Erschienen in:
Open Access
01.09.2012 | Meeting abstract
Longitudinal analysis of mRNA transcripts and plasma proteins to define a biomarker associated with lupus disease activity
verfasst von:
M Olferiev, W-T Huang, KA Kirou, E Gkrouzman, D Lundsgaard, KS Frederiksen, J Fleckner, MK Crow
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 3/2012
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Excerpt
Lupus, a chronic autoimmune disease, is characterized by a variable clinical course, with periods of active disease. Identification of a biomarker or biomarker panel associated with clinical disease activity would be useful for disease management, assessment of response to therapeutic intervention in practice or clinical trials, and might suggest cellular or molecular targets for future therapies. To identify biomarkers that reflect lupus disease activity, we assessed longitudinal clinical, gene expression and proteomic data from SLE patients. …