Position of draining venous cannula in extracorporeal membrane oxygenation for respiratory and respiratory/circulatory support in adult patients

In V-V ECMO, the oxygenated blood is returned into the venous system. Some of this blood will in turn be drained by the draining cannula, which is referred to as recirculation (Rf). A high Rf will raise the Sat_preox and therefore lower the oxygen delivery. To support the patient efficiently, Rf should thus be as small as possible. Rf is affected by many factors including positioning of the cannulas, ECMO flow, ECMO flow direction, cardiac output, and intrathoracic/intra-abdominal pressures [5]. V-V ECMO can be accomplished either through a dual-lumen cannula (with one draining canal and one infusion canal) or through two single-lumen cannulas. When the latter mode is used, possible configurations are femoral vein to IJV, IJV vein to femoral vein, and femoral vein (one side) to femoral vein (other side). One should also bear in mind that it is not the insertion site that matters, but from where the blood is drained and reinfused. Draining cannulas are equipped with an end-hole and several side-holes. So-called multistage cannulas have side-holes at several different levels and, if these lie freely and unobstructed in a vessel, they will primarily drain from the most proximal side-holes (i.e., from the side-holes furthest away from the tip). The configurations are therefore better described as IVC–RA (drainage from the inferior caval vein (IVC) through a femoral cannula and return to the right atrium (RA) via a cannula in the right IJV or in the other femoral vein) or RA–IVC (drainage from the RA and infusion in the IVC) (Fig. 1). With a multistage cannula inserted in the jugular vein, blood will be drained both from the superior caval vein (SVC) and the RA (i.e., SVC/RA). In the early ECMO era the RA–IVC route was traditionally routine in the United States [6], while the IVC–RA route was used in Europe [7]. Rich et al. [8] prospectively compared efficient oxygenation between RA–IVC and IVC–RA flow directions and concluded that recirculation was less when draining from the IVC and returning blood via the RA. Furthermore, they were able to maintain a higher ECMO flow when using this flow direction. Following this, the policy was changed in North America and today the majority of ECMO centers use the IVC–RA route for two single-lumen cannula V-V ECMO [9]. However, in the study of Rich et al. the patients were all paralyzed and subjected to inverse-ratio pressure-controlled ventilation. As pointed out by the authors, this may have contributed to a lesser ability to drain from the RA and improvement in the ability to drain from the IVC. Furthermore, the study was performed during the first day of support and no attempt had been made to withdraw fluid. The authors mention that intravascular volume depletion may compromise IVC–RA flow more than RA–IVC flow, thereby limiting the value of their finding. In a recent study, the amount of recirculation was studied in RA–IVC ECMO patients by an ultrasound dilution technique [10]. The authors found, that by using a multistage cannula (Maquet HLS, 25 French/38 cm, Maquet Cardiopulmonary/Getinge Group, Hirrlingen, Germany) inserted via the right IJV with the tip in the RA as compared with a conventional lighthouse tip cannula (Bio-Medicus 23 French/25 cm, Medtronic Europe Sárl, Tolochenaz, Switzerland) inserted in the same way, Rf was reduced from an average of 38% to 19%. This multistage cannula has side-holes up to 10 cm from the tip and, in adult patients, it can be inserted in the right jugular vein without any risk of proximal side-holes being too close to the skin. The lower Rf was explained by a larger proportion of SVC drainage via the proximal side holes. In Stockholm, we have a tradition of performing V-V ECMO via the SVC/RA–IVC route and have demonstrated excellent results [11]. By using a multistage cannula in the SVC with exact placement of its tip at the entry of the RA, recirculation is minimized.

In V-A ECMO, blood is returned to a major artery. The most commonly used artery in adults is the femoral artery, meaning there will be a retrograde flow in the descending aorta meeting the blood that is ejected from the left ventricle (LV) into the ascending aorta (Fig. 2). The level of the mixing zone is dependent on the native cardiac output and the ECMO flow. In patients with pulmonary failure, the blood ejected from the LV is desaturated and will predominantly support the upper part of the body (coronary, subclavian, and carotid arteries). If the venous blood is drained from the IVC (i.e., via a femoral cannula) the patient is at risk of developing a dual circulation (Harlequin syndrome, North-South syndrome, differential oxygenation) meaning that the highly oxygenated blood from the ECMO machine enters the descending aorta, supporting the lower body (splanchnic circulation, kidneys, legs, etc.) and drains into the IVC and further to the ECMO circuit [12]. On the other hand, the desaturated blood ejected from the LV that supports the upper body (heart, brain, etc.) drains into the SVC and is pumped through the failing native lungs to the left atrium and LV without being mixed with the oxygenated blood from the ECMO machine. This results in low arterial and venous saturations in the upper body and a well oxygenated lower body (Fig. 3). Early assessment is accomplished by blood gas analysis showing that Sat_preox exceeds or is similar to saturation in the upper body. If instead blood is drained from the SVC there will be a favorable mixture of the circulations in the upper and lower body. The relatively well-saturated blood from the IVC enters the pulmonary circulation (instead of being drained to the ECMO machine) and is ejected from the LV to support the upper body. The most desaturated blood in this situation is in the SVC and is drained to the ECMO machine instead of entering the pulmonary circulation. Furthermore, by draining the most desaturated blood, more oxygen can be delivered to the patient. The efficiency of draining from the SVC to avoid dual circulation in V-A ECMO has been shown both experimentally, in a computerized model, and in clinical practice [13, 14] (Table 1). In patients on V-A bypass only for circulatory support, the blood ejected by the LV may be well oxygenated (if not pulmonary edema) and the venous drainage site is therefore often of less importance with regard to dual circulation. In patients with extremely low native cardiac output, the retrograde flow from the ECMO machine will sometimes reach the aortic arch, but in this situation flow stagnation in the LV, pulmonary congestion, and coronary hypoxemia may be threatening. However, in patients with circulatory support, pulmonary function may also deteriorate due to LV failure worsening due to ECMO-induced high afterload, atelectasis, infection, etc. The risk of dual circulation syndrome therefore always exists when blood is drained from the IVC. We therefore argue that in V-A ECMO with blood return in the femoral artery venous blood should routinely be drained from the SVC and upper part of the RA. In our opinion the best way to accomplish this is with a multistage cannula inserted via the right IJV and with its tip located at the entrance to the RA. An exception from the recommended route for drainage is when the patient is cannulated during refractory cardiac arrest. In such cases cannulation via the groin may be quicker especially as the neck may be difficult to reach due to the resuscitation.

Another common way to solve the oxygenation problem when/if the dual circulation phenomenon is discovered in V-A ECMO via femoral vessels is to implant an extra venous reinfusion cannula via the IJV. V-A ECMO is thereby converted to V-AV [15]. By doing this, oxygen is introduced to the upper (native) circuit increasing central venous oxygen content. The saturation of the blood leaving the LV will be higher compared with before. However, it should be noted that the Sat_preox most likely also increases due to recirculation (from oxygenated blood in the RA to the draining cannula in the IVC), and thus the total amount of oxygen it is possible to deliver via the ECMO support may not increase but rather decrease if there is a limit in compensatory maximum ECMO flow. Drainage capacity may be restricted by the physical properties of the draining cannula, or hypovolemia, etc. An alternative in V-A ECMO is to return the blood in the subclavian artery instead of the femoral artery. This would eliminate the risk for a dual circulation as the fully oxygenated blood from the ECMO machine will be equally distributed in the body. However, subclavian artery cannulation is technically more demanding than femoral artery cannulation and also carries the risk of hyperperfusion of the ipsilateral arm, surgical site bleeding [16], and cerebral embolization.

Although serious complications such as right ventricular rupture and cardiac tamponade have been described using double-lumen ECMO cannulas in the RA inserted via the IJV and with its tip located in the IVC [17], we consider having large single-lumen draining cannulas inserted via the right IJV in the upper part of the RA as a safe procedure. Since the start of our adult ECMO program in 1996 and until 2018 we have treated 462 adult patients on ECMO with such draining without any cardiac perforations.