Introduction
Methods
Ascertainment of Subjects
Dual-source CT image analysis
Laboratory procedures
Statistical Analysis
Results
Characteristics: | n = 260 |
---|---|
Age (yrs)
| 63 (54 - 69) |
Men (%)
| 66.8 |
Classical CV-Risk Factors (%)
| |
Diabetes* | 6.2 |
Hypertension* | 47.3 |
Family history of CAD** | 26.9 |
Smoking** | 15 |
Body Mass Index (kg/m2)
| 26.2 (24.2 - 29.3) |
Laboratory profile
| |
Total cholesterol (mg/dl) | 209 (181.2 - 239) |
LDL cholesterol (mg/dl) | 125 (96.7 - 151) |
HDL cholesterol (mg/dl) | 52 (44 - 60) |
Triglycerides (mg/dl) | 141 (103 - 197.5) |
C-reactive protein (mg/dl) | 0.23 (0 - 0.53) |
Adiponectin (ug/ml) | 5.05 (3.25 - 7.67) |
MMP-1 (ng/ml) | 3.91 (2.24 - 5.67) |
MMP-9 (ng/ml) | 211.3 (147.1 - 283) |
Medical treatment (%)***
| |
Statin | 37.7 |
Anticoagulation/Antiplatelet | 63.5 |
Betablocker | 64.9 |
ACE-I or ARB | 51.8 |
Diuretics | 30.6 |
CT data
| |
Pericardial adipose tissue in volume (ml)§ | 184.1 (128.6 - 255.8) |
Number of coronary artery plaques (total)§§ | 3 (1 - 6) |
Number of calcified plaques (154 patients) | 1 (0 - 3) |
Number of mixed plaques (102 patients) | 0 (0 - 1) |
Number of non-calcified plaques (126 patients) | 0 (0 - 2) |
Association of MMP-1 and MMP-9 serum levels with cardiovascular risk factors and coronary atherosclerosis
MMP-1 | MMP-9 | ||||
---|---|---|---|---|---|
Median (IQR) | P | Median (IQR) | P | ||
Rho | Rho | ||||
Age
| -0.003 | 0.97 | 0.004 | 0.50 | |
Sex
| |||||
- female | 4.46 (2.24 - 5.69) | 0.6 | 207 (137-169) | 0.16 | |
- male | 3.38 (2.12 - 5.52) | 220 (160-288) | |||
BMI
| 0.025 | 0.69 | 0.149 |
0.018
| |
Diabetes mellitus:
|
Yes
| 4.34 (2.99 - 5.82) | 0.60 | 243.2 (189.9-354.1) | 0.89 |
No
| 3.78 (2.09 - 5.67) | 209.6 (144.8-277.2) | |||
Hypertension:
|
Yes
| 3.74 (2.10 - 5.82) | 0.89 | 212.7 (150.1 - 288.1) | 0.67 |
No
| 3.96 (2.23 - 5.67) | 195.6 (135.5 - 266.9) | |||
Family history of CAD:
|
Yes
| 3.73 (1.80 - 5.64) | 0.45 | 195.6 (140.4 - 268.4) | 0.15 |
No
| 3.93 (2.24 - 5.69) | 212.4 (148.1 - 287.5) | |||
Smoking:
|
Yes
| 4.08 (1.90 - 5.70) | 0.86 | 185.6 (133.6 - 283.2) | 0.97 |
No
| 3.73 (2.24 - 5.67) | 212.3 (146.0 - 275.8) | |||
Statin treatment:
|
Yes
| 4.11 (2.44 - 5.90) | 0.25 | 205.2 (138.8 - 284.1) | 0.44 |
No
| 3.52 (2.09 - 5.65) | 212.3 (153.7 - 280.6) | |||
Anticoagulation:
|
Yes
| 3.71 (2.18 - 5.65) | 0.32 | 180.9 (137.0 - 257.5) | 0.06 |
No
| 3.67 (2.02 - 5.61) | 235.0 (157.6 - 313.5) | |||
Betablocker:
|
Yes
| 3.91 (2.44 - 5.23) | 0.80 | 206.5 (139.5 - 273.5) |
0.049
|
No
| 3.48 (2.07 - 6.07) | 217.8 (158.5 - 339.3) | |||
ACE-I or ARB:
|
Yes
| 4.11 (2.44 - 5.65) | 0.51 | 207.6 (144.7 - 283.2) | 0.66 |
No
| 3.5 (2.09 - 5.82) | 210.3 (153.7 - 282.3) | |||
Diuretics:
|
Yes
| 4.06 (2.90 - 5.59) | 0.32 | 211.8 (141.3 - 300.0) | 0.76 |
No
| 3.6 (2.07 - 5.79) | 209.6 (151.1 - 276.9) | |||
Pericardial adipose tissue
| 0.068 | 0.28 | 0.253 |
<0.0001
| |
Adiponectin
| -0.111 | 0.08 | -0.084 | 0.18 | |
High-sensitivity CRP
| 0.194 |
0.001
| 0.173 |
0.005
| |
Triglycerides
| 0.195 |
0.002
| 0.135 |
0.028
| |
Total-cholesterol
| 0.041 | 0.52 | -0.037 | 0.53 | |
LDL-cholesterol
| -0.002 | 0.97 | -0.049 | 0.43 | |
HDL-cholesterol
| -0.048 | 0.45 | -0.018 | 0.77 | |
MMP-1
| 0.269 |
<0.0001
| |||
Total-Plaque burden
| 0.16 |
0.013
| 0.087 | 0.17 | |
Non-Calcified Plaques
| 0.157 |
0.014
| 0.002 | 0.98 | |
Mixed Plaques
| 0.119 | 0.07 | 0.12 | 0.06 | |
Calcified Plaques
| 0.118 | 0.07 | 0.058 | 0.37 |
MMP-1 serum level predict total plaque burden
Total Plaque | MMP-1 | MMP-9 | ||
---|---|---|---|---|
Adjusted for
|
OR (CI)
|
P value
|
OR (CI)
|
P value
|
Age, Gender, BMI
| 1.28 (1.02 to 1.59) |
0.031
| 0.97 (0.90 to 1.05) | 0.49 |
Age, Gender, BMI, RF*
| 1.30 (1.01 to 1.66) |
0.040
| 0.96 (0.90 to 1.03) | 0.29 |
Age, Gender, BMI, RF*, CRP
| 1.29 (1.00 to 1.67) |
0.044
| 0.96 (0.90 to 1.03) | 0.28 |
Age, Gender, BMI, RF*, CRP, AD, PCF
| 1.32 (1.01 to 1.72) |
0.040
| 0.97 (0.90 to 1.03) | 0.32 |
Age, Gender, BMI, RF*, CRP, AD, PCF, Med
| 1.37 (1.02 to 1.85) |
0.037
| 0.98 (0.90 to 1.06) | 0.63 |
MMP-1 serum levels predict calcified and non-calcified lesions
Non-calcified Plaque | MMP-1 | MMP-9 | ||
---|---|---|---|---|
Adjusted for
|
OR (CI)
|
P value
|
OR (CI)
|
P value
|
Age, Gender, BMI
| 1.19 (1.04 to 1.37) |
0.012
| 0.99 (0.95 to 1.04) | 0.74 |
Age, Gender, BMI, RF*
| 1.19 (1.03 to 1.37) |
0.017
| 0.99 (0.95 to 1.04) | 0.76 |
Age, Gender, BMI, RF*, CRP
| 1.20 (1.04 to 1.38) |
0.014
| 1 (0.95 to 1.05) | 0.90 |
Age, Gender, BMI, RF*, CRP, AD, PCF
| 1.18 (1.03 to 1.37) |
0.021
| 0.99 (0.94 to 1.04) | 0.80 |
Age, Gender, BMI, RF*, CRP, AD, PCF, Med
| 1.16 (1.00 to 1.34) |
0.050
| 1 (0.95 to 1.05) | 0.90 |
Mixed Plaque
|
MMP-1
|
MMP-9
| ||
Adjusted for
|
OR (CI)
|
P value
|
OR (CI)
|
P value
|
Age, Gender, BMI
| 1.19 (1.03 to 1.38) |
0.019
| 0.99 (0.94 to 1.04) | 0.71 |
Age, Gender, BMI, RF*
| 1.19 (1.02 to 1.39) |
0.014
| 0.99 (0.94 to 1.04) | 0.77 |
Age, Gender, BMI, RF*, CRP
| 1.19 (1.02 to 1.39) |
0.024
| 0.99 (0.94 to 1.05) | 0.79 |
Age, Gender, BMI, RF*, CRP, AD, PCF
| 1.17 (1.00 to 1.37) |
0.047
| 0.99 (0.94 to 1.04) | 0.67 |
Age, Gender, BMI, RF*, CRP, AD, PCF, Med
| 1.14 (0.96 to 1.35) | 0.12 | 0.99 (0.94 to 1.05) | 0.83 |
Calcified Plaque
|
MMP-1
|
MMP-9
| ||
Adjusted for
|
OR (CI)
|
P value
|
OR (CI)
|
P value
|
Age, Gender, BMI
| 1.22 (1.04 to 1.43) |
0.013
| 0.99 (0.94 to 1.05) | 0.78 |
Age, Gender, BMI, RF*
| 1.22 (1.04 to 1.43) |
0.016
| 0.98 (0.93 to 1.04) | 0.69 |
Age, Gender, BMI, RF*, CRP
| 1.21 (1.03 to 1.42) |
0.020
| 0.98 (0.93 to 1.04) | 0.49 |
Age, Gender, BMI, RF*, CRP, AD, PCF
| 1.21 (1.03 to 1.43) |
0.019
| 0.98 (0.94 to 1.05) | 0.57 |
Age, Gender, BMI, RF*, CRP, AD, PCF, Med
| 1.22 (1.03 to 1.45) |
0.023
| 0.98 (0.9 w to 1.05) | 0.64 |