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06.10.2020 | Original Article

Mood disorders are associated with the reduction of brain derived neurotrophic factor in the hypocampus in rats submitted to the hipercaloric diet

verfasst von: Rafael Tamborena Malheiros, Helena Oliveira Delgado, Daniel Tassinari Felber, Scheila Iria Kraus, Adair Roberto Soares dos Santos, Vanusa Manfredini, Morgana Duarte da Silva

Erschienen in: Metabolic Brain Disease | Ausgabe 1/2021

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Abstract

Adipose tissue accumulation, resulting from the consumption of hypercaloric foods, can cause a dysfunction of the endocrine system. Such endocrine changes can influence the expression of various neurochemicals including brain-derived neurotrophic factor (BDNF) - associated with cognitive and emotional problems. Here, we investigated the effects of a hypercaloric diet on depression- and anxiety-like behaviors in young rats along with concomitant changes in BDNF expression levels in the hippocampus. Eight week-old Wistar rats (n = 20) were divided in: control diet (CD) group which received industrial food (n = 8) and hypercaloric diet (HD) group which received animal fat and soybean oil (n = 12). After 45 days on the diet, the animals were evaluated: body weight and blood biochemical analisys. Changes in mood disposition were evaluated using forced swim test and the elevated plus-maze, whereas hippocampal BDNF expression levels were quantified by ELISA. After 45 weeks, the CD group showed a significant increase in body weight relative to the HD group. However, the HD rats had a body fat percentage and exhibited increased level of the biochemical markers. Furthermore, the animals in the HD group presented increased immobility time in the forced swimming test, as well as reduced response to plus-maze test suggesting a depression- and anxiety-like emotional state. In addition, the HD group also showed lower BDNF expression levels in the hippocampus. This study demonstrates that a hypercaloric diet induced increase in adipose tissue concentration in young rats was associated with reduced hippocampal BDNF expression and resulted in an increase in depression- and anxiety-like behaviors.

Akbaraly TN, Brunner EJ, Ferrie JE, Marmot MG, Kivimaki M, Singh-Manoux A (2009) Dietary pattern and depressive symptoms in middle age. Br J Psychiatry 195(5):408–413. https://doi.org/10.1192/bjp.bp.108.058925CrossRefPubMedPubMedCentral

Ambrósio G, Kaufmann FN, Manosso L, Platt N, Ghisleni G, Rodrigues ALS, Rieger DK, Kaster MP (2018) Depression and peripheral inflammatory profile of patients with obesity. Psychoneuroendocrinology. 91:132–141. https://doi.org/10.1016/j.psyneuen.2018.03.005CrossRefPubMed

André C, Dinel AL, Ferreira G, Layé S, Castanon N (2014) Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2, 3-dioxygenase activation. Brain Behav Immun 41:10–21. https://doi.org/10.1016/j.bbi.2014.03.012CrossRefPubMed

Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M (2005) IKK-β links inflammation to obesity-induced insulin resistance. Nat Med 11(2):191. https://doi.org/10.1038/nm1185CrossRefPubMed

Boitard C, Etchamendy N, Sauvant J, Aubert A, Tronel S, Marighetto A, Layé S, Ferreira G (2012) Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice. Hippocampus. 22(11):2095–2100. https://doi.org/10.1002/hipo.22032CrossRefPubMed

Castanon N, Lasselin J, Capuron L (2014) Neuropsychiatric comorbidity in obesity: role of inflammatory processes. Front Endocrinol 15:5–74. https://doi.org/10.3389/fendo.2014.00074CrossRef

de Wit L, Luppino F, van Straten A, Penninx B, Zitman F, Cuijpers P (2010) Depression and obesity: a meta-analysis of community-based studies. Psychiatry Res 178(2):230–235. https://doi.org/10.1016/j.psychres.2009.04.015CrossRefPubMed

Duman RS, Monteggia LM (2006) A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59(12):1116–1127. https://doi.org/10.1016/j.biopsych.2006.02.013CrossRefPubMed

Ferreira A, Castro JP, Andrade JP, Dulce Madeira M, Cardoso A (2018) Cafeteria-diet effects on cognitive functions, anxiety, fear response and neurogenesis in the juvenile rat. Neurobiol Learn Mem 155:197–207. https://doi.org/10.1016/j.nlm.2018.07.014CrossRefPubMed

Fu Z, Wu J, Nesil T, Li MD, Aylor KW, Liu Z (2016) Long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction. Am J Phys Heart Circ Phys 312:E89–E97. https://doi.org/10.1152/ajpendo.00297.2016CrossRef

Gariepy G, Nitka D, Schmitz N (2010) The association between obesity and anxiety disorders in the population: a systematic review and meta-analysis. Int J Obes 34(3):407. https://doi.org/10.1038/ijo.2009.252CrossRef

Gohil BC, Rosenblum LA, Coplan JD, Kral JG (2001) Hypothalamic-pituitary-adrenal axis function and the metabolic syndrome X of obesity. CNS Spectr 6(7):581–586, 589. https://doi.org/10.1017/s1092852900002121CrossRefPubMed

Goodman E, Whitaker RC (2002) A prospective study of the role of depression in the development and persistence of adolescent obesity. Pediatrics. 110(3):497–504. https://doi.org/10.1542/peds.110.3.497CrossRefPubMed

Hargrave SL, Jones S, Davidson TI (2016) The outward spiral: a vicious cycle model of obesity and cognitive dysfunction. Curr Opin Behav Sci 9:40–46. https://doi.org/10.1016/j.cobeha.2015.12.001CrossRefPubMedPubMedCentral

Jacka FN, Kremer PJ, Berk M, Silva-Sanigorski AM, Moodie M, Leslie ER, Pasco JA, Swinburn BA (2011) A prospective study of diet quality and mental health in adolescents. PLoS ONE 6:e24805. https://doi.org/10.1371/journal.pone.0024805CrossRefPubMedPubMedCentral

Kanoski SE, Meisel RL, Mullins AJ, Davidson TL (2007) The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behav Brain Res 182(1):57–66. https://doi.org/10.1016/j.bbr.2007.05.004CrossRefPubMedPubMedCentral

Kim JY, Kim D, Park K, Lee JH, Jahng JW (2018) Highly palatable food access during adolescence increased anxiety−/depression-like behaviors in male, but not in female, rats. Nutr Neurosci 21(7):502–510. https://doi.org/10.1080/1028415X.2017.1313583CrossRefPubMed

Kishi T, Hirooka Y, Nagayama T, Isegawa K, Katsuki M, Takesue K, Sunagawa K (2014) Calorie restriction improves cognitive decline via up-regulation of brain-derived neurotrophic factor. Int Heart J 56(1):110–115. https://doi.org/10.1536/ihj.14-168CrossRefPubMed

Kohlboeck G, Sausenthaler S, Standl M, Koletzko S, Bauer CP, von Berg A, Berdel D, Krämer U, Schaaf B, Lehmann I, Herbarth O, Heinrich J, GINI-plus and LISA-plus Study Groups (2012) Food intake, diet quality and behavioral problems in children: results from the GINI-plus/LISA-plus studies. Ann Nutr Metab 60:247–256. https://doi.org/10.1159/000337552CrossRefPubMed

Liu X, Zhu Z, Kalyani M, Janik JM, Shi H (2014) Effects of energy status and diet on Bdnf expression in the ventromedial hypothalamus of male and female rats. Physiol Behav 130:99–107. https://doi.org/10.1016/j.physbeh.2014.03.028CrossRefPubMedPubMedCentral

Lopresti AL, Drummond PD (2013) Obesity and psychiatric disorders: commonalities in dysregulated biological pathways and their implications for treatment. Prog Neuro-Psychopharmacol Biol Psychiatry 1(45):92–99. https://doi.org/10.1016/j.pnpbp.2013.05.005CrossRef

Malberg JE, Eisch AJ, Nestler EJ, Duman RS (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20(24):9104–9110. https://doi.org/10.1523/JNEUROSCI.20-24-09104.2000CrossRefPubMedPubMedCentral

Mansur RB, Brietzke E, Mcintyre RS (2015) Is there a “metabolicmood syndrome”? A review of the relationship between obesity and mood disorders. Neurosci Biobehav Rev 52:89–104. https://doi.org/10.1016/j.neubiorev.2014.12.017CrossRefPubMed

Martinowich K, Manji H, Lu B (2007) New insights into BDNF function in depression and anxiety. Nat Neurosci 10(9):1089–1093. https://doi.org/10.1038/nn1971CrossRefPubMed

Oliveira MC, Menezes-Garcia Z, Henriques MC, Soriani FM, Pinho V, Faria AM, Santiago AF, Cara DC, Souza DG, Teixeira MM, Ferreira AV (2013) Acute and sustained inflammation and metabolic dysfunction induced by high refined carbohydrate-containing diet in mice. Obesity 21(9):E396–E406. https://doi.org/10.1002/oby.20230CrossRefPubMed

Ozanne SE, Lewis R, Jennings BJ, Hales CN (2004) Early programming of weight gain in mice prevents the induction of obesity by a highly palatable diet. Clin Sci 106(2):141–145. https://doi.org/10.1042/CS20030278CrossRef

Park HR, Park M, Choi J, Park KY, Chung HY, Lee J (2010) A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor. Neurosci Lett 482(3):235–239. https://doi.org/10.1016/j.neulet.2010.07.046CrossRefPubMed

Pelleymounter MA, Cullen MJ, Wellman CI (1995) Characteristics of BDNF-induced weight loss. Exp Neurol 131(2):229–238. https://doi.org/10.1016/0014-4886(95)90045-4CrossRefPubMed

Pellow S, Chopin P, File SE, Briley M (1985) Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14(3):149–167. https://doi.org/10.1016/0165-0270(85)90031-7CrossRefPubMed

Pini RTB, Ferreira do Vales LDM, Braga Costa TM, Almeida SS (2017) Effects of cafeteria diet and high fat diet intake on anxiety, learning and memory in adult male rats. Nutr Neurosci 20(7):396–408. https://doi.org/10.1080/1028415X.2016.1149294CrossRefPubMed

Porsolt R, Le Pichon M, Jalfre M (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266(5604):730. https://doi.org/10.1038/266730a0CrossRefPubMed

Prado WLD, Lofrano MC, Oyama LM, Dâmaso AR (2009) Obesidade e adipocinas inflamatórias: implicações práticas para a prescrição de exercício. Rev Bras Med Esporte 15:378–383. https://doi.org/10.1590/S1517-86922009000600012CrossRef

Price JL, Drevets WC (2010) Neurocircuitry of mood disorders. Neuropsychopharmacol Rev 35:192–216. https://doi.org/10.1038/npp.2009.104CrossRef

Reeves PG (1997) Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr 127(5 Suppl):838S–841S. https://doi.org/10.1093/jn/127.5.838SCrossRefPubMed

Sales AJ, Biojone C, Terceti MS, Guimarães FS, Gomes MV, Joca SR (2011) Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors. Br J Pharmacol 164(6):1711–1721. https://doi.org/10.1111/j.1476-5381.2011.01489.xCrossRefPubMedPubMedCentral

Sanchez-Villegas A, Toledo E, Irala J, Ruiz-Canela M, Pla-Vidal J, Martınez-Gonzalez MA (2012) Fast-food and commercial baked goods consumption and the risk of depression. Public Health Nutr 15:424–432. https://doi.org/10.1017/S1368980011001856CrossRefPubMed

Santos CJ, Ferreira AVM, Oliveira AL, Oliveira MC, Gomes JS, Aguiar DC (2018) Carbohydrate-enriched diet predispose to anxiety and depression-like behavior after stress in mice. Nutr Neurosci 21(1):33–39. https://doi.org/10.1080/1028415X.2016.1213529CrossRefPubMed

Schleicher E, Wieland O (1978) Evaluation of the Bradford method for protein determination in body fluids. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie 16(9):533–534PubMed

Shi YS, Li CB, Li XY, Wu J, Li Y, Fu X, Zhang Y, Hu WZ (2018) Fisetin attenuates metabolic dysfunction in mice challenged with a high-fructose diet. J Agric Food Chem 66(31):8291–8298. https://doi.org/10.1021/acs.jafc.8b02140CrossRefPubMed

Taylor BA, Phillips SJ (1996) Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling. Genomics. 34(3):389–398. https://doi.org/10.1006/geno.1996.0302CrossRefPubMed

Thoenen H (1995) Neurotrophins and neuronal plasticity. Science. 270(5236):593–598. https://doi.org/10.1126/science.270.5236.593CrossRefPubMed

Wensveen FM, Jelenčić V, Valentić S, Šestan M, Wensveen TT, Theurich S, Glasner A, Mendrila D, Štimac D, Wunderlich FT, Brüning JC, Mandelboim O, Polić B (2015) NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol 16(4):376–385. https://doi.org/10.1038/ni.3120CrossRefPubMed

Yamada N, Katsuura G, Ochi Y, Ebihara K, Kusakabe T, Hosoda K, Nakao K (2011) Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology. 152(7):2634–2643. https://doi.org/10.1210/en.2011-0004CrossRefPubMed

Yamada-Goto N, Katsuura G, Ochi Y, Ebihara K, Kusakabe T, Hosoda K, Nakao K (2012) Impairment of fear-conditioning responses and changes of brain neurotrophic factors in diet-induced obese mice. J Neuroendocrinol 24(8):1120–1125. https://doi.org/10.1111/j.1365-2826.2012.02327.xCrossRefPubMed

Titel: Mood disorders are associated with the reduction of brain derived neurotrophic factor in the hypocampus in rats submitted to the hipercaloric diet
verfasst von: Rafael Tamborena Malheiros
Helena Oliveira Delgado
Daniel Tassinari Felber
Scheila Iria Kraus
Adair Roberto Soares dos Santos
Vanusa Manfredini
Morgana Duarte da Silva
Publikationsdatum: 06.10.2020
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 1/2021
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-020-00625-z

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