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Journal of Clinical Monitoring and Computing

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15.11.2023 | Original Research

Assessment of changes in blood volume during lower body negative pressure-induced hypovolemia using bioelectrical impedance analysis

verfasst von: Suthawan Anakmeteeprugsa, Antonio Gonzalez-Fiol, Rostislav Vychodil, Kirk Shelley, Aymen Alian

Erschienen in: Journal of Clinical Monitoring and Computing | Ausgabe 2/2024

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Abstract

Background

Lower body negative Pressure (LBNP)-induced hypovolemia is simulating acute hemorrhage by sequestrating blood into lower extremities. Bioelectrical Impedance Analysis (BIA) is based on the electrical properties of biological tissues, as electrical current flows along highly conductive body tissues (such as blood). Changes in blood volume will lead to changes in bioimpedance. This study aims to study changes in upper (UL) and lower (LL) extremities bioimpedance during LBNP-induced hypovolemia.

Methods

This was a prospective observational study of healthy volunteers who underwent gradual LBNP protocol which consisted of 3-minute intervals: at baseline, -15, -30, -45, -60 mmHg, then recovery phases at -30 mmHg and baseline. The UL&LL extremities bioimpedance were measured and recorded at each phase of LBNP and the percentage changes of bioimpedance from baseline were calculated and compared using student’s t-test. A P-value of < 0.05 was considered significant. Correlation between relative changes in UL&LL bioimpedance and estimated blood loss (EBL) from LBNP was calculated using Pearson correlation.

Results

26 healthy volunteers were enrolled. As LBNP-induced hypovolemia progressed, there were a significant increase in UL bioimpedance and a significant decrease in LL bioimpedance. During recovery phases (where blood was shifted from the legs to the body), there were a significant increase in LL bioimpedance and a reduction in UL bioimpedance. There were significant correlations between estimated blood loss from LBNP model with UL (R = 0.97) and LL bioimpedance (R = − 0.97).

Conclusion

During LBNP-induced hypovolemia, there were reciprocal changes in UL&LL bioimpedance. These changes reflected hemodynamic compensatory mechanisms to hypovolemia.

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Titel: Assessment of changes in blood volume during lower body negative pressure-induced hypovolemia using bioelectrical impedance analysis
verfasst von: Suthawan Anakmeteeprugsa
Antonio Gonzalez-Fiol
Rostislav Vychodil
Kirk Shelley
Aymen Alian
Publikationsdatum: 15.11.2023
Verlag: Springer Netherlands
Erschienen in: Journal of Clinical Monitoring and Computing / Ausgabe 2/2024
Print ISSN: 1387-1307
Elektronische ISSN: 1573-2614
DOI: https://doi.org/10.1007/s10877-023-01098-y

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Assessment of changes in blood volume during lower body negative pressure-induced hypovolemia using bioelectrical impedance analysis

Abstract

Background

Methods

Results

Conclusion

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Abstract

Background

Methods

Results

Conclusion

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