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Pediatric Nephrology

Erschienen in:

01.12.2006 | Review

Vitamin E in renal therapeutic regimens

verfasst von: Mohamed Alaa Thabet, James C. M. Chan

Erschienen in: Pediatric Nephrology | Ausgabe 12/2006

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Abstract

Administration of vitamin E in children with immunoglobulin A (IgA) nephropathy, focal segmental glomerulosclerosis (FSGS) and type I diabetes demonstrated potential towards ameliorating progression. Oral vitamin E therapy reduced endothelial dysfunction, lipid peroxidation and oxidative stress in patients with chronic kidney failure (CKF). Moreover, the use of vitamin E-bonded hemodialyzers reduced atherosclerotic changes, erythropoietin dosage and muscular cramps in patients on hemodialysis (HD). However, several controlled clinical trials failed to document beneficial effects on the study subjects’ cardiovascular and renal outcomes. A recent report of increased all-cause mortality in adult patients receiving high dose vitamin E therapy has caused considerable concern and debate. These issues regarding the efficacy and safety of vitamin E in renal therapeutic regimens will be reviewed in this article.

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Titel: Vitamin E in renal therapeutic regimens
verfasst von: Mohamed Alaa Thabet
James C. M. Chan
Publikationsdatum: 01.12.2006
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 12/2006
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-006-0211-6

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