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Erschienen in: Indian Journal of Surgery 5/2015

01.10.2015 | Original Article

Surgery for Pancreatic and Periampullary Carcinoma

verfasst von: Abhishek Mitra, Ashwin D’Souza, Mahesh Goel, Shailesh V. Shrikhande

Erschienen in: Indian Journal of Surgery | Ausgabe 5/2015

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Abstract

Surgical resection for pancreatic and periampullary cancer has evolved over several decades. The postoperative mortality for these resections has declined to less than 5 %. However, morbidity associated with these resections is still considerable. Various technical modifications like pylorus preservation, reconstruction techniques and methods to perform pancreaticoenteric anastomosis have been suggested to improve postoperative outcomes after pancreaticoduodenectomy. Surgical modifications to improve oncological clearance and decrease fistula rates after distal pancreatic resections have also been suggested. Dilemma still exists whether interventions like pancreatic duct stents, octreotide and drains help to improve postoperative outcomes. The role of extended lymph node dissection and extended resections for pancreatic and periampullary cancer is still controversial, as is the management of borderline resectable pancreatic cancer. In this review, we discuss the literature pertaining to various surgical aspects of pancreatic and periampullary carcinoma.
Literatur
1.
Zurück zum Zitat McPhee JT, Hill JS, Whalen GF, Zayaruzny M, Litwin DE, Sullivan ME, Anderson FA, Tseng JF (2007) Perioperative mortality for pancreatectomy: a national perspective. Ann Surg 246:246–253PubMedPubMedCentralCrossRef McPhee JT, Hill JS, Whalen GF, Zayaruzny M, Litwin DE, Sullivan ME, Anderson FA, Tseng JF (2007) Perioperative mortality for pancreatectomy: a national perspective. Ann Surg 246:246–253PubMedPubMedCentralCrossRef
2.
Zurück zum Zitat Bassi C, Falconi M, Salvia R, Mascetta G, Molinari E, Pederzoli P (2001) Management of complications after pancreaticoduodenectomy in a high volume centre: results on 150 consecutive patients. Dig Surg 18:453–457PubMedCrossRef Bassi C, Falconi M, Salvia R, Mascetta G, Molinari E, Pederzoli P (2001) Management of complications after pancreaticoduodenectomy in a high volume centre: results on 150 consecutive patients. Dig Surg 18:453–457PubMedCrossRef
3.
Zurück zum Zitat Vin Y, Sima CS, Getrajdman GI, Brown KT, Covey A, Brennan MF, Allen PJ (2008) Management and outcomes of postpancreatectomy fistula, leak, and abscess: results of 908 patients resected at a single institution between 2000 and 2005. J Am Coll Surg 207:490–498PubMedCrossRef Vin Y, Sima CS, Getrajdman GI, Brown KT, Covey A, Brennan MF, Allen PJ (2008) Management and outcomes of postpancreatectomy fistula, leak, and abscess: results of 908 patients resected at a single institution between 2000 and 2005. J Am Coll Surg 207:490–498PubMedCrossRef
6.
7.
Zurück zum Zitat Wenger FA, Jacobi CA, Haubold K, Zieren HU, Müller JM (1999) Gastrointestinal quality of life after duodenopancreatectomy in pancreatic carcinoma. Preliminary results of a prospective randomized study: pancreatoduodenectomy or pylorus-preserving pancreatoduodenectomy. Chirurg 70:1454–1459PubMedCrossRef Wenger FA, Jacobi CA, Haubold K, Zieren HU, Müller JM (1999) Gastrointestinal quality of life after duodenopancreatectomy in pancreatic carcinoma. Preliminary results of a prospective randomized study: pancreatoduodenectomy or pylorus-preserving pancreatoduodenectomy. Chirurg 70:1454–1459PubMedCrossRef
8.
Zurück zum Zitat Williamson RC, Bliouras N, Cooper MJ, Davies ER (1993) Gastric emptying and enterogastric reflux after conservative and conventional pancreatoduodenectomy. Surgery 114:82–86PubMed Williamson RC, Bliouras N, Cooper MJ, Davies ER (1993) Gastric emptying and enterogastric reflux after conservative and conventional pancreatoduodenectomy. Surgery 114:82–86PubMed
9.
Zurück zum Zitat Park YC, Kim SW, Jang JY, Ahn YJ, Park YH (2003) Factors influencing delayed gastric emptying after pylorus-preserving pancreatoduodenectomy. J Am Coll Surg 196:859–865PubMedCrossRef Park YC, Kim SW, Jang JY, Ahn YJ, Park YH (2003) Factors influencing delayed gastric emptying after pylorus-preserving pancreatoduodenectomy. J Am Coll Surg 196:859–865PubMedCrossRef
10.
Zurück zum Zitat Diener MK, Fitzmaurice C, Schwarzer G, Seiler CM, Hüttner FJ, Antes G, Knaebel HP, Büchler MW (2014) Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma. Cochrane Database Syst Rev 11, CD006053PubMedPubMedCentral Diener MK, Fitzmaurice C, Schwarzer G, Seiler CM, Hüttner FJ, Antes G, Knaebel HP, Büchler MW (2014) Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma. Cochrane Database Syst Rev 11, CD006053PubMedPubMedCentral
11.
Zurück zum Zitat Kawai M, Tani M, Hirono S, Okada K, Miyazawa M, Yamaue H (2014) Pylorus-resecting pancreaticoduodenectomy offers long-term outcomes similar to those of pylorus-preserving pancreaticoduodenectomy: results of a prospective study. World J Surg 38:1476–1483PubMedCrossRef Kawai M, Tani M, Hirono S, Okada K, Miyazawa M, Yamaue H (2014) Pylorus-resecting pancreaticoduodenectomy offers long-term outcomes similar to those of pylorus-preserving pancreaticoduodenectomy: results of a prospective study. World J Surg 38:1476–1483PubMedCrossRef
12.
Zurück zum Zitat Kawai M, Tani M, Hirono S, Miyazawa M, Shimizu A, Uchiyama K, Yamaue H (2011) Pylorus ring resection reduces delayed gastric emptying in patients undergoing pancreatoduodenectomy: a prospective, randomized, controlled trial of pylorus-resecting versus pylorus-preserving pancreatoduodenectomy. Ann Surg 253:495–501PubMedCrossRef Kawai M, Tani M, Hirono S, Miyazawa M, Shimizu A, Uchiyama K, Yamaue H (2011) Pylorus ring resection reduces delayed gastric emptying in patients undergoing pancreatoduodenectomy: a prospective, randomized, controlled trial of pylorus-resecting versus pylorus-preserving pancreatoduodenectomy. Ann Surg 253:495–501PubMedCrossRef
13.
Zurück zum Zitat Yang C, Wu HS, Chen XL, Wang CY, Gou SM, Xiao J, He ZQ, Chen QJ, Li YF (2014) Pylorus-preserving versus pylorus-resecting pancreaticoduodenectomy for periampullary and pancreatic carcinoma: a meta-analysis. PLoS One 9, e90316PubMedPubMedCentralCrossRef Yang C, Wu HS, Chen XL, Wang CY, Gou SM, Xiao J, He ZQ, Chen QJ, Li YF (2014) Pylorus-preserving versus pylorus-resecting pancreaticoduodenectomy for periampullary and pancreatic carcinoma: a meta-analysis. PLoS One 9, e90316PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Shrikhande SV, Kleeff J, Büchler MW, Friess H (2007) Pancreatic anastomosis after pancreaticoduodenectomy: how we do it. Indian J Surg 69:224–229PubMedPubMedCentralCrossRef Shrikhande SV, Kleeff J, Büchler MW, Friess H (2007) Pancreatic anastomosis after pancreaticoduodenectomy: how we do it. Indian J Surg 69:224–229PubMedPubMedCentralCrossRef
15.
Zurück zum Zitat Berger AC, Howard TJ, Kennedy EP, Sauter PK, Bower-Cherry M, Dutkevitch S, Hyslop T, Schmidt CM, Rosato EL, Lavu H, Nakeeb A, Pitt HA, Lillemoe KD, Yeo CJ (2009) Does type of pancreaticojejunostomy after pancreaticoduodenectomy decrease rate of pancreatic fistula? A randomized, prospective, dual-institution trial. J Am Coll Surg 208:738–747PubMedCrossRef Berger AC, Howard TJ, Kennedy EP, Sauter PK, Bower-Cherry M, Dutkevitch S, Hyslop T, Schmidt CM, Rosato EL, Lavu H, Nakeeb A, Pitt HA, Lillemoe KD, Yeo CJ (2009) Does type of pancreaticojejunostomy after pancreaticoduodenectomy decrease rate of pancreatic fistula? A randomized, prospective, dual-institution trial. J Am Coll Surg 208:738–747PubMedCrossRef
16.
Zurück zum Zitat Peng S, Mou Y, Cai X, Peng C (2002) Binding pancreaticojejunostomy is a new technique to minimize leakage. Am J Surg 183:283–285PubMedCrossRef Peng S, Mou Y, Cai X, Peng C (2002) Binding pancreaticojejunostomy is a new technique to minimize leakage. Am J Surg 183:283–285PubMedCrossRef
17.
Zurück zum Zitat Peng SY, Wang JW, Lau WY, Cai XJ, Mou YP, Liu YB, Li JT (2007) Conventional versus binding pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial. Ann Surg 245:692–698PubMedPubMedCentralCrossRef Peng SY, Wang JW, Lau WY, Cai XJ, Mou YP, Liu YB, Li JT (2007) Conventional versus binding pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial. Ann Surg 245:692–698PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Maggiori L, Sauvanet A, Nagarajan G, Dokmak S, Aussilhou B, Belghiti J (2010) Binding versus conventional pancreaticojejunostomy after pancreaticoduodenectomy: a case-matched study. J Gastrointest Surg 14:1395–1400PubMedCrossRef Maggiori L, Sauvanet A, Nagarajan G, Dokmak S, Aussilhou B, Belghiti J (2010) Binding versus conventional pancreaticojejunostomy after pancreaticoduodenectomy: a case-matched study. J Gastrointest Surg 14:1395–1400PubMedCrossRef
19.
Zurück zum Zitat Casadei R, Ricci C, Silvestri S, Campra D, Ercolani G, D’Ambra M, Pinna AD, Fronda GR, Minni F (2013) Peng’s binding pancreaticojejunostomy after pancreaticoduodenectomy. An Italian, prospective, dual institution study. Pancreatology 13:305–309PubMedCrossRef Casadei R, Ricci C, Silvestri S, Campra D, Ercolani G, D’Ambra M, Pinna AD, Fronda GR, Minni F (2013) Peng’s binding pancreaticojejunostomy after pancreaticoduodenectomy. An Italian, prospective, dual institution study. Pancreatology 13:305–309PubMedCrossRef
20.
Zurück zum Zitat Li X, Dong M, Sheng W, Yue L, Liu Q, Dong Q (2014) A meta-analysis of pancreaticojejunostomy on pancreatic fistula after pancreaticoduodenectomy. Zhonghua Wai Ke Za Zhi 52:662–667PubMed Li X, Dong M, Sheng W, Yue L, Liu Q, Dong Q (2014) A meta-analysis of pancreaticojejunostomy on pancreatic fistula after pancreaticoduodenectomy. Zhonghua Wai Ke Za Zhi 52:662–667PubMed
21.
Zurück zum Zitat Shrikhande SV, Qureshi SS, Rajneesh N, Shukla PJ (2005) Pancreatic anastomoses after pancreaticoduodenectomy: do we need further studies? World J Surg 29:1642–1649PubMedCrossRef Shrikhande SV, Qureshi SS, Rajneesh N, Shukla PJ (2005) Pancreatic anastomoses after pancreaticoduodenectomy: do we need further studies? World J Surg 29:1642–1649PubMedCrossRef
22.
Zurück zum Zitat Shrikhande SV, Barreto G, Shukla PJ (2008) Pancreatic fistula after pancreaticoduodenectomy: the impact of a standardized technique of pancreaticojejunostomy. Langenbecks Arch Surg 393:87–91PubMedCrossRef Shrikhande SV, Barreto G, Shukla PJ (2008) Pancreatic fistula after pancreaticoduodenectomy: the impact of a standardized technique of pancreaticojejunostomy. Langenbecks Arch Surg 393:87–91PubMedCrossRef
23.
Zurück zum Zitat Waugh JM, Clagett OT (1946) Resection of the duodenum and head of the pancreas for carcinoma; an analysis of thirty cases. Surgery 20:224–232PubMed Waugh JM, Clagett OT (1946) Resection of the duodenum and head of the pancreas for carcinoma; an analysis of thirty cases. Surgery 20:224–232PubMed
24.
Zurück zum Zitat Ohigashi H, Ishikawa O, Eguchi H, Sasaki Y, Yamada T, Kishi K, Noura S, Takachi K, Miyashiro I, Oue M, Yano M, Imaoka S (2008) A simple and safe anastomosis in pancreaticogastrostomy using mattress sutures. Am J Surg 196:130–134PubMedCrossRef Ohigashi H, Ishikawa O, Eguchi H, Sasaki Y, Yamada T, Kishi K, Noura S, Takachi K, Miyashiro I, Oue M, Yano M, Imaoka S (2008) A simple and safe anastomosis in pancreaticogastrostomy using mattress sutures. Am J Surg 196:130–134PubMedCrossRef
25.
Zurück zum Zitat Takao S, Shinchi H (2012) Pancreaticogastrostomy: a pancreas-transfixing method with duct-to-mucosa anastomosis (with video). J Hepatobiliary Pancreat Sci 19:131–134PubMedPubMedCentralCrossRef Takao S, Shinchi H (2012) Pancreaticogastrostomy: a pancreas-transfixing method with duct-to-mucosa anastomosis (with video). J Hepatobiliary Pancreat Sci 19:131–134PubMedPubMedCentralCrossRef
26.
Zurück zum Zitat Osman MM, Abd El Maksoud W (2014) Evaluation of a new modification of pancreaticogastrostomy after pancreaticoduodenectomy: anastomosis of the pancreatic duct to the gastric mucosa with invagination of the pancreatic remnant end into the posterior gastric wall for patients with cancer head of pancreas and periampullary carcinoma in terms of postoperative pancreatic fistula formation. Int J Surg Oncol 2014:490386PubMed Osman MM, Abd El Maksoud W (2014) Evaluation of a new modification of pancreaticogastrostomy after pancreaticoduodenectomy: anastomosis of the pancreatic duct to the gastric mucosa with invagination of the pancreatic remnant end into the posterior gastric wall for patients with cancer head of pancreas and periampullary carcinoma in terms of postoperative pancreatic fistula formation. Int J Surg Oncol 2014:490386PubMed
27.
Zurück zum Zitat Peng SY, An WX, Liu Y, Hong D, Li J, Tao F, Tan Z (2009) Peng’s pancreaticogastrostomy—comparative study on types I and II procedures (with types III and IV appended). J Surg Concepts Prac 14:5 Peng SY, An WX, Liu Y, Hong D, Li J, Tao F, Tan Z (2009) Peng’s pancreaticogastrostomy—comparative study on types I and II procedures (with types III and IV appended). J Surg Concepts Prac 14:5
28.
Zurück zum Zitat Bartsch DK, Langer P, Kanngießer V, Fendrich V, Dietzel K (2012) A simple and safe anastomosis for pancreatogastrostomy using one binding purse-string and two transfixing mattress sutures. Int J Surg Oncol 2012:718637PubMedPubMedCentral Bartsch DK, Langer P, Kanngießer V, Fendrich V, Dietzel K (2012) A simple and safe anastomosis for pancreatogastrostomy using one binding purse-string and two transfixing mattress sutures. Int J Surg Oncol 2012:718637PubMedPubMedCentral
29.
Zurück zum Zitat Zhu F, Wang M, Wang X, Tian R, Shi C, Xu M, Shen M, Han J, Luo N, Qin R (2013) Modified technique of pancreaticogastrostomy for soft pancreas with two continuous hemstitch sutures: a single-center prospective study. J Gastrointest Surg 17:1306–1311PubMedPubMedCentralCrossRef Zhu F, Wang M, Wang X, Tian R, Shi C, Xu M, Shen M, Han J, Luo N, Qin R (2013) Modified technique of pancreaticogastrostomy for soft pancreas with two continuous hemstitch sutures: a single-center prospective study. J Gastrointest Surg 17:1306–1311PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Fernández-Cruz L, Cosa R, Blanco L, López-Boado MA, Astudillo E (2008) Pancreatogastrostomy with gastric partition after pylorus-preserving pancreatoduodenectomy versus conventional pancreatojejunostomy: a prospective randomized study. Ann Surg 248:930–938PubMedCrossRef Fernández-Cruz L, Cosa R, Blanco L, López-Boado MA, Astudillo E (2008) Pancreatogastrostomy with gastric partition after pylorus-preserving pancreatoduodenectomy versus conventional pancreatojejunostomy: a prospective randomized study. Ann Surg 248:930–938PubMedCrossRef
31.
Zurück zum Zitat Bassi C, Falconi M, Molinari E, Salvia R, Butturini G, Sartori N, Mantovani W, Pederzoli P (2005) Reconstruction by pancreaticojejunostomy versus pancreaticogastrostomy following pancreatectomy: results of a comparative study. Ann Surg 242:767–771PubMedPubMedCentralCrossRef Bassi C, Falconi M, Molinari E, Salvia R, Butturini G, Sartori N, Mantovani W, Pederzoli P (2005) Reconstruction by pancreaticojejunostomy versus pancreaticogastrostomy following pancreatectomy: results of a comparative study. Ann Surg 242:767–771PubMedPubMedCentralCrossRef
32.
Zurück zum Zitat Duffas JP, Suc B, Msika S, Fourtanier G, Muscari F, Hay JM, Fingerhut A, Millat B, Radovanowic A, Fagniez PL, French Associations for Research in Surgery (2005) A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreatoduodenectomy. Am J Surg 189:720–729PubMedCrossRef Duffas JP, Suc B, Msika S, Fourtanier G, Muscari F, Hay JM, Fingerhut A, Millat B, Radovanowic A, Fagniez PL, French Associations for Research in Surgery (2005) A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreatoduodenectomy. Am J Surg 189:720–729PubMedCrossRef
33.
Zurück zum Zitat Topal B, Fieuws S, Aerts R, Weerts J, Feryn T, Roeyen G, Bertrand C, Hubert C, Janssens M, Closset J, Belgian Section of Hepatobiliary and Pancreatic Surgery (2013) Pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy for pancreatic or periampullary tumours: a multicentre randomised trial. Lancet Oncol 14:655–662PubMedCrossRef Topal B, Fieuws S, Aerts R, Weerts J, Feryn T, Roeyen G, Bertrand C, Hubert C, Janssens M, Closset J, Belgian Section of Hepatobiliary and Pancreatic Surgery (2013) Pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy for pancreatic or periampullary tumours: a multicentre randomised trial. Lancet Oncol 14:655–662PubMedCrossRef
34.
Zurück zum Zitat Wente MN, Shrikhande SV, Müller MW, Diener MK, Seiler CM, Friess H, Büchler MW (2007) Pancreaticojejunostomy versus pancreaticogastrostomy: systematic review and meta-analysis. Am J Surg 193:171–183PubMedCrossRef Wente MN, Shrikhande SV, Müller MW, Diener MK, Seiler CM, Friess H, Büchler MW (2007) Pancreaticojejunostomy versus pancreaticogastrostomy: systematic review and meta-analysis. Am J Surg 193:171–183PubMedCrossRef
35.
Zurück zum Zitat Menahem B, Guittet L, Mulliri A, Alves A, Lubrano J (2015) Pancreaticogastrostomy is superior to pancreaticojejunostomy for prevention of pancreatic fistula after pancreaticoduodenectomy: an updated meta-analysis of randomized controlled trials. Ann Surg 261:882–887PubMedCrossRef Menahem B, Guittet L, Mulliri A, Alves A, Lubrano J (2015) Pancreaticogastrostomy is superior to pancreaticojejunostomy for prevention of pancreatic fistula after pancreaticoduodenectomy: an updated meta-analysis of randomized controlled trials. Ann Surg 261:882–887PubMedCrossRef
36.
Zurück zum Zitat Hallet J, Zih FS, Deobald RG, Scheer AS, Law CH, Coburn NG, Karanicolas PJ (2015) The impact of pancreaticojejunostomy versus pancreaticogastrostomy reconstruction on pancreatic fistula after pancreaticoduodenectomy: meta-analysis of randomized controlled trials. HPB (Oxford) 17:113–122CrossRef Hallet J, Zih FS, Deobald RG, Scheer AS, Law CH, Coburn NG, Karanicolas PJ (2015) The impact of pancreaticojejunostomy versus pancreaticogastrostomy reconstruction on pancreatic fistula after pancreaticoduodenectomy: meta-analysis of randomized controlled trials. HPB (Oxford) 17:113–122CrossRef
37.
Zurück zum Zitat Machado MC, da Cunha JE, Bacchella T, Bove P (1976) A modified technique for the reconstruction of the alimentary tract after pancreatoduodenectomy. Surg Gynecol Obstet 143:271–272PubMed Machado MC, da Cunha JE, Bacchella T, Bove P (1976) A modified technique for the reconstruction of the alimentary tract after pancreatoduodenectomy. Surg Gynecol Obstet 143:271–272PubMed
38.
Zurück zum Zitat Khan AW, Agarwal AK, Davidson BR (2002) Isolated Roux Loop duct-to-mucosa pancreaticojejunostomy avoids pancreatic leaks in pancreaticoduodenectomy. Dig Surg 19:199–204PubMedCrossRef Khan AW, Agarwal AK, Davidson BR (2002) Isolated Roux Loop duct-to-mucosa pancreaticojejunostomy avoids pancreatic leaks in pancreaticoduodenectomy. Dig Surg 19:199–204PubMedCrossRef
39.
Zurück zum Zitat Sutton CD, Garcea G, White SA, O’Leary E, Marshall LJ, Berry DP, Dennison AR (2004) Isolated Roux-loop pancreaticojejunostomy: a series of 61 patients with zero postoperative pancreaticoenteric leaks. J Gastrointest Surg 8:701–705PubMedCrossRef Sutton CD, Garcea G, White SA, O’Leary E, Marshall LJ, Berry DP, Dennison AR (2004) Isolated Roux-loop pancreaticojejunostomy: a series of 61 patients with zero postoperative pancreaticoenteric leaks. J Gastrointest Surg 8:701–705PubMedCrossRef
40.
Zurück zum Zitat Klaiber U, Probst P, Knebel P, Contin P, Diener MK, Büchler MW, Hackert T (2015) Meta-analysis of complication rates for single-loop versus dual-loop (Roux-en-Y) with isolated pancreaticojejunostomy reconstruction after pancreaticoduodenectomy. Br J Surg 102:331–340PubMedCrossRef Klaiber U, Probst P, Knebel P, Contin P, Diener MK, Büchler MW, Hackert T (2015) Meta-analysis of complication rates for single-loop versus dual-loop (Roux-en-Y) with isolated pancreaticojejunostomy reconstruction after pancreaticoduodenectomy. Br J Surg 102:331–340PubMedCrossRef
41.
Zurück zum Zitat Dong Z, Xu J, Wang Z, Petrov MS (2013) Stents for the prevention of pancreatic fistula following pancreaticoduodenectomy. Cochrane Database Syst Rev 6, CD008914PubMed Dong Z, Xu J, Wang Z, Petrov MS (2013) Stents for the prevention of pancreatic fistula following pancreaticoduodenectomy. Cochrane Database Syst Rev 6, CD008914PubMed
42.
Zurück zum Zitat Winter JM, Cameron JL, Campbell KA, Chang DC, Riall TS, Schulick RD et al (2006) Does pancreatic duct stenting decrease the rate of pancreatic fistula following pancreaticoduodenectomy? Results of a prospective randomized trial. J Gastrointest Surg 10:1280–1290PubMedCrossRef Winter JM, Cameron JL, Campbell KA, Chang DC, Riall TS, Schulick RD et al (2006) Does pancreatic duct stenting decrease the rate of pancreatic fistula following pancreaticoduodenectomy? Results of a prospective randomized trial. J Gastrointest Surg 10:1280–1290PubMedCrossRef
43.
Zurück zum Zitat Pessaux P, Sauvanet A, Mariette C, Paye F, Muscari F, Cunha A et al (2011) External pancreatic duct stent decreases pancreatic fistula rate after pancreaticoduodenectomy: prospective multicenter randomized trial. Ann Surg 253:879–885PubMedCrossRef Pessaux P, Sauvanet A, Mariette C, Paye F, Muscari F, Cunha A et al (2011) External pancreatic duct stent decreases pancreatic fistula rate after pancreaticoduodenectomy: prospective multicenter randomized trial. Ann Surg 253:879–885PubMedCrossRef
44.
Zurück zum Zitat Poon RT, Fan ST, Lo CM, Ng KK, Yuen WK, Yeung C et al (2007) External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial. Ann Surg 246:425–435PubMedPubMedCentralCrossRef Poon RT, Fan ST, Lo CM, Ng KK, Yuen WK, Yeung C et al (2007) External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial. Ann Surg 246:425–435PubMedPubMedCentralCrossRef
45.
Zurück zum Zitat Motoi F, Egawa S, Rikiyama T, Katayose Y, Unno M (2012) Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy. Br J Surg 99:524–531PubMedCrossRef Motoi F, Egawa S, Rikiyama T, Katayose Y, Unno M (2012) Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy. Br J Surg 99:524–531PubMedCrossRef
46.
Zurück zum Zitat Wang G, Sun B, Jiang H, Li L, Ma Y, Wu L, Liu J, Li P, Wu X (2014) A prospective randomized controlled trial of pancreatic duct stent internal versus external drainage with pancreaticojejunostomy for the early curative effect after pancreaticoduodenectomy. Zhonghua Wai Ke Za Zhi 52:333–337PubMed Wang G, Sun B, Jiang H, Li L, Ma Y, Wu L, Liu J, Li P, Wu X (2014) A prospective randomized controlled trial of pancreatic duct stent internal versus external drainage with pancreaticojejunostomy for the early curative effect after pancreaticoduodenectomy. Zhonghua Wai Ke Za Zhi 52:333–337PubMed
47.
Zurück zum Zitat Büchler M, Friess H, Klempa I, Hermanek P, Sulkowski U, Becker H, Schafmayer A, Baca I, Lorenz D, Meister R et al (1992) Role of octreotide in the prevention of postoperative complications following pancreatic resection. Am J Surg 163:125–130PubMedCrossRef Büchler M, Friess H, Klempa I, Hermanek P, Sulkowski U, Becker H, Schafmayer A, Baca I, Lorenz D, Meister R et al (1992) Role of octreotide in the prevention of postoperative complications following pancreatic resection. Am J Surg 163:125–130PubMedCrossRef
48.
Zurück zum Zitat Pederzoli P, Bassi C, Falconi M, Camboni MG (1994) Efficacy of octreotide in the prevention of complications of elective pancreatic surgery. Italian Study Group. Br J Surg 81:265–269PubMedCrossRef Pederzoli P, Bassi C, Falconi M, Camboni MG (1994) Efficacy of octreotide in the prevention of complications of elective pancreatic surgery. Italian Study Group. Br J Surg 81:265–269PubMedCrossRef
49.
Zurück zum Zitat Montorsi M, Zago M, Mosca F, Capussotti L, Zotti E, Ribotta G, Fegiz G, Fissi S, Roviaro G, Peracchia A et al (1995) Efficacy of octreotide in the prevention of pancreatic fistula after elective pancreatic resections: a prospective, controlled, randomized clinical trial. Surgery 117:26–31PubMedCrossRef Montorsi M, Zago M, Mosca F, Capussotti L, Zotti E, Ribotta G, Fegiz G, Fissi S, Roviaro G, Peracchia A et al (1995) Efficacy of octreotide in the prevention of pancreatic fistula after elective pancreatic resections: a prospective, controlled, randomized clinical trial. Surgery 117:26–31PubMedCrossRef
50.
Zurück zum Zitat Friess H, Beger HG, Sulkowski U, Becker H, Hofbauer B, Dennler HJ, Büchler MW (1995) Randomized controlled multicentre study of the prevention of complications by octreotide in patients undergoing surgery for chronic pancreatitis. Br J Surg 82:1270–1273PubMedCrossRef Friess H, Beger HG, Sulkowski U, Becker H, Hofbauer B, Dennler HJ, Büchler MW (1995) Randomized controlled multicentre study of the prevention of complications by octreotide in patients undergoing surgery for chronic pancreatitis. Br J Surg 82:1270–1273PubMedCrossRef
51.
Zurück zum Zitat Yeo CJ, Cameron JL, Lillemoe KD, Sauter PK, Coleman J, Sohn TA, Campbell KA, Choti MA (2000) Does prophylactic octreotide decrease the rates of pancreatic fistula and other complications after pancreaticoduodenectomy? Results of a prospective randomized placebo-controlled trial. Ann Surg 232:419–429PubMedPubMedCentralCrossRef Yeo CJ, Cameron JL, Lillemoe KD, Sauter PK, Coleman J, Sohn TA, Campbell KA, Choti MA (2000) Does prophylactic octreotide decrease the rates of pancreatic fistula and other complications after pancreaticoduodenectomy? Results of a prospective randomized placebo-controlled trial. Ann Surg 232:419–429PubMedPubMedCentralCrossRef
52.
Zurück zum Zitat Gouillat C, Chipponi J, Baulieux J, Partensky C, Saric J, Gayet B (2001) Randomized controlled multicentre trial of somatostatin infusion after pancreaticoduodenectomy. Br J Surg 88:1456–1462PubMedCrossRef Gouillat C, Chipponi J, Baulieux J, Partensky C, Saric J, Gayet B (2001) Randomized controlled multicentre trial of somatostatin infusion after pancreaticoduodenectomy. Br J Surg 88:1456–1462PubMedCrossRef
53.
Zurück zum Zitat Kollmar O, Moussavian MR, Richter S, de Roi P, Maurer CA, Schilling MK (2008) Prophylactic octreotide and delayed gastric emptying after pancreaticoduodenectomy: results of a prospective randomized double-blinded placebo-controlled trial. Eur J Surg Oncol 34:868–875PubMedCrossRef Kollmar O, Moussavian MR, Richter S, de Roi P, Maurer CA, Schilling MK (2008) Prophylactic octreotide and delayed gastric emptying after pancreaticoduodenectomy: results of a prospective randomized double-blinded placebo-controlled trial. Eur J Surg Oncol 34:868–875PubMedCrossRef
54.
Zurück zum Zitat Gurusamy KS, Koti R, Fusai G, Davidson BR (2010) Somatostatin analogues for pancreatic surgery. Cochrane Database Syst Rev 2, CD008370PubMed Gurusamy KS, Koti R, Fusai G, Davidson BR (2010) Somatostatin analogues for pancreatic surgery. Cochrane Database Syst Rev 2, CD008370PubMed
55.
Zurück zum Zitat Mutter D, Panis Y, Escat J (1999) Drainage in digestive surgery. French Society of Digestive Surgery. J Chir (Paris) 136:117–123 Mutter D, Panis Y, Escat J (1999) Drainage in digestive surgery. French Society of Digestive Surgery. J Chir (Paris) 136:117–123
56.
Zurück zum Zitat Conlon KC, Labow D, Leung D, Smith A, Jarnagin W, Coit DG, Merchant N, Brennan MF (2001) Prospective randomized clinical trial of the value of intraperitoneal drainage after pancreatic resection. Ann Surg 234:487–493PubMedPubMedCentralCrossRef Conlon KC, Labow D, Leung D, Smith A, Jarnagin W, Coit DG, Merchant N, Brennan MF (2001) Prospective randomized clinical trial of the value of intraperitoneal drainage after pancreatic resection. Ann Surg 234:487–493PubMedPubMedCentralCrossRef
57.
Zurück zum Zitat Van Buren G, Bloomston M, Hughes SJ, Winter J, Behrman SW, Zyromski NJ, Vollmer C, Velanovich V, Riall T, Muscarella P, Trevino J, Nakeeb A, Schmidt CM, Behrns K, Ellison EC, Barakat O, Perry KA, Drebin J, House M, Abdel-Misih S, Silberfein EJ, Goldin S, Brown K, Mohammed S, Hodges SE, McElhany A, Issazadeh M, Jo E, Mo Q, Fisher WE (2014) A randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage. Ann Surg 259:605–612PubMedCrossRef Van Buren G, Bloomston M, Hughes SJ, Winter J, Behrman SW, Zyromski NJ, Vollmer C, Velanovich V, Riall T, Muscarella P, Trevino J, Nakeeb A, Schmidt CM, Behrns K, Ellison EC, Barakat O, Perry KA, Drebin J, House M, Abdel-Misih S, Silberfein EJ, Goldin S, Brown K, Mohammed S, Hodges SE, McElhany A, Issazadeh M, Jo E, Mo Q, Fisher WE (2014) A randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage. Ann Surg 259:605–612PubMedCrossRef
58.
Zurück zum Zitat Dou CW, Liu ZK, Jia YL, Zheng X, Tu KS, Yao YM, Liu QG (2015) Systematic review and meta-analysis of prophylactic abdominal drainage after pancreatic resection. World J Gastroenterol 21:5719–5734PubMedPubMedCentralCrossRef Dou CW, Liu ZK, Jia YL, Zheng X, Tu KS, Yao YM, Liu QG (2015) Systematic review and meta-analysis of prophylactic abdominal drainage after pancreatic resection. World J Gastroenterol 21:5719–5734PubMedPubMedCentralCrossRef
59.
Zurück zum Zitat Lim C, Dokmak S, Cauchy F, Aussilhou B, Belghiti J, Sauvanet A (2013) Selective policy of no drain after pancreaticoduodenectomy is a valid option in patients at low risk of pancreatic fistula: a case–control analysis. World J Surg 37:1021–1027PubMedCrossRef Lim C, Dokmak S, Cauchy F, Aussilhou B, Belghiti J, Sauvanet A (2013) Selective policy of no drain after pancreaticoduodenectomy is a valid option in patients at low risk of pancreatic fistula: a case–control analysis. World J Surg 37:1021–1027PubMedCrossRef
60.
Zurück zum Zitat Kawai M, Tani M, Terasawa H, Ina S, Hirono S, Nishioka R, Miyazawa M, Uchiyama K, Yamaue H (2006) Early removal of prophylactic drains reduces the risk of intra-abdominal infections in patients with pancreatic head resection: prospective study for 104 consecutive patients. Ann Surg 244:1–7PubMedPubMedCentralCrossRef Kawai M, Tani M, Terasawa H, Ina S, Hirono S, Nishioka R, Miyazawa M, Uchiyama K, Yamaue H (2006) Early removal of prophylactic drains reduces the risk of intra-abdominal infections in patients with pancreatic head resection: prospective study for 104 consecutive patients. Ann Surg 244:1–7PubMedPubMedCentralCrossRef
61.
Zurück zum Zitat Zink SI, Soloff EV, White RR, Clary BM, Tyler DS, Pappas TN, Paulson EK (2009) Pancreaticoduodenectomy: frequency and outcome of post-operative imaging-guided percutaneous drainage. Abdom Imaging 34:767–771PubMedCrossRef Zink SI, Soloff EV, White RR, Clary BM, Tyler DS, Pappas TN, Paulson EK (2009) Pancreaticoduodenectomy: frequency and outcome of post-operative imaging-guided percutaneous drainage. Abdom Imaging 34:767–771PubMedCrossRef
62.
Zurück zum Zitat Shrikhande SV, Barreto SG, Shetty G, Suradkar K, Bodhankar YD, Shah SB, Goel M (2013) Post-operative abdominal drainage following major upper gastrointestinal surgery: single drain versus two drains. J Cancer Res Ther 9:267–271PubMedCrossRef Shrikhande SV, Barreto SG, Shetty G, Suradkar K, Bodhankar YD, Shah SB, Goel M (2013) Post-operative abdominal drainage following major upper gastrointestinal surgery: single drain versus two drains. J Cancer Res Ther 9:267–271PubMedCrossRef
63.
Zurück zum Zitat Pai E, Shrikhande SV (2014) Drainage after pancreaticoduodenectomy: to step back may be the way forward, but are randomized controlled trials making us any wiser? Ann Surg Pai E, Shrikhande SV (2014) Drainage after pancreaticoduodenectomy: to step back may be the way forward, but are randomized controlled trials making us any wiser? Ann Surg
64.
Zurück zum Zitat Strasberg SM, Linehan DC, Hawkins WG (2007) Radical antegrade modular pancreatosplenectomy procedure for adenocarcinoma of the body and tail of the pancreas: ability to obtain negative tangential margins. J Am Coll Surg 204:244–249PubMedCrossRef Strasberg SM, Linehan DC, Hawkins WG (2007) Radical antegrade modular pancreatosplenectomy procedure for adenocarcinoma of the body and tail of the pancreas: ability to obtain negative tangential margins. J Am Coll Surg 204:244–249PubMedCrossRef
65.
Zurück zum Zitat Strasberg SM, Drebin JA, Linehan D (2003) Radical antegrade modular pancreatosplenectomy. Surgery 133:521–527PubMedCrossRef Strasberg SM, Drebin JA, Linehan D (2003) Radical antegrade modular pancreatosplenectomy. Surgery 133:521–527PubMedCrossRef
66.
Zurück zum Zitat Mitchem JB, Hamilton N, Gao F, Hawkins WG, Linehan DC, Strasberg SM (2012) Long-term results of resection of adenocarcinoma of the body and tail of the pancreas using radical antegrade modular pancreatosplenectomy procedure. J Am Coll Surg 214:46–52PubMedCrossRef Mitchem JB, Hamilton N, Gao F, Hawkins WG, Linehan DC, Strasberg SM (2012) Long-term results of resection of adenocarcinoma of the body and tail of the pancreas using radical antegrade modular pancreatosplenectomy procedure. J Am Coll Surg 214:46–52PubMedCrossRef
67.
Zurück zum Zitat Christein JD, Kendrick ML, Iqbal CW, Nagorney DM, Farnell MB (2005) Distal pancreatectomy for resectable adenocarcinoma of the body and tail of the pancreas. J Gastrointest Surg 9:922–927PubMedCrossRef Christein JD, Kendrick ML, Iqbal CW, Nagorney DM, Farnell MB (2005) Distal pancreatectomy for resectable adenocarcinoma of the body and tail of the pancreas. J Gastrointest Surg 9:922–927PubMedCrossRef
68.
Zurück zum Zitat Kooby DA, Hawkins WG, Schmidt CM, Weber SM, Bentrem DJ, Gillespie TW, Sellers JB, Merchant NB, Scoggins CR, Martin RC 3rd, Kim HJ, Ahmad S, Cho CS, Parikh AA, Chu CK, Hamilton NA, Doyle CJ, Pinchot S, Hayman A, McClaine R, Nakeeb A, Staley CA, McMasters KM, Lillemoe KD (2010) A multicenter analysis of distal pancreatectomy for adenocarcinoma: is laparoscopic resection appropriate? J Am Coll Surg 210:779–785PubMedCrossRef Kooby DA, Hawkins WG, Schmidt CM, Weber SM, Bentrem DJ, Gillespie TW, Sellers JB, Merchant NB, Scoggins CR, Martin RC 3rd, Kim HJ, Ahmad S, Cho CS, Parikh AA, Chu CK, Hamilton NA, Doyle CJ, Pinchot S, Hayman A, McClaine R, Nakeeb A, Staley CA, McMasters KM, Lillemoe KD (2010) A multicenter analysis of distal pancreatectomy for adenocarcinoma: is laparoscopic resection appropriate? J Am Coll Surg 210:779–785PubMedCrossRef
69.
Zurück zum Zitat Yamamoto J, Saiura A, Koga R, Seki M, Katori M, Kato Y, Sakamoto Y, Kokudo N, Yamaguchi T (2010) Improved survival of left-sided pancreas cancer after surgery. Jpn J Clin Oncol 40:530–536PubMedCrossRef Yamamoto J, Saiura A, Koga R, Seki M, Katori M, Kato Y, Sakamoto Y, Kokudo N, Yamaguchi T (2010) Improved survival of left-sided pancreas cancer after surgery. Jpn J Clin Oncol 40:530–536PubMedCrossRef
70.
Zurück zum Zitat Kang CM, Kim DH, Lee WJ (2010) Ten years of experience with resection of left-sided pancreatic ductal adenocarcinoma: evolution and initial experience to a laparoscopic approach. Surg Endosc 24:1533–1541PubMedCrossRef Kang CM, Kim DH, Lee WJ (2010) Ten years of experience with resection of left-sided pancreatic ductal adenocarcinoma: evolution and initial experience to a laparoscopic approach. Surg Endosc 24:1533–1541PubMedCrossRef
71.
Zurück zum Zitat Ferrone CR, Warshaw AL, Rattner DW, Berger D, Zheng H, Rawal B, Rodriguez R, Thayer SP, Fernandez-del Castillo C (2008) Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates. J Gastrointest Surg 12:1691–1697PubMedPubMedCentralCrossRef Ferrone CR, Warshaw AL, Rattner DW, Berger D, Zheng H, Rawal B, Rodriguez R, Thayer SP, Fernandez-del Castillo C (2008) Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates. J Gastrointest Surg 12:1691–1697PubMedPubMedCentralCrossRef
72.
Zurück zum Zitat Nathan H, Cameron JL, Goodwin CR, Seth AK, Edil BH, Wolfgang CL, Pawlik TM, Schulick RD, Choti MA (2009) Risk factors for pancreatic leak after distal pancreatectomy. Ann Surg 250:277–281PubMedCrossRef Nathan H, Cameron JL, Goodwin CR, Seth AK, Edil BH, Wolfgang CL, Pawlik TM, Schulick RD, Choti MA (2009) Risk factors for pancreatic leak after distal pancreatectomy. Ann Surg 250:277–281PubMedCrossRef
73.
Zurück zum Zitat Diener MK, Seiler CM, Rossion I, Kleeff J, Glanemann M, Butturini G, Tomazic A, Bruns CJ, Busch OR, Farkas S, Belyaev O, Neoptolemos JP, Halloran C, Keck T, Niedergethmann M, Gellert K, Witzigmann H, Kollmar O, Langer P, Steger U, Neudecker J, Berrevoet F, Ganzera S, Heiss MM, Luntz SP, Bruckner T, Kieser M, Büchler MW (2011) Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial. Lancet 377:1514–1522PubMedCrossRef Diener MK, Seiler CM, Rossion I, Kleeff J, Glanemann M, Butturini G, Tomazic A, Bruns CJ, Busch OR, Farkas S, Belyaev O, Neoptolemos JP, Halloran C, Keck T, Niedergethmann M, Gellert K, Witzigmann H, Kollmar O, Langer P, Steger U, Neudecker J, Berrevoet F, Ganzera S, Heiss MM, Luntz SP, Bruckner T, Kieser M, Büchler MW (2011) Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial. Lancet 377:1514–1522PubMedCrossRef
74.
Zurück zum Zitat Zhang H, Zhu F, Shen M, Tian R, Shi CJ, Wang X, Jiang JX, Hu J, Wang M, Qin RY (2015) Systematic review and meta-analysis comparing three techniques for pancreatic remnant closure following distal pancreatectomy. Br J Surg 102:4–15PubMedCrossRef Zhang H, Zhu F, Shen M, Tian R, Shi CJ, Wang X, Jiang JX, Hu J, Wang M, Qin RY (2015) Systematic review and meta-analysis comparing three techniques for pancreatic remnant closure following distal pancreatectomy. Br J Surg 102:4–15PubMedCrossRef
75.
Zurück zum Zitat Frozanpor F, Lundell L, Segersvärd R, Arnelo U (2012) The effect of prophylactic transpapillary pancreatic stent insertion on clinically significant leak rate following distal pancreatectomy: results of a prospective controlled clinical trial. Ann Surg 255:1032–1036PubMedCrossRef Frozanpor F, Lundell L, Segersvärd R, Arnelo U (2012) The effect of prophylactic transpapillary pancreatic stent insertion on clinically significant leak rate following distal pancreatectomy: results of a prospective controlled clinical trial. Ann Surg 255:1032–1036PubMedCrossRef
76.
Zurück zum Zitat Hamilton NA, Porembka MR, Johnston FM, Gao F, Strasberg SM, Linehan DC, Hawkins WG (2012) Mesh reinforcement of pancreatic transection decreases incidence of pancreatic occlusion failure for left pancreatectomy: a single-blinded, randomized controlled trial. Ann Surg 255:1037–1042PubMedPubMedCentralCrossRef Hamilton NA, Porembka MR, Johnston FM, Gao F, Strasberg SM, Linehan DC, Hawkins WG (2012) Mesh reinforcement of pancreatic transection decreases incidence of pancreatic occlusion failure for left pancreatectomy: a single-blinded, randomized controlled trial. Ann Surg 255:1037–1042PubMedPubMedCentralCrossRef
77.
Zurück zum Zitat Pedrazzoli S, DiCarlo V, Dionigi R, Mosca F, Pederzoli P, Pasquali C, Klöppel G, Dhaene K, Michelassi F (1998) Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group. Ann Surg 228:508–517PubMedPubMedCentralCrossRef Pedrazzoli S, DiCarlo V, Dionigi R, Mosca F, Pederzoli P, Pasquali C, Klöppel G, Dhaene K, Michelassi F (1998) Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group. Ann Surg 228:508–517PubMedPubMedCentralCrossRef
78.
Zurück zum Zitat Riall TS, Cameron JL, Lillemoe KD, Campbell KA, Sauter PK, Coleman J, Abrams RA, Laheru D, Hruban RH, Yeo CJ (2005) Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma—part 3: update on 5-year survival. J Gastrointest Surg 9:1191–1204PubMedCrossRef Riall TS, Cameron JL, Lillemoe KD, Campbell KA, Sauter PK, Coleman J, Abrams RA, Laheru D, Hruban RH, Yeo CJ (2005) Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma—part 3: update on 5-year survival. J Gastrointest Surg 9:1191–1204PubMedCrossRef
79.
Zurück zum Zitat Farnell MB, Pearson RK, Sarr MG, DiMagno EP, Burgart LJ, Dahl TR et al (2005) A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma. Surgery 138:618–630PubMedCrossRef Farnell MB, Pearson RK, Sarr MG, DiMagno EP, Burgart LJ, Dahl TR et al (2005) A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma. Surgery 138:618–630PubMedCrossRef
80.
Zurück zum Zitat Nimura Y, Nagino M, Takao S, Takada T, Miyazaki K, Kawarada Y, Miyagawa S, Yamaguchi A, Ishiyama S, Takeda Y, Sakoda K, Kinoshita T, Yasui K, Shimada H, Katoh H (2012) Standard versus extended lymphadenectomy in radical pancreatoduodenectomy for ductal adenocarcinoma of the head of the pancreas: long-term results of a Japanese multicenter randomized controlled trial. J Hepatobiliary Pancreat Sci 19:230–241PubMedCrossRef Nimura Y, Nagino M, Takao S, Takada T, Miyazaki K, Kawarada Y, Miyagawa S, Yamaguchi A, Ishiyama S, Takeda Y, Sakoda K, Kinoshita T, Yasui K, Shimada H, Katoh H (2012) Standard versus extended lymphadenectomy in radical pancreatoduodenectomy for ductal adenocarcinoma of the head of the pancreas: long-term results of a Japanese multicenter randomized controlled trial. J Hepatobiliary Pancreat Sci 19:230–241PubMedCrossRef
81.
Zurück zum Zitat Tol JA, Gouma DJ, Bassi C, Dervenis C, Montorsi M, Adham M, Andrén-Sandberg A, Asbun HJ, Bockhorn M, Büchler MW, Conlon KC, Fernández-Cruz L, Fingerhut A, Friess H, Hartwig W, Izbicki JR, Lillemoe KD, Milicevic MN, Neoptolemos JP, Shrikhande SV, Vollmer CM, Yeo CJ, Charnley RM, International Study Group on Pancreatic Surgery (2014) Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: a consensus statement by the International Study Group on Pancreatic Surgery (ISGPS). Surgery 156:591–600PubMedCrossRef Tol JA, Gouma DJ, Bassi C, Dervenis C, Montorsi M, Adham M, Andrén-Sandberg A, Asbun HJ, Bockhorn M, Büchler MW, Conlon KC, Fernández-Cruz L, Fingerhut A, Friess H, Hartwig W, Izbicki JR, Lillemoe KD, Milicevic MN, Neoptolemos JP, Shrikhande SV, Vollmer CM, Yeo CJ, Charnley RM, International Study Group on Pancreatic Surgery (2014) Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: a consensus statement by the International Study Group on Pancreatic Surgery (ISGPS). Surgery 156:591–600PubMedCrossRef
82.
Zurück zum Zitat Murakami Y, Uemura K, Sudo T, Hashimoto Y, Yuasa Y, Sueda T (2010) Prognostic impact of para-aortic lymph node metastasis in pancreatic ductal adenocarcinoma. World J Surg 34:1900–1907PubMedCrossRef Murakami Y, Uemura K, Sudo T, Hashimoto Y, Yuasa Y, Sueda T (2010) Prognostic impact of para-aortic lymph node metastasis in pancreatic ductal adenocarcinoma. World J Surg 34:1900–1907PubMedCrossRef
83.
Zurück zum Zitat Shrikhande SV, Kleeff J, Reiser C, Weitz J, Hinz U, Esposito I, Schmidt J, Friess H, Büchler MW (2007) Pancreatic resection for M1 pancreatic ductal adenocarcinoma. Ann Surg Oncol 14:118–127PubMedCrossRef Shrikhande SV, Kleeff J, Reiser C, Weitz J, Hinz U, Esposito I, Schmidt J, Friess H, Büchler MW (2007) Pancreatic resection for M1 pancreatic ductal adenocarcinoma. Ann Surg Oncol 14:118–127PubMedCrossRef
84.
Zurück zum Zitat Yamada S, Nakao A, Fujii T, Sugimoto H, Kanazumi N, Nomoto S, Kodera Y, Takeda S (2009) Pancreatic cancer with paraaortic lymph node metastasis: a contraindication for radical surgery? Pancreas 38:e13–e17PubMedCrossRef Yamada S, Nakao A, Fujii T, Sugimoto H, Kanazumi N, Nomoto S, Kodera Y, Takeda S (2009) Pancreatic cancer with paraaortic lymph node metastasis: a contraindication for radical surgery? Pancreas 38:e13–e17PubMedCrossRef
85.
Zurück zum Zitat Hartwig W, Hackert T, Hinz U, Hassenpflug M, Strobel O, B€uchler MW et al (2009) Multivisceral resection for pancreatic malignancies: risk-analysis and long-term outcome. Ann Surg 250:81–87PubMedCrossRef Hartwig W, Hackert T, Hinz U, Hassenpflug M, Strobel O, B€uchler MW et al (2009) Multivisceral resection for pancreatic malignancies: risk-analysis and long-term outcome. Ann Surg 250:81–87PubMedCrossRef
86.
Zurück zum Zitat Burdelski CM, Reeh M, Bogoevski D, Gebauer F, Tachezy M, Vashist YK et al (2011) Multivisceral resections in pancreatic cancer: identification of risk factors. World J Surg 35:2756–2763PubMedCrossRef Burdelski CM, Reeh M, Bogoevski D, Gebauer F, Tachezy M, Vashist YK et al (2011) Multivisceral resections in pancreatic cancer: identification of risk factors. World J Surg 35:2756–2763PubMedCrossRef
87.
Zurück zum Zitat Suzuki Y, Fujino Y, Tanioka Y, Sakai T, Ajiki T, Ueda T et al (2004) Resection of the colon simultaneously with pancreaticoduodenectomy for tumors of the pancreas and periampullary region: short-term and long-term results. World J Surg 28:1007–1010PubMedCrossRef Suzuki Y, Fujino Y, Tanioka Y, Sakai T, Ajiki T, Ueda T et al (2004) Resection of the colon simultaneously with pancreaticoduodenectomy for tumors of the pancreas and periampullary region: short-term and long-term results. World J Surg 28:1007–1010PubMedCrossRef
88.
Zurück zum Zitat Hartwig W, Vollmer CM, Fingerhut A, Yeo CJ, Neoptolemos JP, Adham M, Andrén-Sandberg A, Asbun HJ, Bassi C, Bockhorn M, Charnley R, Conlon KC, Dervenis C, Fernandez-Cruz L, Friess H, Gouma DJ, Imrie CW, Lillemoe KD, Milićević MN, Montorsi M, Shrikhande SV, Vashist YK, Izbicki JR, Büchler MW, International Study Group on Pancreatic Surgery (2014) Extended pancreatectomy in pancreatic ductal adenocarcinoma: definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS). Surgery 156:1–14PubMedCrossRef Hartwig W, Vollmer CM, Fingerhut A, Yeo CJ, Neoptolemos JP, Adham M, Andrén-Sandberg A, Asbun HJ, Bassi C, Bockhorn M, Charnley R, Conlon KC, Dervenis C, Fernandez-Cruz L, Friess H, Gouma DJ, Imrie CW, Lillemoe KD, Milićević MN, Montorsi M, Shrikhande SV, Vashist YK, Izbicki JR, Büchler MW, International Study Group on Pancreatic Surgery (2014) Extended pancreatectomy in pancreatic ductal adenocarcinoma: definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS). Surgery 156:1–14PubMedCrossRef
89.
Zurück zum Zitat Takahashi S, Kinoshita T, Konishi M, Gotohda N, Kato Y, Kinoshita T, Kobayashi T, Mitsunaga S, Nakachi K, Ikeda M (2011) Borderline resectable pancreatic cancer: rationale for multidisciplinary treatment. J Hepatobiliary Pancreat Sci 18:567–574PubMedCrossRef Takahashi S, Kinoshita T, Konishi M, Gotohda N, Kato Y, Kinoshita T, Kobayashi T, Mitsunaga S, Nakachi K, Ikeda M (2011) Borderline resectable pancreatic cancer: rationale for multidisciplinary treatment. J Hepatobiliary Pancreat Sci 18:567–574PubMedCrossRef
90.
Zurück zum Zitat Shrikhande SV, Arya S, Barreto SG, Ingle S, D’Souza MA, Hawaldar R, Shukla PJ (2011) Borderline resectable pancreatic tumors: is there a need for further refinement of this stage? Hepatobiliary Pancreat Dis Int 10:319–324PubMedCrossRef Shrikhande SV, Arya S, Barreto SG, Ingle S, D’Souza MA, Hawaldar R, Shukla PJ (2011) Borderline resectable pancreatic tumors: is there a need for further refinement of this stage? Hepatobiliary Pancreat Dis Int 10:319–324PubMedCrossRef
91.
Zurück zum Zitat Siriwardana HP, Siriwardena AK (2006) Systematic review of outcome of synchronous portal-superior mesenteric vein resection during pancreatectomy for cancer. Br J Surg 93:662–673PubMedCrossRef Siriwardana HP, Siriwardena AK (2006) Systematic review of outcome of synchronous portal-superior mesenteric vein resection during pancreatectomy for cancer. Br J Surg 93:662–673PubMedCrossRef
92.
Zurück zum Zitat Zhou Y, Zhang Z, Liu Y, Li B, Xu D (2012) Pancreatectomy combined with superior mesenteric vein-portal vein resection for pancreatic cancer: a meta-analysis. World J Surg 36:884–891PubMedCrossRef Zhou Y, Zhang Z, Liu Y, Li B, Xu D (2012) Pancreatectomy combined with superior mesenteric vein-portal vein resection for pancreatic cancer: a meta-analysis. World J Surg 36:884–891PubMedCrossRef
93.
Zurück zum Zitat Bockhorn M, Uzunoglu FG, Adham M, Imrie C, Milicevic M, Sandberg AA, Asbun HJ, Bassi C, Büchler M, Charnley RM, Conlon K, Cruz LF, Dervenis C, Fingerhutt A, Friess H, Gouma DJ, Hartwig W, Lillemoe KD, Montorsi M, Neoptolemos JP, Shrikhande SV, Takaori K, Traverso W, Vashist YK, Vollmer C, Yeo CJ, Izbicki JR, International Study Group of Pancreatic Surgery (2014) Borderline resectable pancreatic cancer: a consensus statement by the International Study Group of Pancreatic Surgery (ISGPS). Surgery 155:977–988PubMedCrossRef Bockhorn M, Uzunoglu FG, Adham M, Imrie C, Milicevic M, Sandberg AA, Asbun HJ, Bassi C, Büchler M, Charnley RM, Conlon K, Cruz LF, Dervenis C, Fingerhutt A, Friess H, Gouma DJ, Hartwig W, Lillemoe KD, Montorsi M, Neoptolemos JP, Shrikhande SV, Takaori K, Traverso W, Vashist YK, Vollmer C, Yeo CJ, Izbicki JR, International Study Group of Pancreatic Surgery (2014) Borderline resectable pancreatic cancer: a consensus statement by the International Study Group of Pancreatic Surgery (ISGPS). Surgery 155:977–988PubMedCrossRef
94.
Zurück zum Zitat Mollberg N, Rahbari NN, Koch M, Hartwig W, Hoeger Y, Büchler MW, Weitz J (2011) Arterial resection during pancreatectomy for pancreatic cancer: a systematic review and meta-analysis. Ann Surg 254:882–893PubMedCrossRef Mollberg N, Rahbari NN, Koch M, Hartwig W, Hoeger Y, Büchler MW, Weitz J (2011) Arterial resection during pancreatectomy for pancreatic cancer: a systematic review and meta-analysis. Ann Surg 254:882–893PubMedCrossRef
95.
Zurück zum Zitat Sanjay P, Takaori K, Govil S, Shrikhande SV, Windsor JA (2012) ‘Artery first’ approaches to pancreatoduodenectomy. Br J Surg 99:1027–1035PubMedCrossRef Sanjay P, Takaori K, Govil S, Shrikhande SV, Windsor JA (2012) ‘Artery first’ approaches to pancreatoduodenectomy. Br J Surg 99:1027–1035PubMedCrossRef
96.
Zurück zum Zitat Shrikhande SV, Barreto SG, Bodhankar YD, Suradkar K, Shetty G, Hawaldar R, Goel M, Shukla PJ (2011) Superior mesenteric artery first combined with uncinate process approach versus uncinate process first approach in pancreatoduodenectomy: a comparative study evaluating perioperative outcomes. Langenbecks Arch Surg 396:1205–1212PubMedCrossRef Shrikhande SV, Barreto SG, Bodhankar YD, Suradkar K, Shetty G, Hawaldar R, Goel M, Shukla PJ (2011) Superior mesenteric artery first combined with uncinate process approach versus uncinate process first approach in pancreatoduodenectomy: a comparative study evaluating perioperative outcomes. Langenbecks Arch Surg 396:1205–1212PubMedCrossRef
Metadaten
Titel
Surgery for Pancreatic and Periampullary Carcinoma
verfasst von
Abhishek Mitra
Ashwin D’Souza
Mahesh Goel
Shailesh V. Shrikhande
Publikationsdatum
01.10.2015
Verlag
Springer India
Erschienen in
Indian Journal of Surgery / Ausgabe 5/2015
Print ISSN: 0972-2068
Elektronische ISSN: 0973-9793
DOI
https://doi.org/10.1007/s12262-015-1358-9

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Chirurginnen und Chirurgen sind stark suizidgefährdet

07.05.2024 Suizid Nachrichten

Der belastende Arbeitsalltag wirkt sich negativ auf die psychische Gesundheit der Angehörigen ärztlicher Berufsgruppen aus. Chirurginnen und Chirurgen bilden da keine Ausnahme, im Gegenteil.

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S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.