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Cognitive Therapy and Research

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01.12.2013 | Original Article

Is Performance on the Go/Nogo Task Related to Not Just Right Experiences in Patients with Obsessive Compulsive Disorder?

verfasst von: Marta Ghisi, Gioia Bottesi, Claudio Sica, Ezio Sanavio, Mark H. Freeston

Erschienen in: Cognitive Therapy and Research | Ausgabe 6/2013

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Abstract

Patients with obsessive compulsive disorder (OCD) generally show difficulties in suppressing obsessions and compulsions. Evidence suggests deficits in motor inhibition ability in OCD patients but studies using Go/Nogo paradigms show mixed results. Not just right experiences (NJREs) have been proposed to be involved in difficulties terminating compulsions. This study assesses the relationship between NJREs and Go/Nogo performance among OCD patients. Twenty-two OCD patients and 22 healthy controls matched on age, gender and education completed a battery of self-report questionnaires and a Go/Nogo task. An association was found between higher NJRE severity and slower reaction times. There was no association between OCD severity and Go/Nogo performance. OCD patients made more commission errors than healthy controls, but there were no differences on omission errors and reaction times for Go and Nogo trials. The current study supports a possible role of NJREs in the slowness characterizing OCD performance and appears promising from both theoretical and empirical perspectives.

Although ANCOVA is commonly used to control for clinical characteristics such as anxiety and depression, it fits a regression line to the entire sample. When there are known differences between the groups, the major contributor to this line may be the group difference rather than the within group variability. Using a covariate under these circumstances will underestimate the group effect on the dependent variables. Further, within the OCD group, performance was not related to anxiety and depression (or OCD severity), so partialling anxiety and depression would mainly remove group differences, not within group variance. Finally, although there are circumstances when it may be of interest to ask the “what if” question that ANCOVA can ask, asking what people with OCD were like if they were not also anxious and depressed (or had OCD symptoms) is a question of no relevance in the real world: Anxiety and depression (and OCD symptoms) are associated features of OCD, not confounds. The same argument applies to NJRE, which resulted to be a feature associated with OCD.

If groups are matched on anxiety and depression, then ANCOVA becomes a viable option.

Abramovitch, A., Dar, R., Hermesh, H., & Schweiger, A. (2012). Comparative neuropsychology of adult obsessive-compulsive disorder and attention deficit/hyperactivity disorder: Implications for a novel executive overload model of OCD. Journal of Neuropsychology, 6, 161–191.PubMedCrossRef

American Psychiatric Association. (2000). DSM–IV–TR, diagnostic and statistical manual of mental disorders, fourth edition, text revision. Washington (DC): Author.CrossRef

Antony, M. M., Purdon, C. L., Huta, V., & Swinson, R. P. (1998). Dimensions of perfectionism across the anxiety disorders. Behaviour Research and Therapy, 36, 1143–1154.PubMedCrossRef

Aron, A. R. (2007). The neural basis of inhibition in cognitive control. Neuroscientist, 13, 214–228.PubMedCrossRef

Aron, A. R., Fletcher, P. C., Bullmore, E. T., Sahakian, B. J., & Robbins, T. W. (2003). Neuropsychological functions in obsessive compulsive disorder: Effects of comorbid conditions on task performance. European Psychiatry, 18, 241–248.CrossRef

Aycicegi, A., Dinn, W. M., Harris, C. L., & Erkmen, H. (2003). Neuropsychological function in obsessive-compulsive disorder: Effects of comorbid conditions on task performance. European Psychiatry, 18, 241–248.PubMedCrossRef

Bannon, S., Gonsalvez, C. J., Croft, R. J., & Boyce, P. M. (2002). Response inhibition in obsessive-compulsive disorder. Psychiatry Research, 110, 165–174.PubMedCrossRef

Bannon, S., Gonsalvez, C. J., Croft, R. J., & Boyce, P. M. (2006). Executive functions in obsessive-compulsive disorder: State or trait deficits? Australian and New Zeeland Journal of Psychiatry, 40, 1031–1038.

Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893–897.PubMedCrossRef

Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Beck depression inventory second edition manual. San Antonio: The Psychological Corporation Harcourt Brace & Company.

Bobes, J., Gonzalez, M. P., Bascaran, M. T., Arango, C., Saiz, P. A., & Bousono, M. (2001). Quality of life in patients with obsessive-compulsive disorder. European Psychiatry, 16, 239–245.PubMedCrossRef

Bohne, A., Savage, C. R., Deckersbach, T., Keuthen, N. J., & Wilhelm, S. (2008). Motor inhibition in trichotillomania and obsessive-compulsive disorder. Journal of Psychiatric Research, 42, 141–150.PubMedCrossRef

Chamberlain, S. R., Blackwell, A. D., Fineberg, N., Robbins, T. W., & Sahakian, B. J. (2005). The neuropsychology of obsessive compulsive disorder: The importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neuroscience and Biobehavioral Reviews, 29, 399–419.PubMedCrossRef

Coles, M. E., Frost, R. O., Heimberg, R. G., & Rhéaume, J. (2003). ‘‘Not just right experiences’’: Perfectionism, obsessive-compulsive features and general psychopathology. Behaviour Research and Therapy, 41, 681–700.PubMedCrossRef

Coles, M. E., Heimberg, R. G., Frost, R. O., & Steketee, G. (2005). Not just right experiences and obsessive-compulsive features: Experimental and self-monitoring perspectives. Behaviour Research and Therapy, 43, 153–157.PubMedCrossRef

Cougle, J. R., Goetz, A. R., Fitch, K. E., & Hawkins, K. A. (2011). Termination of washing compulsions: A problem of internal reference criteria or “not just right” experience? Journal of Anxiety Disorders, 25, 801–805.PubMedCrossRef

Dillon, D. G., & Pizzagalli, D. A. (2007). Inhibition of action, thought, and emotion: A selective neurobiological review. Applied and Preventive Psychology, 12, 99–114.PubMedCrossRef

Dorz, S., Novara, C., Pastore, M., Sanavio, E., Chiri, L. R., & Sica, C. (2009a). A test of the cognitive theory of obsessions: Study of internal structure and validity of the obsessive beliefs questionnaire in Italian individuals. In S. P. Weingarten & H. O. Penat (Eds.), Cognitive psychology research developments (pp. 65–94). Hauppauge, NY: Nova Science Publishers.

Dorz, S., Novara, C., Pastore, M., Sica, C., & Sanavio, E. (2009b). Presentazione della versione italiana dell’obsessive beliefs questionnaire (OBQ): Struttura fattoriale e analisi di attendibilità (parte 1). Psicoterapia Cognitiva e Comportamentale, 15, 139–170.

Feinstein, S. B., Faloon, B. A., Petkova, E., & Liebowitz, M. R. (2003). Item by factor analysis of the Yale-brown obsessive compulsive scale symptom checklist. Journal of Neuropsychiatry and Clinical Neurosciences, 15, 187–193.PubMedCrossRef

Ferrão, Y. A., Shavitt, R. G., Prado, H., Fontenelle, L. F., Malavazzi, D. M., de Mathis, M. A., et al. (2012). Sensory phenomena associated with repetitive behaviours in obsessive-compulsive disorder: An exploratory study of 1001 patients. Psychiatry Research. doi:10.1016/j.psychres.2011.09.017.PubMed

First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1996a). Structured clinical interview for DSM-IV-patient edition (SCID-I/P). New York: Biometrics Research Department, New York State Psychiatric Institute.

First, M. B., Spitzer, R. L., Gibbon, M., Williams, J. B. W., & Benjamin, L. (1996b). Structured clinical interview for DSM-IV Axis-II personality disorder (SCID-II). New York, NY: Biometrics Research Department New York State Psychiatric Institute.

Foa, E. B., Abramowitz, J. S., Franklin, M. E., & Kozak, M. J. (1999). Feared consequences, fixity of belief, and treatment outcome in patients with obsessive-compulsive disorder. Behavior Therapy, 30, 717–724.CrossRef

Foa, E. B., Huppert, J. D., Leiberg, S., Langner, R., Kichik, R., Hajcak, G., et al. (2002). The obsessive-compulsive inventory: Development and validation of a short version. Psychological Assessment, 4, 485–496.CrossRef

Fuentes, D., Tavares, H., Artes, R., & Gorenstein, C. (2006). Self reported and neuropsychological measures of impulsivity in pathological gambling. Journal of the International Neuropsychological Society, 12, 907–912.PubMedCrossRef

Gentsch, A., Schütz-Bosbach, S., Endrass, T., & Kathmann, N. (2012). Dysfunctional forward model mechanisms and aberrant sense of agency in obsessive-compulsive disorder. Biological Psychiatry, 71, 652–659.PubMedCrossRef

Ghisi, M., Chiri, L. R., Marchetti, I., Sanavio, E., & Sica, C. (2010). In search of specificity: “Not just right experiences” and obsessive-compulsive symptoms in non-clinical and clinical Italian individuals. Journal of Anxiety Disorders, 24, 879–886.PubMedCrossRef

Ghisi, M., Flebus, G. B., Montano, A., Sanavio, E., & Sica, C. (2006). Beck depression inventory-second edition. adattamento italiano: Manuale. Firenze: Organizzazioni Speciali.

Goudriaan, A. E., Oosterlaan, J., De Beurs, E., & van den Brink, W. (2005). Decision making in pathological gambling: A comparison between pathological gamblers, alcohol dependents, persons with Tourette syndrome, and normal controls. Cognitive Brain Research, 23, 137–151.PubMedCrossRef

Graybiel, A. M., & Rauch, S. L. (2000). Toward a neurobiology of obsessive-compulsive disorder. Neuron, 28, 343–347.PubMedCrossRef

Harnishfeger, K. K. (1995). The development of cognitive inhibition: Theories, definitions and research evidence. In F. N. Dempster & C. J. Brainerd (Eds.), New perspectives on interferences and inhibition in cognitions (pp. 175–204). San Diego: Academic Press.CrossRef

Harris, C. L., & Dinn, W. M. (2003). Sub typing obsessive-compulsive disorder: Neuropsychological correlates. Behavioural Neurology, 14, 75–87.PubMed

Hermann, M. J., Jacob, C., Unterecker, S., & Fallgatter, A. J. (2003). Reduced response-inhibition in obsessive-compulsive disorder measured with topographic evoked potential mapping. Psychiatry Research, 120, 265–271.CrossRef

Iversen, S. D., & Mishkin, M. (1970). Perseverative interference in monkey following selective lesions of the inferior prefrontal convexity. Experimental Brain Research, 11, 376–386.CrossRef

Johannes, S., Wieringa, B. M., Mantey, M., Nager, W., Rada, D., Muller-Vahl, K. R., et al. (2001). Altered inhibition of motor responses in Tourette syndrome and obsessive-compulsive disorder. Acta Neurologica Scandinavica, 104, 36–43.PubMedCrossRef

Kertzman, S., Lowengrub, K., Aizer, A., Vainder, M., Kotler, M., & Dannon, P. N. (2008). Go-no-go performance in pathological gamblers. Psychiatry Research, 161, 1–10.PubMedCrossRef

Kim, M. S., Kim, Y. Y., Yoo, S. Y., & Kwon, J. S. (2007). Electrophysiological correlates of behavioral response inhibition in patients with obsessive-compulsive disorder. Depression and Anxiety, 24, 22–31.PubMedCrossRef

Koran, L. M. (2000). Quality of life in obsessive-compulsive disorder. Psychiatric Clinic of North America, 23, 509–517.CrossRef

Leckman, J. F., Walker, D. E., Goodman, W. K., Pauls, D. L., & Cohen, D. J. (1994). “Just right” perceptions associated with compulsive behaviour in Tourette’s syndrome. American Journal of Psychiatry, 151, 675–680.PubMed

Malloy, P., Bihrle, A., Duffy, J., & Cimino, C. (1993). The orbitomedial frontal syndrome. Archives of Clinical Neuropsychology, 8, 185–201.PubMed

Maltby, N., Tolin, D. F., Worhunsky, P., O’Keefe, T. M., & Kiehl, K. A. (2005). Dysfunctional action monitoring hyperactivates frontal–striatal circuits in obsessive-compulsive disorder: An event-related fMRI study. Neuroimage, 24, 495–503.PubMedCrossRef

Mataix-Cols, D., Alonso, P., Pifarre, J., Menchon, J. M., & Vallejo, J. (2002). Neuropsychological performance in medicated vs. unmedicated patients with obsessive-compulsive disorder. Psychiatry Research, 109, 255–264.PubMedCrossRef

Mataix-Cols, D., Wooderson, S., Lawrence, N., Brammer, M. L., Speckens, A., & Philips, M. L. (2004). Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Archives of General Psychiatry, 61, 564–576.PubMedCrossRef

Menzies, L. A., Chamberlain, S. R., Laird, A. R., Thelen, S. M., Sahakian, B. J., & Bullmore, E. T. (2008). Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited. Neuroscience and Biobehavioral Reviews, 32, 525–549.PubMedCrossRef

Miguel, E. C., Rosario-Campos, M. C., Prado, H. D., Valle, R., Rauch, S. L., Coffey, B. J., et al. (2000). Sensory phenomena in obsessive-compulsive disorder and Tourette’s disorder. Journal of Clinical Psychiatry, 61, 150–156.PubMedCrossRef

Morein-Zamir, S., Fineberg, N. A., Robbins, T. W., & Sahakian, B. J. (2010). Inhibition of thoughts and actions in obsessive-compulsive disorder: Extending the endophenotype? Psychological Medicine, 40, 263–272.PubMedCrossRef

Nigg, J. T. (2000). On inhibition/disinhibition in developmental psychopathology: Views from cognitive and personality psychology and a working inhibition taxonomy. Psychological Bulletin, 126, 220–246.PubMedCrossRef

Obsessive Compulsive Cognitions Working Group. (2005). Psychometric validation of the obsessive belief questionnaire and interpretation of intrusion inventory. Part II. Behaviour Research and Therapy, 43, 1527–1542.CrossRef

Omori, I. M., Murata, Y., Yamanishi, T., Nakaaki, S., Akechi, T., Mikuni, M., et al. (2007). The differential impact of executive attention dysfunction on episodic memory in obsessive-compulsive disorder patients with checking symptoms vs. those with washing symptoms. Journal of Psychiatric Research, 41, 776–784.PubMedCrossRef

Penadés, R., Catalàn, R., Rubia, K., Andrés, S., Salamero, M., & Gastò, C. (2007). Impaired response inhibition in obsessive compulsive disorder. European Psychiatry, 22, 404–410.PubMedCrossRef

Pietrefesa, A. S., & Coles, M. E. (2009). Moving beyond an exclusive focus on harm avoidance in obsessive–compulsive disorder: Behavioral validation for the separability of harm avoidance and incompleteness. Behavior Therapy, 40, 251–259.PubMedCrossRef

Pitman, R. K. (1987). A cybernetic model of obsessive-compulsive psychopathology. Comprehensive Psychiatry, 28, 334–343.PubMedCrossRef

Prado, H. S., Rosário, M. C., Lee, J., Hounie, A. G., Shavitt, R. G., & Miguel, E. C. (2008). Sensory phenomena in obsessive-compulsive disorder and tic disorders: A review of the literature. CNS Spectrum, 13, 425–432.

Purcell, R., Kyrios, M., Pantelis, C., & Maruff, P. (1998). Cognitive deficits in obsessive-compulsive disorder on tests of frontal-striatal function. Biological Psychiatry, 43, 348–357.PubMedCrossRef

Rachman, S. (1998). A cognitive theory of obsessions: Elaborations. Behaviour Research and Therapy, 36, 385–401.PubMedCrossRef

Reed, G. F. (1977). The obsessional–compulsive experience: A phenomenological reemphasis. Philosophy and Phenomenological Research, 37, 381–384.CrossRef

Rotge, J. Y., Guehl, D., Dilharreguy, B., Cuny, E., Tignol, J., Bioulac, B., et al. (2008). Provocation of obsessive-compulsive symptoms: A quantitative voxel-based meta-analysis of functional neuroimaging studies. Journal of Psychiatry and Neuroscience, 33, 405–412.PubMed

Roth, R. M., Saykin, A. J., Flashman, L. A., Pixley, H. S., West, J. D., & Mamourian, A. C. (2007). Event-related functional magnetic resonance imaging of response inhibition in obsessive-compulsive disorder. Biological Psychiatry, 63, 901–909.CrossRef

Ruchsow, M., Gron, G., Reuter, K., Spitzer, M., Hermle, L., & Kiefer, M. (2005). Error-related brain activity in patients with obsessive-compulsive disorder and in healthy controls. Journal of Psychophysiology, 19, 298–304.CrossRef

Ruchsow, M., Reuter, K., Hermle, L., Ebert, D., Kiefer, M., & Falkenstein, M. (2007). Executive control in obsessive-compulsive disorder: Event-related potentials in a Go/Nogo task. Journal of Neural Transmission, 114, 1595–1601.PubMedCrossRef

Ruscio, A. M., Stein, D. J., Chiu, W. T., & Kessler, R. C. (2010). The epidemiology of obsessive–compulsive disorder in the national comorbidity survey replication. Molecular Psychiatry, 15, 53–63.PubMedCrossRef

Sakurai, S., & Sugimoto, S. (1985). Effects of lesions of prefrontal cortex and dorsomedial thalamus on delayed go/no-go alternation in rats. Behavioral Brain Research, 17, 295–301.CrossRef

Salkovskis, P. M. (1985). Obsessional-compulsive problems: A cognitive-behavioral analysis. Behaviour Research and Therapy, 23, 571–583.PubMedCrossRef

Sica, C., Caudek, C., Bottesi, G., De Fazio, E., Ghisi, M., Marchetti, I., et al. (2013). Fathers’ “Not Just Right Experiences” predict obsessive-compulsive symptoms in their sons: A family study on non-clinical Italian sample. Journal of Obsessive Compulsive and Related Disorders, 2, 263–272.CrossRef

Sica, C., Caudek, C., Chiri, L. R., Ghisi, M., & Marchetti, I. (2012). ‘‘Not just right experiences’’ predict obsessive–compulsive symptoms in non-clinical Italian individuals: A one-year longitudinal study. Journal of Obsessive-Compulsive and Related Disorders, 1, 159–167.CrossRef

Sica, C., Coradeschi, D., Ghisi, M., & Sanavio, E. (2006). Beck anxiety inventory. adattamento italiano: Manuale. Firenze: Organizzazioni Speciali.

Sica, C., & Ghisi, M. (2007). The Italian versions of the beck anxiety inventory and the beck depression inventory-II: Psychometric properties and discriminant power. In M. A. Lange (Ed.), Leading-edge psychological tests and testing research (pp. 27–50). Hauppauge, NY: NOVA Publishers.

Sica, C., Ghisi, M., Altoè, G., Chiri, L. R., Franceschini, S., Coradeschi, D., et al. (2009). The Italian version of the obsessive compulsive inventory: Its psychometric properties on community and clinical samples. Journal of Anxiety Disorder, 2, 204–211.CrossRef

Stein, D. J. (2002). Obsessive compulsive disorder. Lancet, 360, 397–405.PubMedCrossRef

Summerfeldt, L. J. (2004). Understanding and treating incompleteness in obsessive compulsive disorder. Journal of Clinical Psychology, 60, 1155–1168.PubMedCrossRef

Szechtman, H., & Woody, E. (2004). Obsessive-compulsive disorder as a disturbance of security motivation. Psychological Review, 111, 111–127.PubMedCrossRef

Tallis, F. (1996). Compulsive washing in the absence of phobic and illness anxiety. Behaviour Research and Therapy, 34, 361–362.PubMedCrossRef

Wahl, K., Salkovskis, P. M., & Cotter, I. (2008). “I wash until it feels right”. The phenomenology of stopping criteria in obsessive-compulsive washing. Journal of Anxiety Disorders, 22, 143–161.PubMedCrossRef

Watkins, L. H., Sahakian, B. J., Robertson, M. M., Veale, D. M., Rogers, R. D., Pickard, K. M., et al. (2005). Executive function in Tourette’s syndrome and obsessive-compulsive disorder. Psychological Medicine, 35, 571–582.PubMedCrossRef

Titel: Is Performance on the Go/Nogo Task Related to Not Just Right Experiences in Patients with Obsessive Compulsive Disorder?
verfasst von: Marta Ghisi
Gioia Bottesi
Claudio Sica
Ezio Sanavio
Mark H. Freeston
Publikationsdatum: 01.12.2013
Verlag: Springer US
Erschienen in: Cognitive Therapy and Research / Ausgabe 6/2013
Print ISSN: 0147-5916
Elektronische ISSN: 1573-2819
DOI: https://doi.org/10.1007/s10608-013-9560-1

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Is Performance on the Go/Nogo Task Related to Not Just Right Experiences in Patients with Obsessive Compulsive Disorder?

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