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Breast Cancer Research
Erschienen in: Breast Cancer Research 3/2003

01.06.2003 | Review

Breast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironment

verfasst von: Nancy Boudreau, Connie Myers

Erschienen in: Breast Cancer Research | Ausgabe 3/2003

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Abstract

Growth and progression of breast cancers are accompanied by increased neovascularization (angiogenesis). A variety of factors, including hypoxia and genetic changes in the tumor cells, contribute to increased production of angiogenic factors. Furthermore, cells within the activated tumor stroma also contribute to the increase in production of vascular endothelial growth factor and other angiogenic factors, including basic fibroblast growth factor and platelet-derived growth factor. The contribution of the microenvironment to tumor-induced angiogenesis is underscored by findings that breast tumors implanted into different tissue sites show marked differences in the extent and nature of the angiogenic response. These findings have important implications for designing anti-angiogenic therapies.
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Metadaten
Titel
Breast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironment
verfasst von
Nancy Boudreau
Connie Myers
Publikationsdatum
01.06.2003
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 3/2003
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr589

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