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01.11.2004 | Übersicht

Toleranzinduktion gegen Nickel

Vom Tiermodell zum Menschen

verfasst von: Dr. S. Artik, E. Gleichmann, T. Ruzicka

Erschienen in: Die Dermatologie | Ausgabe 11/2004

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Zusammenfassung

Nickel ist das häufigste Kontaktallergen des Menschen. Dennoch waren bis vor kurzem viele Fragen insbesondere bezüglich der Toleranzmechanismen gegenüber Nickel nicht geklärt. Neben humanen Ex-vivo-, Interventions- und Beobachtungsstudien hat die Etablierung eines reproduzierbaren Mausmodells nun dazu beigetragen, diese Mechanismen besser zu analysieren. Erst das genauere Verständnis der Pathogenese der Nickelallergie und Toleranz gegenüber Nickel durch Untersuchungen im Tiermodell sowie in humanen Studien wird dazu beitragen, eine gezielte Prävention bzw. Therapie der Nickelallergie zu entwickeln. Wir beabsichtigen, mit dieser Arbeit einen Überblick über die im Tiermodell und im Menschen erhobenen Erkenntnisse zur Nickelallergie und vor allem zur oralen Toleranzinduktion gegenüber Nickel zu geben.

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Titel: Toleranzinduktion gegen Nickel
Vom Tiermodell zum Menschen
verfasst von: Dr. S. Artik
E. Gleichmann
T. Ruzicka
Publikationsdatum: 01.11.2004
Verlag: Springer-Verlag
Erschienen in: Die Dermatologie / Ausgabe 11/2004
Print ISSN: 2731-7005
Elektronische ISSN: 2731-7013
DOI: https://doi.org/10.1007/s00105-004-0815-3

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