Firstly, three-dimensional volume rendered reconstructions were used to obtain general information regarding the status and anatomy of the grafts and coronary arteries. Subsequently, axial slices were visually examined for the presence of significant narrowing by determining the presence of ≥50% reduction of luminal diameter and vessel occlusion [28]. The analysis was assisted by curved multiplanar reconstructions of all vessels. Data were analyzed on a vessel and patient basis. All vessels were evaluated, including those <1.5 mm in diameter. In the evaluation of a bypass graft, the distal anastomosis was regarded as part of the graft.
The recipient vessel sections distal to the graft anastomosis were regarded as separate vessels. Sections proximal to the graft anastomosis were not evaluated. However, in case a graft was occluded, patency of coronary vessel sections proximal to the site of anastomosis of the graft was also evaluated (owing to the therapeutic importance with regard to eligibility for revascularization). Of nongrafted vessels, the left anterior descending coronary artery (LAD), left circumflex coronary artery (LCx) and the right coronary artery (RCA) were assessed as separate vessels. The left main and diagonal vessels were considered to be part of the LAD. The intermediate branch and obtuse marginal branch were considered part of the LCx.
All grafts, recipient vessels and nongrafted vessels were deemed interpretable or uninterpretable. Subsequently, interpretable grafts, recipient vessels and nongrafted vessels were evaluated for the presence of significant stenosis and occlusion. Finally, patient-based analysis was performed. In case one vessel was uninterpretable, an intention to diagnose strategy was applied. However, if more than one vessel was uninterpretable, the entire examination was considered to be of non-diagnostic image quality. Subsequently, CTA investigations were evaluated for the presence of significant stenosis and occlusion. Uninterpretable grafts, recipient vessels and nongrafted vessels as well as non-diagnostic examinations were included in the analysis and considered positive for the presence of significant stenosis or occlusion.
Quantitative coronary angiography
ICA was performed according to a standard procedure using a femoral approach. Angiograms were assessed by an independent experienced observer blinded to CTA data. All grafs, recipient vessels and nongrafted vessels were visually classified as normal (no atherosclerosis or minor wall irregularities with ≤20% luminal narrowing) or abnormal (> 20% luminal narrowing). To objectively determine stenosis severity, all vessels visually scored as abnormal were quantified using a dedicated and validated quantitative coronary angiography software package (QAngioXA 6.0, CA-CMS, Medis Medical Imaging Systems, Leiden, The Netherlands). Quantitative coronary angiography was performed according to standardized methods [29, 30]. All vessels were evaluated for the presence of significant (≥50%) stenosis in the angiographic view with most severe luminal narrowing. Figure 1 shows an example of a significant stenosis in a venous graft on CTA and confirmed on quantitative coronary angiography.
Fig. 1
An example of a significant stenosis in a venous graft visualized using 320-slice CTA and confirmed on quantitative coronary angiography. A significant lesion in the proximal venous graft supplying the OM and PLCx was identified on CTA. A) Curved multiplanar reconstruction depicting a severe lesion in the proximal graft (arrow). B) Enlarged curved multiplanar reconstruction of the proximal graft and lesion (arrow) showing significant luminal narrowing. C) The findings were confirmed on ICA. D) Quantitative coronary angiography analysis demonstrating 55% luminal narrowing (arrow). Abbreviations: CTA: computed tomography coronary angiography. ICA: invasive coronary angiography. OM: obtuse marginal branch. PLCx: posterolateral branch of the left circumflex coronary artery
×
Statistical analysis
CTA data were compared to ICA analyses. Data were analyzed on a vessel and patient basis. Sensitivity, specificity and positive and negative predictive values, including 95% confidence intervals (CI), for the detection of significant stenosis and occlusion on ICA were calculated for all vessels. Continuous data were expressed as mean ± SD. A value of p < 0.05 was considered statistically significant and all reported p-values were two-sided. Statistical analyses were performed using SPSS software version 16 (SPSS, Inc., Chicago, Illinois).
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Results
Patient population
A total of 40 patients were eligible for CTA and were included in the study. The clinical baseline characteristics of the patient population are shown in Table 1. CTA examinations were successfully completed in 38 patients. One CTA examination was of non-diagnostic image quality due image degradation related to motion artifacts in a patient with a heart rate of 93 beats/min during image acquisition. A second CTA examination was rendered non-diagnostic due to image noise. As a result, 38 patients with a mean of 2.3 ± 1.0 grafts (range 1–6) and a mean of 3.4 ± 1.5 anastomoses (range 1–8) were available for vessel-based analysis. A total of 89 grafts were available for evaluation (28 arterial grafts and 61 venous grafts). Graft characteristics are summarized in Table 2.
Table 2
Graft characteristics
Total number of grafts
89
Single arterial grafts
18 (20%)
Sequential arterial grafts
10 (11%)
Single venous grafts
38 (43%)
Sequential venous grafts
23 (26%)
Total number of nongrafted vessels
26
LAD
4 (15%)
LCx
6 (23%)
RCA
16 (62%)
Total number of anastomosis
129
LADa
60 (46%)
LCxa
45 (35%)
RCAa
24 (19%)
aDenotes vessel territory
Values in parentheses are percentages
LAD left anterior descending coronary artery. LCx left circumflex coronary artery. RCA right coronary artery
Detection of significant graft and coronary stenosis
On ICA, 89 grafts were available for evaluation. A total of 26 grafts had a significant stenosis on ICA. Two grafts (2.2%) were of non-diagnostic image quality on CTA and considered positive for the presence of significant stenosis. Both grafts were arterial grafts which were rendered non-diagnostic due to clip-artifacts. CTA accurately detected 25 grafts with significant stenosis. However, in 5 grafts stenosis severity was overestimated whereas 1 graft was incorrectly identified as having non-significant stenosis. Table 3 shows the diagnostic accuracy of 320-slice CTA in the detection of significant graft stenosis. Figures 2 and 3 show examples of 320-slice CTA investigations of patients with a patent venous and arterial graft, respectively.
Table 3
Diagnostic accuracy of 320-slice CTA for the detection of significant stenosis in grafts, recipient vessels and nongrafted vessels
Vessel Type
Non-diagnostic
Sensitivity
Specificity
PPV
NPV
Diagnostic accuracy
All grafts
2/89 (2.2%)
25/26 (96%, 89%–100%)
58/63 (92%, 85%–99%)
25/30 (83%, 70%–97%)
58/59 (98%, 95%–100%)
83/89 (93%, 88%–98%)
Arterial grafts
2/28 (7.1%)
5/5 (100%)
21/23 (91%, 80%–100%)
5/7 (71%, 38%–100%)
21/21 (100%)
26/28 (93%, 83%–100%)
Venous grafts
–
20/21 (95%, 86%–100%)
37/40 (93%, 84%–100%)
20/23 (87%, 73%–10%)
37/38 (97%, 92%–100%)
57/61 (93%, 87%–100%)
Recipient Vessels
9/127 (7.1%)
22/25 (88%, 75%–100%)
91/102 (89%, 83%–95%)
22/33 (67%, 51%–83%)
91/94 (97%, 93%–100%)
113/127 (89%, 84%–94%)
Nongrafted Vessels
1/25 (4.0%)
10/12 (83%, 62%–100%)
10/13 (77%, 54%–100%)
10/13 (77%, 54%–100%)
10/12 (83%, 62%–100%)
20/25 (80%, 64%–96%)
Data are absolute values used to calculate percentages. Data in parenthesis are percentages with 95% CI. Uninterpretable vessels were included in the analysis and considered positive for the presence of significant stenosis.
CI confidence interval. CTA computed tomography coronary angiography. ICA invasive coronary angiography. NPV negative predictive value. PPV positive predictive value
Fig. 2
Example of 320-slice CTA of a 75 year-old man with a history of CABG and PCI. Panel A shows a three-dimensional volume rendered reconstruction of the heart. A single venous graft is shown with an anastomosis on the IM (arrowhead). The LAD is functionally occluded (arrow). Panel B shows a curved multiplanar reconstruction, revealing a diseased native IM, with a severely calcified lesion at the origin (long arrow) and small vessel caliber. Furthermore, a patent stent in the LM is observed. In panel C, a curved multiplanar reconstruction of the venous graft is shown revealing proximal luminal narrowing (long arrow). Two patent stents are identified in the venous graft (short arrows), without the presence of in-stent restenosis. Additionally, a patent anastomosis with the IM is shown (arrowhead) with good distal runoff and a non-significant calcified lesion. In addition, signs of an old myocardial infarction are observed, with calcifications in the anteroseptal, anterior apical and midventricular myocardium (*). Graft and anastomosis (arrowhead) patency as well as good distal runoff in the IM were confirmed on ICA (panel D). Abbreviations: CABG: coronary artery bypass grafting. CTA: computed tomography coronary angiography. ICA: invasive coronary angiography. IM: intermediate branch. LAD: left anterior descending coronary artery. LM: left main artery. PCI: percutaneous coronary intervention
Fig. 3
Example of 320-slice CTA of an arterial graft in a 74 year-old man who underwent CABG 7 years ago. Panel A shows a three-dimensional volume rendered reconstruction of the heart, and bypass trajectory. An arterial graft is visible, with anastomoses to the D1 and LAD. Panel B shows the curved multiplanar reconstruction of a patent graft without the presence of significant graft stenosis. A patent anastomosis is observed (arrowhead) with good runoff in the distal LAD. In Panel C, the curved multiplanar reconstruction of a heavily diseased LAD is shown, with severe stenosis of the proximal LAD (arrow). In Panel D, a curved multiplanar reconstruction of the arterial graft and D1 are shown. The anastomosis of the graft to the patent D1 is uninterpretable due to a dense calcification. In Panel E and F the concordant ICA examinations are shown, confirming graft and vessel patency. Abbreviations: CABG: coronary artery bypass grafting. CTA: computed tomography coronary angiography. D1: first diagonal branch. ICA: invasive coronary angiography. LAD: left anterior descending coronary artery
×
×
A total of 127 recipient vessels were available for evaluation as 2 recipient vessels of obstructed grafts were not visualized on ICA. Nine recipient vessels (7.1%) were of non-diagnostic image quality on CTA and considered positive. CTA correctly identified 22 significant recipient vessel stenoses. A total of 3 significant recipient vessel stenoses were underestimated by CTA while 11 recipient vessels were incorrectly deemed significant. Table 3 shows the diagnostic accuracy of 320-slice CTA in the detection of significant recipient vessel stenosis.
On ICA, 25 nongrafted vessels were assessed, with a total of 12 significant stenoses. One nongrafted vessel was not available on ICA. On CTA, one nongrafted vessel (4.0%) was of non-diagnostic image quality and considered positive. Ten significant nongrafted vessel stenoses were accurately detected by CTA. However, 2 nongrafted vessels were incorrectly deemed non-significant while the degree of stenosis in 3 nongrafted vessels was overestimated. Table 3 shows an overview of the diagnostic accuracy of 320-slice CTA in the detection of significant nongrafted vessel stenosis.
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Detection of graft and coronary occlusion
Of 89 grafts available on ICA, 23 grafts (25.8%) were occluded. CTA accurately identified all graft occlusions while 4 grafts were incorrectly deemed occluded. Table 4 shows an overview of the diagnostic accuracy of 320-slice CTA in the detection of grafts occlusion. Figure 4 shows an example of an occluded venous graft visualized using 320-slice CTA.
Table 4
Diagnostic accuracy of 320-slice CTA for the detection of occlusion in grafts, recipient vessels and nongrafted vessels
Vessel Type
Non-diagnostic
Sensitivity
Specificity
PPV
NPV
Diagnostic accuracy
All grafts
2/89 (2.2%)
23/23 (100%)
62/66 (94%, 88%–100%)
23/27 (85%, 72%–99%)
62/62 (100%)
85/89 (96%, 55%–75%)
Arterial grafts
2/28 (7.1%)
5/5 (100%)
21/23 (91%, 80%–100%)
5/7 (71%, 38%–100%)
21/21 (100%)
26/28 (93%, 83%–100%)
Venous grafts
–
18/18 (100%)
41/43 (95%, 89–100)
18/20 (90%, 77%–100%)
41/41 (100%)
59/61 (97%, 92%–100%)
Recipient Vessels
9/127 (7.1%)
11/11 (100%)
106/116 (91%, 86%–96%)
11/21 (52%, 31%–74%)
106/106 (100%)
117/127 (92%, 87%–97%)
Nongrafted Vessels
1/25 (4.0%)
6/6 (100%)
19/19 (100%)
6/6 (100%)
19/19 (100%)
25/25 (100%)
Data are absolute values used to calculate percentages. Data in parenthesis are percentages with 95% CI. Uninterpretable vessels were included in the analysis and considered positive for the presence of occlusion.
CI confidence interval. CTA computed tomography coronary angiography. ICA invasive coronary angiography. NPV negative predictive value. PPV positive predictive value
Fig. 4
Example of 320-slice CTA of an occluded venous graft in a 79 year-old man who underwent CABG 25 years ago. Panel A shows a three-dimensional volume rendered reconstruction of the heart. A venous graft is shown, with anastomoses to the MO, PLCx and PDA. Two stents are present in the distal graft (arrow). Panel B shows a curved multiplanar reconstruction indicating the presence of a graft occlusion in the stented distal graft, immediately before the anastomosis to the RDP. The graft occlusion was confirmed on ICA (arrow, Panel C). Abbreviations: CABG: coronary artery bypass grafting. CTA: computed tomography coronary angiography. ICA: invasive coronary angiography. OM: obtuse marginal branch. PDA: posterior descending coronary artery. PLCx: posterolateral branch of the left circumflex coronary artery
×
In 127 recipient vessels eligible for evaluation, 11 occluded vessels were identified on ICA. CTA correctly identified all occluded recipient vessels while a total of 10 vessels were inaccurately judged to be occluded. The diagnostic accuracy for the detection of recipient vessel occlusion is shown in Table 4.
On ICA, 25 nongrafted vessels were assessed, with a total of 6 nongrafted vessel occlusions. No nongrafted vessel occlusions were missed or incorrectly identified on CTA. Table 4 shows an overview of the diagnostic accuracy of 320-slice CTA in the detection of nongrafted vessel occlusion.
Patient-based analysis
A total of 40 patients were available for analysis on ICA. However, in 2 patients (5.0%) CT was of of non-diagnostic image quality, and considered positive for the presence of significant stenosis. A total of 32 patients with a significant graft or coronary stenosis were identified on ICA. On CTA, 3 patients were incorrectly diagnosed with significant stenosis. In 1 patient, the recipient LAD of a sequential arterial graft was incorrectly judged obstructed. In a second patient, the anastomosis of a sequential venous graft to the first diagonal branch was inaccurately deemed occluded. In a third patient, the examination was of non-diagnostic quality and therefore considered positive for the presence of significant stenosis. Of the remaining patients, CTA correctly excluded the presence of significant stenosis in 5 patients, while 30 patients were accurately diagnosed with significant graft, recipient vessel or nongrafted vessel stenosis. Accordingly, on a patient basis, the sensitivity, specificity, positive and negative predictive values were 94%, 62%, 91% and 71%, respectively. As a result, the diagnostic accuracy was 88%.
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Discussion
The present investigation demonstrated good diagnostic accuracy of 320-slice CTA in the evaluation of significant graft, recipient and nongrafted vessel stenosis and occlusion in patients with prior CABG.
Detection of graft and native vessel stenosis
The current findings showed high diagnostic accuracy in the detection of significant graft stenosis and occlusion using 320-slice CTA. Importantly, only 2% of grafts were uninterpretable. Diagnostic accuracy in the detection native vessel stenosis was slightly lower as compared to the evaluation of grafts, mainly due to lower positive predictive values.
The current results compare favorably with prior data obtained with previous generations, including 64-slice CTA. Although the diagnostic performance for 320-slice CTA was not higher than that reported by prior diagnostic accuracy studies for 64-slice CTA[31], in the present analysis non-diagnostic vessels and scans were included. In addition all segments (including mall segments (<1.5 mm)) were included in the analysis. In many other prior diagnostic accuracy studies segments <1.5 mm as well as non-diagnostic vessels were excluded from the analysis, thereby increasing the reported diagnostic accuracy. Nevertheless, although graft evaluation was good, also in the current study the assessment of native vessels remained challenging [32, 33]. To a large extent, this observed difference in diagnostic performance may be attributed to the fact that patients with prior CABG are generally older with longstanding CAD and thus more advanced and calcified CAD in both distal runoff and native coronary arteries [18, 32, 34]. Indeed, Ropers et al., assessing 50 patients with a total of 138 grafts using 64-row CTA, reported that the diagnostic accuracy in the assessment of recipient and nongrafted vessels was considerably lower (85% and 73% respectively) as compared to the performance in grafts (96%) on a per segment basis [32]. Although diagnostic accuracy in the evaluation of grafts was good, 9% of nongrafted vessels were nondiagnostic, even while small segments (<1.5 mm) were excluded from analysis [32]. Moreover, in a study by Malagutti et al. performing 64-row CTA in 52 symptomatic patients with a total of 109 grafts, while the performance of CTA for graft assessment was good (98% on a patient basis), nongrafted coronary stenosis was overestimated in 8 out of 19 patients without significant CAD yielding a low positive predictive value of 42% [33]. The current study showed superior results, especially taking into account that small and uninterpretable vessels were included in the analysis. Consistent with what has been previously reported however [20, 21], the diagnostic performance of 320-slice CTA for the detection of significant stenosis in native coronary arteries in patients with prior CABG remained lower than in patients without prior CABG [20, 22].
Slightly higher diagnostic accuracy for the evaluation of grafts and native vessels has been reported with other novel CTA technologies. Weustink et al., using dual-source CTA in 52 patients with prior CABG, reported excellent diagnostic accuracy in the evaluation of patients with a history of CABG, with a diagnostic accuracy of 100% in the evaluation of graft stenosis on a segment basis [35]. The high diagnostic accuracy may be partly contributed to the superior temporal resolution of dual-source CTA. Importantly, it is further explained by the fact that average patient age was 10 years younger than the present population and average duration of graft implantation was shorter (9.6 years vs 16.3 years in the present study). Considering the fact that older patients with longstanding graft implantation tend to have more advanced CAD and heavy calcifications, it is conceivable that the impact of these patient characteristics on image quality and diagnostic performance of CTA may have been substantial. Furthermore, small segments (<1.5 mm) and non-diagnostic segments (2%) were excluded from analysis in the study by Weustink et al., while these were included in the present investigation.
Volumetric 320-slice CTA
Volumetric imaging offers several advantages as compared to helical or step-and-shoot techniques. First, volumetric data acquisition reduces patient radiation burden, as it eliminates helical oversampling [21, 36, 37]. At present, owing to novel technology, radiation exposure for CTA in the general population referred for CTA may be equivalent to or lower than diagnostic ICA [38]. Preliminary results showed that radiation dose below 5 mSv can be achieved in patient without known CAD, using 320-slice CTA with a heart rate below 65 beats/min [20, 39]. However, in patients with prior CABG, CTA radiation exposure is generally higher than in patients evaluated for the exclusion of CAD [20], since the enlarged anatomical range covers the entire bypass trajectory. Novel developments in 320-slice CTA protocols or other technologies, such as high-pitch spiral CTA may indeed further reduce radiation exposure [40, 41]. A second advantage of volumetric imaging using 320-slice CTA is that the contrast load is reduced, due to a small data acquisition window, which is a particular advantage to patients with prior CABG, in whom reduced renal function is prevalent [42]. Furthermore, the short time of breath-hold reduces the problem of respiratory motion artifacts, which is of particularly benefit in patients of more advanced age (such as CABG patients) who may be unable to perform extended breath-holds.
Clinical implications
Although ICA remains the gold standard for the evaluation of patients with prior CABG, in patients in whom only graft visualization is required (for instance following failed invasive imaging or equivocal functional test results) CTA may omit the need for (repeat) ICA. CTA may furthermore be a useful alternative in patients in whom ICA is preferably avoided due to a higher risk of procedural complications. In addition, in patients with a history of CABG, CTA may aid planning of subsequent percutaneous coronary intervention by providing detailed anatomical information, thereby shortening the time of procedure, contrast load and radiation burden [43]. CTA may also be useful for presurgical evaluation in patients undergoing reoperative cardiac surgery [44]. Moreover, CTA enables the rapid and comprehensive representation of complex graft anatomy and could thus be used in patients with an incomplete surgical history, in whom precise graft anatomy is unknown. Accordingly, in clinical practice CTA may be used as a noninvasive alternative to ICA in carefully selected patients. The precise role of CTA in clinical practice for the assessment of patients with a history of CABG merits further investigation.
Limitations
Several limitations of the present study merit further consideration. First, CTA is inherently associated with radiation exposure [45]. Still, radiation dose reported in the present study was relatively high as compared to other 320-slice CT studies in which patients without prior CABG were evaluated [20]. Optimizing scan protocols for individual patients is relevant. In the present study, a relatively large (30–80%) RR interval was used for image acquisition to optimize image quality. Patients with bypasses typically have heavily diseased native coronary arteries [34]. Good image quality is especially needed for evaluation of these poor quality native arteries, as well as for evaluating distal bypass anastomoses, which are small structures. Moreover, the extra rotation up to the subclavian arteries in patients with arterial bypasses increased radiation dose.
Although 320-slice CTA is associated with patient radiation and contrast exposure, referral for ICA may expose patients to even higher doses of radiation and contrast material, particularly in the case of patients with prior CABG. Although comparison in patients with prior CABG is lacking, CTA radiation doses equal or lower than that of diagnostic ICA have been reported in the general population referred for ICA [38, 46]. Second, in certain cases, results of CTA investigation may have resulted in patient referral for ICA. Third, the present study group was not a randomly selected patient cohort. While the direct study of randomly selected patients with a history of CABG is currently not feasible due to lack of indication for CTA, the present investigation represents an adequate pilot study. Furthermore, the present investigation is limited by a small study population and additional investigations in larger patient cohort and preferably in a multi-center setting are preferred. Last, an important limitation of CTA remains the evaluation native vessels due to decreased performance in the presence of dense calcified plaque or small coronary branches.
Conclusion
The present investigation demonstrated a good diagnostic accuracy of 320-slice CTA for the non-invasive evaluation of venous and arterial grafts. In addition, recipient vessels and nongrafted vessels may be evaluated with fair diagnostic accuracy, although the assessment of small coronary branches and heavily calcified vessels remains challenging. Nevertheless, in selected cases, CTA my potentially aid the work up of patients with prior CABG.
Acknowledgements
Dr. de Graaf is co-supported by the Dutch Technology Foundation STW (Utrecht, the Netherlands), applied science division of NWO and the Technology Program of the Ministry of Economic Affairs, grant nr. 10084. Dr. van Velzen is supported by the Netherlands Heart Foundation (The Hague, The Netherlands), grant nr 2007B223. Dr. Bax has research grants from Medtronic (Minneapolis, United States), Boston Scientific (Natick, United States), BMS medical imaging (New York, United States), St. Jude Medical (St. Paul, United States), GE Healthcare (Chalfont St Giles, United Kingdom), Biotronik (Berlin, Germany), and Edwards Lifesciences (Irvine, United States). Dr. Jukema has research grants from and was speaker on (CME accredited) meetings sponsored by Astellas (Tokyo, Japan), Astra-Zeneca (London, United Kingdom), Biotronik (Berlin, Germany), Boston Scientific (Natick, United States), Bristol Myers Squibb (New York, United States), Cordis (Roden, Netherlands), Daiichi Sankyo (Tokyo, Japan), Ely Lilly (Indianapolis, United States), Medtronic (Minneapolis, United States), Merck-Schering-Plough (Whitehouse Station, United States), Pfizer (Groton/New London, United States), Orbus Neich (Hong Kong, China), Novartis (Basel, Switserland), Roche (Basel, Switserland), Servier (Neuilly-sur-Seine, France).
Open Access
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Open AccessThis is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
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Diagnostic performance of 320-slice multidetector computed tomography coronary angiography in patients after coronary artery bypass grafting
verfasst von
Fleur R. de Graaf Joëlla E. van Velzen Agnieszka J. Witkowska Joanne D. Schuijf Noortje van der Bijl Lucia J. Kroft Albert de Roos Johan H. C. Reiber Jeroen J. Bax Greetje J. de Grooth J. Wouter Jukema Ernst E. van der Wall
