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01.10.2012 | Magnetic Resonance

Prediction of prostate cancer extracapsular extension with high spatial resolution dynamic contrast-enhanced 3-T MRI

verfasst von: B. Nicolas Bloch, Elizabeth M. Genega, Daniel N. Costa, Ivan Pedrosa, Martin P. Smith, Herbert Y. Kressel, Long Ngo, Martin G. Sanda, William C. DeWolf, Neil M. Rofsky

Erschienen in: European Radiology | Ausgabe 10/2012

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Abstract

Objectives

To assess the value of dynamic contrast-enhanced (DCE) combined with T2-weighted (T2W) endorectal coil (ERC) magnetic resonance imaging (MRI) at 3 T for determining extracapsular extension (ECE) of prostate cancer.

Methods

In this IRB-approved study, ERC 3-T MRI of the prostate was performed in 108 patients before radical prostatectomy. T2W fast spin-echo and DCE 3D gradient echo images were acquired. The interpretations of readers with varied experience were analysed. MRI-based staging results were compared with radical prostatectomy histology. Descriptive statistics were generated for prediction of ECE and staging accuracies were determined by the area under the receiver-operating characteristic curve.

Results

The overall sensitivity, specificity, positive predictive value and negative predictive value for ECE were 75 %, 92 %, 79 % and 91 %, respectively. Diagnostic accuracy for staging was 86 %, 80 % and 91 % for all readers, experienced and less experienced readers, respectively.

Conclusions

ERC 3-T MRI of the prostate combining DCE and T2W imaging is an accurate pretherapeutic staging tool for assessment of ECE in clinical practice across varying levels of reader experience.

Key Points

• Endorectal coil (ERC) magnetic resonance imaging is widely used for imaging prostatic disease.

• ERC 3-T MRI is reasonably accurate for local prostate cancer staging.

• High diagnostic accuracy is achievable across different levels of reader experience.

• MRI facilitates therapeutic decisions in patients with prostate cancer.

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Titel: Prediction of prostate cancer extracapsular extension with high spatial resolution dynamic contrast-enhanced 3-T MRI
verfasst von: B. Nicolas Bloch
Elizabeth M. Genega
Daniel N. Costa
Ivan Pedrosa
Martin P. Smith
Herbert Y. Kressel
Long Ngo
Martin G. Sanda
William C. DeWolf
Neil M. Rofsky
Publikationsdatum: 01.10.2012
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 10/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2475-5

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Prediction of prostate cancer extracapsular extension with high spatial resolution dynamic contrast-enhanced 3-T MRI