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01.12.2012 | Review | Ausgabe 1/2012 Open Access

Molecular Cancer 1/2012

Wnt signaling pathways in urological cancers: past decades and still growing

Zeitschrift:
Molecular Cancer > Ausgabe 1/2012
Autoren:
Shahana Majid, Sharanjot Saini, Rajvir Dahiya
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1476-4598-11-7) contains supplementary material, which is available to authorized users.

Authors' contributions

SM prepared the manuscript. SS assisted in the preparation and RD edited and modified this review article. All authors read and approved the final manuscript.

Abstract

The Wnt signaling pathway is involved in a wide range of embryonic patterning events and maintenance of homeostasis in adult tissues. The pathological role of the Wnt pathway has emerged from studies showing a high frequency of specific human cancers associated with mutations that constitutively activate the transcriptional response of these pathways. Constitutive activation of the Wnt signaling pathway is a common feature of solid tumors and contributes to tumor development, progression and metastasis in various cancers. In this review, the Wnt pathway will be covered from the perspective of urological cancers with emphasis placed on the recent published literature. Regulation of the Wnt signaling pathway by microRNAs (miRNA), small RNA sequences that modify gene expression profiles will also be discussed. An improved understanding of the basic genetics and biology of Wnt signaling pathway will provide insights into the development of novel chemopreventive and therapeutic strategies for urological cancers.
Zusatzmaterial
Authors’ original file for figure 1
12943_2011_986_MOESM1_ESM.pdf
Authors’ original file for figure 2
12943_2011_986_MOESM2_ESM.pdf
Literatur
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