nach oben

European Archives of Oto-Rhino-Laryngology

Erschienen in:

01.08.2019 | Otology

The relationship of high-frequency distortion product otoacoustic emission (DPOAE) values with hematological parameters in tinnitus patients

verfasst von: Akif Gunes, Elif Karali, Ahmet Ural, Fatih Ruzgar, Tugba Bayatkara

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 11/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

In this study, we aimed to investigate whether there is any positive or negative correlation between high-frequency distortion product otoacoustic emission (DPOAE) values and mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) in tinnitus patients.

Methods

The study was performed with 52 volunteers (27 females, 25 males) aged between 35 and 50 years who presented with tinnitus to the otolaryngology outpatient clinic of a tertiary care center. Pure voice audiometric examination, DPOAE measurement, complete blood count values of the study participants were examined.

Results

In both ears, a significant and negative correlation was observed between 4000 and 8000 Hz airway and 4000 Hz bone conduction pathways with NLR rates (p < 0.05). A statistically significant relationship was found between the bone conduction pathway PTA and discrimination values for both ears and NLR s (p < 0.05). A positive correlation was detected between NLRs and DPOAE measurements recorded at 4444 Hz, 5000 Hz, 8000 Hz, 8889 Hz, 10,000 Hz and 11,429 Hz frequencies in the right and 4444 Hz, 5000 Hz, 6154 Hz, 8000 Hz, 10,000 Hz and 11,429 Hz frequencies in the left ears, respectively (p < 0.05).

Conclusions

We concluded that there is a significant correlation between high-frequency pure tone audiometry measurements and high frequency DPOAE measurements and NLR. Further studies are needed to determine the utility of NLR as a marker for the recognition and follow-up of hearing loss in patients with tinnitus.

Lockwood AH, Salvi RJ, Burkard RF (2002) Tinnitus. N Engl J Med 347(12):904–910. https://doi.org/10.1056/NEJMra013395 CrossRefPubMed

Crummer RW, Hassan GA (2004) Diagnostic approach to tinnitus. Am Fam Physician 69(1):120–126PubMed

Jastreboff PJ, Hazell JW (1993) A neurophysiological approach to tinnitus: clinical implications. Br J Audiol 27(1):7–17. https://doi.org/10.3109/03005369309077884 CrossRefPubMed

Zhao F, Stephens SD, Ishak WS, Meyer-Bisch C (2014) The characteristics of Audioscan and DPOAE measures in tinnitus patients with normal hearing thresholds. Int J Audiol 53(5):309–317. https://doi.org/10.3109/14992027.2013.868047 CrossRefPubMed

Ami M, Abdullah A, Awang MA, Liyab B, Saim L (2008) Relation of distortion product optoacoustic emission with tinnitus. Laryngoscope 118(4):712–717. https://doi.org/10.1097/MLG.0b013e318161e521 CrossRefPubMed

Bayram A, Yaşar M, Doğan M, Güneri E, Özcan İ (2015) Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus. ENT Updates 5(3):103–106CrossRef

Daemen MA, Van't Veer C, Denecker G et al (1999) Inhibition of apoptosis induced by ischemia–reperfusion prevents inflammation. J Clin Invest 104(5):541–549. https://doi.org/10.1172/JCI6974 CrossRefPubMedPubMedCentral

Sarıkaya Y, Bayraktar C, Karataş M et al (2016) Increased mean platelet volume in patients with idiopathic subjective tinnitus. Eur Arch Otorhinolaryngol 273(11):3533–3536. https://doi.org/10.1007/s00405-016-3942-4 CrossRefPubMed

Ozbay I, Kahraman C, Balikci HH et al (2015) Neutrophil-to-lymphocyte ratio in patients with severe tinnitus: prospective, controlled clinical study. J Laryngol Otol 129(6):544–547. https://doi.org/10.1017/S0022215115000845 CrossRefPubMed

10.

Dogan M, Akyel A, Bilgin M et al (2015) Can admission neutrophil to lymphocyte ratio predict infarct-related artery patency in ST-segment elevation myo-cardial infarction. Clin Appl Thromb Hemost 21:172–176CrossRef

11.

Ozbay I, Kahraman C, Balikci HH et al (2014) Neutrophil-to-lymphocyte ratio in patients with peripheral vertigo: a prospective controlled clinical study. Am J Otolaryngol 35:699–702CrossRef

12.

Ikinciogulları A, Koseoglu S, Kılıç M et al (2014) New inflamation parameters in sudden sensorineural hearing loss: neutrophil-to-lymphocyte ratio and platelet to lymphocyte ratio. Int Adv Otol 10:197–200CrossRef

13.

Bucak A, Ulu S, Oruc S et al (2014) Neutrophil-to-lymphocyte ratio as a novel-potential marker for predicting prognosis of Bell palsy. Laryngoscope 124:1678–1681CrossRef

14.

Atan D, Ikinciogulları A, Koseoglu S et al (2015) New predictive parameters of Bell’s palsy: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Balkan Med J 32:167–170CrossRef

15.

Rachidi S, Wallace K, Wrangle JM et al (2016) Neutrophil-to-lymphocyte ratio and overall survival in all sites of head and neck squamous cell carcinoma. Head Neck 38(Suppl 1):E1068–E1074. https://doi.org/10.1002/hed.24159 CrossRefPubMed

16.

Jung MR, Park YK, Jeong O et al (2011) Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer. J Surg Oncol 104(5):504–510. https://doi.org/10.1002/jso.21986 CrossRefPubMed

17.

Seo YJ, Jeong JH, Choi JY, Moon IS (2014) Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers 2014:702807. https://doi.org/10.1155/2014/702807 CrossRefPubMedPubMedCentral

18.

Karli R, Alacam H, Unal R et al (2013) Mean platelet volume: is it a predictive parameter in the diagnosis of sudden sensorineural hearing loss? Indian J Otolaryngol Head Neck Surg 65(4):350–353. https://doi.org/10.1007/s12070-013-0648-4 CrossRefPubMedPubMedCentral

19.

Chu SG, Becker RC, Berger PB et al (2010) Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 8(1):148–156. https://doi.org/10.1111/j.1538-7836.2009.03584.x CrossRef

20.

Kemal O, Müderris T, Başar F, Kutlar G, Gül F (2016) Prognostic value of mean platelet volume on tinnitus. J Laryngol Otol 130(2):162–165. https://doi.org/10.1017/S0022215115003254 CrossRefPubMed

21.

Yenigün A, Doğan R, Aksoy F, Akyüz S, Dabak H (2014) Assessment of tinnitus with tinnitus severity index, tinnitus handicap inventory and distortion product otoacoustic emissions in patients with normal hearing and hearing loss. Kulak Burun Bogaz Ihtis Derg. 24(1):11–16. https://doi.org/10.5606/kbbihtisas.2014.60783 CrossRefPubMed

22.

Hameed HM, Eleue AH, Al Mosawi AMT (2018) The use of distortion product otoacoustic emissions (DPOAE) records to estimate effect of vitamin B complex on changing severity of tinnitus. Ann Med Surg (Lond) 36:203–211. https://doi.org/10.1016/j.amsu.2018.10.035 CrossRef

23.

Linke R, Mazurek B, Matschke RG (2000) Distortion products of otoacoustic emissions (DPOAE) in acute tinnitus aurium. Laryngorhinootologie 79(9):517–522. https://doi.org/10.1055/s-2000-6946 CrossRefPubMed

24.

Shiomi Y, Tsuji J, Naito Y, Fujiki N, Yamamoto N (1997) Characteristics of DPOAE audiogram in tinnitus patients. Hear Res 108(1–2):83–88CrossRef

25.

Paglialonga A, Fiocchi S, Del Bo L, Ravazzani P, Tognola G (2011) Quantitative analysis of cochlear active mechanisms in tinnitus subjects with normal hearing sensitivity: time-frequency analysis of transient evoked otoacoustic emissions and contralateral suppression. Auris Nasus Larynx 38(1):33–40. https://doi.org/10.1016/j.anl.2010.04.006 CrossRefPubMed

26.

Gouveris H, Maurer J, Mann W (2005) DPOAE-grams in patients with acute tonal tinnitus. Otolaryngol Head Neck Surg 132(4):550–553. https://doi.org/10.1016/j.otohns.2004.09.031 CrossRefPubMed

Titel: The relationship of high-frequency distortion product otoacoustic emission (DPOAE) values with hematological parameters in tinnitus patients
verfasst von: Akif Gunes
Elif Karali
Ahmet Ural
Fatih Ruzgar
Tugba Bayatkara
Publikationsdatum: 01.08.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 11/2019
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-019-05585-4

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

The relationship of high-frequency distortion product otoacoustic emission (DPOAE) values with hematological parameters in tinnitus patients

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet HNO

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

Update HNO

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2019

Increased risk of psoriasis in patients with chronic rhinosinusitis without nasal polyps: a longitudinal follow-up study using Korean national sample cohort

Healing acceleration of mastoidectomy through the external auditory canal incisionless approach

Immunohistochemical analysis of MMP-13 and EMMPRIN in epithelial odontogenic lesions

Indications and results of extended total laryngectomy with en-bloc resection of overlying cervical skin

Trans-canal endoscopic ear surgery and canal wall-up tympano-mastoidectomy for pediatric middle ear cholesteatoma

Effects of an antiadhesive agent on functional recovery of the greater auricular nerve after parotidectomy: a double-blind randomized controlled trial

Neu im Fachgebiet HNO

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

Update HNO