Ausgabe 1/2012
Inhalt (90 Artikel)
Neurotrophic factor changes in the rat thick skin following chronic constriction injury of the sciatic nerve
Jennifer C Peleshok, Alfredo Ribeiro-da-Silva
Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6)
Jin Yan, Ohannes K Melemedjian, Theodore J Price, Gregory Dussor
Retracted: Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states
Jose A Martinez, Manami Kasamatsu, Alma Rosales-Hernandez, Leah R Hanson, William H Frey, Cory C Toth
Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain
Dipti V Tillu, Ohannes K Melemedjian, Marina N Asiedu, Ning Qu, Milena De Felice, Gregory Dussor, Theodore J Price
L type Ca2+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats
Takehiro Kawashiri, Nobuaki Egashira, Kentaro Kurobe, Kuniaki Tsutsumi, Yuji Yamashita, Soichiro Ushio, Takahisa Yano, Ryozo Oishi
Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K2P) and voltage-gated (Kv1.1 and Kv1.2) potassium channels
Jaekwang Lee, Taekeun Kim, Jinpyo Hong, Junsung Woo, Hyunjung Min, Eunmi Hwang, Sung Joong Lee, C Justin Lee
Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury
Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Hirosato Kanda, Yi Dai, Koichi Noguchi
P2X7 receptors in satellite glial cells mediate high functional expression of P2X3 receptors in immature dorsal root ganglion neurons
Yong Chen, Guangwen Li, Li-Yen Mae Huang
Stimulation of peripheral Kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway
Thiago M Cunha, Guilherme R Souza, Andressa C Domingues, Eleonora U Carreira, Celina M Lotufo, Mani I Funez, Waldiceu A Verri Jr, Fernando Q Cunha, Sergio H Ferreira
Chronic pain, perceived stress, and cellular aging: an exploratory study
Kimberly T Sibille, Taimour Langaee, Ben Burkley, Yan Gong, Toni L Glover, Chris King, Joseph L Riley III, Christiaan Leeuwenburgh, Roland Staud, Laurence A Bradley, Roger B Fillingim
Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn
Jeong IL Choi, Fred J Koehrn, Linda S Sorkin
Elevated interleukin-8 enhances prefrontal synaptic transmission in mice with persistent inflammatory pain
Guang-bin Cui, Jia-ze An, Nan Zhang, Ming-gao Zhao, Shui-bing Liu, Jun Yi
Progesterone produces antinociceptive and neuroprotective effects in rats with microinjected lysophosphatidic acid in the trigeminal nerve root
Min Ji Kim, Hea Jung Shin, Kyoung Ae Won, Kui Ye Yang, Jin Sook Ju, Yoon Yub Park, Jae Sik Park, Yong Cheol Bae, Dong Kuk Ahn
Translational investigation and treatment of neuropathic pain
Bo Xu, Giannina Descalzi, Hai-Rong Ye, Min Zhuo, Ying-Wei Wang
Minocycline markedly reduces acute visceral nociception via inhibiting neuronal ERK phosphorylation
Ik-Hyun Cho, Min Jung Lee, Minhee Jang, Nam Gil Gwak, Ka Yeon Lee, Hyuk-Sang Jung
Warmth suppresses and desensitizes damage-sensing ion channel TRPA1
Sen Wang, Jongseok Lee, Jin Y Ro, Man-Kyo Chung
The expression of spinal methyl-CpG-binding protein 2, DNA methyltransferases and histone deacetylases is modulated in persistent pain states
Keri K Tochiki, Joel Cunningham, Stephen P Hunt, Sandrine M Géranton
Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice
Yen-Chin Liu, Temugin Berta, Tong Liu, Ping-Heng Tan, Ru-Rong Ji
Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9
Temugin Berta, Tong Liu, Yen-Chin Liu, Zhen-Zhong Xu, Ru-Rong Ji
Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception
Lara W Crock, Kristina M Stemler, David G Song, Philip Abbosh, Sherri K Vogt, Chang-Shen Qiu, H Henry Lai, Indira U Mysorekar, Robert W Gereau IV
Sodium channels and mammalian sensory mechanotransduction
Ramin Raouf, Francois Rugiero, Hannes Kiesewetter, Rachel Hatch, Edith Hummler, Mohammed A Nassar, Fan Wang, John N Wood
Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain
Qin Zheng, Dong Fang, Jie Cai, You Wan, Ji-Sheng Han, Guo-Gang Xing
Inhibition of Ca2+/Calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in Rats
Masafumi Shirahama, Soichiro Ushio, Nobuaki Egashira, Shota Yamamoto, Hikaru Sada, Ken Masuguchi, Takehiro Kawashiri, Ryozo Oishi
Satellite glial cell P2Y12 receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats
Ayano Katagiri, Masamichi Shinoda, Kuniya Honda, Akira Toyofuku, Barry J Sessle, Koichi Iwata
Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy
Munmun Chattopadhyay, Zhigang Zhou, Shuanglin Hao, Marina Mata, David J Fink
Inflammation-induced changes in BKCa currents in cutaneous dorsal root ganglion neurons from the adult rat
Xiu-Lin Zhang, Lee-Peng Mok, Kwan Yeop Lee, Marcel Charbonnet, Michael S Gold
PAPupuncture has localized and long-lasting antinociceptive effects in mouse models of acute and chronic pain
Julie K Hurt, Mark J Zylka
Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor
Richard P Hulse, Lucy F Donaldson, David Wynick
Patients with fibromyalgia display less functional connectivity in the brain’s pain inhibitory network
Karin B Jensen, Rita Loitoile, Eva Kosek, Frank Petzke, Serena Carville, Peter Fransson, Hanke Marcus, Steven CR Williams, Ernest Choy, Yves Mainguy, Olivier Vitton, Richard H Gracely, Randy Gollub, Martin Ingvar, Jian Kong
Effects of peripheral inflammation on the blood-spinal cord barrier
Dimitris N Xanthos, Isabella Püngel, Gabriele Wunderbaldinger, Jürgen Sandkühler
Milnacipran inhibits glutamatergic N-Methyl-D-Aspartate receptor activity in Spinal Dorsal Horn Neurons
Tatsuro Kohno, Masafumi Kimura, Mika Sasaki, Hideaki Obata, Fumimasa Amaya, Shigeru Saito
The effect of minocycline on the masticatory movements following the inferior alveolar nerve transection in freely moving rats
Rahman Md Mostafeezur, Hossain Md Zakir, Yoshiaki Yamada, Kensuke Yamamura, Koichi Iwata, Barry J Sessle, Junichi Kitagawa
Contribution of microglia and astrocytes to the central sensitization, inflammatory and neuropathic pain in the juvenile rat
Hiroshi Ikeda, Takaki Kiritoshi, Kazuyuki Murase
Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse
Giusi Manassero, Ivan E Repetto, Stefano Cobianchi, Valeria Valsecchi, Christophe Bonny, Ferdinando Rossi, Alessandro Vercelli
The emergence of adolescent onset pain hypersensitivity following neonatal nerve injury
David Vega-Avelaira, Rebecca McKelvey, Gareth Hathway, Maria Fitzgerald
Distinct degree of radiculopathy at different levels of peripheral nerve injury
Noboru Takiguchi, Munehito Yoshida, Wataru Taniguchi, Hiroshi Hashizume, Hiroshi Yamada, Nobuyuki Miyazaki, Naoko Nishio, Terumasa Nakatsuka
Role of capsaicin-sensitive C-fiber afferents in neuropathic pain-induced synaptic potentiation in the nociceptive amygdala
Ayano Nakao, Yukari Takahashi, Masashi Nagase, Ryo Ikeda, Fusao Kato
Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain
Christian Ndong, Russell P Landry, Joyce A DeLeo, Edgar Alfonso Romero-Sandoval
Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation
Min Jung Lee, Minhee Jang, Hyuk-Sang Jung, Sung-Hoon Kim, Ik-Hyun Cho
Regulation of Wnt signaling by nociceptive input in animal models
Yuqiang Shi, Subo Yuan, Bei Li, Jigong Wang, Susan M Carlton, Kyungsoon Chung, Jin Mo Chung, Shao-Jun Tang
In vivo USPIO magnetic resonance imaging shows that minocycline mitigates macrophage recruitment to a peripheral nerve injury
Pejman Ghanouni, Deepak Behera, Jin Xie, Xiaoyuan Chen, Michael Moseley, Sandip Biswal
Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study
Javeria A Hashmi, Marwan N Baliki, Lejian Huang, Elle L Parks, Mona L Chanda, Thomas Schnitzer, A Vania Apkarian
Network dynamics in nociceptive pathways assessed by the neuronal avalanche model
José Jiun-Shian Wu, Hsi-Chien Shih, Chen-Tung Yen, Bai-Chuang Shyu
Painful nerve injury increases plasma membrane Ca2+-ATPase activity in axotomized sensory neurons
Geza Gemes, Katherine D Oyster, Bin Pan, Hsiang-En Wu, Madhavi Latha Yadav Bangaru, Qingbo Tang, Quinn H Hogan
Trigeminal-Rostral Ventromedial Medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury
Bryan Chai, Wei Guo, Feng Wei, Ronald Dubner, Ke Ren
The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain
Shivani Ruparel, Dustin Green, Paul Chen, Kenneth M Hargreaves
Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation
Narender R Gavva, Carl Davis, Sonya G Lehto, Sara Rao, Weiya Wang, Dawn XD Zhu
Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura
Dongyue Huang, Shuyang Li, Ajay Dhaka, Gina M Story, Yu-Qing Cao
GCH1-polymorphism and pain sensitivity among women with provoked vestibulodynia
Ulrika Heddini, Nina Bohm-Starke, Alfhild Grönbladh, Fred Nyberg, Kent W Nilsson, Ulrika Johannesson
Peripheral nerve injury increases glutamate-evoked calcium mobilization in adult spinal cord neurons
Suzanne Doolen, Camille B Blake, Bret N Smith, Bradley K Taylor
Spatiotemporal dynamics of re-innervation and hyperinnervation patterns by uninjured CGRP fibers in the rat foot sole epidermis after nerve injury
Liron S Duraku, Mehdi Hossaini, Sieske Hoendervangers, Lukas L Falke, Shoista Kambiz, Vivek C Mudera, Joan C Holstege, Erik T Walbeehm, Tom J H Ruigrok
Serotonin-Induced Hypersensitivity via Inhibition of Catechol O-Methyltransferase Activity
Douglas Tsao, Jeffrey S Wieskopf, Naim Rashid, Robert E Sorge, Rachel L Redler, Samantha K Segall, Jeffrey S Mogil, William Maixner, Nikolay V Dokholyan, Luda Diatchenko
Dose-dependent expression of neuronal injury markers during experimental osteoarthritis induced by monoiodoacetate in the rat
Joana Ferreira-Gomes, Sara Adães, Raquel Meireles Sousa, Marcelo Mendonça, José Manuel Castro-Lopes
The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons
Michael S Fleming, Daniel Ramos, Seung Baek Han, Jianyuan Zhao, Young-Jin Son, Wenqin Luo
Characterization of neuronal intrinsic properties and synaptic transmission in layer I of anterior cingulate cortex from adult mice
Xiang-Yao Li, Tao Chen, Giannina Descalzi, Kohei Koga, Shuang Qiu, Min Zhuo
Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice
Meng Zhao, Kouichi Isami, Saki Nakamura, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
Neural mobilization reverses behavioral and cellular changes that characterize neuropathic pain in rats
Fabio M Santos, Joyce T Silva, Aline C Giardini, Priscila A Rocha, Arnold PP Achermann, Adilson S Alves, Luiz RG Britto, Marucia Chacur
Identification of 5-HT receptor subtypes enhancing inhibitory transmission in the rat spinal dorsal horn in vitro
Du-Jie Xie, Daisuke Uta, Peng-Yu Feng, Masahito Wakita, Min-Chul Shin, Hidemasa Furue, Megumu Yoshimura
Involvement of Tyr1472 phosphorylation of NMDA receptor NR2B subunit in postherpetic neuralgia in model mice
Sawako Unezaki, Atsushi Sasaki, Tamaki Mabuchi, Shinji Matsumura, Tayo Katano, Takanobu Nakazawa, Naoko Nishio, Tsugunobu Andoh, Tadashi Yamamoto, Terumasa Nakatsuka, Yasushi Kuraishi, Seiji Ito
Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptors
Sheldon R Garrison, Audra A Kramer, Nashaat Z Gerges, Cheryl A Hillery, Cheryl L Stucky
Genome-wide analysis of pain-, nerve- and neurotrophin -related gene expression in the degenerating human annulus
Helen E Gruber, Gretchen L Hoelscher, Jane A Ingram, Edward N Hanley Jr
Non-peptidergic primary afferents are presynaptic to neurokinin-1 receptor immunoreactive lamina I projection neurons in rat spinal cord
Abeer W Saeed, Alfredo Ribeiro-da-Silva
Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons
Alexandra B Klinger, Mirjam Eberhardt, Andrea S Link, Barbara Namer, Lisa K Kutsche, E Theresa Schuy, Ruth Sittl, Tali Hoffmann, Christian Alzheimer, Tobias Huth, Richard W Carr, Angelika Lampert
Sensory discrimination between innocuous and noxious cold by TRPM8-expressing DRG neurons of rats
Ignacio Sarria, Jennifer Ling, Guang-Yin Xu, Jianguo G Gu
Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons
Sharon J Yu, Chun-mei Xia, Jarren C Kay, Li-Ya Qiao
CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy
Andrew D Piekarz, Michael R Due, May Khanna, Bo Wang, Matthew S Ripsch, Ruizhong Wang, Samy O Meroueh, Michael R Vasko, Fletcher A White, Rajesh Khanna
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB2 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy
Liting Deng, Josée Guindon, V Kiran Vemuri, Ganesh A Thakur, Fletcher A White, Alexandros Makriyannis, Andrea G Hohmann
The non-synonymous SNP, R1150W, in SCN9A is not associated with chronic widespread pain susceptibility
Kate L Holliday, Wendy Thomson, Tuhina Neogi, David T Felson, Ke Wang, Frederick C Wu, Ilpo T Huhtaniemi, Gyorgy Bartfai, Felipe Casanueva, Gianni Forti, Krzysztof Kula, Margus Punab, Dirk Vanderschueren, Gary J Macfarlane, Michael A Horan, William Ollier, Antony Payton, Neil Pendleton, John McBeth
Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis
Yaohui Zhu, Tugba Colak, Mohan Shenoy, Liansheng Liu, Kshama Mehta, Reetesh Pai, Bende Zou, Xinmin Simon Xie, Pankaj J Pasricha
Molecular and cellular mechanisms of the age-dependency of opioid analgesia and tolerance
Jing Zhao, Xin Xin, Guo-xi Xie, Pamela Pierce Palmer, Yu-guang Huang
Anti-hyperalgesic effects of calcitonin on neuropathic pain interacting with its peripheral receptors
Akitoshi Ito, Mineko Takeda, Takeshi Yoshimura, Takayuki Komatsu, Takeshi Ohno, Hiroshi Kuriyama, Akio Matsuda, Megumu Yoshimura
Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn
Joel A Black, Noémie Frézel, Sulayman D Dib-Hajj, Stephen G Waxman
Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection
Francesca Guida, Livio Luongo, Gabriella Aviello, Enza Palazzo, Maria De Chiaro, Luisa Gatta, Serena Boccella, Ida Marabese, Jordan K Zjawiony, Raffaele Capasso, Angelo A Izzo, Vito de Novellis, Sabatino Maione
Reduced basal ganglia μ-opioid receptor availability in trigeminal neuropathic pain: A pilot study
Marcos Fabio DosSantos, Ilkka Kristian Martikainen, Thiago Dias Nascimento, Tiffany M Love, Misty Dawn Deboer, Eric C Maslowski, André Antonio Monteiro, Maurice Borges Vincent, Jon-Kar Zubieta, Alexandre F DaSilva
Lamina I NK1 expressing projection neurones are functional in early postnatal rats and contribute to the setting up of adult mechanical sensory thresholds
Sharon HW Man, Sandrine M Géranton, Stephen P Hunt
Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception
Yingqi Weng, Patricia A Batista-Schepman, Marie E Barabas, Eli Q Harris, Thomas B Dinsmore, Elena A Kossyreva, Audra M Foshage, Michelle H Wang, Matthew J Schwab, Victoria M Wang, Cheryl L Stucky, Gina M Story
Increased nociceptive sensitivity and nociceptin/orphanin FQ levels in a rat model of PTSD
Yong Zhang, Priyam R Gandhi, Kelly M Standifer
N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors
Matteo Bernabucci, Serena Notartomaso, Cristina Zappulla, Francesco Fazio, Milena Cannella, Marta Motolese, Giuseppe Battaglia, Valeria Bruno, Roberto Gradini, Ferdinando Nicoletti
NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation
Toshihiko Yamada, Daiying Zuo, Tatsuo Yamamoto, Rafal T Olszewski, Tomasz Bzdega, John R Moffett, Joseph H Neale
Neuropeptide deficient mice have attenuated nociceptive, vascular, and inflammatory changes in a tibia fracture model of complex regional pain syndrome
Tian-Zhi Guo, Tzuping Wei, Xiaoyou Shi, Wen-Wu Li, Saiyun Hou, Liping Wang, Kazutake Tsujikawa, Kenner C Rice, Kejun Cheng, David J Clark, Wade S Kingery
1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1
Masayuki Takaishi, Fumitaka Fujita, Kunitoshi Uchida, Satoshi Yamamoto, Maki Sawada (Shimizu), Chihiro Hatai (Uotsu), Mayumi Shimizu, Makoto Tominaga
Cutaneous nociceptors lack sensitisation, but reveal μ-opioid receptor-mediated reduction in excitability to mechanical stimulation in neuropathy
Yvonne Schmidt, Dominika Labuz, Paul A Heppenstall, Halina Machelska
Galanin-expression and galanin-dependent sensory neurons are not required for itch
Fiona E Holmes, Penny Vanderplank, David Wynick
Differential lumbar spinal cord responses among wild type, CD4 knockout, and CD40 knockout mice in spinal nerve L5 transection-induced neuropathic pain
Ling Cao, Holly Beaulac, Adriana Eurich
Upregulation of cystathionine beta-synthetase expression by nuclear factor-kappa B activation contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation
Lin Li, Ruihua Xie, Shufen Hu, Yongmeng Wang, Tianzhu Yu, Ying Xiao, Xinghong Jiang, Jianguo Gu, Chuang-Ying Hu, Guang-Yin Xu
Genetic enhancement of neuropathic and inflammatory pain by forebrain upregulation of CREB-mediated transcription
Giannina Descalzi, Hotaka Fukushima, Akinobu Suzuki, Satoshi Kida, Min Zhuo
JAK-STAT1/3-induced expression of signal sequence-encoding proopiomelanocortin mRNA in lymphocytes reduces inflammatory pain in rats
Melanie Busch-Dienstfertig, Dominika Labuz, Theresa Wolfram, Nicole N Vogel, Christoph Stein
Positive allosteric modulation of TRPV1 as a novel analgesic mechanism
Evan E Lebovitz, Jason M Keller, Hal Kominsky, Krisztian Kaszas, Dragan Maric, Michael J Iadarola
p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI)
Xiao-Yan Zhu, Chang-Sheng Huang, Qian Li, Rui-min Chang, Zong-bing Song, Wang-yuan Zou, Qu-Lian Guo
Secretagogin is expressed in sensory CGRP neurons and in spinal cord of mouse and complements other calcium-binding proteins, with a note on rat and human
Tie-Jun Sten Shi, Qiong Xiang, Ming-Dong Zhang, Giuseppe Tortoriello, Henrik Hammarberg, Jan Mulder, Kaj Fried, Ludwig Wagner, Anna Josephson, Mathias Uhlén, Tibor Harkany, Tomas Hökfelt