Erschienen in:
Open Access
01.09.2012 | Meeting abstract
Regulatory natural autoantibodies suppress inflammation and SLE disease activity
verfasst von:
GJ Silverman, J Vas, C Grönwall
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 3/2012
Einloggen, um Zugang zu erhalten
Excerpt
Our recent studies have shown that IgM natural antibodies (NAbs) that recognize epitopes on apoptotic cells (ACs) are present from birth and can have potent immunoregulatory properties. These antibodies, by recruiting early complement recognition factors, C1q or mannose-binding lectin, enhance AC clearance by innate immune cells and also mediate suppression of proinflammatory responses induced by Toll-like receptor (TLR) agonists [
1,
2]. Furthermore,
in vivo administration blocks the development of inflammatory autoimmune disease in experimental murine models [
2]. We therefore explored the mechanistic basis for these properties and assessed for potential clinical relevance. …