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21.06.2017 | Neuro

Evaluating anorexia-related brain atrophy using MP2RAGE-based morphometry

verfasst von: José Boto, Georgios Gkinis, Alexis Roche, Tobias Kober, Bénédicte Maréchal, Nadia Ortiz, Karl-Olof Lövblad, François Lazeyras, Maria Isabel Vargas

Erschienen in: European Radiology | Ausgabe 12/2017

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Abstract

Aim

To evaluate brain atrophy in anorexic patients by automated cerebral segmentation with the magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) MRI sequence.

Material and methods

Twenty patients (female; mean age, 27.9 years), presenting consecutively for brain MRI between August 2014–December 2016 with clinical suspicion of anorexia nervosa and BMI<18.5 kg/m² were included. Controls were ten healthy females (mean age, 26.5 years). Automated brain morphometry was performed based on MP2RAGE. Means of morphometric results in the two groups were compared and correlation with BMI was analysed.

Results

Significantly lower volumes of total brain, grey matter (GM), white matter (WM), cerebellum and insula were found in anorexic patients. Anorexics had higher volumes of CSF, ventricles, lateral ventricles and third ventricle. When adjusted means for weight and height were compared, the volume of WM and cerebellum were not significantly different. However, volume of WM was significantly affected by weight and positively correlated with BMI. Significant positive correlations were found between BMI and volumes of total brain, GM, cortical GM and WM. BMI was negatively correlated with volumes of CSF and third ventricle.

Conclusion

Brain atrophy was demonstrated in anorexic patients with MP2RAGE-based automated segmentation, which seems to reliably estimate brain volume.

Key points

• Automated brain segmentation based on 3-D MRI seems to reliably estimate brain volume.

• This technique detected brain atrophy in patients suffering from anorexia nervosa.

• Brain changes in anorexia nervosa can be quantitatively and qualitatively followed-up by MRI.

Swanson SA, Crow SJ, Le Grange D, Swendsen J, Merikangas KR (2011) Prevalence and correlates of eating disorders in adolescents. Results from the national comorbidity survey replication adolescent supplement. Arch Gen Psychiatry 68:714–723CrossRefPubMedPubMedCentral

Legenbauer T, Herpertz S (2008) Eating disorders--diagnosis and treatment. Dtsch Med Wochenschr 133:961–965CrossRefPubMed

The ICD-10 Classification of Mental and Behavioural Disorders.

(2017) Body mass index - BMI. WHO/Europe.

Addolorato G, Taranto C, Capristo E, Gasbarrini G (1998) A case of marked cerebellar atrophy in a woman with anorexia nervosa and cerebral atrophy and a review of the literature. Int J Eat Disord 24:443–447CrossRefPubMed

Amianto F, Caroppo P, D'Agata F, Spalatro A, Lavagnino L, Caglio M et al (2013) Brain volumetric abnormalities in patients with anorexia and bulimia nervosa: a voxel-based morphometry study. Psychiatry Res 213:210–216CrossRefPubMed

Hoffman GW, Ellinwood EH, Rockwell WJ, Herfkens RJ, Nishita JK, Guthrie LF (1989) Cerebral atrophy in anorexia nervosa: a pilot study. Biol Psychiatry 26:321–324CrossRefPubMed

Inui A, Asakawa A, Kasuga M, Kamikawa S, Uemoto M, Watanabe T (2002) Paracentral cortical atrophy in patients with eating disorders. Am J Med 112:681–683CrossRefPubMed

Katzman DK, Lambe EK, Mikulis DJ, Ridgley JN, Goldbloom DS, Zipursky RB (1996) Cerebral gray matter and white matter volume deficits in adolescent girls with anorexia nervosa. J Pediatr 129:794–803CrossRefPubMed

10.

Mühlau M, Gaser C, Ilg R, Conrad B, Leibl C, Cebulla MH et al (2007) Gray matter decrease of the anterior cingulate cortex in anorexia nervosa. Am J Psychiatry 164:1850–1857CrossRefPubMed

11.

Seitz J, Bühren K, von Polier GG, Heussen N, Herpertz-Dahlmann B, Konrad K (2014) Morphological changes in the brain of acutely ill and weight-recovered patients with anorexia nervosa. A meta-analysis and qualitative review. Z Kinder Jugendpsychiatr Psychother 42:7–17, quiz 17–18

12.

Swayze VW, Andersen AE, Andreasen NC, Arndt S, Sato Y, Ziebell S (2003) Brain tissue volume segmentation in patients with anorexia nervosa before and after weight normalization. Int J Eat Disord 33:33–44CrossRefPubMed

13.

Bernardoni F, King JA, Geisler D, Stein E, Jaite C, Nätsch D et al (2016) Weight restoration therapy rapidly reverses cortical thinning in anorexia nervosa: A longitudinal study. Neuroimage 130:214–222CrossRefPubMed

14.

Solstrand Dahlberg L, Wiemerslage L, Swenne I, Larsen A, Stark J, Rask-Andersen M, Salonen-Ros H, Larsson EM, Schiöth HB, Brooks SJ (2016) Adolescents newly diagnosed with eating disorders have structural differences in brain regions linked with eating disorder symptoms. Nord J Psychiatry:1–9.

15.

Fonville L, Giampietro V, Williams SC, Simmons A, Tchanturia K (2014) Alterations in brain structure in adults with anorexia nervosa and the impact of illness duration. Psychol Med 44:1965–1975CrossRefPubMed

16.

Boghi A, Sterpone S, Sales S, D'Agata F, Bradac GB, Zullo G et al (2011) In vivo evidence of global and focal brain alterations in anorexia nervosa. Psychiatry Res 192:154–159CrossRefPubMed

17.

Rinholm JE, Vervaeke K, Tadross MR, Tkachuk AN, Kopek BG, Brown TA et al (2016) Movement and structure of mitochondria in oligodendrocytes and their myelin sheaths. Glia 64:810–825CrossRefPubMed

18.

Husain MM, Black KJ, Doraiswamy PM, Shah SA, Rockwell WJ, Ellinwood EH Jr et al (1992) Subcortical brain anatomy in anorexia and bulimia. Biol Psychiatry 31:735–738CrossRefPubMed

19.

Kingston K, Szmukler G, Andrewes D, Tress B, Desmond P (1996) Neuropsychological and structural brain changes in anorexia nervosa before and after refeeding. Psychol Med 26:15–28CrossRefPubMed

20.

Vargas MI, Lenz V, Bin JF, Bogorin A, Abu Eid M, Jacques C et al (2003) Brain MR imaging of chronic alcoholism. J Radiol 84:369–379PubMed

21.

Golden NH, Ashtari M, Kohn MR, Patel M, Jacobson MS, Fletcher A et al (1996) Reversibility of cerebral ventricular enlargement in anorexia nervosa, demonstrated by quantitative magnetic resonance imaging. J Pediatr 128:296–301CrossRefPubMed

22.

Katzman DK, Zipursky RB, Lambe EK, Mikulis DJ (1997) A longitudinal magnetic resonance imaging study of brain changes in adolescents with anorexia nervosa. Arch Pediatr Adolesc Med 151:793–797CrossRefPubMed

23.

Lambe EK, Katzman DK, Mikulis DJ, Kennedy SH, Zipursky RB (1997) Cerebral gray matter volume deficits after weight recovery from anorexia nervosa. Arch Gen Psychiatry 54:537–542CrossRefPubMed

24.

Wagner A, Greer P, Bailer UF, Frank GK, Henry SE, Putnam K et al (2006) Normal brain tissue volumes after long-term recovery in anorexia and bulimia nervosa. Biol Psychiatry 59:291–293CrossRefPubMed

25.

Katzman DK, Christensen B, Young AR, Zipursky RB (2001) Starving the brain: structural abnormalities and cognitive impairment in adolescents with anorexia nervosa. Semin Clin Neuropsychiatry 6:146–152CrossRefPubMed

26.

Ashburner J, Friston KJ (2000) Voxel-based morphometry--the methods. Neuroimage 11:805–821CrossRefPubMed

27.

Good CD, Johnsrude I, Ashburner J, Henson RN, Friston KJ, Frackowiak RS (2001) Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage 14:685–700CrossRefPubMed

28.

Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS (2001) A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14:21–36CrossRefPubMed

29.

Schmitter D, Roche A, Maréchal B, Ribes D, Abdulkadir A, Bach-Cuadra M et al (2015) An evaluation of volume-based morphometry for prediction of mild cognitive impairment and Alzheimer's disease. Neuroimage Clin 7:7–17CrossRefPubMed

30.

Fujimoto K, Polimeni JR, van der Kouwe AJ, Reuter M, Kober T, Benner T et al (2014) Quantitative comparison of cortical surface reconstructions from MP2RAGE and multi-echo MPRAGE data at 3 and 7 T. Neuroimage 90:60–73CrossRefPubMed

31.

Næss-Schmidt E, Tietze A, Blicher JU, Petersen M, Mikkelsen IK, Coupé P et al (2016) Automatic thalamus and hippocampus segmentation from MP2RAGE: comparison of publicly available methods and implications for DTI quantification. Int J Comput Assist Radiol Surg 11:1979–1991CrossRefPubMed

32.

Streitbürger DP, Pampel A, Krueger G, Lepsien J, Schroeter ML, Mueller K et al (2014) Impact of image acquisition on voxel-based-morphometry investigations of age-related structural brain changes. Neuroimage 87:170–182CrossRefPubMed

33.

Marques JP, Kober T, Krueger G, van der Zwaag W, Van de Moortele PF, Gruetter R (2010) MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field. Neuroimage 49:1271–1281CrossRefPubMed

34.

Sugimoto T, Murata T, Omori M, Wada Y (2003) Central pontine myelinolysis associated with hypokalaemia in anorexia nervosa. J Neurol Neurosurg Psychiatry 74:353–355CrossRefPubMedPubMedCentral

35.

(2013) IBM SPSS Statistics for Windows. IBM Corp, Armonk, NY.

36.

Gold PW, Gwirtsman H, Avgerinos PC, Nieman LK, Gallucci WT, Kaye W et al (1986) Abnormal hypothalamic-pituitary-adrenal function in anorexia nervosa. Pathophysiologic mechanisms in underweight and weight-corrected patients. N Engl J Med 314:1335–1342CrossRefPubMed

37.

Counts DR, Gwirtsman H, Carlsson LM, Lesem M, Cutler GB (1992) The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins. J Clin Endocrinol Metab 75:762–767PubMed

38.

Brooks SJ, Rask-Andersen M, Benedict C, Schioth HB (2012) A debate on current eating disorder diagnoses in light of neurobiological findings: is it time for a spectrum model? BMC Psychiatry 12:76CrossRefPubMedPubMedCentral

39.

Solstrand Dahlberg L, Wiemerslage L, Swenne I, Larsen A, Stark J, Rask-Andersen M et al (2017) Adolescents newly diagnosed with eating disorders have structural differences in brain regions linked with eating disorder symptoms. Nord J Psychiatry 71:188–196CrossRefPubMed

40.

Schmahmann JD, Weilburg JB, Sherman JC (2007) The neuropsychiatry of the cerebellum – insights from the clinic. Cerebellum 6:254–267CrossRefPubMed

41.

Mokri B (2001) The Monro-Kellie hypothesis: applications in CSF volume depletion. Neurology 56:1746–1748CrossRefPubMed

42.

Okubo G, Okada T, Yamamoto A, Kanagaki M, Fushimi Y, Murata K et al (2016) MP2RAGE for deep gray matter measurement of the brain: A comparative study with MPRAGE. J Magn Reson Imaging 43:55–62CrossRefPubMed

43.

O'Brien KR, Kober T, Hagmann P, Maeder P, Marques J, Lazeyras F et al (2014) Robust T1-weighted structural brain imaging and morphometry at 7T using MP2RAGE. PLoS One 9:e99676CrossRefPubMedPubMedCentral

44.

Fartaria MJ, Bonnier G, Roche A, Kober T, Meuli R, Rotzinger D et al (2016) Automated detection of white matter and cortical lesions in early stages of multiple sclerosis. J Magn Reson Imaging 43:1445–1454CrossRefPubMed

Titel: Evaluating anorexia-related brain atrophy using MP2RAGE-based morphometry
verfasst von: José Boto
Georgios Gkinis
Alexis Roche
Tobias Kober
Bénédicte Maréchal
Nadia Ortiz
Karl-Olof Lövblad
François Lazeyras
Maria Isabel Vargas
Publikationsdatum: 21.06.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 12/2017
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-4914-9

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Evaluating anorexia-related brain atrophy using MP2RAGE-based morphometry

Abstract