Skip to main content

2019 | Schmerzsyndrome | OriginalPaper | Buchkapitel

10. Psychophysische und Neurophysiologische Messverfahren in der Schmerzmedizin

verfasst von : Rolf-Detlef Treede

Erschienen in: Praktische Schmerzmedizin

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Die Funktionsfähigkeit des somatosensorischen Systems wird durch klinische Sensibilitätsprüfung, quantitative sensorische Testung (QST) oder elektrophysiologische Messverfahren geprüft. Dabei geht es um evozierten Schmerz, der vermindert (Hypalgesie) oder gesteigert (Hyperalgesie, Allodynie) sein kann, sowie um veränderten Tastsinn, Propriozeption oder Temperatursinn. Die QST zeichnet sich durch eine stärkere Formalisierung des Untersuchungsablaufs, die Verwendung von kalibrierten Reizstärken und die Standardisierung der Instruktionen für den Patienten aus und liefert reproduzierbare und vom Untersucher unabhängige Befunde. Elektrophysiologische Messverfahren liefern objektive Befunde zur Funktion des somatosensorischen Systems. Mittels Elektroneurogramms (ENG) und somatosensorisch evozierter Potenziale (SEP) werden die dicken myelinisierten Afferenzen und die Hinterstrangbahnen geprüft. Durch Laser-evozierte Potenziale (LEP) werden Veränderungen der Funktion der dünnen nozizeptiven Afferenzen und des spinothalamischen Traktes erfasst.
Literatur
Zurück zum Zitat Baron R, Wasner G (1998) Quantitative Thermotestung. Untersuchung der thermosensiblen und nozizeptiven. Afferenzen bei Neuropathien Schmerz 12:209–211 Baron R, Wasner G (1998) Quantitative Thermotestung. Untersuchung der thermosensiblen und nozizeptiven. Afferenzen bei Neuropathien Schmerz 12:209–211
Zurück zum Zitat Baron R, Maier C, Attal N, Binder A, Bouhassira D, Cruccu G, Finnerup NB, Haanpää M, Hansson P, Hüllemann P, Jensen TS, Freynhagen R, Kennedy JD, Magerl W, Mainka T, Reimer M, Rice AS, Segerdahl M, Serra J, Sindrup S, Sommer C, Tölle T, Vollert J, Treede RD (2017) Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles. Pain 158:261–272CrossRef Baron R, Maier C, Attal N, Binder A, Bouhassira D, Cruccu G, Finnerup NB, Haanpää M, Hansson P, Hüllemann P, Jensen TS, Freynhagen R, Kennedy JD, Magerl W, Mainka T, Reimer M, Rice AS, Segerdahl M, Serra J, Sindrup S, Sommer C, Tölle T, Vollert J, Treede RD (2017) Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles. Pain 158:261–272CrossRef
Zurück zum Zitat Baumgärtner U, Magerl W, Klein T, Hopf HC, Treede RD (2002) Neurogenic hyperalgesia versus painful hypoalgesia: two distinct mechanisms of neuropathic pain. Pain 96:141–151CrossRef Baumgärtner U, Magerl W, Klein T, Hopf HC, Treede RD (2002) Neurogenic hyperalgesia versus painful hypoalgesia: two distinct mechanisms of neuropathic pain. Pain 96:141–151CrossRef
Zurück zum Zitat Beise RD, Carstens E, Kohllöffel LUE (1998) Psychophysical study of stinging pain evoked by brief freezing of superficial skin and ensuing short-lasting changes in sensations of cool and cold pain. Pain 74:275–286CrossRef Beise RD, Carstens E, Kohllöffel LUE (1998) Psychophysical study of stinging pain evoked by brief freezing of superficial skin and ensuing short-lasting changes in sensations of cool and cold pain. Pain 74:275–286CrossRef
Zurück zum Zitat Chan AW, MacFarlane IA, Bowsher D, Campbell JA (1992) Weighted needle pinprick sensory thresholds: a simple test of sensory function in diabetic peripheral neuropathy. J Neurol Neurosurg Psychiatr 55:56–59CrossRef Chan AW, MacFarlane IA, Bowsher D, Campbell JA (1992) Weighted needle pinprick sensory thresholds: a simple test of sensory function in diabetic peripheral neuropathy. J Neurol Neurosurg Psychiatr 55:56–59CrossRef
Zurück zum Zitat Cruccu G, Sommer C, Anand P, Attal N, Baron R, Garcia-Larrea L, Haanpää M, Jensen TS, Serra J, Treede RD (2010) EFNS guidelines on neuropathic pain assessment; revised 2009. Eur J Neurol 17:1010–1018CrossRef Cruccu G, Sommer C, Anand P, Attal N, Baron R, Garcia-Larrea L, Haanpää M, Jensen TS, Serra J, Treede RD (2010) EFNS guidelines on neuropathic pain assessment; revised 2009. Eur J Neurol 17:1010–1018CrossRef
Zurück zum Zitat Frost SA, Raja SN, Campbell JN, Meyer RA, Khan AA (1988) Does hyperalgesia to cooling stimuli characterize patients with sympathetically maintained pain (reflex sympathetic dystrophy)? In: Dubner R, Gebhart GF, Bond MR (Hrsg) Proceedings of the Vth world congress on pain. Elsevier, Amsterdam, S 151–156 Frost SA, Raja SN, Campbell JN, Meyer RA, Khan AA (1988) Does hyperalgesia to cooling stimuli characterize patients with sympathetically maintained pain (reflex sympathetic dystrophy)? In: Dubner R, Gebhart GF, Bond MR (Hrsg) Proceedings of the Vth world congress on pain. Elsevier, Amsterdam, S 151–156
Zurück zum Zitat Fruhstorfer H, Lindblom U, Schmidt WG (1976) Method for quantitative estimation of thermal thresholds in patients. J Neurol Neurosurg Psychiatr 39:1071–1075CrossRef Fruhstorfer H, Lindblom U, Schmidt WG (1976) Method for quantitative estimation of thermal thresholds in patients. J Neurol Neurosurg Psychiatr 39:1071–1075CrossRef
Zurück zum Zitat Fruhstorfer H, Gross W, Selbmann O (2001) von Frey hairs: new materials for a new design. Eur J Pain 5:341–342CrossRef Fruhstorfer H, Gross W, Selbmann O (2001) von Frey hairs: new materials for a new design. Eur J Pain 5:341–342CrossRef
Zurück zum Zitat Geber C, Scherens A, Pfau D, Nestler N, Zenz M, Tolle T, Baron R, Treede RD, Maier C (2009) Procedure for certification of QST laboratories. Schmerz 23:65–69CrossRef Geber C, Scherens A, Pfau D, Nestler N, Zenz M, Tolle T, Baron R, Treede RD, Maier C (2009) Procedure for certification of QST laboratories. Schmerz 23:65–69CrossRef
Zurück zum Zitat Gracely RH, Grant MAB, Giesecke T (2003) Evoked pain measures in fibromyalgia. Best Pract Res Clin Rheumatol 17:593–609CrossRef Gracely RH, Grant MAB, Giesecke T (2003) Evoked pain measures in fibromyalgia. Best Pract Res Clin Rheumatol 17:593–609CrossRef
Zurück zum Zitat Greenspan JD, McGillis SLB (1991) Stimulus features relevant to the perception of sharpness and mechanically evoked cutaneous pain. Somatosens Mot Res 8:137–147CrossRef Greenspan JD, McGillis SLB (1991) Stimulus features relevant to the perception of sharpness and mechanically evoked cutaneous pain. Somatosens Mot Res 8:137–147CrossRef
Zurück zum Zitat Jensen TS, Baron R (2003) Translation of symptoms and signs into mechanisms in neuropathic pain. Pain 102:1–8CrossRef Jensen TS, Baron R (2003) Translation of symptoms and signs into mechanisms in neuropathic pain. Pain 102:1–8CrossRef
Zurück zum Zitat Koltzenburg M, Lundberg LER, Torebjörk HE (1992) Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain 51:207–219CrossRef Koltzenburg M, Lundberg LER, Torebjörk HE (1992) Dynamic and static components of mechanical hyperalgesia in human hairy skin. Pain 51:207–219CrossRef
Zurück zum Zitat Magerl W, Krumova EK, Baron R, Tölle T, Treede RD, Maier C (2010) Reference data for quantitative sensory testing (QST): refined stratification for age and a novel method for statistical comparison of group data. Pain 151:598–605CrossRef Magerl W, Krumova EK, Baron R, Tölle T, Treede RD, Maier C (2010) Reference data for quantitative sensory testing (QST): refined stratification for age and a novel method for statistical comparison of group data. Pain 151:598–605CrossRef
Zurück zum Zitat Maier C, Baron R, Tölle TR, Binder A, Birbaumer N, Birklein F, Giertmühlen J, Flor H, Geber C, Huge V, Krumova EK, Landwehrmeyer GB, Magerl W, Maihöfner C, Richter H, Rolke R, Scherens A, Schwarz A, Sommer C, Tronnier V, Üceyler N, Valet M, Wasner G, Treede RD (2010) Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain 150:439–450CrossRef Maier C, Baron R, Tölle TR, Binder A, Birbaumer N, Birklein F, Giertmühlen J, Flor H, Geber C, Huge V, Krumova EK, Landwehrmeyer GB, Magerl W, Maihöfner C, Richter H, Rolke R, Scherens A, Schwarz A, Sommer C, Tronnier V, Üceyler N, Valet M, Wasner G, Treede RD (2010) Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain 150:439–450CrossRef
Zurück zum Zitat Merskey H, Albe-Fessard D, Bonica JJ, Carmon A, Dubner R, Kerr FWL, Lindblom U, Mumford JM, Nathan PW, Noordenbos W, Pagni CA, Renaer MJ, Sternbach RA, Sunderland S (1979) Pain terms: a list with definitions and notes on usage. Recommended by the IASP subcommittee on taxonomy. Pain 6:249–252CrossRef Merskey H, Albe-Fessard D, Bonica JJ, Carmon A, Dubner R, Kerr FWL, Lindblom U, Mumford JM, Nathan PW, Noordenbos W, Pagni CA, Renaer MJ, Sternbach RA, Sunderland S (1979) Pain terms: a list with definitions and notes on usage. Recommended by the IASP subcommittee on taxonomy. Pain 6:249–252CrossRef
Zurück zum Zitat Ochoa JL, Yarnitsky D (1993) Mechanical hyperalgesias in neuropathic pain patients: dynamic and static subtypes. Ann Neurol 33:465–472CrossRef Ochoa JL, Yarnitsky D (1993) Mechanical hyperalgesias in neuropathic pain patients: dynamic and static subtypes. Ann Neurol 33:465–472CrossRef
Zurück zum Zitat Perkins BA, Bril V (2003) Diabetic neuropathy: a review emphasizing diagnostic methods. Clin Neurophysiol 114:1167–1175CrossRef Perkins BA, Bril V (2003) Diabetic neuropathy: a review emphasizing diagnostic methods. Clin Neurophysiol 114:1167–1175CrossRef
Zurück zum Zitat Pestronk A, Florence J, Levine T, Al-Lozi MT, Lopate G, Miller T, Ramneantu I, Waheed W, Stambuk M (2004) Sensory exam with a quantitative tuning fork. Rapid, sensitive and predictive of SNAP amplitude. Neurology 62:461–464CrossRef Pestronk A, Florence J, Levine T, Al-Lozi MT, Lopate G, Miller T, Ramneantu I, Waheed W, Stambuk M (2004) Sensory exam with a quantitative tuning fork. Rapid, sensitive and predictive of SNAP amplitude. Neurology 62:461–464CrossRef
Zurück zum Zitat Pfau DB, Geber C, Birklein F, Treede RD (2012) Quantitative sensory testing of neuropathic pain patients: potential mechanistic and therapeutic implications. Curr Pain Headache Rep 16:199–206CrossRef Pfau DB, Geber C, Birklein F, Treede RD (2012) Quantitative sensory testing of neuropathic pain patients: potential mechanistic and therapeutic implications. Curr Pain Headache Rep 16:199–206CrossRef
Zurück zum Zitat Rolke R, Magerl W, Andrews-Campbell K, Schalber C, Caspari S, Birklein F, Treede RD (2006) Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain 10:77–88CrossRef Rolke R, Magerl W, Andrews-Campbell K, Schalber C, Caspari S, Birklein F, Treede RD (2006) Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain 10:77–88CrossRef
Zurück zum Zitat Shy ME, Frohman EM, So YT, Arezzo JC, Cornblath DR, Giuliani MJ, Kincaid JC, Ochoa JL, Parry GJ, Weimer LH (2003) Quantitative sensory testing: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 60:898–904CrossRef Shy ME, Frohman EM, So YT, Arezzo JC, Cornblath DR, Giuliani MJ, Kincaid JC, Ochoa JL, Parry GJ, Weimer LH (2003) Quantitative sensory testing: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 60:898–904CrossRef
Zurück zum Zitat Treede RD, Meyer RA, Raja SN, Campbell JN (1995) Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin. J Physiol 483:747–758CrossRef Treede RD, Meyer RA, Raja SN, Campbell JN (1995) Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin. J Physiol 483:747–758CrossRef
Zurück zum Zitat Treede RD, Rolke R, Andrews K, Magerl W (2002) Pain elicited by blunt pressure: neurobiological basis and clinical relevance. Pain 98:235–240CrossRef Treede RD, Rolke R, Andrews K, Magerl W (2002) Pain elicited by blunt pressure: neurobiological basis and clinical relevance. Pain 98:235–240CrossRef
Zurück zum Zitat Treede RD, Handwerker HO, Baumgärtner U, Meyer RA, Magerl W (2004) Hyperalgesia and allodynia: taxonomy, assessment, and mechanisms. In: Brune K, Handwerker HO (Hrsg) Hyperalgesia: molecular mechanisms and clinical implications. IASP Press, Seattle, S 1–15 Treede RD, Handwerker HO, Baumgärtner U, Meyer RA, Magerl W (2004) Hyperalgesia and allodynia: taxonomy, assessment, and mechanisms. In: Brune K, Handwerker HO (Hrsg) Hyperalgesia: molecular mechanisms and clinical implications. IASP Press, Seattle, S 1–15
Zurück zum Zitat Vollert J, Maier C, Attal N, Bennett DLH, Bouhassira D, Enax-Krumova EK, Finnerup NB, Freynhagen R, Gierthmühlen J, Haanpää M, Hansson P, Hüllemann P, Jensen TS, Magerl W, Ramirez JD, Rice ASC, Schuh-Hofer S, Segerdahl M, Serra J, Shillo PR, Sindrup S, Tesfaye S, Themistocleous AC, Tölle TR, Treede RD, Baron R (2017) Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations. Pain 158:1446–1455CrossRef Vollert J, Maier C, Attal N, Bennett DLH, Bouhassira D, Enax-Krumova EK, Finnerup NB, Freynhagen R, Gierthmühlen J, Haanpää M, Hansson P, Hüllemann P, Jensen TS, Magerl W, Ramirez JD, Rice ASC, Schuh-Hofer S, Segerdahl M, Serra J, Shillo PR, Sindrup S, Tesfaye S, Themistocleous AC, Tölle TR, Treede RD, Baron R (2017) Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations. Pain 158:1446–1455CrossRef
Zurück zum Zitat Yarnitsky D (1997) Quantitative sensory testing. Muscle Nerve 20:198–204CrossRef Yarnitsky D (1997) Quantitative sensory testing. Muscle Nerve 20:198–204CrossRef
Zurück zum Zitat Yarnitsky D, Sprecher E (1994) Thermal testing: normative data and repeatability for various test algorithms. J Neurol Sci 125:39–45CrossRef Yarnitsky D, Sprecher E (1994) Thermal testing: normative data and repeatability for various test algorithms. J Neurol Sci 125:39–45CrossRef
Zurück zum Zitat Yarnitsky D, Sprecher E, Zaslansky R, Hemli JA (1995) Heat pain thresholds: normative data and repeatability. Pain 60:329–332CrossRef Yarnitsky D, Sprecher E, Zaslansky R, Hemli JA (1995) Heat pain thresholds: normative data and repeatability. Pain 60:329–332CrossRef
Zurück zum Zitat Ziegler D, Mayer P, Gries FA (1988) Evaluation of thermal, pain, and vibration sensation thresholds in newly diagnosed type 1 diabetic patients. J Neurol Neurosurg Psychiatry 51:1420–1424CrossRef Ziegler D, Mayer P, Gries FA (1988) Evaluation of thermal, pain, and vibration sensation thresholds in newly diagnosed type 1 diabetic patients. J Neurol Neurosurg Psychiatry 51:1420–1424CrossRef
Zurück zum Zitat Ziegler EA, Magerl W, Meyer RA, Treede RD (1999) Secondary hyperalgesia to punctate mechanical stimuli: central sensitization to A – fibre nociceptor input. Brain 122:2245–2257CrossRef Ziegler EA, Magerl W, Meyer RA, Treede RD (1999) Secondary hyperalgesia to punctate mechanical stimuli: central sensitization to A – fibre nociceptor input. Brain 122:2245–2257CrossRef
Zurück zum Zitat Babiloni C, Brancucci A, Babiloni F, Capotosto P, Carducci F, Cincotti F, Arendt-Nielsen L, Chen ACN, Rossini PM (2003) Anticipatory cortical responses during the expectancy of a predictable painful stimulation. A high-resolution electroencephalography study. Eur J Neurosci 18:1692–1700CrossRef Babiloni C, Brancucci A, Babiloni F, Capotosto P, Carducci F, Cincotti F, Arendt-Nielsen L, Chen ACN, Rossini PM (2003) Anticipatory cortical responses during the expectancy of a predictable painful stimulation. A high-resolution electroencephalography study. Eur J Neurosci 18:1692–1700CrossRef
Zurück zum Zitat Backonja M, Howland EW, Wang J, Smith J, Salinsky M, Cleeland CS (1991) Tonic changes in alpha power during immersion of the hand in cold water. Electroenceph Clin Neurophysiol 79:192–203CrossRef Backonja M, Howland EW, Wang J, Smith J, Salinsky M, Cleeland CS (1991) Tonic changes in alpha power during immersion of the hand in cold water. Electroenceph Clin Neurophysiol 79:192–203CrossRef
Zurück zum Zitat Baron R, Saguer M (1993) Postherpetic neuralgia. Are C-nociceptors involved in signalling and maintenance of tactile allodynia? Brain 116:1477–1496CrossRef Baron R, Saguer M (1993) Postherpetic neuralgia. Are C-nociceptors involved in signalling and maintenance of tactile allodynia? Brain 116:1477–1496CrossRef
Zurück zum Zitat Baumgärtner U, Greffrath W, Treede RD (2012) Contact heat and cold, mechanical, electrical and chemical stimuli to elicit small fiber-evoked potentials: merits and limitations for basic science and clinical use. Neurophysiol Clin 42:267–280CrossRef Baumgärtner U, Greffrath W, Treede RD (2012) Contact heat and cold, mechanical, electrical and chemical stimuli to elicit small fiber-evoked potentials: merits and limitations for basic science and clinical use. Neurophysiol Clin 42:267–280CrossRef
Zurück zum Zitat Biasiotta A, Casato M, La Cesa S, Colantuono S, Di Stefano G, Leone C, Carlesimo M, Piroso S, Cruccu G, Truini A (2014) Clinical, neurophysiological, and skin biopsy findings in peripheral neuropathy associated with hepatitis C virus-related cryoglobulinemia. J Neurol 261:725–731CrossRef Biasiotta A, Casato M, La Cesa S, Colantuono S, Di Stefano G, Leone C, Carlesimo M, Piroso S, Cruccu G, Truini A (2014) Clinical, neurophysiological, and skin biopsy findings in peripheral neuropathy associated with hepatitis C virus-related cryoglobulinemia. J Neurol 261:725–731CrossRef
Zurück zum Zitat Birklein F, Riedl B, Neundörfer B, Handwerker HO (1998) Sympathetic vasoconstrictor reflex pattern in patients with complex regional pain syndrome. Pain 75:93–100CrossRef Birklein F, Riedl B, Neundörfer B, Handwerker HO (1998) Sympathetic vasoconstrictor reflex pattern in patients with complex regional pain syndrome. Pain 75:93–100CrossRef
Zurück zum Zitat Bromm B, Lorenz J (1998) Neurophysiological evaluation of pain. Electroenceph Clin Neurophysiol 107:227–253CrossRef Bromm B, Lorenz J (1998) Neurophysiological evaluation of pain. Electroenceph Clin Neurophysiol 107:227–253CrossRef
Zurück zum Zitat Bromm B, Jahnke MT, Treede RD (1984) Responses of human cutaneous afferents to CO2 laser stimuli causing pain. Exp Brain Res 55:158–166CrossRef Bromm B, Jahnke MT, Treede RD (1984) Responses of human cutaneous afferents to CO2 laser stimuli causing pain. Exp Brain Res 55:158–166CrossRef
Zurück zum Zitat Cruccu G, Aminoff MJ, Curio G, Guerit JM, Kakigi R, Mauguiere F, Rossini PM, Treede RM, Garcia-Larrea L (2008) 3. Recommendations for the clinical use of somatosensory-evoked potentials. Clin Neurophysiol 119:1705–1719CrossRef Cruccu G, Aminoff MJ, Curio G, Guerit JM, Kakigi R, Mauguiere F, Rossini PM, Treede RM, Garcia-Larrea L (2008) 3. Recommendations for the clinical use of somatosensory-evoked potentials. Clin Neurophysiol 119:1705–1719CrossRef
Zurück zum Zitat Cruccu G, Sommer C, Anand P, Attal N, Baron R, Garcia-Larrea L, Haanpää M, Jensen TS, Serra J, Treede RD (2010) EFNS guidelines on neuropathic pain assessment; revised 2009. Eur J Neurol 17: 1010–1018CrossRef Cruccu G, Sommer C, Anand P, Attal N, Baron R, Garcia-Larrea L, Haanpää M, Jensen TS, Serra J, Treede RD (2010) EFNS guidelines on neuropathic pain assessment; revised 2009. Eur J Neurol 17: 1010–1018CrossRef
Zurück zum Zitat Davis KD, Flor H, Greely HT, Iannetti GD, Mackey S, Ploner M, Pustilnik A, Tracey I, Treede RD, Wager TD (2017) Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations. Nat Rev Neurol 13:624–638CrossRef Davis KD, Flor H, Greely HT, Iannetti GD, Mackey S, Ploner M, Pustilnik A, Tracey I, Treede RD, Wager TD (2017) Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations. Nat Rev Neurol 13:624–638CrossRef
Zurück zum Zitat Duysens J, Trippel M, Horstmann GA, Dietz V (1990) Gating and reversal of reflexes in ankle muscles during human walking. Exp Brain Res 82:351–358CrossRef Duysens J, Trippel M, Horstmann GA, Dietz V (1990) Gating and reversal of reflexes in ankle muscles during human walking. Exp Brain Res 82:351–358CrossRef
Zurück zum Zitat Ebenezer GJ, Hauer P, Gibbons C, McArthur JC, Polydefkis M (2007) Assessment of epidermal nerve fibers: a new diagnostic and predictive tool for peripheral neuropathies. J Neuropathol Exp Neurol 66:1059–1073CrossRef Ebenezer GJ, Hauer P, Gibbons C, McArthur JC, Polydefkis M (2007) Assessment of epidermal nerve fibers: a new diagnostic and predictive tool for peripheral neuropathies. J Neuropathol Exp Neurol 66:1059–1073CrossRef
Zurück zum Zitat Fitzek S, Baumgärtner U, Fitzek C, Magerl W, Urban P, Thömke F, Marx J, Treede RD, Stoeter P, Hopf HC (2001) Mechanisms and predictors of chronic facial pain in lateral medullary infarction. Ann Neurol 49:493–500CrossRef Fitzek S, Baumgärtner U, Fitzek C, Magerl W, Urban P, Thömke F, Marx J, Treede RD, Stoeter P, Hopf HC (2001) Mechanisms and predictors of chronic facial pain in lateral medullary infarction. Ann Neurol 49:493–500CrossRef
Zurück zum Zitat García-Larrea L, Convers P, Magnin M, André-Obadia N, Peyron R, Laurent B, Mauguière F (2002) Laser-evoked potential abnormalities in central pain patients: the influence of spontaneous and provoked pain. Brain 125:2766–2781CrossRef García-Larrea L, Convers P, Magnin M, André-Obadia N, Peyron R, Laurent B, Mauguière F (2002) Laser-evoked potential abnormalities in central pain patients: the influence of spontaneous and provoked pain. Brain 125:2766–2781CrossRef
Zurück zum Zitat Gibson SJ, Littlejohn GO, Gorman MM, Helme RD, Granges G (1994) Altered heat pain thresholds and cerebral event-related potentials following painful CO2 laser stimulation in subjects with fibromyalgia syndrome. Pain 58:185–193CrossRef Gibson SJ, Littlejohn GO, Gorman MM, Helme RD, Granges G (1994) Altered heat pain thresholds and cerebral event-related potentials following painful CO2 laser stimulation in subjects with fibromyalgia syndrome. Pain 58:185–193CrossRef
Zurück zum Zitat Grönroos M, Pertovaara A (1993) Capsaicin-induced central facilitation of a nociceptive flexion reflex in humans. Neurosci Lett 159:215–218CrossRef Grönroos M, Pertovaara A (1993) Capsaicin-induced central facilitation of a nociceptive flexion reflex in humans. Neurosci Lett 159:215–218CrossRef
Zurück zum Zitat Hopf HC, Thömke F, Gutmann L (1991) Midbrain vs. pontine medial longitudinal fasciculus lesions: the utilization of masseter and blink reflexes. Muscle Nerve 14:326–330CrossRef Hopf HC, Thömke F, Gutmann L (1991) Midbrain vs. pontine medial longitudinal fasciculus lesions: the utilization of masseter and blink reflexes. Muscle Nerve 14:326–330CrossRef
Zurück zum Zitat Kleggetveit IP, Namer B, Schmidt R, Helås T, Rückel M, Ørstavik K, Schmelz M, Jørum E (2012) High spontaneous activity of C-nociceptors in painful polyneuropathy. Pain 153:2040–2047CrossRef Kleggetveit IP, Namer B, Schmidt R, Helås T, Rückel M, Ørstavik K, Schmelz M, Jørum E (2012) High spontaneous activity of C-nociceptors in painful polyneuropathy. Pain 153:2040–2047CrossRef
Zurück zum Zitat Lorenz J, Grasedyck K, Bromm B (1996) Middle and long latency somatosensory evoked potentials after painful laser stimulation in patients with fibromyalgia syndrome. Electroenceph Clin Neurophysiol 100:165–168CrossRef Lorenz J, Grasedyck K, Bromm B (1996) Middle and long latency somatosensory evoked potentials after painful laser stimulation in patients with fibromyalgia syndrome. Electroenceph Clin Neurophysiol 100:165–168CrossRef
Zurück zum Zitat Papanas N, Ziegler D (2015) Corneal confocal microscopy: recent progress in the evaluation of diabetic neuropathy. J Diab Invest 6:381–389CrossRef Papanas N, Ziegler D (2015) Corneal confocal microscopy: recent progress in the evaluation of diabetic neuropathy. J Diab Invest 6:381–389CrossRef
Zurück zum Zitat Perkins BA, Bril V (2003) Diabetic neuropathy: a review emphasizing diagnostic methods. Clin Neurophysiol 114:1167–1175CrossRef Perkins BA, Bril V (2003) Diabetic neuropathy: a review emphasizing diagnostic methods. Clin Neurophysiol 114:1167–1175CrossRef
Zurück zum Zitat Peyron R, Frot M, Schneider F, Garcia-Larrea L, Mertens P, Barral FG, Sindou M, Laurent B, Mauguière F (2002) Role of operculoinsular cortices in human pain processing: converging evidence from PET, fMRI, dipole modeling, and intracerebral recordings of evoked potentials. NeuroImage 17:1336–1346CrossRef Peyron R, Frot M, Schneider F, Garcia-Larrea L, Mertens P, Barral FG, Sindou M, Laurent B, Mauguière F (2002) Role of operculoinsular cortices in human pain processing: converging evidence from PET, fMRI, dipole modeling, and intracerebral recordings of evoked potentials. NeuroImage 17:1336–1346CrossRef
Zurück zum Zitat Ploner M, May ES (2018) Electroencephalography and magnetoencephalography in pain research–current state and future perspectives. Pain 159:206–211CrossRef Ploner M, May ES (2018) Electroencephalography and magnetoencephalography in pain research–current state and future perspectives. Pain 159:206–211CrossRef
Zurück zum Zitat Schomburg ED (1997) Restrictions on the interpretation of spinal reflex modulation in pain and analgesia research. Pain Forum 6:101–109CrossRef Schomburg ED (1997) Restrictions on the interpretation of spinal reflex modulation in pain and analgesia research. Pain Forum 6:101–109CrossRef
Zurück zum Zitat Schüller TB, Hermann K, Baron R (2000) Quantitative assessment and correlation of sympathetic, parasympathetic, and afferent small fiber function in peripheral neuropathy. J Neurol 247:267–272CrossRef Schüller TB, Hermann K, Baron R (2000) Quantitative assessment and correlation of sympathetic, parasympathetic, and afferent small fiber function in peripheral neuropathy. J Neurol 247:267–272CrossRef
Zurück zum Zitat Serra J, Bostock H, Solà R, Aleu J, García E, Cokic B, Navarro X, Quiles C (2012) Microneurographic identification of spontaneous activity in C-nociceptors in neuropathic pain states in humans and rats. Pain 153:42–55CrossRef Serra J, Bostock H, Solà R, Aleu J, García E, Cokic B, Navarro X, Quiles C (2012) Microneurographic identification of spontaneous activity in C-nociceptors in neuropathic pain states in humans and rats. Pain 153:42–55CrossRef
Zurück zum Zitat Spiegel J, Hansen C, Treede RD (2000) Clinical evaluation criteria for the assessment of impaired pain sensitivity by thulium-laser evoked potentials. Clin Neurophysiol 111:725–735CrossRef Spiegel J, Hansen C, Treede RD (2000) Clinical evaluation criteria for the assessment of impaired pain sensitivity by thulium-laser evoked potentials. Clin Neurophysiol 111:725–735CrossRef
Zurück zum Zitat Tarkka IM, Treede RD (1993) Equivalent electrical source analysis of pain-related somatosensory evoked potentials elicited by a CO2 laser. J Clin Neurophysiol 10:513–519CrossRef Tarkka IM, Treede RD (1993) Equivalent electrical source analysis of pain-related somatosensory evoked potentials elicited by a CO2 laser. J Clin Neurophysiol 10:513–519CrossRef
Zurück zum Zitat Torebjörk E (1993) Human microneurography and intraneural microstimulation in the study of neuropathic pain. Muscle Nerve 16:1063–1065CrossRef Torebjörk E (1993) Human microneurography and intraneural microstimulation in the study of neuropathic pain. Muscle Nerve 16:1063–1065CrossRef
Zurück zum Zitat Treede RD (2005) Funktionsprüfung der nozizeptiven Bahnen durch SEP nach schmerzhaften Laser-Hitzereizen. In: Stöhr M, Dichgans J, Buettner UW, Hess CW (Hrsg) Evozierte Potenziale, 4. Aufl. Springer, Berlin/Heidelberg/New York, S 600–621 Treede RD (2005) Funktionsprüfung der nozizeptiven Bahnen durch SEP nach schmerzhaften Laser-Hitzereizen. In: Stöhr M, Dichgans J, Buettner UW, Hess CW (Hrsg) Evozierte Potenziale, 4. Aufl. Springer, Berlin/Heidelberg/New York, S 600–621
Zurück zum Zitat Treede RD, Lorenz J, Baumgärtner U (2003) Clinical usefulness of laser-evoked potentials. Neurophysiol Clin 33:303–314CrossRef Treede RD, Lorenz J, Baumgärtner U (2003) Clinical usefulness of laser-evoked potentials. Neurophysiol Clin 33:303–314CrossRef
Zurück zum Zitat Urasaki E, Wada SI, Kadoya C, Tokimura T, Yokota A, Matsuoka S, Fukumura A, Hamada S (1990) Skin and epidural recording of spinal somatosensory evoked potentials following median nerve stimulation: correlation between the absence of spinal N13 and impaired pain sense. J Neurol 237:410–415CrossRef Urasaki E, Wada SI, Kadoya C, Tokimura T, Yokota A, Matsuoka S, Fukumura A, Hamada S (1990) Skin and epidural recording of spinal somatosensory evoked potentials following median nerve stimulation: correlation between the absence of spinal N13 and impaired pain sense. J Neurol 237:410–415CrossRef
Zurück zum Zitat Valeriani M, de Tommaso M, Restuccia D, Le Pera D, Guido M, Iannetti GD, Libro G, Truini A, DiTrapani G, Puca F, Tonali P, Cruccu G (2003) Reduced habituation to experimental pain in migraine patients: a CO2 laser evoked potential study. Pain 105:57–64CrossRef Valeriani M, de Tommaso M, Restuccia D, Le Pera D, Guido M, Iannetti GD, Libro G, Truini A, DiTrapani G, Puca F, Tonali P, Cruccu G (2003) Reduced habituation to experimental pain in migraine patients: a CO2 laser evoked potential study. Pain 105:57–64CrossRef
Zurück zum Zitat Wasner G, Schattschneider J, Baron R (2002) Skin temperature side differences – a diagnostic tool for CRPS? Pain 98:19–26CrossRef Wasner G, Schattschneider J, Baron R (2002) Skin temperature side differences – a diagnostic tool for CRPS? Pain 98:19–26CrossRef
Zurück zum Zitat Willer JC (1985) Studies on pain. Effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man. Brain Res 331:105–114CrossRef Willer JC (1985) Studies on pain. Effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man. Brain Res 331:105–114CrossRef
Zurück zum Zitat Zhang ZG, Hu L, Hung YS, Mouraux A, Iannetti GD (2012) Gamma-band oscillations in the primary somatosensory cortex – a direct and obligatory correlate of subjective pain intensity. J Neurosci 32:7429–7438CrossRef Zhang ZG, Hu L, Hung YS, Mouraux A, Iannetti GD (2012) Gamma-band oscillations in the primary somatosensory cortex – a direct and obligatory correlate of subjective pain intensity. J Neurosci 32:7429–7438CrossRef
Metadaten
Titel
Psychophysische und Neurophysiologische Messverfahren in der Schmerzmedizin
verfasst von
Rolf-Detlef Treede
Copyright-Jahr
2019
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-57487-4_9

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 Appendizitis Nachrichten

Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Mehr Schaden als Nutzen durch präoperatives Aussetzen von GLP-1-Agonisten?

23.04.2024 Operationsvorbereitung Nachrichten

Derzeit wird empfohlen, eine Therapie mit GLP-1-Rezeptoragonisten präoperativ zu unterbrechen. Eine neue Studie nährt jedoch Zweifel an der Notwendigkeit der Maßnahme.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.