The reported mean total encephalic volume of 1,093,437 mm
3 (SD 111,353) is within the range of previous studies, for example that of Filipek et al. (
1994) with 1,380,100 mm
3 (SD 113,900), Hammers et al. (
2003) with 1,289,861 mm
3 (SD 147,973) or Lancaster et al. (
2010) with 1,179,978 mm
3 (SD 112,537). The absolute lobar volumes are slightly below those in the aforementioned studies, most likely due to differences in the lobar classification systems used. The reported volumes of the gyral segments are higher than the volumes described by Shattuck et al. (
2008), Hammers et al. (
2003), Crespo-Facorro et al. (
2000) or Kennedy et al. (
1998). This is best explained in that our study analyzed the entire gyral segment (cortex and white matter), while the aforementioned studies only considered the cortical volume of a gyral segment. Isolated cortical volumes are provided in the Supplemental Raw Data for our study. Since neoplastic or vascular pathologies are often not only localized cortically, but rather affect whole gyral segments (Yasargil
1994; Akeret et al.
2020), the approach adopted in this study is tailored to volume-standardization in topographic studies. This study provides one of the most detailed volumetric analyses of the central prosencephalic anatomy, infratentorial structures and anatomical segments of the ventricular system. The volumes of the corpus callosum (Hammers et al.
2003), the putamen (Filipek et al.
1994; Hammers et al.
2003; Shattuck et al.
2008; Lancaster et al.
2010), the caudate (Filipek et al.
1994; Hammers et al.
2003; Shattuck et al.
2008; Lancaster et al.
2010), the globus pallidum (Filipek et al.
1994; Hammers et al.
2003), the thalamus (Hammers et al.
2003), the hippocampus (Filipek et al.
1994; Hammers et al.
2003; Shattuck et al.
2008; Lancaster et al.
2010) as well as the amygdala (Filipek et al.
1994; Hammers et al.
2003) are comparable to previous reports. The volumes reported for the brainstem (Filipek et al.
1994; Hammers et al.
2003; Shattuck et al.
2008; Lancaster et al.
2010) and the cerebellum (Filipek et al.
1994; Hammers et al.
2003; Shattuck et al.
2008; Lancaster et al.
2010) are consistent with previous studies. The cerebellum has been claimed to represent a phylogenetically-preserved constant fraction of the total encephalic volume of 0.13 (SD 0.02) across mammalian taxa (Clark et al.
2001), an approximation consistent with our results (10.7%, SD 1.17). The total ventricular volume (DeLisi et al.
1991; Shenton et al.
1992b; Coffey et al.
1992; Filipek et al.
1994) as well as the volumes of the lateral ventricles (Filipek et al.
1994), the third (Filipek et al.
1994; Hammers et al.
2003) and the fourth ventricle (Filipek et al.
1994) correspond to previous reports.