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01.06.2010 | Original Article

Gated blood-pool SPECT versus cardiac magnetic resonance imaging for the assessment of left ventricular volumes and ejection fraction

verfasst von: François Harel, MD, BEng, Vincent Finnerty, MSc, Jean Grégoire, MD, Bernard Thibault, MD, François Marcotte, MD, Patricia Ugolini, MD, Paul Khairy, MD, PhD

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 3/2010

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Abstract

Background

We evaluated the accuracy of planar radionuclide angiography and different count-based and space-based electrocardiogram (ECG)-gated blood-pool single-photon emission computed tomography (GBPS) algorithms for assessment of left ventricular end-diastolic volume (LVEDV), end-systolic volume (LVESV), and ejection fraction (LVEF) compared with the gold standard of cardiac magnetic resonance imaging (cMRI). The goal is to assess the accuracy of a recently developed GBPS algorithm.

Methods and Results

Subjects had planar, GBPS, and cMRI sequentially. Datasets were processed by QBS software (Cedar-Sinai) and by MHI software (Montreal Heart Institute). Space-based approaches were used to compute LVEDV, LVESV, and LVEF. Count-based techniques were also used to assess LVEF. All results were compared to cMRI. Fifty-five patients (85% male; mean age 63 ± 9 years) completed the study. LVEFs and their correlations to cMRI values were 43 ± 12% (r = .82), 39 ± 14% (r = .82), and 39 ± 13% for MHI_space, QBS_space, and cMRI methodologies, respectively. LVEF by count-based methods also demonstrated good correlation to LVEF provided by cMRI (42 ± 13%, r = .88 for MHI_count and 46 ± 15%, r = .84 for QBS_count). Strong correlations were obtained for LVEDV (r = .96 for MHI and r = .92 for QBS) and for LVESV (.97 for MHI and r = .94 for QBS).

Conclusions

All Gated blood-pool SPECT algorithms had significant variation in estimating LVEF. Nevertheless our software provides good estimates of LV volumes and LVEF. Such software may, therefore, be applied to assess LV morphology and function.

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Titel: Gated blood-pool SPECT versus cardiac magnetic resonance imaging for the assessment of left ventricular volumes and ejection fraction
verfasst von: François Harel, MD, BEng
Vincent Finnerty, MSc
Jean Grégoire, MD
Bernard Thibault, MD
François Marcotte, MD
Patricia Ugolini, MD
Paul Khairy, MD, PhD
Publikationsdatum: 01.06.2010
Verlag: Springer-Verlag
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 3/2010
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-010-9195-5

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Gated blood-pool SPECT versus cardiac magnetic resonance imaging for the assessment of left ventricular volumes and ejection fraction