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BMC Cancer

Ausgabe 1/2020

Inhalt (1209 Artikel)

Open Access Research article

Comorbidity prevalence among cancer patients: a population-based cohort study of four cancers

Helen Fowler, Aurelien Belot, Libby Ellis, Camille Maringe, Miguel Angel Luque-Fernandez, Edmund Njeru Njagi, Neal Navani, Diana Sarfati, Bernard Rachet

Open Access Research article

Loss of Stag2 cooperates with EWS-FLI1 to transform murine Mesenchymal stem cells

Marc El Beaino, Jiayong Liu, Amanda R. Wasylishen, Rasoul Pourebrahim, Agata Migut, Bryan J. Bessellieu, Ke Huang, Patrick P. Lin

Open Access Research article

TP53 and PTEN mutations were shared in concurrent germ cell tumor and acute megakaryoblastic leukemia

Keiichi Akizuki, Masaaki Sekine, Yasunori Kogure, Takuro Kameda, Kotaro Shide, Junji Koya, Ayako Kamiunten, Yoko Kubuki, Yuki Tahira, Tomonori Hidaka, Takumi Kiwaki, Hiroyuki Tanaka, Yuichiro Sato, Hiroaki Kataoka, Keisuke Kataoka, Kazuya Shimoda

Open Access Research article

Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas

Julio Enríquez Pérez, Jan Kopecky, Edward Visse, Anna Darabi, Peter Siesjö

Open Access Study protocol

Radiation therapy before radical cystectomy combined with immunotherapy in locally advanced bladder cancer – study protocol of a prospective, single arm, multicenter phase II trial (RACE IT)

Sebastian C. Schmid, Florestan J. Koll, Claus Rödel, Philipp Maisch, Andreas Sauter, Franziska Beckert, Anna Seitz, Hubert Kübler, Michael Flentje, Felix Chun, Stephanie E. Combs, Kilian Schiller, Jürgen E. Gschwend, Margitta Retz

Open Access Research article

A cross sectional study to determine the prevalence of cough and its impact in patients with lung cancer: a patient unmet need

Amélie Harle, Alex Molassiotis, Oliver Buffin, Jack Burnham, Jaclyn Smith, Janelle Yorke, Fiona H. Blackhall

Open Access Research article

Nomogram for predicting the survival of gastric adenocarcinoma patients who receive surgery and chemotherapy

Chao-Yang Wang, Jin Yang, Hao Zi, Zhong-Li Zheng, Bing-Hui Li, Yang Wang, Zheng Ge, Guang-Xu Jian, Jun Lyu, Xiao-Dong Li, Xue-Qun Ren

Open Access Research article

Complete blood count-based inflammatory score (CBCS) is a novel prognostic marker for gastric cancer patients after curative resection

Jian-Xian Lin, Jun-Peng Lin, Jian-Wei Xie, Jia-bin Wang, Jun Lu, Qi-Yue Chen, Long-long Cao, Mi Lin, Ruhong Tu, Chao-Hui Zheng, Chang-Ming Huang, Ping Li

Open Access Research article

Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma

Simon Schallenberg, Julian Bork, Ahlem Essakly, Hakan Alakus, Reinhard Buettner, Axel M. Hillmer, Christiane Bruns, Wolfgang Schroeder, Thomas Zander, Heike Loeser, Florian Gebauer, Alexander Quaas

Open Access Case report

Simultaneous occurrence of invasive pulmonary aspergillosis and diffuse large B-cell lymphoma: case report and literature review

Lianyou Shao, Longxiang Jiang, Siyao Wu, Lihua Yu, Liangxing Wang, Xiaoying Huang

Open Access Study protocol

Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review

J. Salchow, J. Mann, B. Koch, J. von Grundherr, W. Jensen, S. Elmers, L. A. Straub, E. Vettorazzi, G. Escherich, S. Rutkowski, S. Dwinger, C. Bergelt, M. Sokalska-Duhme, S. Bielack, G. Calaminus, K. Baust, C. F. Classen, C. Rössig, J. Faber, H. Faller, I. Hilgendorf, J. Gebauer, T. Langer, M. Metzler, S. Schuster, C. Niemeyer, A. Puzik, D. Reinhardt, U. Dirksen, A. Sander, M. Köhler, J. K. Habermann, C. Bokemeyer, A. Stein

Open Access Research article

Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours

Zuzana Cierna, Vera Miskovska, Jan Roska, Dana Jurkovicova, Lucia Borszekova Pulzova, Zuzana Sestakova, Lenka Hurbanova, Katarina Machalekova, Michal Chovanec, Katarina Rejlekova, Daniela Svetlovska, Katarina Kalavska, Karol Kajo, Pavel Babal, Jozef Mardiak, Thomas A. Ward, Michal Mego, Miroslav Chovanec

Open Access Research article

AJCC 8th edition prognostic staging provides no better discriminatory ability in prognosis than anatomical staging in triple negative breast cancer

Jiehua He, Julia Y. Tsang, Xiaodan Xu, Jibin Li, Mei Li, Xue Chao, Yuanyuan Xu, Rongzhen Luo, Gary M. Tse, Peng Sun

Open Access Research article

Effect of adjuvant chemotherapy on survival benefit in stage III colon cancer patients stratified by age: a Japanese real-world cohort study

Hidetaka Kawamura, Toshitaka Morishima, Akira Sato, Michitaka Honda, Isao Miyashiro

Open Access Research article

Long-term outcomes of surgical resection for T1b gallbladder cancer: an institutional evaluation

Kizuki Yuza, Jun Sakata, Pankaj Prasoon, Yuki Hirose, Taku Ohashi, Koji Toge, Kohei Miura, Masayuki Nagahashi, Takashi Kobayashi, Toshifumi Wakai

Open Access Case report

Adaptive radiotherapy in locally advanced esophageal cancer with atelectasis: a case report

Katsuyuki Sakanaka, Kota Fujii, Takashi Mizowaki

Open Access Research article

Expression of the NEK family in normal and cancer tissue: an immunohistochemical study

Talita Diniz Melo-Hanchuk, Mariana Bonjiorno Martins, Lucas Leite Cunha, Fernando Augusto Soares, Laura Sterian Ward, José Vassallo, Jörg Kobarg

Open Access Research article

Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells

Kazushige Yoshida, Masanori Okamoto, Jun Sasaki, Chika Kuroda, Haruka Ishida, Katsuya Ueda, Hirokazu Ideta, Takayuki Kamanaka, Atsushi Sobajima, Takashi Takizawa, Manabu Tanaka, Kaoru Aoki, Takeshi Uemura, Hiroyuki Kato, Hisao Haniu, Naoto Saito

Open Access Research article

P53, Somatostatin receptor 2a and Chromogranin A immunostaining as prognostic markers in high grade gastroenteropancreatic neuroendocrine neoplasms

Kirstine Nielsen, Tina Binderup, Seppo W. Langer, Andreas Kjaer, Pauline Knigge, Veronica Grøndahl, Linea Melchior, Birgitte Federspiel, Ulrich Knigge

Open Access Research article

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway

Ye Yang, Ping Yin Liu, Wei Bao, Song Jun Chen, Fang Su Wu, Ping Ya Zhu

Open Access Research article

A systematic review reporting quality of radiomics research in neuro-oncology: toward clinical utility and quality improvement using high-dimensional imaging features

Ji Eun Park, Ho Sung Kim, Donghyun Kim, Seo Young Park, Jung Youn Kim, Se Jin Cho, Jeong Hoon Kim

Open Access Research article

Childhood cancer incidence and survival trends in Estonia (1970–2016): a nationwide population-based study

Keiu Paapsi, Aleksei Baburin, Sirje Mikkel, Margit Mägi, Kadri Saks, Kaire Innos

Open Access Research article

Hypoxic induction of vasculogenic mimicry in hepatocellular carcinoma: role of HIF-1 α, RhoA/ROCK and Rac1/PAK signaling

Ji-Gang Zhang, He-Ming Zhou, Xue Zhang, Wan Mu, Juan-Ni Hu, Gao-Lin Liu, Qin Li

Open Access Research article

Elevated matrix metalloproteinase 7 expression promotes the proliferation, motility and metastasis of tongue squamous cell carcinoma

Shuo Yuan, Li-song Lin, Rui-Huan Gan, Li Huang, Xiao-ting Wu, Yong Zhao, Bo-hua Su, Dali Zheng, You-Guang Lu

Open Access Research article

Young-onset gastric cancer and Epstein–Barr Virus (EBV) – a major player in the pathogenesis?

Assaf Moore, Elad Hikri, Tal Goshen-Lago, Tamar Barkan, Sara Morgenstern, Elena Brook, Annett Maderer, Wilfried Roth, Noa Gordon, Hanoch Kashtan, Baruch Brenner, Markus Moehler, Irit Ben Aharon

Open Access Research article

Prognostic factors of patients with Gliomas – an analysis on 335 patients with Glioblastoma and other forms of Gliomas

Jianfeng Liang, Xiaomin Lv, Changyu Lu, Xun Ye, Xiaolin Chen, Jia Fu, Chenghua Luo, Yuanli Zhao

Open Access Case report

Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report

Claire M. Connell, Rebecca Brais, Hayley Whitaker, Sara Upponi, Ian Beh, Jane Risdall, Pippa Corrie, Tobias Janowitz, Duncan I. Jodrell

Open Access Research article

Bacteriocin production by mucosal bacteria in current and previous colorectal neoplasia

Darina Kohoutova, Miroslava Forstlova, Paula Moravkova, Jiri Cyrany, Juraj Bosak, David Smajs, Stanislav Rejchrt, Jan Bures

Open Access Research article

Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma

Fan Zhou, Dongjiao Wang, Wei Wei, Haimin Chen, Haotian Shi, Nian Zhou, Lixia Wu, Rong Peng

Open Access Research article

GC-PROM: validation of a patient-reported outcomes measure for Chinese patients with gastric cancer

Xiaojuan Hu, Fen Zhao, Hongmei Yu, Yanhong Luo, Jinchun Liu, Yanbo Zhang

Open Access Correction

Correction to: Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects

Hongwei Tian, Gang Shi, Guoyou Yang, Junfeng Zhang, Yiming Li, Tao Du, Jianzhou Wang, Fen Xu, Lin Cheng, Xiaomei Zhang, Lei Dai, Xiaolei Chen, Shuang Zhang, Yang Yang, Dechao Yu, Yuquan Wei, Hongxin Deng

Open Access Correction

Correction to: TOPK promotes metastasis of esophageal squamous cell carcinoma by activating the Src/GSK3β/STAT3 signaling pathway via γ-catenin

Yanan Jiang, Jing Zhang, Jimin Zhao, Zhenzhen Li, Hanyong Chen, Yan Qiao, Xinhuan Chen, Kangdong Liu, Ziming Dong

Open Access Research article

3D visualization ablation planning system assisted microwave ablation for hepatocellular carcinoma (Diameter >3): a precise clinical application

Chao An, Xin Li, Min Zhang, Jian Yang, Zhigang Cheng, Xiaoling Yu, Zhiyu Han, Fangyi Liu, Linan Dong, Jie Yu, Ping Liang

Open Access Research article

Identification of dissociation factors in pancreatic Cancer using a mass spectrometry-based proteomic approach

Peng Liu, Lingming Kong, Keke Liang, Yunhao Wu, Haoyi Jin, Bing Song, Xiaodong Tan

Open Access Research article

IL-1-conferred gene expression pattern in ERα+ BCa and AR+ PCa cells is intrinsic to ERα− BCa and AR− PCa cells and promotes cell survival

Afshan F. Nawas, Mohammed Kanchwala, Shayna E. Thomas-Jardin, Haley Dahl, Kelly Daescu, Monica Bautista, Vanessa Anunobi, Ally Wong, Rachel Meade, Ragini Mistry, Nisha Ghatwai, Felix Bayerl, Chao Xing, Nikki A. Delk

Open Access Research article

Space-time clustering of childhood leukemia in Colombia: a nationwide study

Laura Andrea Rodriguez-Villamizar, Marcela Pilar Rojas Díaz, Lizbeth Alexandra Acuña Merchán, Feisar Enrique Moreno-Corzo, Paula Ramírez-Barbosa

Open Access Research article

Pathological complete response due to a prolonged time interval between preoperative chemoradiation and surgery in locally advanced rectal cancer: analysis from the German StuDoQ|Rectalcarcinoma registry

Sven Lichthardt, Johanna Wagner, Stefan Löb, Niels Matthes, Caroline Kastner, Friedrich Anger, Christoph-Thomas Germer, Armin Wiegering

Open Access Research article

Improving management of comorbidity in patients with colorectal cancer using comprehensive medical assessment: a pilot study

Virginia Signal, Christopher Jackson, Louise Signal, Claire Hardie, Kirsten Holst, Marie McLaughlin, Courtney Steele, Diana Sarfati

Open Access Research article

The relative risk of second primary cancers in Switzerland: a population-based retrospective cohort study

Anita Feller, Katarina L. Matthes, Andrea Bordoni, Christine Bouchardy, Jean-Luc Bulliard, Christian Herrmann, Isabelle Konzelmann, Manuela Maspoli, Mohsen Mousavi, Sabine Rohrmann, Katharina Staehelin, Volker Arndt

Open Access Study protocol

Intrafractional vaginal dilation in anal cancer patients undergoing pelvic radiotherapy (DILANA) – a prospective, randomized, 2-armed phase-II-trial

Nathalie Arians, Matthias Häfner, Johannes Krisam, Kristin Lang, Antje Wark, Stefan A. Koerber, Adriane Hommertgen, Jürgen Debus

Open Access Research article

Systemic treatment of hormone receptor positive, human epidermal growth factor 2 negative metastatic breast cancer: retrospective analysis from Leeds Cancer Centre

Chris Twelves, Sue Cheeseman, Will Sopwith, Matthew Thompson, Majid Riaz, Necibe Ahat-Donker, Melissa Myland, Adam Lee, Raymond Przybysz, Stuart Turner, Geoff Hall, Tim Perren

Open Access Research article

Hepatocellular carcinoma with hilar bile duct tumor thrombus versus hilar Cholangiocarcinoma on enhanced computed tomography: a diagnostic challenge

Xiaoqi Zhou, Jifei Wang, Mimi Tang, Mengqi Huang, Ling Xu, Zhenpeng Peng, Zi-Ping Li, Shi-Ting Feng

Open Access Research article

Efficacy and safety of self-expanding metallic stent placement followed by neoadjuvant chemotherapy and scheduled surgery for treatment of obstructing left-sided colonic cancer

Jia Gang Han, Zhen Jun Wang, Wei Gen Zeng, Yan Bin Wang, Guang Hui Wei, Zhi Wei Zhai, Bao Cheng Zhao, Bing Qiang Yi

Open Access Research article

Immune classification for the PD-L1 expression and tumour-infiltrating lymphocytes in colorectal adenocarcinoma

Byeong-Joo Noh, Jae Young Kwak, Dae-Woon Eom

Open Access Research article

CT features and quantitative analysis of subsolid nodule lung adenocarcinoma for pathological classification prediction

Xiaohu Li, Wei Zhang, Yongqiang Yu, Guihong Zhang, Lifen Zhou, Zongshan Wu, Bin Liu

Open Access Research article

The effect of renal function change on renal cell carcinoma patients with tumor thrombus after nephrectomy and thrombectomy: a large Chinese center experience

Zhuo Liu, Shiying Tang, Xiaojun Tian, Hongxian Zhang, Guoliang Wang, Shudong Zhang, Lulin Ma

Open Access Research article

NFкB is a critical transcriptional regulator of atypical cadherin FAT1 in glioma

Chitrangda Srivastava, Khushboo Irshad, Yakhlesh Gupta, Chitra Sarkar, Ashish Suri, Parthaprasad Chattopadhyay, Subrata Sinha, Kunzang Chosdol

Open Access Research article

Women’s knowledge of and attitudes toward cervical cancer and cervical cancer screening in Zanzibar, Tanzania: a cross-sectional study

Qiao Weng, Jie Jiang, Fatma Mrisho Haji, Lamlet Hassan Nondo, Huaijun Zhou

Open Access Research article

Detection of early adenocarcinoma of the esophagogastric junction by spraying an enzyme-activatable fluorescent probe targeting Dipeptidyl peptidase-IV

Keiko Yamamoto, Shunsuke Ohnishi, Takeshi Mizushima, Junichi Kodaira, Masayoshi Ono, Yutaka Hatanaka, Kanako C. Hatanaka, Yugo Kuriki, Mako Kamiya, Nobuyuki Ehira, Keisuke Shinada, Hiroaki Takahashi, Yuichi Shimizu, Yasuteru Urano, Naoya Sakamoto

Open Access Research article

Key genes with prognostic values in suppression of osteosarcoma metastasis using comprehensive analysis

Mi Li, Xin Jin, Hao Li, Gang Wu, Shanshan Wang, Caihong Yang, Sisi Deng

Open Access Research article

The neurocognitive function change criteria after whole-brain radiation therapy for brain metastasis, in reference to health-related quality of life changes: a prospective observation study

Toshimichi Nakano, Hidefumi Aoyama, Hirotake Saito, Satoshi Tanabe, Kensuke Tanaka, Katsuya Maruyama, Tomoya Oshikane, Atsushi Ohta, Eisuke Abe, Motoki Kaidu

Open Access Research article

Ovarian hyperstimulation closely associated with resumption of follicular growth after chemotherapy during tamoxifen treatment in premenopausal women with breast cancer: a multicenter retrospective cohort study

Rena Yamazaki, Masafumi Inokuchi, Satoko Ishikawa, Takuya Ayabe, Hiromitsu Jinno, Takashi Iizuka, Masanori Ono, Subaru Myojo, Soko Uchida, Toshiya Matsuzaki, Akira Tangoku, Masato Kita, Tomoharu Sugie, Hiroshi Fujiwara

Open Access Research article

Combination therapy with Olaratumab/doxorubicin in advanced or metastatic soft tissue sarcoma -a single-Centre experience

Jana Käthe Striefler, Franziska Brandes, Alexander Baur, Berit Maria Pfitzner, David Kaul, Daniel Rau, Anne Dörr, Maren Schmiester, Georgios Koulaxouzidis, Lars Bullinger, Sven Märdian, Anne Flörcken

Open Access Research article

Superiority of NBI endoscopy to PET/CT scan in detecting esophageal cancer among head and neck cancer patients: a retrospective cohort analysis

Hsuan-An Su, Shun-Wen Hsiao, Yu-Chun Hsu, Lien-Yen Wang, Hsu-Heng Yen

Open Access Research article

Childhood maltreatment as a risk factor for cancer: findings from a population-based survey of Canadian adults

Wendy E. Hovdestad, Margot Shields, Amanda Shaw, Lil Tonmyr

Open Access Research article

Real-world use of chemotherapy for Kaposi’s sarcoma in a large community-based HIV primary care system in Kenya

Esther E. Freeman, Naftali Busakhala, Susan Regan, Fredrick Chite Asirwa, Megan Wenger, Divya Seth, Khatiya Chelidze Moon, Aggrey Semeere, Toby Maurer, Kara Wools-Kaloustian, Ingrid Bassett, Jeffrey Martin

Open Access Research article

Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients

Vahinipriya Manoharan, Eric Hamilton Karunanayake, Kamani Hemamala Tennekoon, Sumadee De Silva, Ahamed Ilyas Ahamed Imthikab, Kanishka De Silva, Preethika Angunawela, Sameera Vishwakula, John Lunec

Open Access Study protocol

Treatment intensification with hepatic arterial infusion chemotherapy in patients with liver-only colorectal metastases still unresectable after systemic induction chemotherapy – a randomized phase II study -- SULTAN UCGI 30/PRODIGE 53 (NCT03164655)- study protocol

Alice Boilève, Aline Maillard, Mathilde Wagner, Clarisse Dromain, Christophe Laurent, Eric Dupont Bierre, Samuel Le Sourd, Franck Audemar, Ayhan Ulusakarya, Veronique Guerin-Meyer, Denis Smisth, Veronica Pezzella, Thierry De Baere, Diane Goere, Maximiliano Gelli, Julien Taieb, Valérie Boige

Open Access Research article

Moderately hypofractionated carbon ion radiotherapy for prostate cancer; a prospective observational study “GUNMA0702”

Hidemasa Kawamura, Nobuteru Kubo, Hiro Sato, Tatsuji Mizukami, Hiroyuki Katoh, Hitoshi Ishikawa, Tatsuya Ohno, Hiroshi Matsui, Kazuto Ito, Kazuhiro Suzuki, Takashi Nakano, Kazuhiro Suzuki, Kazuto Ito, Nobuaki Shimizu, Yutaka Takezawa, Junko Hirato, Hitoshi Ishikawa, Hiroshi Matsui, Hiroyuki Katoh, Tatsuya Ohno, Hidemasa Kawamura

Open Access Research article

Icotinib is as efficacious as gefitinib for brain metastasis of EGFR mutated non-small-cell lung cancer

Kejun Liu, Guanming Jiang, Ailing Zhang, Zhuanghua Li, Jun Jia

Open Access Research article

Prognostic and clinicopathological significance of SNHG6 in human cancers: a meta-analysis

Si Zhao, Hanlong Zhu, Ruonan Jiao, Xueru Wu, Guozhong Ji, Xiuhua Zhang

Open Access Research article

Oncologic outcomes after immediate breast reconstruction following mastectomy: comparison of implant and flap using propensity score matching

Jeong Hyun Ha, Ki Yong Hong, Han-Byoel Lee, Hyeong-Gon Moon, Wonshik Han, Dong-Young Noh, Joonho Lim, Sehoon Yoon, Hak Chang, Ung Sik Jin

Open Access Research article

Incidence of biomarkers in high-grade gliomas and their impact on survival in a diverse SouthEast Asian cohort - a population-based study

Samantha Ya Lyn Ang, Lester Lee, Angela An Qi See, Ting Yao Ang, Beng Ti Ang, Nicolas Kon Kam King

Open Access Software

A web application for the design of multi-arm clinical trials

Michael J. Grayling, James MS. Wason

Open Access Research article

MammaPrint guides treatment decisions in breast Cancer: results of the IMPACt trial

Hatem Soliman, Varsha Shah, Gordan Srkalovic, Reshma Mahtani, Ellis Levine, Blanche Mavromatis, Jayanthi Srinivasiah, Mohamad Kassar, Robert Gabordi, Rubina Qamar, Sarah Untch, Heather M. Kling, Tina Treece, William Audeh

Open Access Software

PDAC-ANN: an artificial neural network to predict pancreatic ductal adenocarcinoma based on gene expression

Palloma Porto Almeida, Cristina Padre Cardoso, Leandro Martins de Freitas

Open Access Research article

Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations

Roberto Ruiz-Cordero, Junsheng Ma, Abha Khanna, Genevieve Lyons, Waree Rinsurongkawong, Roland Bassett, Ming Guo, Mark J. Routbort, Jianjun Zhang, Ferdinandos Skoulidis, John Heymach, Emily B. Roarty, Zhenya Tang, L. Jeffrey Medeiros, Keyur P. Patel, Rajyalakshmi Luthra, Sinchita Roy-Chowdhuri

Open Access Research article

Genomic subtyping of liver cancers with prognostic application

Zhenggang Wu, Xi Long, Shui Ying Tsang, Taobo Hu, Jian-Feng Yang, Wai Kin Mat, Hongyang Wang, Hong Xue

Open Access Research article

Prediction of blood-based biomarkers and subsequent design of bisulfite PCR-LDR-qPCR assay for breast cancer detection

Manny D. Bacolod, Jianmin Huang, Sarah F. Giardina, Philip B. Feinberg, Aashiq H. Mirza, Alexander Swistel, Steven A. Soper, Francis Barany

Open Access Research article

Current status of the clinical use of PD-1/PD-L1 inhibitors: a questionnaire survey of oncologists in China

Bicheng Zhang, Yuxiao Song, Yang Fu, Bo Zhu, Baocheng Wang, Jun Wang

Open Access Correction

Correction to: The relative risk of second primary cancers in Switzerland: a population-based retrospective cohort study

Anita Feller, Katarina L. Matthes, Andrea Bordoni, Christine Bouchardy, Jean-Luc Bulliard, Christian Herrmann, Isabelle Konzelmann, Manuela Maspoli, Mohsen Mousavi, Sabine Rohrmann, Katharina Staehelin, Volker Arndt, K. Staehelin, C. Bouchardy, M. Mousavi, J. L. Bulliard, M. Maspoli, M. Mousavi, A. Bordoni, I. Konzelmann, J. L. Bulliard, R. BlancMoya, S. Rohrmann

Open Access Research article

The influence of radiotherapy techniques on the plan quality and on the risk of secondary tumors in patients with pituitary adenoma

Marius Treutwein, Felix Steger, Rainer Loeschel, Oliver Koelbl, Barbara Dobler

Open Access Research article

Comparing three induction chemotherapy regimens for patients with locoregionally advanced nasopharyngeal carcinoma based on TNM stage and plasma Epstein–Barr virus DNA level

Sai-Lan Liu, Xue-Song Sun, Hao-Jun Xie, Qiu-Yan Chen, Huan-Xin Lin, Hu Liang, Yu-Jing Liang, Xiao-Yun Li, Jin-Jie Yan, Chao Lin, Zhen-Chong Yang, Shan-Shan Guo, Li-Ting Liu, Qing-Nan Tang, Yu-Yun Du, Lin-Quan Tang, Ling Guo, Hai-Qiang Mai

Open Access Research article

Radiotherapy of prostate cancer: impact of treatment characteristics on the incidence of second tumors

Milly BUWENGE, Erica SCIROCCO, Francesco DEODATO, Gabriella MACCHIA, Maria NTRETA, Silvia BISELLO, Giambattista SIEPE, Savino CILLA, Anna Rita ALITTO, Vincenzo VALENTINI, Lidia STRIGARI, Alessio G. MORGANTI, Silvia CAMMELLI

Open Access Research article

Review of metastatic colorectal cancer treatment pathways and early clinical experience of trifluridine/tipiracil in the UK named patient programme

Timothy Iveson, Angela M. Carter, Kai-Keen Shiu, Clare Spooner, Daniel Stevens, Saifee Mullamitha

Open Access Research article

IL-36 s in the colorectal cancer: is interleukin 36 good or bad for the development of colorectal cancer?

Feier Chen, Meng Qu, Feng Zhang, Zhenyu Tan, Qinghua Xia, Brett D. Hambly, Shisan Bao, Kun Tao

Open Access Research article

Prediction of patients with a tumor proportion score > 50% who do not respond to first-line monotherapy with pembrolizumab

Mitsunori Morita, Motohiro Tamiya, Daichi Fujimoto, Akihiro Tamiya, Hidekazu Suzuki, Katsuya Hirano, Yasushi Fukuda, Toshihide Yokoyama, Ryota Kominami, Masaki Kanazu, Junji Uchida, Satoshi Hara, Shuji Yamashita, Hiromi Tomioka

Open Access Research article

Development of a risk-stratification scoring system for predicting lymphovascular invasion in breast cancer

Ma-yi-di-li Ni-jia-ti, Di-li-a-re-mu Ai-hai-ti, Ai-si-ka-er-jiang Huo-jia, Pa-li-dan-mu Wu-mai-er, A-bu-du-ke-you-mu-jiang A-bu-li-zi, Yu Shi, Nu-er-a-mi-na Rou-zi, Wen-jing Su, Guo-zhao Dai, Mai-he-mi-ti-jiang Da-mo-la

Open Access Research article

The prognostic value of neuromedin U in patients with hepatocellular carcinoma

Qiao Li, Lingyu Han, Shengnan Ruan, Shunli Shen, Qinghua Cao, Xiuqin Cai, Yuan Yan, Baogang Peng, Yunpeng Hua

Open Access Research article

A decrease in brown adipose tissue activity is associated with weight gain during chemotherapy in early breast cancer patients

Angeline Ginzac, Bertrand Barres, Marion Chanchou, Emilie Gadéa, Ioana Molnar, Charles Merlin, Bruno Coudert, Emilie Thivat, Xavier Durando

Open Access Research article

Satisfaction with high-resolution anoscopy for anal cancer screening among men who have sex with men: a cross-sectional survey in Abuja, Nigeria

Rebecca G. Nowak, Chinedu H. Nnaji, Wuese Dauda, Andrew Mitchell, Oluwole Olaomi, Paul Jibrin, Trevor A. Crowell, Stefan D. Baral, Nicaise Ndembi, Manhattan E. Charurat, Joel M. Palefsky, Søren M. Bentzen, Kevin J. Cullen, Manhattan Charurat, Julie Ake, Sylvia Adebajo, Stefan Baral, Erik Billings, Trevor Crowell, George Eluwa, Charlotte Gaydos, Sosthenes Ketende, Afoke Kokogho, Hongjie Liu, Jennifer Malia, Olumide Makanjuola, Nelson Michael, Nicaise Ndembi, Jean Njab, Rebecca Nowak, Oluwasolape Olawore, Zahra Parker, Sheila Peel, Habib Ramadhani, Merlin Robb, Cristina Rodriguez-Hart, Eric Sanders-Buell, Sodsai Tovanabutra, Erik Volz

Open Access Research article

Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors

César Serrano, Ana Vivancos, Antonio López-Pousa, Judit Matito, Francesco M. Mancuso, Claudia Valverde, Sergi Quiroga, Stefania Landolfi, Sandra Castro, Cristina Dopazo, Ana Sebio, Anna C. Virgili, María M. Menso, Javier Martín-Broto, Miriam Sansó, Alfonso García-Valverde, Jordi Rosell, Jonathan A. Fletcher, Suzanne George, Joan Carles, Joaquín Arribas

Open Access Research article

Predicting the response to neoadjuvant chemotherapy for breast cancer: wavelet transforming radiomics in MRI

Jiali Zhou, Jinghui Lu, Chen Gao, Jingjing Zeng, Changyu Zhou, Xiaobo Lai, Wenli Cai, Maosheng Xu

Open Access Research article

Coffee drinking and cancer risk: an umbrella review of meta-analyses of observational studies

Long-Gang Zhao, Zhuo-Ying Li, Guo-Shan Feng, Xiao-Wei Ji, Yu-Ting Tan, Hong-Lan Li, Marc J. Gunter, Yong-Bing Xiang

Open Access Research article

Increased plasma concentration of cell-free DNA precedes disease recurrence in children with high-risk neuroblastoma

Yan Su, Lijun Wang, Chiyi Jiang, Zhixia Yue, Hongjun Fan, Huimin Hong, Chao Duan, Mei Jin, Dawei Zhang, Lihua Qiu, Xianfeng Cheng, Zhong Xu, Xiaoli Ma

Open Access Research article

Differential significance of molecular subtypes which were classified into EGFR exon 19 deletion on the first line afatinib monotherapy

Nahomi Tokudome, Yasuhiro Koh, Hiroaki Akamatsu, Daichi Fujimoto, Isamu Okamoto, Kazuhiko Nakagawa, Toyoaki Hida, Fumio Imamura, Satoshi Morita, Nobuyuki Yamamoto

Open Access Research article

Tumour content ratio matters for detecting epidermal growth factor receptor mutation by cobas test in small biopsies; a retrospective study

Mariko Kogo, Daichi Fujimoto, Kazutaka Hosoya, Kazuma Nagata, Atsushi Nakagawa, Ryo Tachikawa, Daisuke Yamashita, Yuka Kitamura, Yukihiro Imai, Keisuke Tomii

Open Access Research article

The combination of CTCs and CEA can help guide the management of patients with SPNs suspected of being lung cancer

Jian Zheng, Xiong Ye, Yanan Liu, Yuxia Zhao, Mudan He, Hui Xiao

Open Access Research article

Linc01234 promotes cell proliferation and metastasis in oral squamous cell carcinoma via miR-433/PAK4 axis

Deyu Liu, Xinchun Jian, Pu Xu, Rong Zhu, Yuan Wang

Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Correction

Correction to: A reactive oxygen species scoring system predicts cisplatin sensitivity and prognosis in ovarian cancer patients

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Open Access Research article

Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing

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Open Access Research article

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Open Access Research article

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Lihong Wang, Jia Ge, Yang Lan, Yu Shi, Ying Luo, Yuhuan Tan, Mei Liang, Song Deng, Xia Zhang, Wenying Wang, Yaoyao Tan, Yuanyuan Xu, Tao Luo

Open Access Research article

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Open Access Research article

Prognostic significance of stem cell/ epithelial-mesenchymal transition markers in periampullary/pancreatic cancers: FGFR1 is a promising prognostic marker

Yosep Chong, Nishant Thakur, Kwang Yeol Paik, Eun Jung Lee, Chang Suk Kang

Open Access Research article

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Jinzhi Li, Xiaoyue Xu, Yanyan Jiang, Nicole G. Hansbro, Philip M. Hansbro, Jincheng Xu, Gang Liu

Open Access Research article

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Open Access Research article

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Open Access Research article

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Bo Chen, De-Hong Cao, Li Lai, Jian-Bing Guo, Ze-Yu Chen, Yin Huang, Shi Qiu, Tian-Hai Lin, Yue Gou, Na Ma, Lu Yang, Liang-Ren Liu, Qiang Wei

Open Access Research article

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Open Access Research article

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Open Access Technical advance

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Retraction Note

Retraction Note: Correlation of CD44v6 expression with ovarian cancer progression and recurrence

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

Longitudinal trajectory patterns of plasma albumin and C-reactive protein levels around diagnosis, relapse, bacteraemia, and death of acute myeloid leukaemia patients

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Open Access Research article

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Open Access Research article

RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors

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Open Access Research article

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Open Access Research article

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Open Access Study protocol

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Open Access Research article

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Fan Yang, Xiang Huang, Chunxiao Sun, Jianbin Li, Biyun Wang, Min Yan, Feng Jin, Haibo Wang, Jin Zhang, Peifen Fu, Tianyu Zeng, Jian Wang, Wei Li, Yongfei Li, Mengzhu Yang, Jun Li, Hao Wu, Ziyi Fu, Yongmei Yin, Zefei Jiang

Open Access Case report

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Open Access Research article

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Open Access Research article

Long non-coding RNA AFAP1-AS1 accelerates the progression of melanoma by targeting miR-653-5p/RAI14 axis

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Study protocol

Phase II, multi-center, open-label, single-arm clinical trial evaluating the efficacy and safety of Mycophenolate Mofetil in patients with high-grade locally advanced or metastatic osteosarcoma (ESMMO): rationale and design of the ESMMO trial

Nut Koonrungsesomboon, Nuttapong Ngamphaiboon, Natavudh Townamchai, Pimpisa Teeyakasem, Chaiyut Charoentum, Pimlak Charoenkwan, Rungrote Natesirinilkul, Lalita Sathitsamitphong, Touch Ativitavas, Parunya Chaiyawat, Jeerawan Klangjorhor, Suradej Hongeng, Dumnoensun Pruksakorn

Open Access Research article

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Open Access Case report

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Open Access Research article

Synergistic enhancement of efficacy of platinum drugs with verteporfin in ovarian cancer cells

Venkata Ramesh Dasari, David J. Carey, Radhika Gogoi

Open Access Research article

Value of digital mammography in predicting lymphovascular invasion of breast cancer

Zhuangsheng Liu, Ruqiong Li, Keming Liang, Junhao Chen, Xiangmeng Chen, Xiaoping Li, Ronggang Li, Xin Zhang, Lilei Yi, Wansheng Long

Open Access Research article

Clinical performance evaluation of the Idylla™ EGFR Mutation Test on formalin-fixed paraffin-embedded tissue of non-small cell lung cancer

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Open Access Research article

Long-term survival trends in patients with unresectable stage III non-small cell lung cancer receiving chemotherapy and radiation therapy: a SEER cancer registry analysis

Ryan N. Hansen, Yiduo Zhang, Brian Seal, Kellie Ryan, Candice Yong, Annie Darilay, Scott D. Ramsey

Open Access Research article

PD-L1 and PD-L2 expression in the tumor microenvironment including peritumoral tissue in primary central nervous system lymphoma

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Open Access Research article

Efficacy and safety of concurrent chemoradiotherapy in ECOG 2 patients with locally advanced non-small-cell lung cancer: a subgroup analysis of a randomized phase III trial

Nan Bi, Lipin Liu, Jun Liang, Shixiu Wu, Ming Chen, Changxing Lv, Lujun Zhao, Anhui Shi, Wei Jiang, Yaping Xu, Zongmei Zhou, Jingbo Wang, Wenqing Wang, Dongfu Chen, Zhouguang Hui, Jima Lv, Hongxing Zhang, Qinfu Feng, Zefen Xiao, Xin Wang, Tao Zhang, Weibo Yin, Junling Li, Jie He, Luhua Wang

Open Access Research article

Landscape of copy number aberrations in esophageal squamous cell carcinoma from a high endemic region of South Africa

Jacqueline Brown, Andrzej J. Stepien, Pascale Willem

Open Access Research article

lncRNA CRNDE promotes the proliferation and metastasis by acting as sponge miR-539-5p to regulate POU2F1 expression in HCC

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Open Access Research article

Racial differences in testicular cancer in the United States: descriptive epidemiology

Yang Li, Qi Lu, Yu Wang, Shuangge Ma

Open Access Research article

CD45dimCD34+CD38−CD133+ cells have the potential as leukemic stem cells in acute myeloid leukemia

Sook-Kyoung Heo, Eui-Kyu Noh, Lan Jeong Ju, Jun Young Sung, Yoo Kyung Jeong, Jaekyung Cheon, Su Jin Koh, Young Joo Min, Yunsuk Choi, Jae-Cheol Jo

Open Access Research article

Final results from IMPROVE: a randomized, controlled, open-label, two-arm, cross-over phase IV study to determine patients’ preference for everolimus in combination with exemestane or capecitabine in combination with bevacizumab in advanced HR-positive, HER2-negative breast cancer

Thomas Decker, Ulrike Söling, Antje Hahn, Christoph Maintz, Christian Martin Kurbacher, Ursula Vehling-Kaiser, Dagmar Sent, Peter Klare, Volker Hagen, Marco Chiabudini, Julia Falkenstein, Martin Indorf, Eva Runkel, Karin Potthoff

Open Access Research article

Dietary factors and risk of mortality among patients with esophageal cancer: a systematic review

Li-Ping Sun, Lu-Bin Yan, Zhen-Zhen Liu, Wen-Jing Zhao, Cai-Xia Zhang, Yu-Min Chen, Xiang Qian Lao, Xudong Liu

Open Access Research article

Trends in the epidemiology of young-onset colorectal cancer: a worldwide systematic review

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Open Access Research article

Overexpression of SLC6A1 associates with drug resistance and poor prognosis in prostate cancer

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Open Access Research article

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Open Access Technical advance

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Open Access Research article

Drug resistance occurred in a newly characterized preclinical model of lung cancer brain metastasis

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Open Access Research article

HPV E6 and E7 oncoproteins cooperatively alter the expression of Disc Large 1 polarity protein in epithelial cells

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Open Access Research article

Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphism

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Open Access Research article

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Open Access Research article

Sequential analysis of transcript expression patterns improves survival prediction in multiple cancers

Jordan Mandel, Raghunandan Avula, Edward V. Prochownik

Open Access Research article

Screening differentially expressed genes of pancreatic cancer between Mongolian and Han people using bioinformatics technology

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Open Access Research article

RIPK1 polymorphisms alter the susceptibility to cervical Cancer among the Uyghur population in China

Zulipiyamu Tuoheti, Lili Han, Sulaiya Husaiyin, Xiaoxi Liu, Chunhua Ma, Mayinuer Niyazi

Open Access Research article

Challenges in diagnosis and management of neutropenia upon exposure to immune-checkpoint inhibitors: meta-analysis of a rare immune-related adverse side effect

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Open Access Correction

Correction to: Clinical and histopathological analyses of VEGF receptors peptide vaccine in patients with primary glioblastoma - a case series

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Open Access Research article

Impact of nuclear YAP1 expression in residual cancer after neoadjuvant chemohormonal therapy with docetaxel for high-risk localized prostate cancer

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Open Access Study protocol

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Open Access Research article

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Wei Fang Dai, Jaclyn M. Beca, Ruth Croxford, Wanrudee Isaranawatchai, Ines B. Menjak, Teresa M. Petrella, Nicole Mittmann, Craig C. Earle, Scott Gavura, Timothy P. Hanna, Kelvin K.W. Chan

Open Access Research article

INHBA is a prognostic predictor for patients with colon adenocarcinoma

Xueying Li, Weiming Yu, Chao Liang, Yuan Xu, Miaozun Zhang, Xiaoyun Ding, Xianlei Cai

Open Access Research article

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Open Access Research article

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Open Access Study protocol

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Open Access Research article

Sepsis-associated pathways segregate cancer groups

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Open Access Research article

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Man-Yee Chan, Bor-Jen Lee, Po-Sheng Chang, Han-Yu Hsiao, Li-Ping Hsu, Chia-Hua Chang, Ping-Ting Lin

Open Access Case report

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Open Access Research article

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Open Access Research article

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Open Access Research article

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All-trans retinoic acid reduces cancer stem cell-like cell-mediated resistance to gefitinib in NSCLC adenocarcinoma cells

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Kavitha Mukund, Natalia Syulyukina, Sonia Ramamoorthy, Shankar Subramaniam

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Characterization of LGR5 expression in poorly differentiated colorectal carcinoma with mismatch repair protein deficiency

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Open Access Study protocol

Preoperative exercise to improve fitness in patients undergoing complex surgery for cancer of the lung or oesophagus (PRE-HIIT): protocol for a randomized controlled trial

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3’UTR polymorphism of Thymidylate Synthase gene increased the risk of persistence of pre-neoplastic cervical lesions

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Miikka Lehtonen, Lauri Heiskanen, Petri Reinikainen, Pirkko-Liisa Kellokumpu-Lehtinen

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Taxane-induced sensory peripheral neuropathy is associated with an SCN9A single nucleotide polymorphism in Japanese patients

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Xiang Jin, Yinghui Guan, Zhen Zhang, Hongyue Wang

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Retrospective analysis of salvage surgery for local progression of brain metastasis previously treated with stereotactic irradiation: diagnostic contribution, functional outcome, and prognostic factors

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Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells

Hanhee Jo, Yusun Park, Taehun Kim, Jisu Kim, Jong Sook Lee, Seon Yoo Kim, Jee-in Chung, Hae yong Ko, Jae-Chul Pyun, Kyung Sik Kim, Misu Lee, Mijin Yun

Open Access Research article

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Open Access Study protocol

TENERGY: multicenter phase II study of Atezolizumab monotherapy following definitive Chemoradiotherapy with 5-FU plus Cisplatin in patients with unresectable locally advanced esophageal squamous cell carcinoma

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Sadayuki Kawai, Naoki Fukuda, Shun Yamamoto, Seiichiro Mitani, Katsuhiro Omae, Takeru Wakatsuki, Ken Kato, Shigenori Kadowaki, Daisuke Takahari, Narikazu Boku, Kei Muro, Nozomu Machida

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Marjut Niinivirta, Maria Georganaki, Gunilla Enblad, Cecilia Lindskog, Anna Dimberg, Gustav J. Ullenhag

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Zhibo Zheng, Zhien Zhou, Weigang Yan, Yi Zhou, Chuyan Chen, Hanzhong Li, Zhigang Ji

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Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population

Chuanyin Li, Yaheng Li, Zhiling Yan, Shuying Dai, Shuyuan Liu, Xia Wang, Jun Wang, Xinwen Zhang, Li Shi, Yufeng Yao

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Anne Marie McCarthy, Nitya Pradeep Kumar, Wei He, Susan Regan, Michaela Welch, Beverly Moy, A. John Iafrate, Andrew T. Chan, Aditya Bardia, Katrina Armstrong

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Open Access Study protocol

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Anti-HER2 induced myeloid cell alterations correspond with increasing vascular maturation in a murine model of HER2+ breast cancer

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Reduction of cycles of neoadjuvant chemotherapy for advanced epithelial ovarian, fallopian or primary peritoneal cancer (ROCOCO): study protocol for a phase III randomized controlled trial

Soo Jin Park, Seung-Hyuk Shim, Yong-Il Ji, Sang-Hoon Kwon, Eun Ji Lee, Maria Lee, Suk Joon Chang, Samina Park, Sang Youn Kim, Sung Jong Lee, Jae-Weon Kim, Ju-Won Roh, San Hui Lee, Taejong Song, Hee Seung Kim

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ALDH1A3 serves as a predictor for castration resistance in prostate cancer patients

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Construction of an integrated human osteosarcoma database, HOsDb, based on literature mining, microarray analysis, and database retrieval

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Clinical validation of full genotyping CLART® HPV4S assay on SurePath and ThinPrep collected screening samples according to the international guidelines for human papillomavirus test requirements for cervical screening

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Knowledge-based analyses reveal new candidate genes associated with risk of hepatitis B virus related hepatocellular carcinoma

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Open Access Research article

Clinical significance of prognostic inflammation-based and/or nutritional markers in patients with stage III gastric cancer

Takahiro Toyokawa, Kazuya Muguruma, Mami Yoshii, Tatsuro Tamura, Katsunobu Sakurai, Naoshi Kubo, Hiroaki Tanaka, Shigeru Lee, Masakazu Yashiro, Masaichi Ohira

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Optimal cumulative dose of cisplatin for concurrent chemoradiotherapy among patients with non-metastatic nasopharyngeal carcinoma: a multicenter analysis in Thailand

Nuttapong Ngamphaiboon, Arunee Dechaphunkul, Jiraporn Setakornnukul, Tanadech Dechaphunkul, Rungarun Jiratrachu, Bhoom Suktitipat, Chuleeporn Jiarpinitnun, Poompis Pattaranutaporn, Pongwut Danchaivijitr

Open Access Research article

Prostate-specific membrane antigen (PSMA) expression in adenoid cystic carcinoma of the head and neck

Thomas J. W. Klein Nulent, Matthijs H. Valstar, Laura A. Smit, Ludwig E. Smeele, Nicolaas P. A. Zuithoff, Bart de Keizer, Remco de Bree, Robert J. J. van Es, Stefan M. Willems

Open Access Research article

Adenocarcinomatous-predominant subtype associated with a better prognosis in adenosquamous lung carcinoma

Yangli Liu, Ying Zhu, Lihong Bai, Fengjia Chen, Jue Wang, Yubiao Guo

Open Access Research article

Prognostic value of OCT4A and SPP1C transcript variant co-expression in early-stage lung adenocarcinoma

Seijiro Koshimune, Mitsuko Kosaka, Nobuhiko Mizuno, Hiromasa Yamamoto, Tomoyuki Miyamoto, Kohta Ebisui, Shinichi Toyooka, Aiji Ohtsuka

Open Access Research article

miR-874 inhibits gastric cancer cell proliferation by targeting SPAG9

Qin Hui Sun, Zong Xiu Yin, Zhi Li, Shu Bo Tian, Hong Chang Wang, Fang Xu Zhang, Le Ping Li, Chun Ning Zheng, Shuai Kong

Open Access Study protocol

INFORM2 NivEnt: The first trial of the INFORM2 biomarker driven phase I/II trial series: the combination of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies

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Open Access Research article

The initial engraftment of tumor cells is critical for the future growth pattern: a mathematical study based on simulations and animal experiments

Bertin Hoffmann, Tobias Lange, Vera Labitzky, Kristoffer Riecken, Andreas Wree, Udo Schumacher, Gero Wedemann

Open Access Research article

Expression of tripartite motif-containing 44 and its prognostic and clinicopathological value in human malignancies:a meta-analysis

Guoliang Xiao, Qiuxi Yang, Ziwei Bao, Haixia Mao, Yi Zhang, Shibu Lin

Open Access Research article

Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase

Katerina Hlozkova, Alena Pecinova, Natividad Alquezar-Artieda, David Pajuelo-Reguera, Marketa Simcikova, Lenka Hovorkova, Katerina Rejlova, Marketa Zaliova, Tomas Mracek, Alexandra Kolenova, Jan Stary, Jan Trka, Julia Starkova

Open Access Research article

Activity of PD1 inhibitor therapy in advanced sarcoma: a single-center retrospective analysis

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Open Access Research article

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Open Access Research article

The patient-level effect of the cost of Cancer care – financial burden in German Cancer patients

Katja Mehlis, Julian Witte, Bastian Surmann, Matthias Kudlich, Leonidas Apostolidis, Jürgen Walther, Dirk Jäger, Wolfgang Greiner, Eva C. Winkler

Open Access Research article

A novel nomogram to predict the reliability of estimated glomerular filtration rate formulae in oncology patients

Yichun Cheng, Liu Huang, Yunfeng Han, Chummun Vanisha, Shuwang Ge, Gang Xu

Open Access Research article

R269C variant of ESR1: high prevalence and differential function in a subset of pancreatic cancers

Tomer Boldes, Keren Merenbakh-Lamin, Shani Journo, Eliya Shachar, Doron Lipson, Adva Yeheskel, Metsada Pasmanik-Chor, Tami Rubinek, Ido Wolf

Open Access Study protocol

Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: neurocognitive testing and biological imaging (HIPPORAD) – a phase II prospective randomized multicenter trial (NOA-14, ARO 2015–3, DKTK-ROG)

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Open Access Research article

The development and validation of a radiomic nomogram for the preoperative prediction of lung adenocarcinoma

Qin Liu, Yan Huang, Huai Chen, Yanwen Liu, Ruihong Liang, Qingsi Zeng

Open Access Research article

A prognostic nomogram for the cancer-specific survival of patients with upper-tract urothelial carcinoma based on the Surveillance, Epidemiology, and End Results Database

Chengzhuo Li, Jin Yang, Fengshuo Xu, Didi Han, Shuai Zheng, Rahel Elishilia Kaaya, Shengpeng Wang, Jun Lyu

Open Access Research article

Single-institutional outcome-analysis of low-dose stereotactic body radiation therapy (SBRT) of adrenal gland metastases

Theresa Voglhuber, Kerstin A. Kessel, Markus Oechsner, Marco M. E. Vogel, Jürgen E. Gschwend, Stephanie E. Combs

Open Access Research article

Elective neck dissection versus wait-and-see policy in cT1N0 buccal squamous cell carcinoma

Qigen Fang, Hua Gao, Qing Gao, Jinlan Sun, Peng Li, Meng Cui, Enxi Zhang, Wenlong Yin, Yuanyuan Dong

Open Access Study protocol

Adjuvant VACcination against HPV in surgical treatment of Cervical Intra-epithelial Neoplasia (VACCIN study) a study protocol for a randomised controlled trial

R. L. O. van de Laar, W. Hofhuis, R. G. Duijnhoven, S. Polinder, W. J. G. Melchers, F. J. van Kemenade, R. L. M. Bekkers, H. J. Van Beekhuizen

Open Access Research article

Role of high-dose salvage radiotherapy for oligometastases of the localised abdominal/pelvic lymph nodes: a retrospective study

Makoto Ito, Takeshi Kodaira, Yutaro Koide, Takahito Okuda, Shinichiro Mizumatsu, Yukihiko Oshima, Arisa Takeuchi, Toshie Mori, Souichirou Abe, Ayumi Asai, Kojiro Suzuki

Open Access Research article

Albumin-to-alkaline phosphatase ratio serves as a prognostic indicator in unresectable pancreatic ductal adenocarcinoma: a propensity score matching analysis

Ke Zhang, Shu Dong, Yan-Hua Jing, Hui-Feng Gao, Lian-Yu Chen, Yong-Qiang Hua, Hao Chen, Zhen Chen

Open Access Research article

LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target

Catharina Hagerling, Mark Owyong, Vaishnavi Sitarama, Chih-Yang Wang, Charlene Lin, Renske J. E. van den Bijgaart, Charlotte D. Koopman, Audrey Brenot, Ankitha Nanjaraj, Fredrik Wärnberg, Karin Jirström, Ophir D. Klein, Zena Werb, Vicki Plaks

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A real-time electronic symptom monitoring system for patients after discharge following surgery: a pilot study in cancer-related surgery

H. S. Richards, J. M. Blazeby, A. Portal, R. Harding, T. Reed, T. Lander, K. A. Chalmers, R. Carter, R. Singhal, K. Absolom, G. Velikova, K. N. L. Avery

Open Access Research article

A predictive model for treatment response in patients with locally advanced esophageal squamous cell carcinoma after concurrent chemoradiotherapy: based on SUVmean and NLR

Chunsheng Wang, Kewei Zhao, Shanliang Hu, Yong Huang, Li Ma, Yipeng Song, Minghuan Li

Open Access Research article

Prognostic value of lymph node to primary tumor standardized uptake value ratio in unresectable esophageal cancer

Po-Jui Chen, Wing-Keen Yap, Yu-Chuan Chang, Chen-Kan Tseng, Yin-Kai Chao, Jason Chia-Hsun Hsieh, Ping-Ching Pai, Ching-Hsin Lee, Chan-Keng Yang, Albert Tsung-Ying Ho, Tsung-Min Hung

Open Access Research article

Alignment of preferences in the treatment of multiple myeloma – a discrete choice experiment of patient, carer, physician, and nurse preferences

Simon J. Fifer, Kerrie-Anne Ho, Sean Lybrand, Laurie J. Axford, Steve Roach

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Correlation study between flash dual source CT perfusion imaging and regional lymph node metastasis of non-small cell lung cancer

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Open Access Research article

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Open Access Research article

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Open Access Research article

Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence

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Open Access Research article

Allogeneic hematopoietic stem cell transplantation can improve the prognosis of high-risk pediatric t(8;21) acute myeloid leukemia in first remission based on MRD-guided treatment

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Open Access Research article

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Open Access Research article

Altered staining patterns and expression level of Engrailed-2 in benign prostatic hyperplasia and prostate Cancer predict prostatic disease progression

Qi Li, Yibo Shi, Rigai Sa, Jun Hao, Jinhao Hu, Mulun Xiao, Chaoliang Wang, Liang Yan, Baoping Qiao, Guoxun Chen

Open Access Research article

Impact of liver fibrosis score on prognosis after common therapies for intrahepatic cholangiocarcinoma: a propensity score matching analysis

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Open Access Study protocol

Stereotactic ablative body radiotherapy (SABR) combined with immunotherapy (L19-IL2) versus standard of care in stage IV NSCLC patients, ImmunoSABR: a multicentre, randomised controlled open-label phase II trial

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Open Access Research article

A prognostic model based on cell-cycle control predicts outcome of breast cancer patients

Heli Repo, Eliisa Löyttyniemi, Samu Kurki, Lila Kallio, Teijo Kuopio, Kati Talvinen, Pauliina Kronqvist

Open Access Research article

Evaluation of adverse effects of chemotherapy regimens of 5-fluoropyrimidines derivatives and their association with DPYD polymorphisms in colorectal cancer patients

Reza Negarandeh, Ebrahim Salehifar, Fatemeh Saghafi, Hossein Jalali, Ghasem Janbabaei, Mohammad Javad Abdhaghighi, Anahita Nosrati

Open Access Research article

Black patients referred to a lung cancer screening program experience lower rates of screening and longer time to follow-up

Michael Lake, Christine S. Shusted, Hee-Soon Juon, Russell K. McIntire, Charnita Zeigler-Johnson, Nathaniel R. Evans, Gregory C. Kane, Julie A. Barta

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Establishment of a serological molecular model for the early diagnosis and progression monitoring of bone metastasis in lung cancer

Xiaoyan Teng, Lirong Wei, Liming Han, Daliu Min, Yuzhen Du

Open Access Research article

Cervical cancer screening in rural Ethiopia: a cross- sectional knowledge, attitude and practice study

Friederike Ruddies, Muluken Gizaw, Brhanu Teka, Sarah Thies, Andreas Wienke, Andreas M. Kaufmann, Tamrat Abebe, Adamu Addissie, Eva Johanna Kantelhardt

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Differentiation of suprasellar meningiomas from non-functioning pituitary macroadenomas by 18F-FDG and 13N-Ammonia PET/CT

Lei Ding, Fangling Zhang, Qiao He, Zhoulei Li, Xinchong Shi, Ruocheng Li, Xiangsong Zhang

Open Access Research article

Multi-nanolayer drug delivery using radiofrequency plasma technology

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Open Access Research article

The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation

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Open Access Research article

A comparative study of long interspersed element-1 protein immunoreactivity in cutaneous malignancies

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Neutrophil-lymphocyte ratio associated with poor prognosis in oral cancer: a retrospective study

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Immune characterization of metastatic colorectal cancer patients post reovirus administration

Ruwan Parakrama, Elisha Fogel, Carol Chandy, Titto Augustine, Matt Coffey, Lydia Tesfa, Sanjay Goel, Radhashree Maitra

Open Access Study protocol

What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420)

David P. French, Susan Astley, Adam R. Brentnall, Jack Cuzick, Richard Dobrashian, Stephen W. Duffy, Louise S. Gorman, Elaine F. Harkness, Fiona Harrison, Michelle Harvie, Anthony Howell, Andrew Jerrison, Matthew Machin, Anthony J. Maxwell, Lorna McWilliams, Katherine Payne, Nadeem Qureshi, Helen Ruane, Sarah Sampson, Paula Stavrinos, Emma Thorpe, Fiona Ulph, Tjeerd van Staa, Victoria Woof, D. Gareth Evans

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Suppression of Mig-6 overcomes the acquired EGFR-TKI resistance of lung adenocarcinoma

Da Hyun Kang, Sung Soo Jung, Min-Kyung Yeo, Da Hye Lee, Geon Yoo, Sang Yeon Cho, In-Jae Oh, Ju-Ock Kim, Hee Sun Park, Chaeuk Chung, Jeong Eun Lee

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Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy

Mayassa J. Bou-Dargham, Linlin Sha, Qing-Xiang Amy Sang, Jinfeng Zhang

Open Access Research article

The effect of pericolic lymph nodes metastasis beyond 10 cm proximal to the tumor on patients with rectal cancer

Xuyang Yang, Erliang Zheng, Lina Ye, Chaoyang Gu, Tao Hu, Dan Jiang, Du He, Bing Wu, Qinbing Wu, Tinghan Yang, Mingtian Wei, Wenjian Meng, Xiangbing Deng, Ziqiang Wang, Zongguang Zhou

Open Access Study protocol

Study protocol of the HYPER-LIV01 trial: a multicenter phase II, prospective and randomized study comparing simultaneous portal and hepatic vein embolization to portal vein embolization for hypertrophy of the future liver remnant before major hepatectomy for colo-rectal liver metastases

Emmanuel Deshayes, Lauranne Piron, Antoine Bouvier, Bruno Lapuyade, Emilie Lermite, Laurent Vervueren, Christophe Laurent, Jean-Baptiste Pinaquy, Patrick Chevallier, Anthony Dohan, Agnès Rode, Christian Sengel, Chloé Guillot, François Quenet, Boris Guiu

Open Access Research article

Prognostic characterization of OAS1/OAS2/OAS3/OASL in breast cancer

Yujie Zhang, Chaoran Yu

Open Access Research article

Plasma omega-3 polyunsaturated fatty acids and recurrence of endometrial cancer

Peiqin Li, Boer Shan, Keyu Jia, Fan Hu, Ying Xiao, Jusheng Zheng, Yu-Tang Gao, Huaying Wang, Ying Gao

Open Access Research article

Self-identity, lived experiences, and challenges of breast, cervical, and prostate cancer survivorship in Mexico: a qualitative study

Felicia Marie Knaul, Svetlana V. Doubova, María Cecilia Gonzalez Robledo, Alessandra Durstine, Gabriela Sophia Pages, Felicia Casanova, Hector Arreola-Ornelas

Open Access Research article

Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients - a controlled cross-over pilot study

Stefanie Zorn, Janine Ehret, Rebecca Schäuble, Beate Rautenberg, Gabriele Ihorst, Hartmut Bertz, Paul Urbain, Anna Raynor

Open Access Research article

The microRNA-130a-5p/RUNX2/STK32A network modulates tumor invasive and metastatic potential in non-small cell lung cancer

Fang Ma, Yangchun Xie, Yiyu Lei, Zengshuyu Kuang, Xianling Liu

Open Access Research article

Prognostic value of circulating tumor cells detected with the CellSearch system in esophageal cancer patients: a systematic review and meta-analysis

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Open Access Research article

Sophoridine exerts tumor-suppressive activities via promoting ESRRG-mediated β-catenin degradation in gastric cancer

Zhiyang Peng, Qing Guan, Jianfei Luo, Wenhong Deng, Jiasheng Liu, Ruicheng Yan, Weixing Wang

Open Access Research article

Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer

Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yan Lin, Liangrui Zhou, Qiang Sun

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Immune-related genes in tumor-specific CD4+ and CD8+ T cells in colon cancer

Xi Yang, Wei Wu, Yuefen Pan, Qing Zhou, Jiamin Xu, Shuwen Han

Open Access Research article

Overexpression of HOXA10 is associated with unfavorable prognosis of acute myeloid leukemia

Chao Guo, Qian-qian Ju, Chun-xia Zhang, Ming Gong, Zhen-ling Li, Ya-yue Gao

Open Access Research article

Amplification of KRAS and its heterogeneity in non-Asian gastric adenocarcinomas

Jan Rehkaemper, Michael Korenkov, Alexander Quaas, Josef Rueschoff, Aylin Pamuk, Thomas Zander, Axel M. Hillmer, Reinhard Buettner, Arnulf Heinrich Hoelscher, Christiane Josephine Bruns, Heike Loeser, Hakan Alakus, Birgid Schoemig-Markiefka

Open Access Research article

DNA methylation signatures of Prostate Cancer in peripheral T-cells

Ali Mehdi, David Cheishvili, Ani Arakelian, Tarek A. Bismar, Moshe Szyf, Shafaat A. Rabbani

Open Access Research article

Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumference

Jin Bong Choi, Jun-Pyo Myong, Yunhee Lee, Inah Kim, Jung Ho Kim, Sung-Hoo Hong, U-Syn Ha

Open Access Research article

Ex vivo modelling of drug efficacy in a rare metastatic urachal carcinoma

Rami Mäkelä, Antti Arjonen, Ville Härmä, Nina Rintanen, Lauri Paasonen, Tobias Paprotka, Kerstin Rönsch, Teijo Kuopio, Juha Kononen, Juha K. Rantala

Open Access Research article

Permanent iodine-125 brachytherapy for patients with progressive or recurrent high-grade gliomas

Congxiao Wang, Shifeng Liu, Lijing Peng, Kaixian Zhang, Wei Li, Hao Zhang, Ying Luan, Peishun Li, Xiaokun Hu

Open Access Research article

Development of a precision medicine pipeline to identify personalized treatments for colorectal cancer

Erdem Altunel, Roham S. Roghani, Kai-Yuan Chen, So Young Kim, Shannon McCall, Kathryn E. Ware, Xiling Shen, Jason A. Somarelli, David S. Hsu

Open Access Research article

Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer

Gina Sizemore, Sarah McLaughlin, Mackenzie Newman, Kathleen Brundage, Amanda Ammer, Karen Martin, Elena Pugacheva, James Coad, Malcolm D. Mattes, Han-Gang Yu

Open Access Research article

Imaging features and prognostic value of 18F-FDG PET/CT detection of soft-tissue metastasis from lung cancer: a retrospective study

Tingting Xu, Xinyi Zhang, Shumao Zhang, Chunfeng Liu, Wenhui Fu, Chengrun Zeng, Yue Chen

Open Access Research article

MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma

Pierre-Antoine Bissey, Mona Teng, Jacqueline H. Law, Wei Shi, Jeff P. Bruce, Valentin Petit, Sai W. Tsao, Kenneth W. Yip, Fei-Fei Liu

Open Access Research article

Prediction of lymph node metastasis by tumor-infiltrating lymphocytes in T1 breast cancer

Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Rika Kouhashi, Akimichi Yabumoto, Tamami Morisaki, Masatsune Shibutani, Tsutomu Takashima, Hisakazu Fujita, Kosei Hirakawa, Masaichi Ohira

Open Access Research article

Cost-effectiveness analysis of proton beam therapy for treatment decision making in paranasal sinus and nasal cavity cancers in China

Guo Li, Bo Qiu, Yi-Xiang Huang, Jerome Doyen, Pierre-Yves Bondiau, Karen Benezery, Yun-Fei Xia, Chao-Nan Qian

Open Access Research article

Integration of genomics, metagenomics, and metabolomics to identify interplay between susceptibility alleles and microbiota in adenoma initiation

Jacob E. Moskowitz, Anthony G. Doran, Zhentian Lei, Susheel B. Busi, Marcia L. Hart, Craig L. Franklin, Lloyd W. Sumner, Thomas M. Keane, James M. Amos-Landgraf

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High expression of RABL6 promotes cell proliferation and predicts poor prognosis in esophageal squamous cell carcinoma

Yanfen Feng, Shumei Yan, Yuhua Huang, Qitao Huang, Fang Wang, Yiyan Lei

Open Access Research article

Potential enhancement of host immunity and anti-tumor efficacy of nanoscale curcumin and resveratrol in colorectal cancers by modulated electro- hyperthermia

I-Ming Kuo, Jih-Jong Lee, Yu-Shan Wang, Hsin-Chien Chiang, Cheng-Chung Huang, Pei-Jong Hsieh, Winston Han, Chiao-Hsu Ke, Albert T. C. Liao, Chen-Si Lin

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Prevalence and incidence of cancer related lymphedema in low and middle-income countries: a systematic review and meta-analysis

Eric Torgbenu, Tim Luckett, Mark A. Buhagiar, Sungwon Chang, Jane L. Phillips

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An agent-based model of prostate Cancer bone metastasis progression and response to Radium223

Stefano Casarin, Eleonora Dondossola

Open Access Research article

MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours

Mikiya Ishihara, Shinichi Kageyama, Yoshihiro Miyahara, Takeshi Ishikawa, Shugo Ueda, Norihito Soga, Hiroaki Naota, Katsumi Mukai, Naozumi Harada, Hiroaki Ikeda, Hiroshi Shiku

Open Access Research article

Tumor necrosis as a poor prognostic predictor on postoperative survival of patients with solitary small hepatocellular carcinoma

Yi-hong Ling, Jie-wei Chen, Shi-hong Wen, Chao-yun Huang, Peng Li, Liang-he Lu, Jie Mei, Shao-hua Li, Wei Wei, Mu-yan Cai, Rong-ping Guo

Open Access Research article

Nomograms that predict the survival of patients with adenocarcinoma in villous adenoma of the colorectum: a SEER-based study

Chao-Tao Tang, Ling Zeng, Jing Yang, Chunyan Zeng, Youxiang Chen

Open Access Research article

Cardio-toxicity among patients with sarcoma: a cardio-oncology registry

Sivan Shamai, Zach Rozenbaum, Ofer Merimsky, Matthew Derakhshesh, Yonatan Moshkovits, Joshua Arnold, Yan Topilsky, Yaron Arbel, Michal Laufer-Perl

Open Access Research article

Sparing the hippocampus and the hypothalamic- pituitary region during whole brain radiotherapy: a volumetric modulated arc therapy planning study

P. Mehta, S. Janssen, F. B. Fahlbusch, S. M. Schmid, J. Gebauer, F. Cremers, C. Ziemann, M. Tartz, D. Rades

Open Access Research article

Texture analysis of MR images to identify the differentiated degree in hepatocellular carcinoma: a retrospective study

Mengmeng Feng, Mengchao Zhang, Yuanqing Liu, Nan Jiang, Qian Meng, Jia Wang, Ziyun Yao, Wenjuan Gan, Hui Dai

Open Access Research article

Analytical evaluation of the clonoSEQ Assay for establishing measurable (minimal) residual disease in acute lymphoblastic leukemia, chronic lymphocytic leukemia, and multiple myeloma

Travers Ching, Megan E. Duncan, Tera Newman-Eerkes, Mollie M. E. McWhorter, Jeffrey M. Tracy, Michelle S. Steen, Ryan P. Brown, Srivatsa Venkatasubbarao, Nicholas K. Akers, Marissa Vignali, Martin E. Moorhead, Drew Watson, Ryan O. Emerson, Tobias P. Mann, B. Melina Cimler, Pamela L. Swatkowski, Ilan R. Kirsch, Charles Sang, Harlan S. Robins, Bryan Howie, Anna Sherwood

Open Access Research article

Impact of breath-hold level on positional error aligned by stent/Lipiodol in Hepatobiliary radiotherapy with breath-hold respiratory control

Tzu-Jie Huang, Yun Tien, Jian-Kuen Wu, Wen-Tao Huang, Jason Chia-Hsien Cheng

Open Access Research article

Postoperative adjuvant treatment strategy for hepatocellular carcinoma with microvascular invasion: a non-randomized interventional clinical study

Liming Wang, Weihu Wang, Weiqi Rong, Zhuo Li, Fan Wu, Yunhe Liu, Yiling Zheng, Kai Zhang, Tana Siqin, Mei Liu, Bo Chen, Jianxiong Wu

Open Access Case report

Sterile, abscess-like cerebral lesion during trastuzumab therapy after HER2 status switch in a triple negative breast cancer patient: a case report and literature review

Tamás Mezei, Melinda Hajdu, Gábor Czigléczki, Gábor Lotz, Judit Kocsis, Janina Kulka, Anna Horváth

Open Access Research article

Impact of the faecal immunochemical test on colorectal cancer survival

María Angeles Gutierrez-Stampa, Vanessa Aguilar, Cristina Sarasqueta, Joaquín Cubiella, Isabel Portillo, Luis Bujanda

Open Access Research article

Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism

Jérôme Ruhnau, Jonas Parczyk, Kerstin Danker, Britta Eickholt, Andreas Klein

Open Access Research article

The impact on quality of life from informing diagnosis in patients with cancer: a systematic review and meta-analysis

Miao Wan, Xianggui Luo, Juan Wang, Louis. B Mvogo Ndzana, Chen Chang, Zhenfen Li, Jianglin Zhang

Open Access Research article

Etoposide-mediated interleukin-8 secretion from bone marrow stromal cells induces hematopoietic stem cell mobilization

Ka-Won Kang, Seung-Jin Lee, Ji Hye Kim, Byung-Hyun Lee, Seok Jin Kim, Yong Park, Byung Soo Kim

Open Access Research article

PODXL might be a new prognostic biomarker in various cancers: a meta-analysis and sequential verification with TCGA datasets

Siying He, Wenjie Du, Menglan Li, Ming Yan, Fang Zheng

Open Access Research article

Fluctuating expression of miR-584 in primary and high-grade gastric cancer

Laleh Ebrahimi Ghahnavieh, Hossein Tabatabaeian, Zhaleh Ebrahimi Ghahnavieh, Mohammad Amin Honardoost, Mansoureh Azadeh, Mohamad Moazeni Bistgani, Kamran Ghaedi

Open Access Study protocol

Design and methods of a national, multicenter, randomized and controlled trial to assess the efficacy of a physical activity program to improve health-related quality of life and reduce fatigue in women with metastatic breast cancer: ABLE02 trial

Lidia Delrieu, Amélie Anota, Olivier Trédan, Damien Freyssenet, Aurélia Maire, Brice Canada, Baptiste Fournier, Olivia Febvey-Combes, Frank Pilleul, Amine Bouhamama, Christophe Caux, Florence Joly, Béatrice Fervers, Vincent Pialoux, David Pérol, Olivia Pérol

Open Access Research article

Incidence, prevalence, mortality, and causes of death in Waldenström macroglobulinemia: a nationwide, population-based cohort study

Seri Jeong, Seom Gim Kong, Da Jung Kim, Sangjin Lee, Ho Sup Lee

Open Access Research article

The immune-checkpoint HLA-G/ILT4 is involved in the regulation of VEGF expression in clear cell renal cell carcinoma

Marcela García, Maria Belen Palma, Jerome Verine, Santiago Miriuka, Ana M. Inda, Ana L. Errecalde, François Desgrandchamps, Edgardo D. Carosella, Diana Tronik-Le Roux

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Sarcoma epidemiology and cancer-related hospitalisation in Western Australia from 1982 to 2016: a descriptive study using linked administrative data

Cameron M. Wright, Georgia Halkett, Richard Carey Smith, Rachael Moorin

Open Access Research article

NR2F2 plays a major role in insulin-induced epithelial-mesenchymal transition in breast cancer cells

Baili Xia, Lijun Hou, Huan Kang, Wenhui Chang, Yi Liu, Yanli Zhang, Yi Ding

Open Access Research article

Starvation stress attenuates the miRNA-target interaction in suppressing breast cancer cell proliferation

Jinhui Lü, Chuyi Zhang, Junyi Han, Zhen Xu, Yuan Li, Lixiao Zhen, Qian Zhao, Yuefan Guo, Zhaohui Wang, Evelyne Bischof, Zuoren Yu

Open Access Research article

Oncolytic vaccinia virus GLV-1h68 exhibits profound antitumoral activities in cell lines originating from neuroendocrine neoplasms

Linus D. Kloker, Susanne Berchtold, Irina Smirnow, Julia Beil, Andreas Krieg, Bence Sipos, Ulrich M. Lauer

Open Access Research article

The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun

Hayaa Moeed Alhuthali, Tracey D. Bradshaw, Kuan-Hon Lim, Toh-Seok Kam, Claire H. Seedhouse

Open Access Case report

A refractory case of CDK4-amplified spinal astrocytoma achieving complete response upon treatment with a Palbociclib-based regimen:a case report

Jietao Lin, Ling Yu, Yuanfeng Fu, Hanrui Chen, Xinting Zheng, Shutang Wang, Chan Gao, Yang Cao, Lizhu Lin

Open Access Research article

Head & neck acinar cell carcinoma: a population-based study using the seer registry

Feiluore Yibulayin, Lei Feng, Meng Wang, Meng-meng Lu, Yuan Luo, Hui Liu, Zhi-cheng Yang, Alimujiang Wushou

Open Access Research article

CCL18-NIR1 promotes oral cancer cell growth and metastasis by activating the JAK2/STAT3 signaling pathway

Xiao Jiang, Zhijie Huang, Xiang Sun, Xianghuai Zheng, Jingpeng Liu, Jun Shen, Bo Jia, Haiyun Luo, Zhaoyi Mai, Guodong Chen, Jianjiang Zhao

Open Access Research article

Meta-analysis examining overall survival in patients with pancreatic cancer treated with second-line 5-fluorouracil and oxaliplatin-based therapy after failing first-line gemcitabine-containing therapy: effect of performance status and comparison with other regimens

Zev A. Wainberg, Kynan Feeney, Myung Ah Lee, Andrés Muñoz, Antonio Cubillo Gracián, Sara Lonardi, Baek-Yeol Ryoo, Annie Hung, Yong Lin, Johanna Bendell, J. Randolph Hecht

Open Access Research article

Proteomics reveals a therapeutic vulnerability via the combined blockade of APE1 and autophagy in lung cancer A549 cells

Shu-Ting Pan, Ji Zhou, Fang Yang, Shu-Feng Zhou, Tao Ren

Open Access Study protocol

Design of the PROstate cancer follow-up care in Secondary and Primary hEalth Care study (PROSPEC): a randomized controlled trial to evaluate the effectiveness of primary care-based follow-up of localized prostate cancer survivors

Barbara M. Wollersheim, Kristel M. van Asselt, Henk G. van der Poel, Henk C. P. M. van Weert, Michael Hauptmann, Valesca P. Retèl, Neil K. Aaronson, Lonneke V. van de Poll-Franse, Annelies H. Boekhout

Open Access Correspondence

Thyroid cancer in Ecuador

Enrique López Gavilanez, Noemí Bautista Litardo, Manuel Navarro Chávez, Mario Hernández Bonilla, Angel Segale Bajaña

Open Access Research article

Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis

Ju-Li Lin, Jian-Xian Lin, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-bin Wang, Jun Lu, Qi-Yue Chen, Long-long Cao, Mi Lin, Chang-Ming Huang

Open Access Research article

Sentinel node theory helps tracking of primary lesions of cancers of unknown primary

Yilin Shao, Xin Liu, Silong Hu, Yingjian Zhang, Wentao Li, Xiaoyan Zhou, Qifeng Wang, Yifeng Hou, Yong Chen, Yanli Wang, Yaohui Wang, Zhiguo Luo, Xichun Hu

Open Access Research article

Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells

L. Absil, F. Journé, D. Larsimont, J. J. Body, L. Tafforeau, D. Nonclercq

Open Access Review

Challenges for cancer patients returning home during SARS-COV-19 pandemic after medical tourism - a consensus report by the emirates oncology task force

Humaid O. Al-Shamsi, Ibrahim Abu-Gheida, Shabeeha K. Rana, Neil Nijhawan, Ahmed S. Abdulsamad, Sadir Alrawi, Mohamed Abuhaleeqa, Taleb M. Almansoori, Thamir Alkasab, Essa M. Aleassa, Martine C. McManus

Open Access Research article

Adjuvant Transarterial chemoembolization does not influence recurrence-free or overall survival in patients with combined hepatocellular carcinoma and Cholangiocarcinoma after curative resection: a propensity score matching analysis

Wei-Ren Liu, Meng-Xin Tian, Chen-Yang Tao, Zheng Tang, Yu-Fu Zhou, Shu-Shu Song, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Wei-Feng Qu, Yuan Fang, Zhen-Bin Ding, Jian Zhou, Jia Fan, Ying-Hong Shi

Open Access Research article

Gynaecological cancer in Caribbean women: data from the French population-based cancer registries of Martinique, Guadeloupe and French Guiana (2007–2014)

Clarisse Joachim, Jacqueline Véronique-Baudin, Laure Desroziers, Édouard Chatignoux, Sophie Belliardo, Juliette Plenet, Jonathan Macni, Stephen Ulric-Gervaise, Jessica Peruvien, Bernard Bhakkan-Mambir, Jacqueline Deloumeaux

Open Access Research article

Evaluation of MiR-1908-3p as a novel serum biomarker for breast cancer and analysis its oncogenic function and target genes

Youzhi Zhu, Qingshui Wang, Yun Xia, Xiaoxue Xiong, Shuyun Weng, Huizhen Ni, Yan Ye, Ling Chen, Junyu Lin, Yajuan Chen, Haitao Niu, Xiangjin Chen, Yao Lin

Open Access Research article

Cost-effectiveness analysis of repeated self-sampling for HPV testing in primary cervical screening: a randomized study

Riina Aarnio, Ellinor Östensson, Matts Olovsson, Inger Gustavsson, Ulf Gyllensten

Open Access Research article

Management of medically inoperable and tyrosine kinase inhibitor-naïve early-stage lung adenocarcinoma with epidermal growth factor receptor mutations: a retrospective multi-institutional analysis

Yuemei Sun, Mengwan Wu, Mingxiu Zhou, Xing Luo, Yan Guo, Hansong Bai, Zican Zhang, Wei Tian, Xiaoshan Wang, Yifeng Bai, Xueqiang Zhu, Haixia Pan, Ying Deng, Honglin Hu, Jianling Xia, Xinbao Hao, Liangfu Han, Min Wei, Yingyi Liu, Ming Zeng

Open Access Research article

IMMUNEPOTENT CRP induces DAMPS release and ROS-dependent autophagosome formation in HeLa and MCF-7 cells

Ana Carolina Martínez-Torres, Alejandra Reyes-Ruiz, Kenny Misael Calvillo-Rodriguez, Karla Maria Alvarez-Valadez, Ashanti C. Uscanga-Palomeque, Reyes S. Tamez-Guerra, Cristina Rodríguez-Padilla

Open Access Research article

Fibroadenoma versus phyllodes tumor: a vexing problem revisited!

Santosh Tummidi, Kanchan Kothari, Mona Agnihotri, Leena Naik, Prashant Sood

Open Access Research article

Real-world efficacy and safety of two doses of cabazitaxel (20 or 25 mg/m2) in patients with castration-resistant prostate cancer: results of a Japanese post-marketing surveillance study

Hideyasu Matsuyama, Nobuaki Matsubara, Hirotaka Kazama, Takeshi Seto, Shoko Tsukube, Kazuhiro Suzuki

Open Access Research article

Defective migration and dysmorphology of neutrophil granulocytes in atypical chronic myeloid leukemia treated with ruxolitinib

Lea Bornemann, Marc Schuster, Saskia Schmitz, Charlyn Sobczak, Clara Bessen, Simon F. Merz, Karl-Heinz Jöckel, Thomas Haverkamp, Matthias Gunzer, Joachim R. Göthert

Open Access Research article

Global targetome analysis reveals critical role of miR-29a in pancreatic stellate cell mediated regulation of PDAC tumor microenvironment

Shatovisha Dey, Sheng Liu, Tricia D. Factora, Solaema Taleb, Primavera Riverahernandez, Lata Udari, Xiaoling Zhong, Jun Wan, Janaiah Kota

Open Access Study protocol

A single-arm confirmatory trial of pazopanib in patients with paclitaxel-pretreated primary cutaneous angiosarcoma: Japan Clinical Oncology Group study (JCOG1605, JCOG-PCAS protocol)

Kohei Oashi, Taro Shibata, Kenjiro Namikawa, Akira Takahashi, Kenji Yokota, Eiji Nakano, Yukiko Teramoto, Arata Tsutsumida, Taku Maeda, Naoya Yamazaki

Open Access Study protocol

Pyrotinib with trastuzumab and aromatase inhibitors as first-line treatment for HER2 positive and hormone receptor positive metastatic or locally advanced breast cancer: study protocol of a randomized controlled trial

Changjun Wang, Yan Lin, Yidong Zhou, Feng Mao, Hanjiang Zhu, Jinghong Guan, Xiaohui Zhang, Songjie Shen, Xin Huang, Chang Chen, Ru Yao, Jialin Zhao, Qiang Sun

Open Access Research article

The relationship between retroperitoneal lymphadenectomy and survival in advanced ovarian cancer patients

Chenyan Fang, Yingli Zhang, Lingqin Zhao, Xi Chen, Liang Xia, Ping Zhang

Open Access Study protocol

Exercise as a diagnostic and therapeutic tool for preventing cardiovascular morbidity in breast cancer patients– the BReast cancer EXercise InTervention (BREXIT) trial protocol

Stephen J. Foulkes, Erin J. Howden, Yoland Antill, Sherene Loi, Agus Salim, Mark J. Haykowsky, Robin M. Daly, Steve F. Fraser, Andre La Gerche

Open Access Research article

Correlation between immune-related adverse events and prognosis in patients with various cancers treated with anti PD-1 antibody

Hiroshi Matsuoka, Takahiro Hayashi, Karen Takigami, Kazuyoshi Imaizumi, Ryoichi Shiroki, Naoki Ohmiya, Kazumitsu Sugiura, Kenji Kawada, Akira Sawaki, Koutaro Maeda, Yousuke Ando, Ichiro Uyama

Open Access Study protocol

Prospective study of oncologic outcomes after laparoscopic modified complete mesocolic excision for non-metastatic right colon cancer (PIONEER study): study protocol of a multicentre single-arm trial

Seung Yoon Yang, Min Jung Kim, Bong-Hyeon Kye, Yoon Dae Han, Min Soo Cho, Seung-Yong Jeong, Hyeon-Min Cho, Hyunki Kim, Gyeong Hoon Kang, Seung Ho Song, Jun Seok Park, Ji-Seon Kim, Soo Yeun Park, Jin Kim, Byung Soh Min

Open Access Research article

Development and validation of a predictive model for estimating EGFR mutation probabilities in patients with non-squamous non-small cell lung cancer in New Zealand

Phyu Sin Aye, Sandar Tin Tin, Mark James McKeage, Prashannata Khwaounjoo, Alana Cavadino, J. Mark Elwood

Open Access Research article

LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study

Yi Zheng, Meng Wang, Shuqian Wang, Peng Xu, Yujiao Deng, Shuai Lin, Na Li, Kang Liu, Yuyao Zhu, Zhen Zhai, Ying Wu, Zhijun Dai, Gaixia Zhu

Open Access Research article

Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis

Jordana Maria Azevedo Martins, Silvia Helena Rabelo-Santos, Maria Cristina do Amaral Westin, Luiz Carlos Zeferino

Open Access Research article

Clinicopathological significance and prognosis of long noncoding RNA SNHG16 expression in human cancers: a meta-analysis

Ruonan Jiao, Wei Jiang, Xin Wei, Mengpei Zhang, Si Zhao, Guangming Huang

Open Access Research article

A prospective, randomized study of Toremifene vs. tamoxifen for the treatment of premenopausal breast cancer: safety and genital symptom analysis

Jin Hong, Jiahui Huang, Lili Shen, Siji Zhu, Weiqi Gao, Jiayi Wu, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Xiaosong Chen, Kunwei Shen

Open Access Research article

Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy

Qingyuan Feng, Xuzhao Bian, Xuan Liu, Ying Wang, Huiting Zhou, Xiaojing Ma, Chunju Quan, Yi Yao, Zhongliang Zheng

Open Access Research article

A nomogram model to predict death rate among non-small cell lung cancer (NSCLC) patients with surgery in surveillance, epidemiology, and end results (SEER) database

Bo Jia, Qiwen Zheng, Jingjing Wang, Hongyan Sun, Jun Zhao, Meina Wu, Tongtong An, Yuyan Wang, Minglei Zhuo, Jianjie Li, Xue Yang, Jia Zhong, Hanxiao Chen, Yujia Chi, Xiaoyu Zhai, Ziping Wang

Open Access Research article

Distribution pattern and prognosis of metastatic lymph nodes in cervical posterior to level V in nasopharyngeal carcinoma patients

Chaoyang Jiang, Hui Gao, Ling Zhang, Hua Li, Tao Zhang, Ji Ma, Bisheng Liu

Open Access Research article

Network-based identification of biomarkers for colon adenocarcinoma

Fuyan Hu, Qing Wang, Zhiyuan Yang, Zeng Zhang, Xiaoping Liu

Open Access Research article

Short-term outcomes of robotic- versus laparoscopic-assisted Total Gastrectomy for advanced gastric Cancer: a propensity score matching study

Changdong Yang, Yan Shi, Shaohui Xie, Jun Chen, Yongliang Zhao, Feng Qian, Yingxue Hao, Bo Tang, Peiwu Yu

Open Access Research article

Treatment patterns and health outcomes in metastatic renal cell carcinoma patients treated with targeted systemic therapies in the UK

Robert Hawkins, Kate Fife, Michael Hurst, Meng Wang, Niroshini Naicker, Sarah Nolasco, Tim Eisen, Athena Matakidou, Jason Gordon

Open Access Research article

The prognosis of hepatoid adenocarcinoma of the stomach: a propensity score-based analysis

Kai Zhou, Anqiang Wang, Sheng Ao, Jiahui Chen, Ke Ji, Qifei He, Xin Ji, Xiaojiang Wu, Ji Zhang, Zhongwu Li, Zhaode Bu, Jiafu Ji

Open Access Research article

The predominant expression of cancer stem cell marker ALDH1A3 in tumor infiltrative area is associated with shorter overall survival of human glioblastoma

Chao Gan, Daniela Pierscianek, Nicolai El Hindy, Yahya Ahmadipour, Kathy Keyvani, Ulrich Sure, Yuan Zhu

Open Access Research article

Suppressing Dazl modulates tumorigenicity and stemness in human glioblastoma cells

Fengyu Zhang, Ruilai Liu, Haishi Zhang, Cheng Liu, Chunfang Liu, Yuan Lu

Open Access Research article

The prognostic values of m6A RNA methylation regulators in uveal melanoma

Jing Tang, Qi Wan, Jianqun Lu

Open Access Research article

Effect of neoadjuvant therapy on breast cancer biomarker profile

Laura Rey-Vargas, Juan Carlos Mejía-Henao, María Carolina Sanabria-Salas, Silvia J. Serrano-Gomez

Open Access Research article

Candidate methylation sites associated with endocrine therapy resistance in ER+/HER2- breast cancer

Maryam Soleimani Dodaran, Simone Borgoni, Emre Sofyalı, Pernette J. Verschure, Stefan Wiemann, Perry D. Moerland, Antoine H. C. van Kampen

Open Access Research article

Three-year outcome after transanal versus laparoscopic total mesorectal excision in locally advanced rectal cancer: a multicenter comparative analysis

F. B. de Lacy, S. X. Roodbeen, J. Ríos, J. van Laarhoven, A. Otero-Piñeiro, R. Bravo, T. Visser, R. van Poppel, S. Valverde, R. Hompes, C. Sietses, A. Castells, W. A. Bemelman, P. J. Tanis, A. M. Lacy

Open Access Research article

Clinical characteristics and prognosis of anal squamous cell carcinoma: a retrospective audit of 144 patients from 11 cancer hospitals in southern China

Yong Lu, Xiaohao Wang, Peiyang Li, Tao Zhang, Jiaming Zhou, Yufeng Ren, Yi Ding, Haihua Peng, Qichun Wei, Kaiyun You, Jason J. Ong, Christopher K. Fairley, Andrew E. Grulich, Meijin Huang, Yuanhong Gao, Huachun Zou

Open Access Research article

Risk stratified breast cancer screening: UK healthcare policy decision-making stakeholders’ views on a low-risk breast screening pathway

Lorna McWilliams, Victoria G. Woof, Louise S. Donnelly, Anthony Howell, D. Gareth Evans, David P. French

Open Access Research article

RETRACTED ARTICLE: Invasion inhibition in pancreatic cancer using the oral iron chelating agent deferasirox

Shogo Amano, Seiji Kaino, Shuhei Shinoda, Hirofumi Harima, Toshihiko Matsumoto, Koichi Fujisawa, Taro Takami, Naoki Yamamoto, Takahiro Yamasaki, Isao Sakaida

Open Access Research article

LINC00511 as a prognostic biomarker for human cancers: a systematic review and meta-analysis

Yannick Luther Agbana, Manzama-Esso Abi, Yueli Ni, Guohang Xiong, Jing Chen, Fang Yun, Zihan Yi, Qiao Zhang, Zhe Yang, Yingmin Kuang, Yuechun Zhu

Open Access Study protocol

AtezoTRIBE: a randomised phase II study of FOLFOXIRI plus bevacizumab alone or in combination with atezolizumab as initial therapy for patients with unresectable metastatic colorectal cancer

Carlotta Antoniotti, Beatrice Borelli, Daniele Rossini, Filippo Pietrantonio, Federica Morano, Lisa Salvatore, Sara Lonardi, Federica Marmorino, Stefano Tamberi, Salvatore Corallo, Giampaolo Tortora, Francesca Bergamo, Di Stefano Brunella, Alessandra Boccaccino, Elisa Grassi, Patrizia Racca, Emiliano Tamburini, Giuseppe Aprile, Roberto Moretto, Luca Boni, Alfredo Falcone, Chiara Cremolini

Open Access Research article

Efficacy and safety of nivolumab for advanced gastric cancer patients with poor performance statuses

Toshihiko Matsumoto, Yosuke Yamamoto, Yusuke Kuriona, Ukyo Okazaki, Shogo Kimura, Kou Miura, Takao Tsuduki, Takanori Watanabe, Yusuke Mastumoto, Masahiro Takatani

Open Access Research article

A novel coordination complex of platinum (PT) induces cell death in colorectal cancer by altering redox balance and modulating MAPK pathway

Khayal Al-Khayal, Mansoor-Ali Vaali-Mohammed, Mohammed Elwatidy, Thamer Bin Traiki, Omar Al-Obeed, Mohammad Azam, Zahid Khan, Maha Abdulla, Rehan Ahmad

Open Access Research article

Differential associations of proinflammatory and anti-inflammatory cytokines with depression severity from noncancer status to breast cancer course and subsequent chemotherapy

Bor-Show Tzang, Vincent Chin-Hung Chen, Ching-Chuan Hsieh, Wen-Ke Wang, Yi-Ping Weng, Hsing-Ying Ho, Ya-Ting Hsu, Han-Pin Hsaio, Jun-Cheng Weng, Yi-Lung Chen

Open Access Study protocol

Protocol of the QUATTRO-II study: a multicenter randomized phase II study comparing CAPOXIRI plus bevacizumab with FOLFOXIRI plus bevacizumab as a first-line treatment in patients with metastatic colorectal cancer

Masaaki Miyo, Takeshi Kato, Takayuki Yoshino, Takeharu Yamanaka, Hideaki Bando, Hironaga Satake, Kentaro Yamazaki, Hiroya Taniguchi, Eiji Oki, Masahito Kotaka, Koji Oba, Yoshinori Miyata, Kei Muro, Yoshito Komatsu, Hideo Baba, Akihito Tsuji

Open Access Research article

A prospective feasibility study of one-year administration of adjuvant S-1 therapy for resected biliary tract cancer in a multi-institutional trial (Tokyo Study Group for Biliary Cancer: TOSBIC01)

Osamu Itano, Yusuke Takemura, Norihiro Kishida, Eiji Tamagawa, Hiroharu Shinozaki, Ken Ikeda, Hidejiro Urakami, Shigenori Ei, Shigeo Hayatsu, Keiichi Suzuki, Tadayuki Sakuragawa, Masatsugu Ishii, Masaya Shito, Koichi Aiura, Hiroto Fujisaki, Kiminori Takano, Junichi Matsui, Takuya Minagawa, Masahiro Shinoda, Minoru Kitago, Yuta Abe, Hiroshi Yagi, Go Oshima, Shutaro Hori, Yuko Kitagawa

Open Access Research article

Detection of genes mutations in cerebrospinal fluid circulating tumor DNA from neoplastic meningitis patients using next generation sequencing

Yue Zhao, Jun Ying He, Jun Zhao Cui, Zi-Qi Meng, Yue Li Zou, Xiao Su Guo, Xin Chen, Xueliang Wang, Li-Tian Yan, Wei Xin Han, Chunyan Li, Li Guo, Hui Bu

Open Access Research article

A panel of DNA methylation signature from peripheral blood may predict colorectal cancer susceptibility

Justina Ucheojor Onwuka, Dapeng Li, Yupeng Liu, Hao Huang, Jing Xu, Ying Liu, Yuanyuan Zhang, Yashuang Zhao

Open Access Research article

Cancer cases and deaths attributable to lifestyle risk factors in Chile

Leandro F. M. Rezende, Eliana Murata, Beatriz Giannichi, Luciana Yuki Tomita, Gabriela Arantes Wagner, Zila M. Sanchez, Carlos Celis-Morales, Gerson Ferrari

Open Access Research article

Efficient mutation screening for cervical cancers from circulating tumor DNA in blood

Sun-Young Lee, Dong-Kyu Chae, Sung-Hun Lee, Yohan Lim, Jahyun An, Chang Hoon Chae, Byung Chul Kim, Jong Bhak, Dan Bolser, Dong-Hyu Cho

Open Access Research article

Low dose environmental radon exposure and breast tumor gene expression

Cheng Peng, Natalie DuPre, Trang VoPham, Yujing J. Heng, Gabrielle M. Baker, Christopher A. Rubadue, Kimberly Glass, Abhijeet Sonawane, Oana Zeleznik, Peter Kraft, Susan E. Hankinson, A. Heather Eliassen, Jaime E. Hart, Francine Laden, Rulla M. Tamimi

Open Access Review

Associations between nutritional factors and KRAS mutations in colorectal cancer: a systematic review

Achraf El Asri, Btissame Zarrouq, Khaoula El Kinany, Laila Bouguenouch, Karim Ouldim, Karima El Rhazi

Open Access Research article

The support and information needs of adolescents and young adults with cancer when active treatment ends

Sarah Lea, Ana Martins, Lorna A. Fern, Matthew Bassett, Maria Cable, Gary Doig, Sue Morgan, Louise Soanes, Michael Whelan, Rachel M. Taylor

Open Access Research article

Albumin-bound paclitaxel and gemcitabine combination therapy in soft tissue sarcoma

Zhichao Tian, Fan Zhang, Po Li, Jiaqiang Wang, Jinpo Yang, Peng Zhang, Weitao Yao, Xin Wang

Open Access Research article

Risk factors of metachronous brain metastasis in patients with EGFR-mutated advanced non-small cell lung cancer

Wen Ouyang, Jing Yu, Yan Zhou, Jing Hu, Zhao huang, Junhong Zhang, Conghua Xie

Open Access Research article

Is thyroid excision mandatory with laryngectomy in carcinoma larynx?

Surendra Singh Baghel, Pawan Singhal, Namita Verma, Ritu Sehra, Rajeev Yadav, Sunita Agarwal, Man Prakash Sharma, D. P. Gupta

Open Access Study protocol

Comparative effectiveness trial of transoral head and neck surgery followed by adjuvant radio(chemo)therapy versus primary radiochemotherapy for oropharyngeal cancer (TopROC)

Lara Bußmann, Simon Laban, Claus Wittekindt, Carmen Stromberger, Silke Tribius, Nikolaus Möckelmann, Arne Böttcher, Christian Stephan Betz, Jens Peter Klussmann, Volker Budach, Adrian Muenscher, Chia-Jung Busch

Open Access Research article

Assessment of the results and hematological side effects of 3D conformal and IMRT/ARC therapies delivered during craniospinal irradiation of childhood tumors with a follow-up period of five years

Zoltán Lőcsei, Róbert Farkas, Kornélia Borbásné Farkas, Klára Sebestyén, Zsolt Sebestyén, Zoltán Musch, Ágnes Vojcek, Noémi Benedek, László Mangel, Gábor Ottóffy

Open Access Research article

Anti-tumor effects of mevalonate pathway inhibition in ovarian cancer

Andy Göbel, Valentina M. Zinna, Stefania Dell’Endice, Nikolai Jaschke, Jan Dominik Kuhlmann, Pauline Wimberger, Tilman D. Rachner

Open Access Research article

Questioning the IGF1 receptor’s assigned role in CRC – a case for rehabilitation?

Steffen M. Heckl, Marie Pellinghaus, Hans-Michael Behrens, Sandra Krüger, Stefan Schreiber, Christoph Röcken

Open Access Research article

Liquid-based cytology for the detection of cervical intraepithelial lesions in Jimma town, Ethiopia

Getnet Tesfaw, Yesuf Ahmed, Lealem Gedefaw, Lamessa Dube, Samson Godu, Kirubel Eshetu, Mesfin Nigussie, Haftamu Hailekiros, Moses Joloba, Gelila Goba, Alemseged Abdissa

Open Access Research article

Dietary Approaches to Stop Hypertension (DASH) diets and breast cancer among women: a case control study

Zeinab Heidari, Elahe Mohammadi, Vahideh Aghamohammadi, Saba Jalali, Arezoo Rezazadeh, Fatemeh Sedaghat, Mojan Assadi, Bahram Rashidkhani

Open Access Research article

Both p53 codon 72 Arg/Arg and pro/Arg genotypes in glioblastoma multiforme are associated with a better prognosis in bevacizumab treatment

Chiung-Chyi Shen, Wen-Yu Cheng, Chung-Hsin Lee, Xue-Jun Dai, Ming-Tsang Chiao, Yea-Jiuen Liang, Wan-Yu Hsieh, Tsuo-Fei Mao, Guo-Shi Lin, Shou-Ren Chen, Bai-Shuan Liu, Jun-Peng Chen

Open Access Research article

Multiple formin proteins participate in glioblastoma migration

Vanina D. Heuser, Aida Kiviniemi, Laura Lehtinen, Sune Munthe, Bjarne Winther Kristensen, Jussi P. Posti, Jussi O. T. Sipilä, Ville Vuorinen, Olli Carpén, Maria Gardberg

Open Access Study protocol

Study protocol of the Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE) trial: a two-arm, two-centre randomized controlled trial

Jennifer Brunet, Meagan Barrett-Bernstein, Kendra Zadravec, Monica Taljaard, Nathalie LeVasseur, Amirrtha Srikanthan, Kelcey A. Bland, Barbara Collins, Julia W. Y. Kam, Todd C. Handy, Sherri Hayden, Christine Simmons, Andra M. Smith, Naznin Virji-Babul, Kristin L. Campbell

Open Access Research article

Evaluating different adoption scenarios for TIL-therapy and the influence on its (early) cost-effectiveness

Melanie Lindenberg, Valesca Retèl, Maartje Rohaan, Joost van den Berg, John Haanen, Wim van Harten

Open Access Research article

Methylation of WT1, CA10 in peripheral blood leukocyte is associated with breast cancer risk: a case-control study

Anqi Ge, Song Gao, Yupeng Liu, Hui Zhang, Xuan Wang, Lei Zhang, Da Pang, Yashuang Zhao

Open Access Research article

Novel bioinformatic classification system for genetic signatures identification in diffuse large B-cell lymphoma

Wei Zhang, Li Yang, Yu’ Qi Guan, Ke’ Feng Shen, Mei’ Lan Zhang, Hao’ Dong Cai, Jia’ Chen Wang, Ying Wang, Liang Huang, Yang Cao, Na Wang, Xiao’ Hong Tan, Ken He Young, Min Xiao, Jian’ Feng Zhou

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Rare osteosarcoma cell subpopulation protein array and profiling using imaging mass cytometry and bioinformatics analysis

Izhar S. Batth, Qing Meng, Qi Wang, Keila E. Torres, Jared Burks, Jing Wang, Richard Gorlick, Shulin Li

Open Access Study protocol

Value of peri-operative chemotherapy in patients with CINSARC high-risk localized grade 1 or 2 soft tissue sarcoma: study protocol of the target selection phase III CHIC-STS trial

Thomas Filleron, Sophie Le Guellec, Christine Chevreau, Bastien Cabarrou, Tom Lesluyes, Sabrina Lodin, Angélique Massoubre, Muriel Mounier, Muriel Poublanc, Frédéric Chibon, Thibaud Valentin

Open Access Research article

Risk adapted approach: How to treat splenic marginal zone lymphoma in resource-poor settings? - The real-life experience of a Brazilian cancer treatment center

Luís Alberto de Pádua Covas Lage, Felipe Faganelli Caboclo dos Santos, Débora Levy, Frederico Rafael Moreira, Samuel Campanelli Freitas Couto, Hebert Fabrício Culler, Renata de Oliveira Costa, Vanderson Rocha, Juliana Pereira

Open Access Research article

Evaluation of radioactive 125I seed implantation for the treatment of refractory malignant tumours based on a CT-guided 3D template-assisted technique: efficacy and safety

Guang Sheng Zhao, Song Liu, Liang Yang, Chuang Li, Ruo Yu Wang, Jun Zhou, Yue Wei Zhang

Open Access Database

Risk of second primary malignancy in adults with pulmonary high-grade neuroendocrine carcinoma (HGNEC)

Xiaomin Wu, Xiaojing Zhang, Leilei Tao, Ping Chen

Open Access Study protocol

Technology-enabled activation of skin cancer screening for hematopoietic cell transplantation survivors and their primary care providers (TEACH)

Saro H. Armenian, Lanie Lindenfeld, Aleksi Iukuridze, Meagan Echevarria, Samantha Bebel, Catherine Coleman, Ryotaro Nakamura, Farah Abdullah, Badri Modi, Kevin C. Oeffinger, Karen M. Emmons, Ashfaq A. Marghoob, Alan C. Geller

Open Access Research article

Clinical impact of PSMA PET/CT in primary prostate cancer compared to conventional nodal and distant staging: a retrospective single center study

Maarten L. Donswijk, Pim J. van Leeuwen, Erik Vegt, Zing Cheung, Stijn W. T. P. J. Heijmink, Henk G. van der Poel, Marcel P. M. Stokkel

Open Access Research article

Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

William D. Gwynne, Mirza S. Shakeel, Adele Girgis-Gabardo, Kwang H. Kim, Emily Ford, Anna Dvorkin-Gheva, Craig Aarts, Methvin Isaac, Rima Al-awar, John A. Hassell

Open Access Research article

Smoking cessation and survival among people diagnosed with non-metastatic cancer

Tracey E. Barnett, Yan Lu, Aaron W. Gehr, Bassam Ghabach, Rohit P. Ojha

Open Access Research article

Clinical outcomes of immune checkpoint inhibitors for patients with recurrent or metastatic head and neck cancer: real-world data in Korea

Hyera Kim, Minsuk Kwon, Binnari Kim, Hyun Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Keunchil Park, Myung-Ju Ahn

Open Access Research article

Prediction of relapse in stage I testicular germ cell tumor patients on surveillance: investigation of biomarkers

João Lobo, Ad J. M. Gillis, Annette van den Berg, Leendert H. J. Looijenga

Open Access Research article

UGT1A1 polymorphism has a prognostic effect in patients with stage IB or II uterine cervical cancer and one or no metastatic pelvic nodes receiving irinotecan chemotherapy: a retrospective study

Hideki Matsuoka, Ryusuke Murakami, Kaoru Abiko, Ken Yamaguchi, Akihito Horie, Junzo Hamanishi, Tsukasa Baba, Masaki Mandai

Open Access Study protocol

A multicenter prospective phase II study of postoperative hypofractionated stereotactic body radiotherapy (SBRT) in the treatment of early-stage oropharyngeal and oral cavity cancers with high risk margins: the STEREO POSTOP GORTEC 2017-03 trial

Julian Biau, Emilie Thivat, Corinne Millardet, Nicolas Saroul, Nathalie Pham-Dang, Ioana Molnar, Bruno Pereira, Xavier Durando, Jean Bourhis, Michel Lapeyre

Open Access Research article

Prognostic value of platelet recovery degree before and after achieving minimal residual disease negative complete remission in acute myeloid leukemia patients

Yang Wang, Hua Wang, Weida Wang, Wenjian Liu, Nawei Liu, Shuang Liu, Yue Lu

Open Access Research article

Does hypothyroidism increase the risk of breast cancer: evidence from a meta-analysis

Bolin Wang, Zhong Lu, Yan Huang, Ruobao Li, Tao Lin

Open Access Study protocol

A prospective, single-arm, phase II clinical trial of intraoperative radiotherapy using a low-energy X-ray source for local advanced Laryngocarcinoma (ILAL): a study protocol

Yining Yang, Li Li, Yongzhe Zheng, Qingfeng Liu, Xianfeng Wei, Xinyuan Gong, Wei Wang, Peng Lin

Open Access Study protocol

A single-center, randomized, non-inferiority study evaluating seroma formation after mastectomy combined with flap fixation with or without suction drainage: protocol for the Seroma reduction and drAin fRee mAstectomy (SARA) trial

Lisa de Rooij, Sander M. J. van Kuijk, Els R. M. van Haaren, Alfred Janssen, Yvonne L. J. Vissers, Geerard L. Beets, James van Bastelaar

Open Access Correction

Correction to: Permanent iodine-125 brachytherapy for patients with progressive or recurrent high-grade gliomas

Congxiao Wang, Shifeng Liu, Lijing Peng, Kaixian Zhang, Wei Li, Hao Zhang, Ying Luan, Peishun Li, Xiaokun Hu

Open Access Research article

Education level as a predictor of survival in patients with multiple myeloma

Limei Xu, Xiuju Wang, Xueyi Pan, Xiaotao Wang, Qing Wang, Bingyi Wu, Jiahui Cai, Ying Zhao, Lijuan Chen, Wuping Li, Juan Li

Open Access Research article

The oncogenic potential of a mutant TP53 gene explored in two spontaneous lung cancer mice models

Julian Ramelow, Christopher D. Brooks, Li Gao, Abeer A. Almiman, Terence M. Williams, Miguel A. Villalona-Calero, Wenrui Duan

Open Access Study protocol

Protocol of the VICTORIA study: personalized vitamin D supplementation for reducing or preventing fatigue and enhancing quality of life of patients with colorectal tumor - randomized intervention trial

Ben Schöttker, Sabine Kuznia, Dana Clarissa Laetsch, David Czock, Annette Kopp-Schneider, Reiner Caspari, Hermann Brenner

Open Access Software

OncoPDSS: an evidence-based clinical decision support system for oncology pharmacotherapy at the individual level

Quan Xu, Jin-Cheng Zhai, Cai-Qin Huo, Yang Li, Xue-Jiao Dong, Dong-Fang Li, Ru-Dan Huang, Chuang Shen, Yu-Jun Chang, Xi-Ling Zeng, Fan-Lin Meng, Fang Yang, Wan-Ling Zhang, Sheng-Nan Zhang, Yi-Ming Zhou, Zhi Zhang

Open Access Research article

USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway

Wenjing Diao, Qisang Guo, Caiying Zhu, Yu Song, Hua Feng, Yuankui Cao, Ming Du, Huifen Chen

Open Access Research article

Prophylactic antibiotic treatment with TMP-SMX decreased the incidence of interstitial pneumonia in patients with B-cell lymphoma on chemotherapy

Cong Li, Fangxiao Lu, Tao Lei, Haifeng Yu, Xi Chen, Shuailing Peng, Shuiyun Han, Haiyan Yang

Open Access Research article

Immunotherapy and associated immune-related adverse events at a large UK centre: a mixed methods study

Liz Jamieson, Martin D. Forster, Kam Zaki, Sanjena Mithra, Heena Alli, Anne O’Connor, Apini Patel, Ian C. K. Wong, Pinkie Chambers

Open Access Research article

Androgen Receptor mRNA levels determine the prognosis in triple-negative breast cancer patients

Sindhu Govindan, Mallikarjuna Siraganahalli Eswaraiah, Chetana Basavaraj, Manjula Adinarayan, Satish Sankaran, Manjiri Bakre

Open Access Research article

Prognosis of pregnancy-associated breast cancer: a meta-analysis

Chunchun Shao, Zhigang Yu, Juan Xiao, Liyuan Liu, Fanzhen Hong, Yuan Zhang, Hongying Jia

Open Access Research article

Screening of BRCA1/2 genes mutations and copy number variations in patients with high risk for hereditary breast and ovarian cancer syndrome (HBOC)

Fatima Zahra El Ansari, Farah Jouali, Nabila Marchoudi, Mohcine Mechita Bennani, Naima Nourouti Ghailani, Amina Barakat, Jamal Fekkak

Open Access Research article

LINC00992 contributes to the oncogenic phenotypes in prostate cancer via targeting miR-3935 and augmenting GOLM1 expression

Jianheng Chen, Xiaodong Liu, Kunbin Ke, Jianan Zou, Zhan Gao, Tomonori Habuchi, Xuezhen Yang

Open Access Research article

Neutrophil to lymphocyte ratio, not platelet to lymphocyte or lymphocyte to monocyte ratio, is predictive of patient survival after resection of early-stage pancreatic ductal adenocarcinoma

David T. Pointer Jr., David Roife, Benjamin D. Powers, Gilbert Murimwa, Sameh Elessawy, Zachary J. Thompson, Michael J. Schell, Pamela J. Hodul, Jose M. Pimiento, Jason B. Fleming, Mokenge P. Malafa

Open Access Research article

Breast cancer diagnosis is associated with relative left ventricular hypertrophy and elevated endothelin-1 signaling

Zaid H. Maayah, Shingo Takahara, Abrar S. Alam, Mourad Ferdaoussi, Gopinath Sutendra, Ayman O. S. El-Kadi, John R. Mackey, Edith Pituskin, D. Ian Paterson, Jason R. B. Dyck

Open Access Research article

Premature mortality of gastrointestinal cancer in Iran: trends and projections 2001–2030

Fatemeh Khosravi Shadmani, Farshad Farzadfar, Moein Yoosefi, Kamyar Mansori, Reza Khosravi Shadman, Aliakbar Haghdoost

Open Access Research article

Increasing of malignancy of breast cancer cells after cryopreservation: molecular detection and activation of angiogenesis after CAM-xenotransplantation

Xinxin Du, Plamen Todorov, Evgenia Isachenko, Gohar Rahimi, Peter Mallmann, Yuanguang Meng, Vladimir Isachenko

Open Access Research article

When to call it off: defining transplant candidacy limits in liver donor liver transplantation for hepatocellular carcinoma

Abu Bakar Hafeez Bhatti, Ammal Imran Qureshi, Rizmi Tahir, Faisal Saud Dar, Nusrat Yar Khan, Haseeb Haider Zia, Shahzad Riyaz, Atif Rana

Open Access Research article

Adjuvant chemotherapy in average-risk adult medulloblastoma patients improves survival: a long term study

E. Franceschi, S. Minichillo, A. Mura, A. Tosoni, M. Mascarin, C. Tomasello, S. Bartolini, A. A. Brandes

Open Access Research article

Tumor expression of miR-448 is a prognostic marker in oral squamous cell carcinoma

Hui Wei, Kang Yu, Yongheng Liu, Lili Li, Guowen Wang

Open Access Research article

Impact on quality of life 3 years after diagnosis of prostate cancer patients below 75 at diagnosis: an observational case-control study

Nadine Houédé, Xavier Rébillard, Sophie Bouvet, Sarah Kabani, Pascale Fabbro-Peray, Brigitte Trétarre, Florence Ménégaux

Open Access Research article

Quality of life and psychological distress during cancer: a prospective observational study involving young breast cancer female patients

Barbara Muzzatti, Francesca Bomben, Cristiana Flaiban, Marika Piccinin, Maria Antonietta Annunziata

Open Access Research article

Gender differences in stage at diagnosis and preoperative radiotherapy in patients with rectal cancer

Cristina Sarasqueta, Mª Victoria Zunzunegui, José María Enríquez Navascues, Arrate Querejeta, Carlos Placer, Amaia Perales, Nerea Gonzalez, Urko Aguirre, Marisa Baré, Antonio Escobar, José María Quintana, Jose María Quintana López, Marisa Baré Mañas, Maximino Redondo Bautista, Eduardo Briones Pérez de la Blanca, Nerea Fernández de Larrea Baz, Cristina Sarasqueta Eizaguirre, Antonio Escobar Martínez, Francisco Rivas Ruiz, Maria M. Morales-Suárez-Varela, Juan Antonio Blasco Amaro, Isabel del Cura González, Inmaculada Arostegui Madariaga, Amaia Bilbao González, Nerea González Hernández, Susana García-Gutiérrez, Iratxe Lafuente Guerrero, Urko Aguirre Larracoechea, Miren Orive Calzada, Josune Martin Corral, Ane Antón-Ladislao, Núria Torà, Marina Pont, María Purificación Martínez del Prado, Alberto Loizate Totorikaguena, Ignacio Zabalza Estévez, José Errasti Alustiza, Antonio Z. Gimeno García, Santiago Lázaro Aramburu, Mercè Comas Serrano, Jose María Enríquez Navascues, Carlos Placer Galán, Amaia Perales Antón, Iñaki Urkidi Valmaña, Jose María Erro Azkárate, Enrique Cormenzana Lizarribar, Adelaida Lacasta Muñoa, Pep Piera Pibernat, Elena Campano Cuevas, Ana Isabel Sotelo Gómez, Segundo Gómez-Abril, F. Medina-Cano, Julia Alcaide, Arturo Del Rey-Moreno, Manuel Jesús Alcántara, Rafael Campo, Alex Casalots, Carles Pericay, Maria José Gil, Miquel Pera, Pablo Collera, Josep Alfons Espinàs, Mercedes Martínez, Mireia Espallargues, Caridad Almazán, Paula Dujovne Lindenbaum, José María Fernández-Cebrián, Rocío Anula Fernández, Julio Mayol Martínez, Ramón Cantero Cid, Héctor Guadalajara Labajo, María Alexandra Heras Garceau, Damián García Olmo, Mariel Morey Montalvo

Open Access Research article

Safety and efficacy of sintilimab combined with oxaliplatin/capecitabine as first-line treatment in patients with locally advanced or metastatic gastric/gastroesophageal junction adenocarcinoma in a phase Ib clinical trial

Haiping Jiang, Yulong Zheng, Jiong Qian, Chenyu Mao, Xin Xu, Ning Li, Cheng Xiao, Huan Wang, Lisong Teng, Hui Zhou, Shuyan Wang, Donglei Zhu, Bo Peng, Lin Shen, Nong Xu

Open Access Research article

Influence of tumor location on short- and long-term outcomes after laparoscopic surgery for rectal cancer: a propensity score matched cohort study

Hong Yang, Zhendan Yao, Ming Cui, Jiadi Xing, Chenghai Zhang, Nan Zhang, Maoxing Liu, Kai Xu, Fei Tan, Xiangqian Su

Open Access Research article

Log odds of positive lymph nodes is prognostically equivalent to lymph node ratio in non-metastatic colon cancer

Ali Riaz Baqar, Simon Wilkins, Wei Wang, Karen Oliva, Paul McMurrick

Open Access Research article

Value of artificial ascites to assist thermal ablation of liver cancer adjacent to the gastrointestinal tract in patients with previous abdominal surgery

Qiannan Huang, Jianguo Li, Qingjing Zeng, Lei Tan, Rongqin Zheng, Xuqi He, Kai Li

Open Access Study protocol

Ipilimumab plus nivolumab and chemoradiotherapy followed by surgery in patients with resectable and borderline resectable T3-4N0–1 non-small cell lung cancer: the INCREASE trial

Chris Dickhoff, Suresh Senan, Famke L. Schneiders, Joris Veltman, Sayed Hashemi, Johannes M. A. Daniels, Marieke Fransen, David J. Heineman, Teodora Radonic, Peter M. van de Ven, Imke H. Bartelink, Lilian J. Meijboom, Juan J. Garcia-Vallejo, Daniela E. Oprea-Lager, Tanja D. de Gruijl, Idris Bahce

Open Access Research article

Tumor burden of persistent disease in patients with differentiated thyroid cancer: correlation with postoperative risk-stratification and impact on outcome

Renaud Ciappuccini, Natacha Heutte, Audrey Lasne-Cardon, Virginie Saguet-Rysanek, Camille Leroy, Véronique Le Hénaff, Dominique Vaur, Emmanuel Babin, Stéphane Bardet

Open Access Research article

Prognostic value of S1PR1 and its correlation with immune infiltrates in breast and lung cancers

Limei Zhong, Linling Xie, Zhiyong Yang, Lijuan Li, Shaohua Song, Donglin Cao, Yufeng Liu

Open Access Research article

Quantified MRI and 25OH-VitD3 can be used as effective biomarkers for patients with neoadjuvant chemotherapy-induced liver injury in CRCLM?

Qian Wang, Feng Ye, Peiqing Ma, Yiqun Che, Weilan Guo, Dong Yan, Xinming Zhao

Open Access Research article

Supporting the patients with advanced cancer and their family caregivers: what are their palliative care needs?

Gek Phin Chua, Grace Su Yin Pang, Alethlea Chung Pheng Yee, Patricia Soek Hui Neo, Siqin Zhou, Cindy Lim, Yin Yee Wong, Debra Limin Qu, Fang Ting Pan, Grace Meijuan Yang

Open Access Study protocol

The efficacy of a leukotriene receptor antagonist in the treatment of human rectal aberrant crypt foci: a nonrandomized, open-label, controlled trial

Takuma Higurashi, Jun Arimoto, Keiichi Ashikari, Tomohiro Takatsu, Noboru Misawa, Tsutomu Yoshihara, Tetsuya Matsuura, Akiko Fuyuki, Hidenori Ohkubo, Atsushi Nakajima

Open Access Research article

Identification of an autophagy-related gene signature that can improve prognosis of hepatocellular carcinoma patients

Xingxing Huo, Jian Qi, Kaiquan Huang, Su Bu, Wei Yao, Ying Chen, Jinfu Nie

Open Access Research article

Identifying predictive biomarkers of CIMAvaxEGF success in non–small cell lung cancer patients

Patricia Lorenzo-Luaces, Lizet Sanchez, Danay Saavedra, Tania Crombet, Wim Van der Elst, Ariel Alonso, Geert Molenberghs, Agustin Lage

Open Access Research article

Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma

Md Gulam Musawwir Khan, Amit Ghosh, Bhavesh Variya, Madanraj Appiya Santharam, Awais Ullah Ihsan, Sheela Ramanathan, Subburaj Ilangumaran

Open Access Research article

PARP inhibitors combined with ionizing radiation induce different effects in melanoma cells and healthy fibroblasts

Verena Weigert, Tina Jost, Markus Hecht, Ilka Knippertz, Lucie Heinzerling, Rainer Fietkau, Luitpold V. Distel

Open Access Study protocol

Improving clinical management of colon cancer through CONNECTION, a nation-wide colon cancer registry and stratification effort (CONNECTION II trial): rationale and protocol of a single arm intervention study

I. van den Berg, S. van de Weerd, J. M. L. Roodhart, G. R. Vink, R. R. J. Coebergh van den Braak, C. R. Jimenez, S. G. Elias, D. van Vliet, M. Koelink, E. Hong, W. M. U. van Grevenstein, M. G. H. van Oijen, R. G. H. Beets-Tan, J. H. J. M. van Krieken, J. N. M. IJzermans, J. P. Medema, M. Koopman

Open Access Research article

Survival predictors of metastatic angiosarcomas: a surveillance, epidemiology, and end results program population-based retrospective study

Shihong Ren, Yucheng Wang, Zhan Wang, Jinxiang Shao, Zhaoming Ye

Open Access Research article

Long-term sexual functioning in germ-cell tumor survivors

M. Chovanec, L. Vasilkova, L. Petrikova, J. Obertova, P. Palacka, K. Rejlekova, Z. Sycova-Mila, K. Kalavska, D. Svetlovska, B. Mladosievicova, J. Mardiak, M. Mego

Open Access Research article

Long term outcome of anastomotic leakage in patients undergoing low anterior resection for rectal cancer

Alice Artus, Nicolas Tabchouri, Othman Iskander, Nicolas Michot, Olivier Muller, Urs Giger-Pabst, Pascal Bourlier, Céline Bourbao-Tournois, Aurore Kraemer-Bucur, Thierry Lecomte, Ephrem Salamé, Mehdi Ouaissi

Open Access Study protocol

The CARDIA-trial protocol: a multinational, prospective, randomized, clinical trial comparing transthoracic esophagectomy with transhiatal extended gastrectomy in adenocarcinoma of the gastroesophageal junction (GEJ) type II

Jessica M. Leers, Laura Knepper, Arjen van der Veen, Wolfgang Schröder, Hans Fuchs, Petra Schiller, Martin Hellmich, Ulrike Zettelmeyer, Lodewijk A. A. Brosens, Alexander Quaas, Jelle P. Ruurda, Richard van Hillegersberg, Christiane J. Bruns

Open Access Research article

A ten-gene signature-based risk assessment model predicts the prognosis of lung adenocarcinoma

Hanliang Jiang, Shan Xu, Chunhua Chen

Open Access Research article

Randomized double-blind clinical trial comparing safety and efficacy of the biosimilar BCD-022 with reference trastuzumab

Sergey M. Alexeev, Andrey V. Khorinko, Guzel Z. Mukhametshina, Konstantin G. Shelepen, Olga N. Burdaeva, Sergey A. Kulik, Chiradoni Thugappa Satheesh, Kirti Srivastava, Mummaneni Vikranth, Fedor Kryukov, Anastasia N. Paltusova, Mariya S. Shustova, Roman A. Ivanov

Open Access Research article

Breast cancer mammospheres secrete Adrenomedullin to induce lipolysis and browning of adjacent adipocytes

Martin Paré, Cédric Y. Darini, Xi Yao, Bérengère Chignon-Sicard, Samah Rekima, Simon Lachambre, Virginie Virolle, Adriana Aguilar-Mahecha, Mark Basik, Christian Dani, Annie Ladoux

Open Access Study protocol

Pneumonitis after radiotherapy for lung cancer (PARALUC): an interventional study to create a symptom-based scoring system for identification of patients developing radiation pneumonitis

Dirk Rades, Elisa Marie Werner, Esther Glatzel, Marie-Christine Eggert, Denise Olbrich, Soeren Tvilsted, Sabine Bohnet

Open Access Research article

Height as a risk factor in meningioma: a study of 2 million Israeli adolescents

Matan Ben-Zion Berliner, Lior Haim Katz, Estela Derazne, Hagai Levine, Lital Keinan-Boker, Alexandra Benouaich-Amiel, Omer Gal, Andrew A Kanner, Yosef Laviv, Asaf Honig, Tali Siegal, Jacob Mandel, Gilad Twig, Shlomit Yust-Katz

Open Access Research article

The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems

Kellie Toohey, Kate Pumpa, Andrew McKune, Julie Cooke, Marijke Welvaert, Joseph Northey, Clare Quinlan, Stuart Semple

Open Access Research article

Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies

Junyu Zhao, Jing Wen, Shengnan Wang, Jinming Yao, Lin Liao, Jianjun Dong

Open Access Research article

MEIS1 promotes expression of stem cell markers in esophageal squamous cell carcinoma

Selma Zargari, Shabnam Negahban Khameneh, Abolfazl Rad, Mohammad Mahdi Forghanifard

Open Access Study protocol

Circulating tumor DNA guided adjuvant chemotherapy in stage II colon cancer (MEDOCC-CrEATE): study protocol for a trial within a cohort study

S. J. Schraa, K. L. van Rooijen, D. E. W. van der Kruijssen, C. Rubio Alarcón, J. Phallen, M. Sausen, J. Simmons, V. M. H. Coupé, W. M. U. van Grevenstein, S. Elias, H. M. Verkooijen, M. M. Laclé, L. J. W. Bosch, D. van den Broek, G. A. Meijer, V. E. Velculescu, R. J. A. Fijneman, G. R. Vink, M. Koopman, Mich S. Dunker, Martijn F. Lutke Holzik, Ronald Hoekstra, Dirkje W. Sommeijer, Jarmila D. W. van der Bilt, Esther C. J. Consten, Geert A. Cirkel, Thijs A. Burghgraef, Emma M. van der Schans, Peter Nieboer, Ron C. Rietbroek, Jan Willem T. Dekker, Arjan J. Verschoor, Koen A. K. Talsma, Rebecca P. M. Brosens, Helgi H. Helgason, Andreas W. K. S. Marinelli, Ignace H. J. T. de Hingh, Corina N. Oldenhuis, Jan Jansen, Henk K. van Halteren, Hein B. A. C. Stockmann, Aart Beeker, Koop Bosscha, Hans F. M. Pruijt, Leontine E. A. M. M. Spierings, Liselot B. J. Valkenburg-Van Iersel, Wouter J. Vles, Felix E. de Jongh, Hester van Cruijsen, Joost T. Heikens, David D. E. Zimmerman, Robert J. van Alphen, Anandi H. W. Schiphorst, Lobke L. van Leeuwen-Snoeks, Jeroen F. J. Vogelaar, Natascha A. J. B. Peters

Open Access Research article

Clinical effects of curcumin in enhancing cancer therapy: A systematic review

Kamran Mansouri, Shna Rasoulpoor, Alireza Daneshkhah, Soroush Abolfathi, Nader Salari, Masoud Mohammadi, Shabnam Rasoulpoor, Shervin Shabani

Open Access Research article

Effectiveness of the AJCC 8th edition staging system for selecting patients with T1–2N1 breast cancer for post-mastectomy radiotherapy: a joint analysis of 1986 patients from two institutions

Shulian Wang, Ge Wen, Yu Tang, Yong Yang, Hao Jing, Jianyang Wang, Jianghu Zhang, Xuran Zhao, Guangyi Sun, Jing Jin, Yongwen Song, Yueping Liu, Hui Fang, Yujing Zhang, Yexiong Li

Open Access Research article

Nomogram model for predicting cause-specific mortality in patients with stage I small-cell lung cancer: a competing risk analysis

Jianjie Li, Qiwen Zheng, Xinghui Zhao, Jun Zhao, Tongtong An, Meina Wu, Yuyan Wang, Minglei Zhuo, Jia Zhong, Xue Yang, Bo Jia, Hanxiao Chen, Zhi Dong, Jingjing Wang, Yujia Chi, Xiaoyu Zhai, Ziping Wang

Open Access Research article

OTX1 exerts an oncogenic role and is negatively regulated by miR129-5p in laryngeal squamous cell carcinoma

Xiu-Ping Tu, Hao Li, Liang-Si Chen, Xiao-Ning Luo, Zhong-Ming Lu, Si-Yi Zhang, Shao-Hua Chen

Open Access Research article

Monitoring and evaluation of breast cancer screening programmes: selecting candidate performance indicators

Sergei Muratov, Carlos Canelo-Aybar, Jean-Eric Tarride, Pablo Alonso-Coello, Nadya Dimitrova, Bettina Borisch, Xavier Castells, Stephen W. Duffy, Patricia Fitzpatrick, Markus Follmann, Livia Giordano, Solveig Hofvind, Annette Lebeau, Cecily Quinn, Alberto Torresin, Claudia Vialli, Sabine Siesling, Antonio Ponti, Paolo Giorgi Rossi, Holger Schünemann, Lennarth Nyström, Mireille Broeders, Mariangela Autelitano, Edoardo Colzani, Jan Daneš, Axel Gräwingholt, Lydia Ioannidou-Mouzaka, Susan Knox, Miranda Langendam, Helen McGarrigle, Elsa Pérez Gómez, Ruben van Engen, Sue Warman, Kenneth Young, Cary van Landsveld-Verhoeven, Donata Lerda, Zuleika Saz-Parkinson, Elena Parmelli, Annett Janusch-Roi

Open Access Research article

HPV infection related immune infiltration gene associated therapeutic strategy and clinical outcome in HNSCC

Hao Zeng, Xindi Song, Jianrui Ji, Linyan Chen, Qimeng Liao, Xuelei Ma

Open Access Research article

Prognostic significance of autophagy-related genes within esophageal carcinoma

Chongxiang Chen, Siliang Chen, Huijiao Cao, Jiaojiao Wang, Tianmeng Wen, Xiaochun Hu, Huan Li

Open Access Research article

Outcomes of treatment with CHOP and EPOCH in patients with HIV associated NHL in a low resource setting

Clement D. Okello, Abrahams Omoding, Henry Ddungu, Yusuf Mulumba, Jackson Orem

Open Access Research article

Differentiating the lung lesions using Intravoxel incoherent motion diffusion-weighted imaging: a meta-analysis

Jianye Liang, Jing Li, Zhipeng Li, Tiebao Meng, Jieting Chen, Weimei Ma, Shen Chen, Xie Li, Yaopan Wu, Ni He

Open Access Research article

Sphingomyelin(d35:1) as a novel predictor for lung adenocarcinoma recurrence after a radical surgery: a case-control study

Yusuke Takanashi, Kazuhito Funai, Shumpei Sato, Akikazu Kawase, Hong Tao, Yutaka Takahashi, Haruhiko Sugimura, Mitsutoshi Setou, Tomoaki Kahyo, Norihiko Shiiya

Open Access Study protocol

Protocol for expanded indications of endoscopic submucosal dissection for early gastric cancer in China: a multicenter, ambispective, observational, open-cohort study

Zhi Zheng, Jie Yin, Ziyu Li, Yingjiang Ye, Bo Wei, Xin Wang, Yantao Tian, Mengyi Li, Qian Zhang, Na Zeng, Rui Xu, Guangyong Chen, Jie Zhang, Peng Li, Jun Cai, Hongwei Yao, Jun Zhang, Zhongtao Zhang, Shutian Zhang

Open Access Research article

Molecular evidence of IGFBP-3 dependent and independent VD3 action and its nonlinear response on IGFBP-3 induction in prostate cancer cells

Ko Igarashi, Yoshihiro Yui, Kenta Watanabe, Jun Kumai, Yasuko Nishizawa, Chisato Miyaura, Masaki Inada, Satoru Sasagawa

Open Access Research article

Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma

Ga-Young Song, Sung-Hoon Jung, Kihyun Kim, Seok Jin Kim, Sang Eun Yoon, Ho Sup Lee, Mihee Kim, Seo-Yeon Ahn, Jae-Sook Ahn, Deok-Hwan Yang, Hyeoung-Joon Kim, Je-Jung Lee

Open Access Research article

Post-diagnostic antipsychotic use and cancer mortality: a population based cohort study

Blánaid M. Hicks, John Busby, Ken Mills, Francis A. O’Neil, Stuart A. McIntosh, Shu-Dong Zhang, Fabio Giuseppe Liberante, Chris R. Cardwell

Open Access Study protocol

The CanMoRe trial – evaluating the effects of an exercise intervention after robotic-assisted radical cystectomy for urinary bladder cancer: the study protocol of a randomised controlled trial

Andrea Porserud, Patrik Karlsson, Elisabeth Rydwik, Markus Aly, Lars Henningsohn, Malin Nygren-Bonnier, Maria Hagströmer

Open Access Study protocol

Thoracic radiotherapy plus Durvalumab in elderly and/or frail NSCLC stage III patients unfit for chemotherapy - employing optimized (hypofractionated) radiotherapy to foster durvalumab efficacy: study protocol of the TRADE-hypo trial

Farastuk Bozorgmehr, Inn Chung, Petros Christopoulos, Johannes Krisam, Marc A. Schneider, Lena Brückner, Daniel Wilhelm Mueller, Michael Thomas, Stefan Rieken

Open Access Research article

Is opium use associated with an increased risk of lung cancer? A case-control study

Ahmad Naghibzadeh-Tahami, Maryam Marzban, Vahid Yazdi-Feyzabadi, Shahryar Dabiri, Shokrollah Mohseni, Reza Abbasi Rayeni, Mitra Samareh Fekri, Mohammad Hasan Larizadeh, Behnaz Karimpour, Narges Khanjani

Open Access Research article

Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma

Xiling Yu, Xueke Li, Yue Xing, Siduo Lu, Silvia Tanumiharjo, Jin Ma

Open Access Research article

The impact of order with radiation therapy in stage IIIA pathologic N2 NSCLC patients: a population-based study

Hongxia Duan, Long Liang, Shuanshuan Xie, Changhui Wang

Open Access Research article

Epidemiological features and survival outcomes in patients with malignant pulmonary blastoma: a US population-based analysis

Xiang Bu, Jing Liu, Linyan Wei, Xiqiang Wang, Mingwei Chen

Open Access Research article

Effect of microwave ablation treatment of hepatic malignancies on serum cytokine levels

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Yun-Gyoo Lee, Eun Joo Kang, Bhumsuk Keam, Jin-Hyuk Choi, Jin-Soo Kim, Keon Uk Park, Kyoung Eun Lee, Jung Hye Kwon, Keun-Wook Lee, Min Kyoung Kim, Hee Kyung Ahn, Seong Hoon Shin, Hye Ryun Kim, Sung-Bae Kim, Hwan Jung Yun

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Comprehensive analysis of prognostic tumor microenvironment-related genes in osteosarcoma patients

Chuan Hu, Chuan Liu, Shaoqi Tian, Yuanhe Wang, Rui Shen, Huili Rao, Jianyi Li, Xu Yang, Bo Chen, Lin Ye

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Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation

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DLBCL with amplification of JAK2/PD-L2 exhibits PMBCL-like CNA pattern and worse clinical outcome resembling those with MYD88 L265P mutation

Xuemin Xue, Wenting Huang, Tian Qiu, Lei Guo, Jianming Ying, Ning Lv

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Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma

Dieter H. Heiland, Robin Ohle, Debora Cipriani, Pamela Franco, Daniel Delev, Simon P. Behriger, Elias Kellner, Gergana Petrova, Nicolas Neidert, Irina Mader, Mateo Fariña Nuñez, Horst Urbach, Roman Sankowski, Jürgen Beck, Oliver Schnell

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Post-diagnosis dietary insulinemic potential and survival outcomes among colorectal cancer patients

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Parental occupational exposure to pesticides and risk of childhood cancer in Switzerland: a census-based cohort study

Astrid Coste, Helen D. Bailey, Mutlu Kartal-Kaess, Raffaele Renella, Aurélie Berthet, Ben D. Spycher

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A machine learning approach to optimizing cell-free DNA sequencing panels: with an application to prostate cancer

Clinton L. Cario, Emmalyn Chen, Lancelote Leong, Nima C. Emami, Karen Lopez, Imelda Tenggara, Jeffry P. Simko, Terence W. Friedlander, Patricia S. Li, Pamela L. Paris, Peter R. Carroll, John S. Witte

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Interleukin-8 is not a predictive biomarker for the development of the acute promyelocytic leukemia differentiation syndrome

Luciana Yamamoto de Almeida, Diego Antonio Pereira-Martins, Ana Sílvia Gouvêa Lima, Márcia Sueli Baggio, Luisa Corrêa de Araujo Koury, Ana Paula Lange, Sarah Cristina Bassi, Priscila Santos Scheucher, Eduardo Magalhães Rego

Open Access Study protocol

Phase II study on first-line treatment of NIVolumab in combination with folfoxiri/bevacizumab in patients with Advanced COloRectal cancer RAS or BRAF mutated – NIVACOR trial (GOIRC-03-2018)

Angela Damato, Francesco Iachetta, Lorenzo Antonuzzo, Guglielmo Nasti, Francesca Bergamo, Roberto Bordonaro, Evaristo Maiello, Alberto Zaniboni, Giuseppe Tonini, Alessandra Romagnani, Annalisa Berselli, Nicola Normanno, Carmine Pinto

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Fei Liang, Sheng Zhang, Qin Wang, Wenfeng Li

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UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target

Kumar Saurabh, Parag P. Shah, Mark A. Doll, Leah J. Siskind, Levi J. Beverly

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Raised CA19–9 and CEA have prognostic relevance in gallbladder carcinoma

Ashish Sachan, Sundeep Singh Saluja, Phani Kumar Nekarakanti, Nimisha, Bhawna Mahajan, Hirdaya H. Nag, Pramod K. Mishra

Open Access Research article

Prophylactic chemotherapeutic hyperthermic intraperitoneal perfusion reduces peritoneal metastasis in gastric cancer: a retrospective clinical study

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A predictive nomogram for lymph node metastasis of incidental gallbladder cancer: a SEER population-based study

Yingnan Yang, Zhuolong Tu, Huajie Cai, Bingren Hu, Chentao Ye, Jinfu Tu

Open Access Research article

Cost-effectiveness analysis of first and second-generation EGFR tyrosine kinase inhibitors as first line of treatment for patients with NSCLC harboring EGFR mutations

Oscar Arrieta, Rodrigo Catalán, Silvia Guzmán-Vazquez, Feliciano Barrón, Luis Lara-Mejía, Herman Soto-Molina, Maritza Ramos-Ramírez, Diana Flores-Estrada, Jaime de la Garza

Open Access Research article

Racial differences in 5-year relative survival rates of cervical cancer by stage at diagnosis, between African American (black) and white women, living in the state of Alabama, USA

Ehsan Abdalla, Roberta Troy, Souleymane Fall, Isra Elhussin, Oyoyo Egiebor-Aiwan, David Nganwa

Open Access Study protocol

Short-course radiation followed by mFOLFOX-6 plus avelumab for locally-advanced rectal adenocarcinoma

Ali Shamseddine, Youssef H. Zeidan, Malek Kreidieh, Ibrahim Khalifeh, Rim Turfa, Joseph Kattan, Deborah Mukherji, Sally Temraz, Kholoud Alqasem, Rula Amarin, Tala Al Awabdeh, Samer Deeba, Faek Jamali, Issa Mohamad, Mousa Elkhaldi, Faiez Daoud, Mahmoud Al Masri, Ali Dabous, Ahmad Hushki, Omar Jaber, Clement Khoury, Ziad El Husseini, Maya Charafeddine, Monita Al Darazi, Fady Geara

Open Access Research article

Dose-dense TPF induction chemotherapy for locally advanced head and neck cancer: a phase II study

Ching-Yun Hsieh, Ming-Yuh Lein, Shih-Neng Yang, Yao-Ching Wang, Yin-Jun Lin, Chen-Yuan Lin, Chun-Hung Hua, Ming-Hsul Tsai, Ching-Chan Lin

Open Access Research article

Calculating the overall survival probability in patients with cervical cancer: a nomogram and decision curve analysis-based study

Guilan Xie, Ruiqi Wang, Li Shang, Cuifang Qi, Liren Yang, Liyan Huang, Wenfang Yang, Mei Chun Chung

Open Access Correction

Correction to: A novel coordination complex of platinum (PT) induces cell death in colorectal cancer by altering redox balance and modulating MAPK pathway

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Alteration of plasma metabolites associated with chemoradiosensitivity in esophageal squamous cell carcinoma via untargeted metabolomics approach

Yaowen Zhang, Jianpo Wang, Ningtao Dai, Peng Han, Jian Li, Jiangman Zhao, Weilan Yuan, Jiahuan Zhou, Fuyou Zhou

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The efficacy of etanercept as anti-breast cancer treatment is attenuated by residing macrophages

Elnaz Shirmohammadi, Seyed-Esmaeil Sadat Ebrahimi, Amir Farshchi, Mona Salimi

Open Access Research article

Prognostic analysis of patients with non-small cell lung cancer harboring exon 19 or 21 mutation in the epidermal growth factor gene and brain metastases

Jing Wang, Zhiyan Liu, Qingsong Pang, Tian Zhang, Xi Chen, Puchun Er, Yuwen Wang, Ping Wang, Jun Wang

Open Access Research article

WDHD1 facilitates G1 checkpoint abrogation in HPV E7 expressing cells by modulating GCN5

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LINC00649 underexpression is an adverse prognostic marker in acute myeloid leukemia

Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong, Zhen-ling Li

Open Access Research article

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Open Access Research article

Cell-in-cell phenomenon associates with aggressive characteristics and cancer-related mortality in early oral tongue cancer

Alhadi Almangush, Antti A. Mäkitie, Jaana Hagström, Caj Haglund, Luiz Paulo Kowalski, Pentti Nieminen, Ricardo D. Coletta, Tuula Salo, Ilmo Leivo

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Metastatic renal cell carcinoma patients of T4 stage who are in status of N1 stage or older than 76 years cannot benefit from cytoreductive nephrectomy

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Promotion of the occurrence of endometrioid carcinoma by S100 calcium binding protein P

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Open Access Research article

Lifetime survival and medical costs of lung cancer: a semi-parametric estimation from South Korea

Hae-Young Park, Jinseub Hwang, Do-Hyang Kim, Soo Min Jeon, Sun Ha Choi, Jin-Won Kwon

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Patient and physician factors associated with Oncotype DX and adjuvant chemotherapy utilization for breast cancer patients in New Hampshire, 2010–2016

Thomas M. Schwedhelm, Judy R. Rees, Tracy Onega, Ronnie J. Zipkin, Andrew Schaefer, Maria O. Celaya, Erika L. Moen

Open Access Research article

Impact of smoking amount on clinicopathological features and survival in non-small cell lung cancer

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Survival analysis of patients with stage T2a and T2b perihilar cholangiocarcinoma treated with radical resection

Jian Zhao, Wei Zhang, Jun Zhang, Yi Zhang, Wen-Jie Ma, Si-Yun Liu, Fu-Yu Li, Bin Song

Open Access Research article

Interconnectivity between molecular subtypes and tumor stage in colorectal cancer

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Young age increases the risk of lymph-node metastasis in patients with muscle-invasive bladder urothelial carcinoma

Zijian Tian, Lingfeng Meng, Xin Wang, Tongxiang Diao, Maolin Hu, Miao Wang, Ming Liu, Jianye Wang

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ERCC6L promotes the progression of hepatocellular carcinoma through activating PI3K/AKT and NF-κB signaling pathway

Han Chen, Hengxiao Wang, Xiqiao Yu, Shuping Zhou, Yueying Zhang, Zhaopeng Wang, Shuhong Huang, Zhaoxia Wang

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Worse treatment response to neoadjuvant chemoradiotherapy in young patients with locally advanced rectal cancer

Yiyi Zhang, Liangliang Yan, Yong Wu, Meifang Xu, Xing Liu, Guoxian Guan

Open Access Research article

Real-world patient-reported outcomes of women receiving initial endocrine-based therapy for HR+/HER2− advanced breast cancer in five European countries

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Bayesian copy number detection and association in large-scale studies

Stephen Cristiano, David McKean, Jacob Carey, Paige Bracci, Paul Brennan, Michael Chou, Mengmeng Du, Steven Gallinger, Michael G. Goggins, Manal M. Hassan, Rayjean J. Hung, Robert C. Kurtz, Donghui Li, Lingeng Lu, Rachel Neale, Sara Olson, Gloria Petersen, Kari G. Rabe, Jack Fu, Harvey Risch, Gary L. Rosner, Ingo Ruczinski, Alison P. Klein, Robert B. Scharpf

Open Access Research article

Magnitude and associated factors of VIA positive test results for cervical cancer screening among refugee women aged 25–49 years in North Ethiopia

Gebretsadik Hailemariam, Hailay Gebreyesus, Tewolde Wubayehu, Tsgehana Gebregyorgis, Kidanemariam Gebrecherkos, Mebrahtu Teweldemedhin, Manaye Kifle

Open Access Research article

Contribution of BRCA1 and BRCA2 germline mutations to early onset breast cancer: a series from north of Morocco

Joaira Bakkach, Mohamed Mansouri, Touria Derkaoui, Ali Loudiyi, ElMostafa El Fahime, Amina Barakat, Naima Ghailani Nourouti, Jaime Martinez De Villarreal, Carlos Cortijo Bringas, Mohcine Bennani Mechita

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Lgr5 and stem/progenitor gene expression in gastric/gastroesophageal junction carcinoma – significance of potentially retained stemness

Ju-Yoon Yoon, Christine Brezden-Masley, Catherine J. Streutker

Open Access Research article

MassARRAY-based single nucleotide polymorphism analysis in breast cancer of north Indian population

Divya Bakshi, Ashna Nagpal, Varun Sharma, Indu Sharma, Ruchi Shah, Bhanu Sharma, Amrita Bhat, Sonali Verma, Gh. Rasool Bhat, Deepak Abrol, Rahul Sharma, Samantha Vaishnavi, Rakesh Kumar

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Bioinformatic analysis reveals hub genes and pathways that promote melanoma metastasis

Wenxing Su, Yi Guan, Biao Huang, Juanjuan Wang, Yuqian Wei, Ying Zhao, Qingqing Jiao, Jiang Ji, Daojiang Yu, Longjiang Xu

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Identification of a metabolism-related gene expression prognostic model in endometrial carcinoma patients

Pinping Jiang, Wei Sun, Ningmei Shen, Xiaohao Huang, Shilong Fu

Open Access Research article

Nomogram for individually predicting overall survival in rectal neuroendocrine tumours

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Homeobox proteins are potential biomarkers and therapeutic targets in gastric cancer: a systematic review and meta-analysis

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Antithrombin use and mortality in patients with stage IV solid tumor-associated disseminated intravascular coagulation: a nationwide observational study in Japan

Kohei Taniguchi, Hiroyuki Ohbe, Kazuma Yamakawa, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga

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Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis

Shiro Saito, Hisaki Aiba, Satoshi Yamada, Hideki Okamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Takanobu Otsuka, Hideki Murakami

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1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression

Luiz Henrique Gomes Matheus, Stephanie Vanin Dalmazzo, Rodrigo Barbosa Oliveira Brito, Lucas Alves Pereira, Robson José de Almeida, Cleber Pinto Camacho, Humberto Dellê

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High BANCR expression is associated with worse prognosis in human malignant carcinomas: an updated systematic review and meta-analysis

Shixu Fang, Zhou Liu, Qiang Guo, Cheng Chen, Xixian Ke, Gang Xu

Open Access Research article

Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development

Jennifer S. Davis, Preeti Kanikarla-Marie, Mihai Gagea, Patrick L. Yu, Dexing Fang, Manu Sebastian, Peiying Yang, Ernest Hawk, Roderick Dashwood, Lenard M. Lichtenberger, David Menter, Scott Kopetz

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5α-reductase inhibitors impact prognosis of urothelial carcinoma

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Open Access Research article

Clinical characteristics and outcome of pediatric patients diagnosed with Langerhans cell histiocytosis in pediatric hematology and oncology centers in Poland

Anna Raciborska, Katarzyna Bilska, Jadwiga Węcławek-Tompol, Olga Gryniewicz-Kwiatkowska, Małgorzata Hnatko-Kołacz, Joanna Stefanowicz, Anna Pieczonka, Katarzyna Jankowska, Filip Pierelejewski, Tomasz Ociepa, Grażyna Sobol-Milejska, Katarzyna Muszyńska-Rosłan, Olga Michoń, Wanda Badowska, Monika Radwańska, Katarzyna Drabko

Open Access Research article

Cost-effectiveness analysis comparing companion diagnostic tests for EGFR, ALK, and ROS1 versus next-generation sequencing (NGS) in advanced adenocarcinoma lung cancer patients

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Open Access Research article

Monofrequency electrical impedance mammography (EIM) diagnostic system in breast cancer screening

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Open Access Study protocol

Salvage chemoradiation therapy for recurrence after radical surgery or palliative surgery in esophageal cancer patients: a prospective, multicenter clinical trial protocol

Xiao Chang, Lei Deng, Wenjie Ni, Chen Li, Weiming Han, Lin-rui Gao, Shijia Wang, Zongmei Zhou, Dongfu Chen, Qinfu Feng, Jun Liang, Nan Bi, Jima Lv, Shugeng Gao, Yousheng Mao, Qi Xue, Zefen Xiao

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ANGPTL4 overexpression inhibits tumor cell adhesion and migration and predicts favorable prognosis of triple-negative breast cancer

Yu-Chen Cai, Hang Yang, Ke-Feng Wang, Tan-Huan Chen, Wen-Qi Jiang, Yan-Xia Shi

Open Access Research article

From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes

Zhishan Chen, Wanqing Wen, Qiuyin Cai, Jirong Long, Ying Wang, Weiqiang Lin, Xiao-ou Shu, Wei Zheng, Xingyi Guo

Open Access Research article

Anti-proliferative activity of A. Oxyphylla and its bioactive constituent nootkatone in colorectal cancer cells

Eunsu Yoo, Jaehak Lee, Pattawika Lertpatipanpong, Junsun Ryu, Chong-Tai Kim, Eul-Yong Park, Seung Joon Baek

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Immunosenescence profile and expression of the aging biomarker (p16INK4a) in testicular cancer survivors treated with chemotherapy

Maria T. Bourlon, Hugo E. Velazquez, Juan Hinojosa, Luis Orozco, Ricardo Rios-Corzo, Guadalupe Lima, Luis Llorente, Diego F. Hernandez-Ramirez, Francisco J. Valentin-Cortez, Irene Medina-Rangel, Yemil Atisha-Fregoso

Open Access Research article

Prognostic factors of metastatic myxoid liposarcoma

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Open Access Study protocol

Lutetium-177-PSMA-I&T as metastases directed therapy in oligometastatic hormone sensitive prostate cancer, a randomized controlled trial

Bastiaan M. Privé, Marcel J. R. Janssen, Inge M. van Oort, Constantijn H. J. Muselaers, Marianne A. Jonker, Michel de Groot, Niven Mehra, J. Fred Verzijlbergen, Tom W. J. Scheenen, Patrik Zámecnik, Jelle O. Barentsz, Martin Gotthardt, Walter Noordzij, Wouter V. Vogel, Andries M. Bergman, Henk G. van der Poel, André N. Vis, Daniela E. Oprea-Lager, Winald R. Gerritsen, J. Alfred Witjes, James Nagarajah

Open Access Research article

Plasma-based longitudinal mutation monitoring as a potential predictor of disease progression in subjects with adenocarcinoma in advanced non-small cell lung cancer

John Jiang, Hans-Peter Adams, Maria Lange, Sandra Siemann, Mirjam Feldkamp, Sylvie McNamara, Sebastian Froehler, Stephanie J. Yaung, Lijing Yao, Aarthi Balasubramanyam, Nalin Tikoo, Christine Ju, H. Jost Achenbach, Rainer Krügel, John F. Palma

Open Access Study protocol

RACE-trial: neoadjuvant radiochemotherapy versus chemotherapy for patients with locally advanced, potentially resectable adenocarcinoma of the gastroesophageal junction - a randomized phase III joint study of the AIO, ARO and DGAV

Sylvie Lorenzen, Alexander Biederstädt, Ulrich Ronellenfitsch, Christoph Reißfelder, Stefan Mönig, Frederik Wenz, Claudia Pauligk, Martin Walker, Salah-Eddin Al-Batran, Bernhard Haller, Ralf-Dieter Hofheinz

Open Access Research article

Incidence and risk factor for short term postoperative cough after thyroidectomy

Junfu Wu, Liyuan Dai, Weihua Lou

Open Access Research article

Nomogram for predicting the overall survival and cancer-specific survival of patients with extremity liposarcoma: a population-based study

Lin Ye, Chuan Hu, Cailin Wang, Weiyang Yu, Feijun Liu, Zhenzhong Chen

Open Access Research article

Development and validation of oral chemotherapy self-management scale

Qi Peng, Wanying Wu

Open Access Research article

ALDH-1-positive cells exhibited a radioresistant phenotype that was enhanced with hypoxia in cervical cancer

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Open Access Research article

Long-term all-cause mortality and its association with cardiovascular risk factors in thyroid cancer survivors: an Israeli population-based study

Elena Izkhakov, Lital Keinan-Boker, Micha Barchana, Yacov Shacham, Iris Yaish, Narin N. Carmel Neiderman, Dan M. Fliss, Naftali Stern, Joseph Meyerovitch

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Survival outcomes in men with a positive family history of prostate cancer: a registry based study

Mann Ang, Martin Borg, Michael E. O’Callaghan

Open Access Research article

FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis

Wei Gao, Jinxiao Liang, Yiru Ye, Jinlan Lu, Tongtong Lin, Na Wang, Jingyin Dong, Jianping Pan

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The interaction between TERT promoter mutation and MGMT promoter methylation on overall survival of glioma patients: a meta-analysis

Huy Gia Vuong, Thu Quynh Nguyen, Tam N. M. Ngo, Hoang Cong Nguyen, Kar-Ming Fung, Ian F. Dunn

Open Access Research article

Identifying metrics of success for transitional care practices in childhood cancer survivorship: a qualitative interview study of survivors

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A pilot study of improved psychological distress with art therapy in patients with cancer undergoing chemotherapy

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Open Access Study protocol

A multicenter prospective phase III clinical randomized study of simultaneous integrated boost intensity-modulated radiotherapy with or without concurrent chemotherapy in patients with esophageal cancer: 3JECROG P-02 study protocol

Lin-rui Gao, Xin Wang, Weiming Han, Wei Deng, Chen Li, Xiaomin Wang, Yidian Zhao, Wenjie Ni, Xiao Chang, Zongmei Zhou, Lei Deng, Wenqing Wang, Wenyang Liu, Jun Liang, Tao Zhang, Nan Bi, Jianyang Wang, Yirui Zhai, Qinfu Feng, Jima Lv, Ling Li, Zefen Xiao

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Combined and interaction effect of chlamydia pneumoniae infection and smoking on lung cancer: a case-control study in Southeast China

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Identification of an alternative splicing signature as an independent factor in colon cancer

Haitao Chen, Jun Luo, Jianchun Guo

Open Access Research article

AHRR methylation in heavy smokers: associations with smoking, lung cancer risk, and lung cancer mortality

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Open Access Research article

World Health Organization grading classification for pancreatic neuroendocrine neoplasms: a comprehensive analysis from a large Chinese institution

Min Yang, Lin Zeng, Neng-wen Ke, Chun-lu Tan, Bo-le Tian, Xu-bao Liu, Bo Xiang, Yi Zhang

Open Access Research article

High platelet-to-lymphocyte ratio is associated with poor prognosis in patients with unresectable intrahepatic cholangiocarcinoma receiving gemcitabine plus cisplatin

Gunn Huh, Ji Kon Ryu, Jung Won Chun, Joo Seong Kim, Namyoung Park, In Rae Cho, Woo Hyun Paik, Sang Hyub Lee, Yong-Tae Kim

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Jia Huang, Guodong Chen, Huan Liu, Yiwei Zhang, Rong Tang, Qiulin Huang, Kai Fu, Xiuda Peng, Shuai Xiao

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Open Access Research article

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Hui-lei Miao, Ai-lin Zhao, Ming-hui Duan, Dao-bin Zhou, Xin-xin Cao, Jian Li

Open Access Research article

Tobacco exposure as a major modifier of oncologic outcomes in human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma

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Interferon-beta enhances sensitivity to gemcitabine in pancreatic cancer

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HLA-DPA1 gene is a potential predictor with prognostic values in multiple myeloma

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The association between HPV gene expression, inflammatory agents and cellular genes involved in EMT in lung cancer tissue

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Upregulation of long non-coding RNA LOC284454 may serve as a new serum diagnostic biomarker for head and neck cancers

Chunmei Fan, Jinpeng Wang, Yanyan Tang, Shanshan Zhang, Fang Xiong, Can Guo, Yanhong Zhou, Zheng Li, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong

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Single-dose fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients receiving moderately emetogenic chemotherapy regimens: a subgroup analysis from a randomized clinical trial of response in subjects by cancer type

Cindy Weinstein, Karin Jordan, Stuart Green, Saleem Khanani, Elizabeth Beckford-Brathwaite, Waldimir Vallejos, Annpey Pong, Stephen J. Noga, Bernardo L. Rapoport

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A high neutrophil-to-lymphocyte ratio is a poor prognostic factor for castration-resistant prostate cancer patients who undergo abiraterone acetate or enzalutamide treatment

Takashi Kawahara, Masashi Kato, Kenichi Tabata, Ippei Kojima, Hiroshi Yamada, Osamu Kamihira, Hideyasu Tsumura, Masatsugu Iwamura, Hiroji Uemura, Yasuhide Miyoshi

Open Access Database

Cohort profile: King’s Health Partners bladder cancer biobank

Pinky Kotecha, Charlotte L. Moss, Deborah Enting, Cheryl Gillett, Magdalene Joseph, Debra Josephs, Sarah Rudman, Simon Hughes, Fidelma Cahill, Harriet Wylie, Anna Haire, James Rosekilly, Muhammad Shamin Khan, Rajesh Nair, Ramesh Thurairaja, Sachin Malde, Mieke Van Hemelrijck

Open Access Research article

Clinical value of selected markers of angiogenesis, inflammation, insulin resistance and obesity in type 1 endometrial cancer

Katarzyna M. Terlikowska, Bozena Dobrzycka, Robert Terlikowski, Anna Sienkiewicz, Maciej Kinalski, Slawomir J. Terlikowski

Open Access Research article

Neutrophil-to-lymphocyte ratio is a prognostic factor for colon cancer: a propensity score analysis

Junichi Mazaki, Kenji Katsumata, Kenta Kasahara, Tomoya Tago, Takahiro Wada, Hiroshi Kuwabara, Masanobu Enomoto, Tetsuo Ishizaki, Yuichi Nagakawa, Akihiko Tsuchida

Open Access Research article

Development of the SPARK family member web pages to improve symptom management for pediatric patients receiving cancer treatments

Cody Z. Watling, Clodagh McCarthy, Alexandra Theodorakidis, Sadie Cook, Emily Vettese, Tal Schechter, Hanan Abubeker, L. Lee Dupuis, Lillian Sung

Open Access Research article

Status of kinases in Epstein-Barr virus and Helicobacter pylori Coinfection in gastric Cancer cells

Charu Sonkar, Tarun Verma, Debi Chatterji, Ajay Kumar Jain, Hem Chandra Jha

Open Access Research article

Establishment of multifactor predictive models for the occurrence and progression of cervical intraepithelial neoplasia

Mengjie Chen, He Wang, Yuejuan Liang, Mingmiao Hu, Li Li

Open Access Research article

Reconstruction of lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveals functional lncRNAs in skin cutaneous melanoma

Junyou Zhu, Jin Deng, Lijun Zhang, Jingling Zhao, Fei Zhou, Ning Liu, Ruizhao Cai, Jun Wu, Bin Shu, Shaohai Qi

Open Access Research article

Relationship of possible biomarkers with malignancy of thymic tumors: a meta-analysis

Huilan Zeng, Weilin Yang, Bo Xu, Jianyong Zou, Chunhua Su, Beilong Zhong, Haoshuai Zhu, Zhenguang Chen

Open Access Research article

Metabolic characterization of aggressive breast cancer cells exhibiting invasive phenotype: impact of non-cytotoxic doses of 2-DG on diminishing invasiveness

Mayumi Fujita, Kaori Imadome, Veena Somasundaram, Miki Kawanishi, Kumiko Karasawa, David A. Wink

Open Access Research article

The role of tissue elasticity in the differential diagnosis of benign and malignant breast lesions using shear wave elastography

Hui Yang, Yongyuan Xu, Yanan Zhao, Jing Yin, Zhiyi Chen, Pintong Huang

Open Access Research article

Immunological and clinicopathological characteristics of C1RL in 2120 glioma patients

Junyou Wang, Luqing Tong, Gaojun Lin, Hui Wang, Liang Zhang, Xuejun Yang

Open Access Research article

Clinicopathological features of breast cancer patients with internal mammary and/or supraclavicular lymph node recurrence without distant metastasis

Hitoshi Inari, Natsuki Teruya, Miki Kishi, Rie Horii, Futoshi Akiyama, Shunji Takahashi, Yoshinori Ito, Takayuki Ueno, Takuji Iwase, Shinji Ohno

Open Access Research article

Treatment response lowers tumor symptom burden in recurrent and/or metastatic head and neck cancer

Markus Hecht, Dennis Hahn, Philipp Wolber, Matthias G. Hautmann, Dietmar Reichert, Steffi Weniger, Claus Belka, Tobias Bergmann, Thomas Göhler, Manfred Welslau, Christina Große-Thie, Orlando Guntinas-Lichius, Jens von der Grün, Panagiotis Balermpas, Katrin Orlowski, Diethelm Messinger, Karsten G. Stenzel, Rainer Fietkau

Open Access Research article

Efficacy of breast MRI for surgical decision in patients with breast cancer: ductal carcinoma in situ versus invasive ductal carcinoma

Jeeyeon Lee, Jin Hyang Jung, Wan Wook Kim, Chan Sub Park, Ryu Kyung Lee, Hye Jung Kim, Won Hwa Kim, Ho Yong Park

Open Access Research article

Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: a theranostic study for the precision medicine

Erkhem-Ochir Bilguun, Kyoichi Kaira, Reika Kawabata-Iwakawa, Susumu Rokudai, Kimihiro Shimizu, Takehiko Yokobori, Tetsunari Oyama, Ken Shirabe, Masahiko Nishiyama

Open Access Research article

Acteoside as a potential therapeutic option for primary hepatocellular carcinoma: a preclinical study

Di Ma, Juan Wang, Lu Liu, Meiqi Chen, Zhiyong Wang

Open Access Research article

Pretreatment peripheral neutrophils, lymphocytes and monocytes predict long-term survival in hepatocellular carcinoma

Young Mi Hong, Ki Tae Yoon, Tae Ho Hwang, Mong Cho

Open Access Research article

Establishment and verification of the nomogram that predicts the 3-year recurrence risk of epithelial ovarian carcinoma

Jun Hu, Xiaobing Jiao, Lirong Zhu, Hongyan Guo, Yumei Wu

Open Access Research article

Quantifying the under-estimation of cervical Cancer in remote regions of Tanzania

Mariah P. Gesink, Robert M. Chamberlain, Julius Mwaiselage, Crispin Kahesa, Kahima Jackson, William Mueller, Jane L. Meza, Amr S. Soliman

Open Access Research article

The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia

N. Oosterom, M. Fiocco, R. Q. H. Kloos, I. M. van der Sluis, R. Pieters, B. D. van Zelst, D. E. C. Smith, M. M. van den Heuvel-Eibrink, R. de Jonge, S. G. Heil

Open Access Research article

Tumor quiescence: elevating SOX2 in diverse tumor cell types downregulates a broad spectrum of the cell cycle machinery and inhibits tumor growth

Ethan P. Metz, Erin L. Wuebben, Phillip J. Wilder, Jesse L. Cox, Kaustubh Datta, Donald Coulter, Angie Rizzino

Open Access Research article

Simple calculation using anatomical features on pre-treatment verification CT for bladder volume estimation during radiation therapy for rectal cancer

Nalee Kim, Hong In Yoon, Jin Sung Kim, Woong Sub Koom, Jee Suk Chang, Yoonsun Chung

Open Access Research article

Profiles of autophagy-related genes in esophageal adenocarcinoma

Lei Zhu, Lin Dong, Minghao Feng, Fugui Yang, Wenhao Jiang, Zhiyuan Huang, Fabing Liu, Lingwei Wang, Guangxue Wang, Qinchuan Li

Open Access Research article

Targeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesions

Toshiaki Akahane, Naoki Kanomata, Oi Harada, Tetsumasa Yamashita, Junichi Kurebayashi, Akihide Tanimoto, Takuya Moriya

Open Access Technical advance

Analytical performance evaluation of a commercial next generation sequencing liquid biopsy platform using plasma ctDNA, reference standards, and synthetic serial dilution samples derived from normal plasma

Suman Verma, Mathew W. Moore, Rebecca Ringler, Abhisek Ghosal, Kyle Horvath, Theodore Naef, Sheri Anvari, Philip D. Cotter, Shelly Gunn

Open Access Research article

Clinical outcomes of chemotherapy in patients with undifferentiated carcinoma of the pancreas: a retrospective multicenter cohort study

Hiroshi Imaoka, Masafumi Ikeda, Kosuke Maehara, Kumiko Umemoto, Masato Ozaka, Satoshi Kobayashi, Takeshi Terashima, Hiroto Inoue, Chihiro Sakaguchi, Kunihiro Tsuji, Kazuhiko Shioji, Keiya Okamura, Yasuyuki Kawamoto, Rei Suzuki, Hirofumi Shirakawa, Hiroaki Nagano, Makoto Ueno, Chigusa Morizane, Junji Furuse

Open Access Study protocol

Carbon ion radiotherapy as definitive treatment in non-metastasized pancreatic cancer: study protocol of the prospective phase II PACK-study

Jakob Liermann, Patrick Naumann, Adriane Hommertgen, Moritz Pohl, Meinhard Kieser, Juergen Debus, Klaus Herfarth

Open Access Research article

The psychosocial determinants of quality of life in breast cancer survivors: a scoping review

Michael G. Culbertson, Kathleen Bennett, Catherine M. Kelly, Linda Sharp, Caitriona Cahir

Open Access Research article

Oncogenic miR-20b-5p contributes to malignant behaviors of breast cancer stem cells by bidirectionally regulating CCND1 and E2F1

Liqin Xia, Feng Li, Jun Qiu, Zhongming Feng, Zihan Xu, Zhengtang Chen, Jianguo Sun

Open Access Research article

Clinical characteristics and blood/serum bound prognostic biomarkers in advanced pancreatic cancer treated with gemcitabine and nab-paclitaxel

Hakon Blomstrand, Henrik Green, Mats Fredrikson, Emma Gränsmark, Bergthor Björnsson, Nils O. Elander

Open Access Research article

Genetic diagnostic features after failure of initial treatment with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors among non-small-cell lung cancer patients harboring EGFR mutations

Yuichiro Takeda, Go Naka, Yoh Yamaguchi, Masao Hashimoto, Manabu Suzuki, Shinyu Izumi, Haruhito Sugiyama

Open Access Research article

Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumors

Susan A. Kennedy, Maria E. Morrissey, Margaret R. Dunne, Fiona O’Connell, Clare T. Butler, Mary-Clare Cathcart, Amy M. Buckley, Brian J. Mehigan, John O. Larkin, Paul McCormick, Breandán N. Kennedy, Jacintha O’Sullivan

Open Access Research article

Genetically-regulated transcriptomics & copy number variation of proctitis points to altered mitochondrial and DNA repair mechanisms in individuals of European ancestry

Gita A. Pathak, Renato Polimanti, Talisa K. Silzer, Frank R. Wendt, Ranajit Chakraborty, Nicole R. Phillips

Open Access Research article

In vivo optical cellular diagnosis for uterine cervical or vaginal intraepithelial neoplasia using flexible gastrointestinal endocytoscopy -a prospective pilot study-

Shoko Ono, Ayako Nozaki, Kana Matsuda, Emi Takakuwa, Naoya Sakamoto, Hidemichi Watari

Open Access Research article

National Italian Delphi panel consensus: which measures are indicated to minimize pegylated-asparaginase associated toxicity during treatment of adult acute lymphoblastic leukemia?

Federico Lussana, Paola Minetto, Felicetto Ferrara, Sabina Chiaretti, Giorgina Specchia, Renato Bassan

Open Access Research article

KIAA0101 and UbcH10 interact to regulate non-small cell lung cancer cell proliferation by disrupting the function of the spindle assembly checkpoint

Han Lei, Kun Wang, Tongying Jiang, Jingjing Lu, Xue Dong, Feilong Wang, Qiang Li, Liming Zhao

Open Access Research article

Integrated analysis identifies a pathway-related competing endogenous RNA network in the progression of pancreatic cancer

Fuqiang Zu, Peng Liu, Huaitao Wang, Ting Zhu, Jian Sun, Weiwei Sheng, Xiaodong Tan

Open Access Research article

Application of ultrasound artificial intelligence in the differential diagnosis between benign and malignant breast lesions of BI-RADS 4A

Sihua Niu, Jianhua Huang, Jia Li, Xueling Liu, Dan Wang, Ruifang Zhang, Yingyan Wang, Huiming Shen, Min Qi, Yi Xiao, Mengyao Guan, Haiyan Liu, Diancheng Li, Feifei Liu, Xiuming Wang, Yu Xiong, Siqi Gao, Xue Wang, Jiaan Zhu

Open Access Research article

TIMP-2 regulates proliferation, invasion and STAT3-mediated cancer stem cell-dependent chemoresistance in ovarian cancer cells

Ruth M. Escalona, Maree Bilandzic, Patrick Western, Elif Kadife, George Kannourakis, Jock K. Findlay, Nuzhat Ahmed

Open Access Research article

The relationship between physical activity and lymphoma: a systematic review and meta analysis

Gwynivere A. Davies, Christopher Strader, Richa Chibbar, Stefania Papatheodorou, Adam A. Dmytriw

Open Access Research article

Translating research into practice: outcomes from the Healthy Living after Cancer partnership project

Elizabeth G. Eakin, Marina M. Reeves, Ana D. Goode, Elisabeth A. H. Winkler, Janette L. Vardy, Frances Boyle, Marion R. Haas, Janet E. Hiller, Gita D. Mishra, Michael Jefford, Bogda Koczwara, Christobel M. Saunders, Kathy Chapman, Liz Hing, Anna G. Boltong, Katherine Lane, Polly Baldwin, Lesley Millar, Sandy McKiernan, Wendy Demark-Wahnefried, Kerry S. Courneya, Jennifer Job, Natasha Reid, Erin Robson, Nicole Moretto, Louisa Gordon, Sandra C. Hayes

Open Access Research article

Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer

Gene Chi Wai Man, Jianzhang Wang, Yi Song, Jack Ho Wong, Yu Zhao, Tat San Lau, Kam Tong Leung, Tak Hang Chan, Huating Wang, Joseph Kwong, Tzi Bun Ng, Chi Chiu Wang

Open Access Research article

NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression

Jian Wang, Yamin Zhang, Lei Liu, Zilin Cui, Rui Shi, Jiancun Hou, Zirong Liu, Long Yang, Lianjiang Wang, Yang Li

Open Access Research article

Malignant tumours of temporomandibular joint

Feiluore Yibulayin, Chen-xi Yu, Lei Feng, Meng Wang, Meng-meng Lu, Yuan Luo, Hui Liu, Zhi-cheng Yang, Alimujiang Wushou

Open Access Research article

Prognosis prediction model based on competing endogenous RNAs for recurrence of colon adenocarcinoma

Li Peng Jin, Tao Liu, Fan Qi Meng, Jian Dong Tai

Open Access Research article

Mitochondrial apurinic/apyrimidinic endonuclease 1 enhances mtDNA repair contributing to cell proliferation and mitochondrial integrity in early stages of hepatocellular carcinoma

Veronica Bazzani, Arianna Barchiesi, Dorota Radecka, Riccardo Pravisani, Antonio Guadagno, Carla Di Loreto, Umberto Baccarani, Carlo Vascotto

Open Access Research article

Increased canonical NF-kappaB signaling specifically in macrophages is sufficient to limit tumor progression in syngeneic murine models of ovarian cancer

Alyssa A. Hoover, Demetra H. Hufnagel, Whitney Harris, Kennady Bullock, Evan B. Glass, Esther Liu, Whitney Barham, Marta A. Crispens, Dineo Khabele, Todd D. Giorgio, Andrew J. Wilson, Fiona E. Yull

Open Access Research article

Modelling the lifetime cost-effectiveness of radical prostatectomy, radiotherapy and active monitoring for men with clinically localised prostate cancer from median 10-year outcomes in the ProtecT randomised trial

S. Sanghera, S. Mohiuddin, J. Coast, K. Garfield, S. Noble, C. Metcalfe, J. A. Lane, E. L. Turner, D. Neal, F. C. Hamdy, R. M. Martin, J. L. Donovan, Prasad Bollina, Andrew Doble, Alan Doherty, David Gillatt, Vincent Gnanapragasam, Owen Hughes, Roger Kockelbergh, Howard Kynaston, Alan Paul, Edgar Paez, Edward Rowe

Open Access Research article

Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia

Mario Preti, Stefano Rosso, Leonardo Micheletti, Carola Libero, Irene Sobrato, Livia Giordano, Paola Busso, Niccolò Gallio, Stefano Cosma, Federica Bevilacqua, Chiara Benedetto

Open Access Research article

Impact of pre-OP independence in patients with limited brain metastases on long-term survival

Annalen Bleckmann, Benjamin Kirchner, Manuel Nietert, Micha Peeck, Marko Balkenhol, Daniela Egert, T. Veit Rohde, Tim Beißbarth, Tobias Pukrop

Open Access Research article

Role of a multidisciplinary team in administering radiotherapy for esophageal cancer

Shengguang Zhao, Weixiang Qi, Jiayi Chen

Open Access Study protocol

Feasibility and efficacy of a supervised home-based physical exercise program for metastatic cancer patients receiving oral targeted therapy: study protocol for the phase II/III - UNICANCER SdS 01 QUALIOR trial

Florence Joly, Claudia Lefeuvre-Plesse, Claire Garnier-Tixidre, Carole Helissey, Nathalie Menneveau, Alain Zannetti, Sebastien Salas, Nadine Houede, Sophie Abadie-Lacourtoisie, Laetitia Stefani, Soazig Nenan, Isabelle Rieger, Isabelle Durand-Zaleski, Jean-Marc Descotes, Amélie Anota

Open Access Research article

Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

Jigao Feng, Yibin Ouyang, Dedong Xu, Qinglong He, Dayuan Liu, Xudong Fan, Pengxiang Xu, Yehe Mo

Open Access Research article

Clinical and imaging characteristics of primary hepatic sarcomatoid carcinoma and sarcoma: a comparative study

Dongli Shi, Jun Sun, Liang Ma, Jing Chang, Hongjun Li

Open Access Study protocol

Is hypofractionated whole pelvis radiotherapy (WPRT) as well tolerated as conventionally fractionated WPRT in prostate cancer patients? The HOPE trial

Lucas C. Mendez, Andrew J. Arifin, Glenn S. Bauman, Vikram M. Velker, Belal Ahmad, Michael Lock, Varagur M. Venkatesan, Tracy L. Sexton, George B. Rodrigues, Jeff Chen, Bryan Schaly, Andrew Warner, David P. D’Souza

Open Access Research article

Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients

Kyung Taek Hong, Da Hye Lee, Bo Kyung Kim, Hong Yul An, Jung Yoon Choi, Ji Hoon Phi, Jung-Eun Cheon, Hyoung Jin Kang, Seung-Ki Kim, Joo-Young Kim, Sung-Hye Park, Il Han Kim, Hee Young Shin

Open Access Research article

Integrated analysis of serum lipid profile for predicting clinical outcomes of patients with malignant biliary tumor

Lejia Sun, Xin Ji, Dongyue Wang, Ai Guan, Yao Xiao, Haifeng Xu, Shunda Du, Yiyao Xu, Haitao Zhao, Xin Lu, Xinting Sang, Shouxian Zhong, Huayu Yang, Yilei Mao

Open Access Research article

The prognostic significance of inflammation-based scores in patients with ampullary carcinoma after pancreaticoduodenectomy

Shuxin Sun, Chaobin He, Jun Wang, Xin Huang, Jiali Wu, Shengping Li

Open Access Research article

A nomogram for predicting survival in patients with de novo metastatic breast cancer: a population-based study

Wen Zhao, Lei Wu, Andi Zhao, Mi Zhang, Qi Tian, Yanwei Shen, Fan Wang, Biyuan Wang, Le Wang, Ling Chen, Xiaoai Zhao, Danfeng Dong, Lingxiao Zhang, Jin Yang

Open Access Research article

Cancer in Moroccan elderly: the first multicenter transverse study exploring the sociodemographic characteristics, clinical profile and quality of life of elderly Moroccan cancer patients

Mounia Amzerin, Mohamed Layachi, Aziz Bazine, Rachid Aassab, Samia Arifi, Zineb Benbrahim, Mohamed Reda Khmamouche, Mouna Kairouani, Hanan Raiss, Noura Majid, Saloua Ouaouch, Mohammed Ichou, Said Afqir, Nawfal Mellas, Mohamed Fetohi, Rachid Razine, Hassan Errihani

Open Access Research article

Venetoclax and alvocidib are both cytotoxic to acute myeloid leukemia cells resistant to cytarabine and clofarabine

Rie Nishi, Hiroko Shigemi, Eiju Negoro, Miyuki Okura, Naoko Hosono, Takahiro Yamauchi

Open Access Technical advance

ECCDIA: an interactive web tool for the comprehensive analysis of clinical and survival data of esophageal cancer patients

Jingcheng Yang, Jun Shang, Qian Song, Zuyi Yang, Jianing Chen, Ying Yu, Leming Shi

Open Access Research article

Identification of common signatures in idiopathic pulmonary fibrosis and lung cancer using gene expression modeling

Dong Leng, Jiawen Yi, Maodong Xiang, Hongying Zhao, Yuhui Zhang

Open Access Research article

The Axin2-snail axis promotes bone invasion by activating cancer-associated fibroblasts in oral squamous cell carcinoma

Yin-Zhe An, Eunae Cho, Junqi Ling, Xianglan Zhang

Open Access Research article

Mean platelet volume and platelet distribution width serve as prognostic biomarkers in skull base chordoma: a retrospective study

Mingxuan Li, Jiwei Bai, Shuai Wang, Yixuan Zhai, Shuheng Zhang, Chuzhong Li, Jiang Du, Yazhuo Zhang

Open Access Research article

Relationship between formulaic breast volume and risk of breast cancer based on linear measurements

Xiaoxia Li, Chunlan Zhou, Yanni Wu, Xiaohong Chen

Open Access Research article

Cost-effectiveness analysis of fruquintinib for metastatic colorectal cancer third-line treatment in China

Zhi Peng, Xingduo Hou, Yangmu Huang, Tong Xie, Xinyang Hua

Open Access Research article

Impact of concomitant systemic treatments on toxicity and intracerebral response after stereotactic radiotherapy for brain metastases

Morgan Guénolé, François Lucia, Vincent Bourbonne, Gurvan Dissaux, Emmanuelle Reygagne, Gaëlle Goasduff, Olivier Pradier, Ulrike Schick

Open Access Research article

Cost-effectiveness of brentuximab vedotin in advanced stage Hodgkin’s lymphoma: a probabilistic analysis

A. J. N. Raymakers, S. Costa, D. Cameron, D. A. Regier

Open Access Research article

A novel nomogram to predict the overall survival in esthesinoeroblastoma

Lijie Jiang, Tengjiao Lin, Yu Zhang, Wenxiang Gao, Jie Deng, Zhaofeng Xu, Xin Luo, Zhaoqi Huang, Fenghong Chen, Jianbo Shi, Yinyan Lai

Open Access Research article

Clinical characteristics and prognostic implications of BRCA-associated tumors in males: a pan-tumor survey

Peng Sun, Yue Li, Xue Chao, Jibin Li, Rongzhen Luo, Mei Li, Jiehua He

Open Access Research article

Limb salvage versus amputation in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database

Daniel R. Evans, Alexander L. Lazarides, Julia D. Visgauss, Jason A. Somarelli, Dan G. Blazer III, Brian E. Brigman, William C. Eward

Open Access Research article

YB-1 transferred by gastric cancer exosomes promotes angiogenesis via enhancing the expression of angiogenic factors in vascular endothelial cells

Xiaoxia Xue, Jin Huang, Kai Yu, Xinyue Chen, Yini He, Dianjun Qi, Ying Wu

Open Access Research article

Analyses of the local control of pulmonary Oligometastases after stereotactic body radiotherapy and the impact of local control on survival

Takaya Yamamoto, Yuzuru Niibe, Masahiko Aoki, Takashi Shintani, Kazunari Yamada, Mitsuru Kobayashi, Hideomi Yamashita, Masatoki Ozaki, Yoshihiko Manabe, Hiroshi Onishi, Katsuya Yahara, Atsushi Nishikawa, Kuniaki Katsui, Ryoong-Jin Oh, Atsuro Terahara, Keiichi Jingu

Open Access Research article

USP6NL mediated by LINC00689/miR-142-3p promotes the development of triple-negative breast cancer

Teng Ma, Huaidong Liu, Yan Liu, Tingting Liu, Hui Wang, Fulu Qiao, Lu Song, Lin Zhang

Open Access Research article

Analysis of the role of the human papillomavirus 16/18 E7 protein assay in screening for cervical intraepithelial neoplasia: a case control study

Linghua Kong, Xiaoping Xiao, Huiping Lou, Pengfei Liu, Shuhui Song, Moudu Liu, Tao Xu, Ying Zhang, Caijuan Li, Ruoli Guan, Yan Li, Xin Yu, Haiyuan Liu, Qingbo Fan, Honghui Shi, Lan Zhu

Open Access Research article

Detection of MCM5 as a novel non-invasive aid for the diagnosis of endometrial and ovarian tumours

J. Stockley, R. Akhand, A. Kennedy, C. Nyberg, E. J. Crosbie, R. J. Edmondson

Open Access Research article

CKD-5, a novel pan-histone deacetylase inhibitor, synergistically enhances the efficacy of sorafenib for hepatocellular carcinoma

Young Chang, Yun Bin Lee, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon

Open Access Research article

Effect of sarcopenia on short- and long-term outcomes in patients with gastric neuroendocrine neoplasms after radical gastrectomy: results from a large, two-institution series

Jia-bin Wang, Zhen Xue, Jun Lu, Qing-liang He, Zhi-fang Zheng, Bin-bin Xu, Jian-wei Xie, Ping Li, Yu Xu, Jian-xian Lin, Qi-yue Chen, Long-long Cao, Mi Lin, Ru-hong Tu, Ze-ning Huang, Ju-li Lin, Chang-ming Huang, Chao-hui Zheng

Open Access Research article

Biomarker exploration of microRNA-203 as a promising substrate for predicting poor survival outcome in colorectal cancer

Qiliang Peng, Yi Shen, Peifeng Zhao, Shang Cai, Zhengyang Feng, Ming Cheng, Yongyou Wu, Yaqun Zhu

Open Access Research article

Impact of pre-existing cardiovascular disease on treatment patterns and survival outcomes in patients with lung cancer

Atul Batra, Dropen Sheka, Shiying Kong, Winson Y. Cheung

Open Access Research article

CircRNAs as potential biomarkers for the clinicopathology and prognosis of glioma patients: a meta-analysis

Xiangqian Ding, Luyao Yang, Xin Geng, Yanghong Zou, Zhigang Wang, Yao Li, Renli Qi, Wei Wang, Jinghui Li, Hualin Yu

Open Access Research article

Role of circulating free DNA in evaluating clinical tumor burden and predicting survival in Chinese metastatic colorectal cancer patients

Xiaojing Xu, Yiyi Yu, Minna Shen, Mengling Liu, Shengchao Wu, Li Liang, Fei Huang, Chenlu Zhang, Wei Guo, Tianshu Liu

Open Access Research article

Inducing multiple antibodies to treat squamous cell esophageal carcinoma

Isamu Hoshino, Yoshihiro Nabeya, Nobuhiro Takiguchi, Hisashi Gunji, Fumitaka Ishige, Yosuke Iwatate, Akiko Kuwajima, Fumiaki Shiratori, Rei Okada, Hideaki Shimada

Open Access Research article

Ovarian cancer cells direct monocyte differentiation through a non-canonical pathway

Kaitlin C. Fogg, Andrew E. Miller, Ying Li, Will Flanigan, Alyssa Walker, Andrea O’Shea, Christina Kendziorski, Pamela K. Kreeger

Open Access Research article

A Swedish Nationwide prospective study of oncological and reproductive outcome following fertility-sparing surgery for treatment of early stage epithelial ovarian cancer in young women

Gry Johansen, Pernilla Dahm-Kähler, Christian Staf, Angelique Flöter Rådestad, Kenny A. Rodriguez-Wallberg

Open Access Research article

Presence of dynapenia and association with anthropometric variables in cancer patients

Ana Beatriz Rechinelli, Isabele Lessa Marques, Eduarda Cristina Rodrigues de Morais Viana, Isadora da Silva Oliveira, Vanusa Felício de Souza, Glenda Blaser Petarli, Jose Luiz Marques Rocha, Valdete Regina Guandalini

Open Access Research article

Seeking healthcare at their ‘right’ time; the iterative decision process for women with breast cancer

Anita Eseenam Agbeko, Joshua Arthur, Jonathan Bayuo, Basil Benduri Kaburi, Ishmael Kyei

Open Access Research article

Discovering the molecular differences between right- and left-sided colon cancer using machine learning methods

Yimei Jiang, Xiaowei Yan, Kun Liu, Yiqing Shi, Changgang Wang, Jiele Hu, You Li, Qinghua Wu, Ming Xiang, Ren Zhao

Open Access Research article

Longitudinal changes in sports activity from pre-diagnosis to first five years post-diagnosis: a prospective Chinese breast cancer cohort study

Yuan-Yuan Lei, Suzanne C. Ho, Carol Kwok, Ashley Cheng, Ka Li Cheung, Roselle Lee, Winnie Yeo

Open Access Research article

Established fibrous peritoneal metastasis in an immunocompetent mouse model similar to clinical immune microenvironment of gastric cancer

Daisuke Fujimori, Jun Kinoshita, Takahisa Yamaguchi, Yusuke Nakamura, Katsuya Gunjigake, Takashi Ohama, Koichi Sato, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Tetsuo Ohta, Sachio Fushida

Open Access Technical advance

An immunochemistry-based screen for chemical inhibitors of DNA-protein interactions and its application to human CGGBP1

Manthan Patel, Divyesh Patel, Subhamoy Datta, Umashankar Singh

Open Access Research article

Improved personalized survival prediction of patients with diffuse large B-cell Lymphoma using gene expression profiling

Adrián Mosquera Orgueira, José Ángel Díaz Arias, Miguel Cid López, Andrés Peleteiro Raíndo, Beatriz Antelo Rodríguez, Carlos Aliste Santos, Natalia Alonso Vence, Ángeles Bendaña López, Aitor Abuín Blanco, Laura Bao Pérez, Marta Sonia González Pérez, Manuel Mateo Pérez Encinas, Máximo Francisco Fraga Rodríguez, José Luis Bello López

Open Access Research article

The association between immune-related adverse events and survival outcomes in Asian patients with advanced melanoma receiving anti-PD-1 antibodies

Chiao-En Wu, Chan-Keng Yang, Meng-Ting Peng, Pei-Wei Huang, Ching-Fu Chang, Kun-Yun Yeh, Chun-Bing Chen, Chih-Liang Wang, Chao-Wei Hsu, I-Wen Chen, Cheng-Tao Lin, Shir-Hwa Ueng, Gigin Lin, Yu-Fen Lin, Chi-Yuan Cheng, John Wen-Cheng Chang

Open Access Research article

microRNA-451a promoter methylation regulated by DNMT3B expedites bladder cancer development via the EPHA2/PI3K/AKT axis

Beibei Liu, Wei Sun, Wuyue Gao, Liqiang Li, Zhenxue Cao, Xiaohuai Yang, Jianmin Liu, Yuanyuan Guo

Open Access Research article

Cell type-specific genotoxicity in estrogen-exposed ovarian and fallopian epithelium

Liang Song, Zizhi Tang, Changsheng Peng, Yueming Yang, Chang Guo, Danqing Wang, Liandi Guo, Jie Chen, Cong Liu

Open Access Research article

Artificial neural networks improve LDCT lung cancer screening: a comparative validation study

Yin-Chen Hsu, Yuan-Hsiung Tsai, Hsu-Huei Weng, Li-Sheng Hsu, Ying-Huang Tsai, Yu-Ching Lin, Ming-Szu Hung, Yu-Hung Fang, Chien-Wei Chen

Open Access Research article

Pharmacodynamic modeling of synergistic birinapant/paclitaxel interactions in pancreatic cancer cells

Jin Niu, Xue Wang, Jun Qu, Donald E. Mager, Robert M. Straubinger

Open Access Research article

14-type HPV mRNA test in triage of HPV DNA-positive postmenopausal women with normal cytology

Katrin Christine Asciutto, Christer Borgfeldt, Ola Forslund

Open Access Research article

Circular RNA hsa_circ_0000282 contributes to osteosarcoma cell proliferation by regulating miR-192/XIAP axis

Houkun Li, Limin He, Yuan Tuo, Yansheng Huang, Bing Qian

Open Access Correction

Correction to: Analysis of the role of the human papillomavirus 16/18 E7 protein assay in screening for cervical intraepithelial neoplasia: a case control study

Linghua Kong, Xiaoping Xiao, Huiping Lou, Pengfei Liu, Shuhui Song, Moudu Liu, Tao Xu, Ying Zhang, Caijuan Li, Ruoli Guan, Yan Li, Xin Yu, Haiyuan Liu, Qingbo Fan, Honghui Shi, Lan Zhu

Open Access Research article

miR-203 inhibits cell proliferation and ERK pathway in prostate cancer by targeting IRS-1

Yang Meng, Xiaoyan Hu, Shasha Li, Xinyi Zeng, Lei Qiu, Mingtian Wei, Ziqing Wang, Junhong Han

Open Access Research article

Upregulation of miR-205 induces CHN1 expression, which is associated with the aggressive behaviour of cervical cancer cells and correlated with lymph node metastasis

Jianbing Liu, Yunfeng Li, Xihua Chen, Xiangbo Xu, Haoqi Zhao, Shufang Wang, Jianqing Hao, Bin He, Shuyan Liu, Jiedong Wang

Open Access Research article

An integrated autophagy-related gene signature predicts prognosis in human endometrial Cancer

Jun Zhang, Ziwei Wang, Rong Zhao, Lanfen An, Xing Zhou, Yingchao Zhao, Hongbo Wang

Open Access Research article

Assessing how health information needs of individuals with colorectal cancer are met across the care continuum: an international cross-sectional survey

Hallie Dau, Abdollah Safari, Khalid Saad El Din, Helen McTaggart-Cowan, Jonathan M. Loree, Sharlene Gill, Mary A. De Vera

Open Access Research article

High expression of fibroblast activation protein (FAP) predicts poor outcome in high-grade serous ovarian cancer

Min Li, Xue Cheng, Rong Rong, Yan Gao, Xiuwu Tang, Youguo Chen

Open Access Research article

Is it the time to implement the routine use of distress thermometer among Egyptian patients with newly diagnosed cancer?

Nashwa Abd El-Aziz, Salah Khallaf, Waleed Abozaid, Ghada Elgohary, Ola Abd El-Fattah, Mai Alhawari, Safaa Khaled, Azza AbdelHaffez, Ehab Kamel, Sherif Mohamed

Open Access Research article

Integrated genomic and transcriptomic analysis revealed mutation patterns of de-differentiated liposarcoma and leiomyosarcoma

Wenshuai Liu, Hanxing Tong, Chenlu Zhang, Rongyuan Zhuang, He Guo, Chentao Lv, Hua Yang, Qiaowei Lin, Xi Guo, Zhiming Wang, Yan Wang, Feng Shen, Shengzhou Wang, Chun Dai, Guan Wang, Jun Liu, Weiqi Lu, Yong Zhang, Yuhong Zhou

Open Access Research article

Increased E2F2 predicts poor prognosis in patients with HCC based on TCGA data

Zhili Zeng, Zebiao Cao, Ying Tang

Open Access Research article

The majority of β-catenin mutations in colorectal cancer is homozygous

Alexander Arnold, Moritz Tronser, Christine Sers, Aysel Ahadova, Volker Endris, Soulafa Mamlouk, David Horst, Markus Möbs, Philip Bischoff, Matthias Kloor, Hendrik Bläker

Open Access Research article

Determining the effects of trastuzumab, cetuximab and afatinib by phosphoprotein, gene expression and phenotypic analysis in gastric cancer cell lines

Karolin Ebert, Gwen Zwingenberger, Elena Barbaria, Simone Keller, Corinna Heck, Rouven Arnold, Vanessa Hollerieth, Julian Mattes, Robert Geffers, Elba Raimúndez, Jan Hasenauer, Birgit Luber

Open Access COVID-19 Research article

Collateral effects of the coronavirus disease 2019 pandemic on lung cancer diagnosis in Korea

Ji Young Park, Ye Jin Lee, Taehee Kim, Chang Youl Lee, Hwan Il Kim, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Ki-Suck Jung, Seung Hun Jang

Open Access Research article

Overexpression of OCT-1 gene is a biomarker of adverse prognosis for diffuse large B-cell lymphoma (DLBCL): data from a retrospective cohort of 77 Brazilian patients

Gisele R. Gouveia, Suzete C. Ferreira, Sheila A. C. Siqueira, Luis Alberto de Pádua Covas Lage, Abrahão E. Hallack Neto, Renata de Oliveira Costa, Juliana Pereira

Open Access Study protocol

The efficacy of aspirin and metformin combination therapy in patients with rectal aberrant crypt foci: a double-blinded randomized controlled trial

Takuma Higurashi, Jun Arimoto, Keiichi Ashikari, Tomohiro Takatsu, Noboru Misawa, Tsutomu Yoshihara, Tetsuya Matsuura, Akiko Fuyuki, Hidenori Ohkubo, Atsushi Nakajima

Open Access Research article

Development and external validation of a nomogram for predicting the effect of tumor size on survival of patients with perihilar cholangiocarcinoma

Yaodong Zhang, Zhengshan Wu, Xing Wang, Changxian Li, Jiang Chang, Wangjie Jiang, Hongwei Wang, Yirui Wang, Xiangcheng Li

Open Access Study protocol

Randomised prospective phase II trial in multiple brain metastases comparing outcomes between hippocampal avoidance whole brain radiotherapy with or without simultaneous integrated boost: HA-SIB-WBRT study protocol

Brendan Seng Hup Chia, Jing Yun Leong, Ashley Li Kuan Ong, Cindy Lim, Shi Hui Poon, Melvin Lee Kiang Chua, Kevin Lee Min Chua, Grace Kusumawidjaja, Eu Tiong Chua, Fuh Yong Wong, Tih Shih Lee

Open Access Research article

A gene-based survival score for lung adenocarcinoma by multiple transcriptional datasets analysis

Yanlu Xiong, Jie Lei, Jinbo Zhao, Qiang Lu, Yangbo Feng, Tianyun Qiao, Shaowei Xin, Yong Han, Tao Jiang

Open Access Research article

Preoperative circulating tumor cells to predict microvascular invasion and dynamical detection indicate the prognosis of hepatocellular carcinoma

Jiangmin Zhou, Zhiwei Zhang, Honghao Zhou, Chao Leng, Bingwu Hou, Chenyang Zhou, Xinsheng Hu, Jinlin Wang, Xiaoping Chen

Open Access Research article

Epigenome-wide DNA methylation and risk of breast cancer: a systematic review

Kaoutar Ennour-Idrissi, Dzevka Dragic, Francine Durocher, Caroline Diorio

Open Access Research article

Diagnostic value of serum HER2 levels in breast cancer: a systematic review and meta-analysis

Amir Shamshirian, Amir Reza Aref, George W. Yip, Majid Ebrahimi Warkiani, Keyvan Heydari, Sajad Razavi Bazaz, Zeinab Hamzehgardeshi, Danial Shamshirian, Mahmood Moosazadeh, Reza Alizadeh-Navaei

Open Access Research article

Health-related quality of life in patients with inoperable malignant bowel obstruction: secondary outcome from a double-blind, parallel, placebo-controlled randomised trial of octreotide

Nikki McCaffrey, Tegan Asser, Belinda Fazekas, Wendy Muircroft, Meera Agar, Katherine Clark, Simon Eckermann, Jessica Lee, Rohit Joshi, Peter Allcroft, Caitlin Sheehan, David C. Currow

Open Access Research article

Prognostic role of vitamin D receptor in breast cancer: a systematic review and meta-analysis

Haiyan Xu, Zhenhua Liu, Hongtai Shi, Chunbin Wang

Open Access Research article

Prediction of prognostic signatures in triple-negative breast cancer based on the differential expression analysis via NanoString nCounter immune panel

Gyeong Back Lim, Young-Ae Kim, Jeong-Han Seo, Hee Jin Lee, Gyungyub Gong, Sung Hee Park

Open Access Research article

Mutation screening of germline TP53 mutations in high-risk Chinese breast cancer patients

Ava Kwong, Vivian Yvonne Shin, Cecilia Y. S. Ho, Chun Hang Au, Thomas P. Slavin, Jeffrey N. Weitzel, Tsun-Leung Chan, Edmond S. K. Ma

Open Access Research article

Differences in clinical characteristics and tumor prognosis between primary and secondary conventional pelvic chondrosarcoma

Jie Zang, Wei Guo, Rongli Yang, Xiaodong Tang, Haijie Liang

Open Access Research article

Novel nomogram to predict risk of bone metastasis in newly diagnosed thyroid carcinoma: a population-based study

Yuexin Tong, Chuan Hu, Zhangheng Huang, Zhiyi Fan, Lujian Zhu, Youxin Song

Open Access Study protocol

The study protocol of the evaluation for the preventive efficacy of the HPV vaccine for persistent HPV16/18 infection in Japanese adult women: the HAKUOH study

Tetsuji Kurokawa, Makoto Yamamoto, Toshimichi Onuma, Hideaki Tsuyoshi, Akiko Shinagawa, Yoko Chino, Yoshio Yoshida

Open Access Research article

Anti-tumor efficacy of CKD-516 in combination with radiation in xenograft mouse model of lung squamous cell carcinoma

Min-Young Kim, Jung-Young Shin, Jeong-Oh Kim, Kyoung-Hwa Son, Yeon Sil Kim, Chan Kwon Jung, Jin-Hyoung Kang

Open Access Review

Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review

Lianwei Wang, Dengyang Fang, Jinming Xu, Runlan Luo

Open Access Research article

Intraventricular neuroepithelial tumors: surgical outcome, technical considerations and review of literature

A. Kaywan Aftahy, Melanie Barz, Philipp Krauss, Friederike Liesche, Benedikt Wiestler, Stephanie E. Combs, Christoph Straube, Bernhard Meyer, Jens Gempt

Open Access Research article

High proportion of anergic B cells in the bone marrow defined phenotypically by CD21(−/low)/CD38- expression predicts poor survival in diffuse large B cell lymphoma

Sewa Rijal, Johanna Kok, Caitlin Coombes, Lillian Smyth, Jayde Hourigan, Sanjiv Jain, Dipti Talaulikar

Open Access Research article

Identification of ALDH3A2 as a novel prognostic biomarker in gastric adenocarcinoma using integrated bioinformatics analysis

Zhenhua Yin, Dejun Wu, Jianping Shi, Xiyi Wei, Nuyun Jin, Xiaolan Lu, Xiaohan Ren

Open Access Research article

RX-5902, a novel β-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer

John J. Tentler, Julie Lang, Anna Capasso, Deog Joong Kim, Ely Benaim, Young B. Lee, Andrew Eisen, Stacey M. Bagby, Sarah J. Hartman, Betelehem W. Yacob, Brian Gittleman, Todd M. Pitts, Roberta Pelanda, S. Gail Eckhardt, Jennifer R. Diamond

Open Access Research article

Over-expression of ANP32E is associated with poor prognosis of pancreatic cancer and promotes cell proliferation and migration through regulating β-catenin

Jianwei Zhang, Zhongmin Lan, Guotong Qiu, Hu Ren, Yajie Zhao, Zongting Gu, Zongze Li, Lin Feng, Jin He, Chengfeng Wang

Open Access Research article

Development and validation of a nomogram to predict overall survival for patients with metastatic renal cell carcinoma

Wenwen Zheng, Weiwei Zhu, Shengqiang Yu, Kangqi Li, Yuexia Ding, Qingna Wu, Qiling Tang, Quan Zhao, Congxiao Lu, Chenyu Guo

Open Access Research article

Retrospective analysis of LNM risk factors and the effect of chemotherapy in early colorectal cancer: A Chinese multicenter study

Chunyan Zeng, Dandan Xiong, Fei Cheng, Qingtian Luo, Qiang Wang, Jun Huang, Guilian Lan, Huan Zhong, Youxiang Chen

Open Access Research article

Phase II study of sequential S-1 and cyclophosphamide therapy in patients with metastatic breast cancer

Keiko Yanai, Takaaki Fujii, Jun Horiguchi, Yuko Nakazawa, Sasagu Kurozumi, Sayaka Obayashi, Reina Yajima, Ken Shirabe

Open Access Research article

Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil

Larissa B. Reis, Renato M. Bakos, Fernanda S. L. Vianna, Gabriel S. Macedo, Vanessa C. Jacovas, André M. Ribeiro-dos-Santos, Sidney Santos, Lúcio Bakos, Patricia Ashton-Prolla

Open Access Research article

Effectiveness of clinical breast examination as a ‘stand-alone’ screening modality: an overview of systematic reviews

Tran Thu Ngan, Nga T. Q. Nguyen, Hoang Van Minh, Michael Donnelly, Ciaran O’Neill

Open Access Research article

Establishment of an immune-related gene pair model to predict colon adenocarcinoma prognosis

Jihang Luo, Puyu Liu, Leibo Wang, Yi Huang, Yuanyan Wang, Wenjing Geng, Duo Chen, Yuju Bai, Ze Yang

Open Access Research article

A nuclear transport-related gene signature combined with IDH mutation and 1p/19q codeletion better predicts the prognosis of glioma patients

Zheng Zhu, Yang Lan, Lihong Wang, Jia Ge, Jiao Wang, Feng Liu, Zhicheng He, Hua Zhang, Min Luo, Dandan Lin, Yaoyao Tan, Yuanyuan Xu, Tao Luo

Open Access Research article

Prediction of the clinicopathological subtypes of breast cancer using a fisher discriminant analysis model based on radiomic features of diffusion-weighted MRI

Ming Ni, Xiaoming Zhou, Jingwei Liu, Haiyang Yu, Yuanxiang Gao, Xuexi Zhang, Zhiming Li

Open Access Study protocol

Efficacy and efficiency of a new therapeutic approach based on activity-oriented proprioceptive antiedema therapy (TAPA) for edema reduction and improved occupational performance in the rehabilitation of breast cancer-related arm lymphedema in women: a controlled, randomized clinical trial

María Nieves Muñoz-Alcaraz, Luis Ángel Pérula-de-Torres, Jesús Serrano-Merino, Antonio José Jiménez-Vílchez, María Victoria Olmo-Carmona, María Teresa Muñoz-García, Cruz Bartolomé-Moreno, Bárbara Oliván-Blázquez, Rosa Magallón-Botaya

Open Access Research article

Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer

Mark S. Williams, Naseer J. Basma, Fabio M. R. Amaral, Gillian Williams, John P. Weightman, Wolfgang Breitwieser, Louisa Nelson, Stephen S. Taylor, Daniel H. Wiseman, Tim C. P. Somervaille

Open Access Research article

EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer

Alexander Ring, Pushpinder Kaur, Julie E. Lang

Open Access Research article

Long-term trends in colorectal cancer: incidence, localization, and presentation

Øystein Høydahl, Tom-Harald Edna, Athanasios Xanthoulis, Stian Lydersen, Birger Henning Endreseth

Open Access Research article

Factors associated with breast cancer awareness and breast self-examination in Fiji and Kashmir India – a cross-sectional study

Rukaiya Malik, Numa Vera, Chandra Dayal, Abhay Choudhari, Jyotishna Mudaliar, Amanda Noovao Hill, Ilisapeci Kubuabola, Ronny Gunnarsson

Open Access Research article

Combination of phenotype and polygenic risk score in breast cancer risk evaluation in the Spanish population: a case –control study

J. C. Triviño, A. Ceba, E. Rubio-Solsona, D. Serra, I. Sanchez-Guiu, G. Ribas, R. Rosa, M. Cabo, L. Bernad, G. Pita, A. Gonzalez-Neira, G. Legarda, J. L. Diaz, A. García-Vigara, A. Martínez-Aspas, M. Escrig, B. Bermejo, P. Eroles, J. Ibáñez, D. Salas, A. Julve, A. Cano, A. Lluch, R. Miñambres, J. Benitez

Open Access Research article

Presentation of breast cancer, help seeking behaviour and experience of patients in their cancer journey in Singapore: a qualitative study

Celene W. Q. Ng, Jennifer N. W. Lim, Jenny Liu, Mikael Hartman

Open Access Research article

Clinicopathological features, risk and survival in lung cancer survivors with therapy-related acute myeloid leukaemia

Huabin Wang, Yin Yin, Ru Wang, Junbin Huang, Hongman Xue, Yucai Cheng, Lidan Zhang, Chun Chen

Open Access Research article

Shortwave infrared emitting multicolored nanoprobes for biomarker-specific cancer imaging in vivo

Harini Kantamneni, Shravani Barkund, Michael Donzanti, Daniel Martin, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Mark C. Pierce, Charles M. Roth, Vidya Ganapathy, Prabhas V. Moghe

Open Access Research article

B7-H6, an immunoligand for the natural killer cell activating receptor NKp30, reveals inhibitory effects on cell proliferation and migration, but not apoptosis, in cervical cancer derived-cell lines

Nehla Banu, Annie Riera-Leal, Jesse Haramati, Pablo Cesar Ortiz-Lazareno, Sandeep Surendra Panikar, Blanca Estela Bastidas-Ramirez, Gloria Yareli Gutierrez-Silerio, Fabiola Solorzano-Ibarra, Martha Cecilia Tellez-Bañuelos, Jorge Gutierrez-Franco, Miriam Ruth Bueno-Topete, Ana Laura Pereira-Suarez, Susana del Toro-Arreola

Open Access Research article

Development, validation and effectiveness of diagnostic prediction tools for colorectal cancer in primary care: a systematic review

Bogdan Grigore, Ruth Lewis, Jaime Peters, Sophie Robinson, Christopher J. Hyde

Open Access Research article

Functional and clinical significance of ROR1 in lung adenocarcinoma

Giovanna Schiavone, Samantha Epistolio, Vittoria Martin, Francesca Molinari, Jessica Barizzi, Luca Mazzucchelli, Milo Frattini, Luciano Wannesson

Open Access Research article

Western influenced lifestyle and Kv2.1 association as predicted biomarkers for Tunisian colorectal cancer

Mouadh Barbirou, Henok G. Woldu, Ikram Sghaier, Sinda A. Bedoui, Amina Mokrani, Radhia Aami, Amel Mezlini, Besma Yacoubi-Loueslati, Peter J. Tonellato, Balkiss Bouhaouala-Zahar

Open Access Research article

Frontline treatment patterns and attrition rates by subsequent lines of therapy in patients with newly diagnosed multiple myeloma

Rafael Fonseca, Saad Z. Usmani, Maneesha Mehra, Mary Slavcev, Jianming He, Sarah Cote, Annette Lam, Jon Ukropec, Eric M. Maiese, Sandhya Nair, Ravi Potluri, Peter M. Voorhees

Open Access Review

Improving outcomes after autologous transplantation in relapsed/refractory Hodgkin lymphoma: a European expert perspective

Anna Sureda, Marc André, Peter Borchmann, Maria G. da Silva, Christian Gisselbrecht, Theodoros P. Vassilakopoulos, Pier Luigi Zinzani, Jan Walewski

Open Access Research article

Clinical study of systemic chemotherapy combined with bronchoscopic interventional cryotherapy in the treatment of lung cancer

Feng Xu, Jian Song, Beizheng Xu, Jiang Wang, Jianjun Mao, Haiyan Liu, Xuanmei Li, Aibing Deng

Open Access Research article

5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts

Vilma Dembitz, Hrvoje Lalic, Ivan Kodvanj, Barbara Tomic, Josip Batinic, Klara Dubravcic, Drago Batinic, Antonio Bedalov, Dora Visnjic

Open Access Research article

Heregulin (HRG) assessment for clinical trial eligibility testing in a molecular registry (PRAEGNANT) in Germany

Hanna Huebner, Christian M. Kurbacher, Geoffrey Kuesters, Andreas D. Hartkopf, Michael P. Lux, Jens Huober, Bernhard Volz, Florin-Andrei Taran, Friedrich Overkamp, Hans Tesch, Lothar Häberle, Diana Lüftner, Markus Wallwiener, Volkmar Müller, Matthias W. Beckmann, Erik Belleville, Matthias Ruebner, Michael Untch, Peter A. Fasching, Wolfgang Janni, Tanja N. Fehm, Hans-Christian Kolberg, Diethelm Wallwiener, Sara Y. Brucker, Andreas Schneeweiss, Johannes Ettl

Open Access Research article

Nutritional and inflammatory measures predict survival of patients with stage IV colorectal cancer

Yasuyuki Takamizawa, Dai Shida, Narikazu Boku, Yuya Nakamura, Yuka Ahiko, Takefumi Yoshida, Taro Tanabe, Atsuo Takashima, Yukihide Kanemitsu

Open Access Research article

A meta-analysis of BRF2 as a prognostic biomarker in invasive breast carcinoma

Stephanie Cabarcas-Petroski, Patricio I. Meneses, Laura Schramm

Open Access Research article

Efficacy of EUS-guided FNB using a Franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesions

Mitsuru Sugimoto, Hiroki Irie, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Mika Takasumi, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Yasuyuki Kobayashi, Yuko Hashimoto, Takuto Hikichi, Hiromasa Ohira

Open Access Research article

A novel prognostic model predicting the long-term cancer-specific survival for patients with hypopharyngeal squamous cell carcinoma

Xin Tang, Tong Pang, Wei-feng Yan, Wen-lei Qian, You-ling Gong, Zhi-gang Yang

Open Access Research article

Patterns of breast, prostate and cervical cancer incidence and mortality in Colombia: an administrative registry data analysis

Juliana Alexandra Hernández Vargas, Paula Ximena Ramírez Barbosa, Ana Milena Gil Quijano, Ana María Valbuena, Lizbeth Acuña, Jaime Alberto González

Open Access Research article

The value of haematological parameters and serum tumour markers for predicting KRAS mutations in 784 Chinese colorectal cancer patients: a retrospective analysis

Yinghao Cao, Junnan Gu, Lizhao Yan, Shenghe Deng, Fuwei Mao, Wentai Cai, Hang Li, Xinghua Liu, Jiliang Wang, Ke Wu, Kailin Cai

Open Access Research article

Preoperative AminoIndex Cancer Screening (AICS) abnormalities predict postoperative recurrence in patients undergoing curative resection for non-small cell lung cancer

Masahiko Higashiyama, Ryohei Miyazaki, Hiroshi Yamamoto, Takashi Anayama, Shinya Kikuchi, Kentaro Hirohashi, Jiro Okami, Tomohiro Maniwa, Toru Kimura, Kazumasa Orihashi, Fumio Imamura

Open Access Research article

Breast and cervical cancer screening services in Malawi: a systematic review

Chiara Pittalis, Emily Panteli, Erik Schouten, Irene Magongwa, Jakub Gajewski

Open Access Research article

Development and utility assessment of a machine learning bloodstream infection classifier in pediatric patients receiving cancer treatments

Lillian Sung, Conor Corbin, Ethan Steinberg, Emily Vettese, Aaron Campigotto, Loreto Lecce, George A. Tomlinson, Nigam Shah

Open Access Research article

Recent epidemiology of patients with gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NEN) in Japan: a population-based study

Toshihiko Masui, Tetsuhide Ito, Izumi Komoto, Shinji Uemoto

Open Access Research article

Phase 2 study of lenvatinib monotherapy as second-line treatment in unresectable biliary tract cancer: primary analysis results

Makoto Ueno, Masafumi Ikeda, Takashi Sasaki, Fumio Nagashima, Nobumasa Mizuno, Satoshi Shimizu, Hiroki Ikezawa, Nozomi Hayata, Ryo Nakajima, Chigusa Morizane

Open Access Research article

Utility of 18F-FDG PET/CT for predicting pathologic complete response in hormone receptor-positive, HER2-negative breast cancer patients receiving neoadjuvant chemotherapy

In Hee Lee, Soo Jung Lee, Jeeyeon Lee, Jin Hyang Jung, Ho Yong Park, Shin Young Jeong, Sang-woo Lee, Yee Soo Chae

Open Access Research article

Cytokeratin-positive cells in the bone marrow from patients with pancreatic, periampullary malignancy and benign pancreatic disease show no prognostic information

Harald Hugenschmidt, Knut Jørgen Labori, Cathrine Brunborg, Caroline Sophie Verbeke, Lars Thomas Seeberg, Cecilie Bendigtsen Schirmer, Anne Renolen, Elin Borgen, Bjørn Naume, Gro Wiedswang

Open Access Research article

A Bibliometric analysis of folate receptor research

Cari A. Didion, Walter A. Henne

Open Access Research article

Prevalence of gastric cancer precursors in gastroscopy-screened adults by family history of gastric cancer and of cancers other than gastric

Rui Wu, Cheng Yang, Lin Ji, Zhi-Ning Fan, Yu-Wen Tao, Qiang Zhan

Open Access Research article

Retrospective cohort study of nanoparticle albumin-bound paclitaxel plus ramucirumab versus paclitaxel plus ramucirumab as second-line treatment in patients with advanced gastric cancer

Mashiro Okunaka, Daisuke Kotani, Ken Demachi, Akihito Kawazoe, Takayuki Yoshino, Toshikatsu Kawasaki, Kohei Shitara

Open Access Research article

Accumulation of the delivered dose based on cone-beam CT and deformable image registration for non-small cell lung cancer treated with hypofractionated radiotherapy

Bin Wang, Da Quan Wang, Mao Sheng Lin, Shi Pei Lu, Jun Zhang, Li Chen, Qi Wen Li, Zhang Kai Cheng, Fang Jie Liu, Jin Yu Guo, Hui Liu, Bo Qiu

Open Access Research article

Analyses of metastasis-associated genes in IDH wild-type glioma

Xiaozhi Li, Yutong Meng

Open Access Study protocol

Early palliative radiation versus observation for high-risk asymptomatic or minimally symptomatic bone metastases: study protocol for a randomized controlled trial

Daniel B. Rosen, Cory D. Benjamin, Joanna C. Yang, Connor Doyle, Zhigang Zhang, Chris A. Barker, Max Vaynrub, T. Jonathan Yang, Erin F. Gillespie

Open Access Research article

Bortezomib administration is a risk factor associated with the development of tumor lysis syndrome in male patients with multiple myeloma: a retrospective study

Masahiro Kondo, Yuji Hotta, Karen Yamauchi, Akimasa Sanagawa, Hirokazu Komatsu, Shinsuke Iida, Kazunori Kimura

Open Access Research article

A randomized phase II trial evaluating the addition of low dose, short course sunitinib to docetaxel in advanced solid tumours

Yvonne L. E. Ang, Gwo Fuang Ho, Ross A. Soo, Raghav Sundar, Sing Huang Tan, Wei Peng Yong, Samuel G. W. Ow, Joline S. J. Lim, Wan Qin Chong, Phyu Pyar Soe, Bee Choo Tai, Lingzhi Wang, Boon Cher Goh, Soo-Chin Lee

Open Access Research article

Exploring treatment with Ribociclib alone or in sequence/combination with Everolimus in ER+HER2−Rb wild-type and knock-down in breast cancer cell lines

Oliviero Marinelli, Emanuela Romagnoli, Federica Maggi, Massimo Nabissi, Consuelo Amantini, Maria Beatrice Morelli, Matteo Santoni, Nicola Battelli, Giorgio Santoni

Open Access Research article

Nomogram-derived prediction of pathologic complete response (pCR) in breast cancer patients treated with neoadjuvant chemotherapy (NCT)

Shengyu Pu, Ke Wang, Yang Liu, Xiaoqin Liao, Heyan Chen, Jianjun He, Jian Zhang

Open Access Research article

Pressurized intraperitoneal aerosol chemotherapy (PIPAC) for rare gynecologic indications: peritoneal metastases from breast and endometrial cancer

Günther A. Rezniczek, Urs Giger-Pabst, Omar Thaher, Clemens B. Tempfer

Open Access Research article

The first evidence for SLFN11 expression as an independent prognostic factor for patients with esophageal cancer after chemoradiotherapy

Takuma Kagami, Mihoko Yamade, Takahiro Suzuki, Takahiro Uotani, Shinya Tani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima, Satoshi Baba, Haruhiko Sugimura, Junko Murai, Yves Pommier, Takahisa Furuta

Open Access Research article

Breast cancer distant recurrence lead time interval by detection method in an institutional cohort

Henry G. Kaplan, Judith A. Malmgren, Mary K. Atwood

Open Access Correction

Correction to: A pilot study of improved psychological distress with art therapy in patients with cancer undergoing chemotherapy

E. B. Elimimian, L. Elson, E. Stone, R. S. Butler, M. Doll, S. Roshon, C. Kondaki, A. Padgett, Z. A. Nahleh

Open Access Correction

Correction to: The efficacy of etanercept as anti-breast cancer treatment is attenuated by residing macrophages

Elnaz Shirmohammadi, Seyed-Esmaeil Sadat Ebrahimi, Amir Farshchi, Mona Salimi

Open Access Correction

Correction to: Determining the effects of trastuzumab, cetuximab and afatinib by phosphoprotein, gene expression and phenotypic analysis in gastric cancer cell lines

Karolin Ebert, Gwen Zwingenberger, Elena Barbaria, Simone Keller, Corinna Heck, Rouven Arnold, Vanessa Hollerieth, Julian Mattes, Robert Geffers, Elba Raimúndez, Jan Hasenauer, Birgit Luber

Open Access Research article

The quality of reporting general safety parameters and immune-related adverse events in clinical trials of FDA-approved immune checkpoint inhibitors

Zahra Karimian, Sandra Mavoungou, Joe-Elie Salem, Florence Tubach, Agnès Dechartres

Open Access Research article

Modification of the 8th American Joint Committee on Cancer staging system for gallbladder carcinoma to improve prognostic precision

Wei Jiang, Bingqing Zhao, Yongcheng Li, Dunfeng Qi, Daxing Wang

Open Access Research article

Hepatocellular carcinoma: Intratumoral EpCAM-positive cancer stem cell heterogeneity identifies high-risk tumor subtype

Jenny Krause, Johann von Felden, Christian Casar, Thorben W. Fründt, Johanna Galaski, Constantin Schmidt, Caroline Jung, Harald Ittrich, Sören A. Weidemann, Till Krech, Asmus Heumann, Jun Li, Lutz Fischer, Guido Sauter, Ansgar W. Lohse, Henning Wege, Kornelius Schulze

Open Access Research article

Risk stratification for prediction of locoregional recurrence in patients with pathologic T1–2N0 breast cancer after mastectomy

Jianyang Wang, Yu Tang, Hao Jing, Guangyi Sun, Jing Jin, Yueping Liu, Yongwen Song, Weihu Wang, Hui Fang, Bo Chen, Shunan Qi, Hua Ren, Ning Li, Yuan Tang, Ningning Lu, Yong Yang, Zihao Yu, Shulian Wang, Yexiong Li

Open Access Research article

Identification and validation of a six-gene signature associated with glycolysis to predict the prognosis of patients with cervical cancer

Luya Cai, Chuan Hu, Shanshan Yu, Lixiao Liu, Xiaobo Yu, Jiahua Chen, Xuan Liu, Fan Lin, Cheng Zhang, Wenfeng Li, Xiaojian Yan

Open Access Research article

Association between five types of Tumor Necrosis Factor-α gene polymorphism and hepatocellular carcinoma risk: a meta-analysis

Citrawati Dyah Kencono Wungu, Fis Citra Ariyanto, Gwenny Ichsan Prabowo, Soetjipto, Retno Handajani

Open Access Research article

Genomics and prognosis analysis of epithelial-mesenchymal transition in colorectal cancer patients

Zizhen Zhang, Sheng Zheng, Yifeng Lin, Jiawei Sun, Ning Ding, Jingyu Chen, Jing Zhong, Liuhong Shi, Meng Xue

Open Access Research article

Development and validation of an RNA binding protein-associated prognostic model for hepatocellular carcinoma

Min Wang, Shan Huang, Zefeng Chen, Zhiwei Han, Kezhi Li, Chuang Chen, Guobin Wu, Yinnong Zhao

Open Access Research article

Impact of prior cancer history on the survival of patients with larynx cancer

Kaiquan Zhu, Renyu Lin, Ziheng Zhang, Huanqi Chen, Xingwang Rao

Open Access Research article

The impact of lifecourse socio-economic position and individual social mobility on breast cancer risk

Eloïse Berger, Noële Maitre, Francesca Romana Mancini, Laura Baglietto, Vittorio Perduca, Hélène Colineaux, Sabina Sieri, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Paolo Vineis, Marie-Christine Boutron-Ruault, Gianluca Severi, Raphaële Castagné, Cyrille Delpierre

Open Access Research article

High cumulative doxorubicin dose for advanced soft tissue sarcoma

Zhichao Tian, Yang Yang, Yonghao Yang, Fan Zhang, Po Li, Jiaqiang Wang, Jinpo Yang, Peng Zhang, Weitao Yao, Xin Wang

Open Access Research article

Haploidentical related donor compared to HLA-identical donor transplantation for chemosensitive Hodgkin lymphoma patients

Luca Castagna, Alessandro Busca, Stefania Bramanti, Maria Raiola Anna, Michele Malagola, Fabio Ciceri, William Arcese, Daniele Vallisa, Francesca Patriarca, Giorgina Specchia, Roberto Raimondi, Raynier Devillier, Sabine Furst, Laura Giordano, Barbara Sarina, Jacopo Mariotti, Attilio Olivieri, Reda Bouabdallah, Carmelo Carlo-Stella, Alessandro Rambaldi, Armando Santoro, Paolo Corradini, Andrea Bacigalupo, Francesca Bonifazi, Didier Blaise

Open Access Correction

Correction to: Identification of ALDH3A2 as a novel prognostic biomarker in gastric adenocarcinoma using integrated bioinformatics analysis

Zhenhua Yin, Dejun Wu, Jianping Shi, Xiyi Wei, Nuyun Jin, Xiaolan Lu, Xiaohan Ren

Open Access Research article

Feasibility and safety of exercise training and nutritional support prior to haematopoietic stem cell transplantation in patients with haematologic malignancies

Erik Rupnik, Matevz Skerget, Matjaz Sever, Irena Preloznik Zupan, Maja Ogrinec, Barbara Ursic, Natasa Kos, Peter Cernelc, Samo Zver

Open Access Research article

Analysis of the expression and potential molecular mechanism of interleukin-1 receptor antagonist (IL1RN) in papillary thyroid cancer via bioinformatics methods

Zhenyu Xie, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Yu Lun, Shijie Xin, Jian Zhang

Open Access Research article

Benefit of dosimetry distribution for patients with multiple brain metastases from non-small cell lung cancer by a Cyberknife stereotactic radiosurgery (SRS) system

Xuyao Yu, Yuwen Wang, Zhiyong Yuan, Hui Yu, Yongchun Song, Lujun Zhao, Ping Wang

Open Access Research article

Risk factors, prognostic factors, and nomograms for bone metastasis in patients with newly diagnosed infiltrating duct carcinoma of the breast: a population-based study

Zhangheng Huang, Chuan Hu, Kewen Liu, Luolin Yuan, Yinglun Li, Chengliang Zhao, Chanchan Hu

Open Access Database

The effect of postmastectomy radiotherapy in node-positive triple-negative breast cancer

Lei Zhang, Ru Tang, Jia-Peng Deng, Wen-Wen Zhang, Huan-Xin Lin, San-Gang Wu, Zhen-Yu He

Open Access Research article

Toluidine blue versus frozen section for assessment of mucosal tumor margins in oral squamous cell carcinoma

Hana’a Hezam Algadi, Amany Abd-Elhameed Abou-Bakr, Omer Mohammed Jamali, Louloua Mohamed Fathy

Open Access Research article

Short-term mortality risks among patients with non-metastatic bladder cancer

Menghe Zhai, Chenye Tang, Ming Li, Xin Chen, Yigang Jin, Xiangjun Ying, Zhiling Tang, Xiao Wang, Yuntao Wu, Chun Sun, Kean Chen, Xiao Guo

Open Access Research article

Prediction of mortality in metastatic colorectal cancer in a real-life population: a multicenter explorative analysis

Holger Rumpold, Dora Niedersüß-Beke, Cordula Heiler, David Falch, Helwig Valenting Wundsam, Sigrid Metz-Gercek, Gudrun Piringer, Josef Thaler

Open Access Correction

Correction to: The majority of β-catenin mutations in colorectal cancer is homozygous

Alexander Arnold, Moritz Tronser, Christine Sers, Aysel Ahadova, Volker Endris, Soulafa Mamlouk, David Horst, Markus Möbs, Philip Bischoff, Matthias Kloor, Hendrik Bläker

Open Access Research article

Effects of reduced platelet count on the prognosis for patients with non-small cell lung cancer treated with EGFR-TKI: a retrospective study

Lu Xu, Fangzhou Xu, Haobo Kong, Meiling Zhao, Yuanzi Ye, Yanbei Zhang

Open Access Research article

Impact of superselective intra-arterial and systemic chemoradiotherapy for gingival carcinoma; analysis of treatment outcomes and prognostic factors

Yuki Mukai, Yuichiro Hayashi, Izumi Koike, Toshiyuki Koizumi, Madoka Sugiura, Senri Oguri, Shoko Takano, Mitomu Kioi, Mizuki Sato, Kenji Mitsudo, Masaharu Hata

Open Access Research article

Radiotherapy plays an important role in improving the survival outcome in patients with T1–2N1M0 breast cancer – a joint analysis of 4262 real world cases from two institutions

Guang-Yi Sun, Ge Wen, Yu-Jing Zhang, Yu Tang, Hao Jing, Jian-Yang Wang, Jiang-Hu Zhang, Yong Yang, Xu-Ran Zhao, Si-Ye Chen, Jing Jin, Yong-Wen Song, Yue-Ping Liu, Hui Fang, Hua Ren, Yuan Tang, Shu-Nan Qi, Ning Li, Bo Chen, Ning-Ning Lu, Shu-Lian Wang, Ye-Xiong Li

Open Access Research article

Long non-coding RNA SNHG15 in various cancers: a meta and bioinformatic analysis

Caizhi Chen, Yeqian Feng, Jingjing Wang, Ye Liang, Wen Zou

Open Access Research article

Cost-utility analysis of pralatrexate for relapsed or refractory peripheral T-cell lymphoma based on a case-matched historical control study along with single arm clinical trial

Seonyoung Park, Ah-Young Kim, Hyeonseok Cho, Deborah Baik, Hankil Lee, Sunghwa Cho, Hye-Young Kang

Open Access Research article

Human CD133-positive hematopoietic progenitor cells enhance the malignancy of breast cancer cells

Zhe Zhang, Qinglian Zheng, Yonghui Liu, Lianqing Sun, Pingping Han, Rui Wang, Jiao Zhao, Shan Hu, Xinhan Zhao

Open Access Research article

Both EZH2 and JMJD6 regulate cell cycle genes in breast cancer

Antara Biswas, Geetashree Mukherjee, Paturu Kondaiah, Kartiki V. Desai

Open Access Research article

Risk factors and socio-economic burden in pancreatic ductal adenocarcinoma operation: a machine learning based analysis

Yijue Zhang, Sibo Zhu, Zhiqing Yuan, Qiwei Li, Ruifeng Ding, Xunxia Bao, Timing Zhen, Zhiliang Fu, Hailong Fu, Kaichen Xing, Hongbin Yuan, Tao Chen

Open Access Research article

An aggressive systemic mastocytosis preceded by ovarian dysgerminoma

Makiko Tsutsumi, Hiroki Miura, Hidehito Inagaki, Yasuko Shinkai, Asuka Kato, Takema Kato, Susumu Hamada-Tsutsumi, Makito Tanaka, Kazuko Kudo, Tetsushi Yoshikawa, Hiroki Kurahashi

Open Access Research article

Phase II randomized trial of capecitabine with bevacizumab and external beam radiation therapy as preoperative treatment for patients with resectable locally advanced rectal adenocarcinoma: long term results

Ramón Salazar, Jaume Capdevila, Jose Luis Manzano, Carles Pericay, Mercedes Martínez-Villacampa, Carlos López, Ferrán Losa, María José Safont, Auxiliadora Gómez-España, Vicente Alonso-Orduña, Pilar Escudero, Javier Gallego, Beatriz García-Paredes, Amalia Palacios, Sebastiano Biondo, Cristina Grávalos, Enrique Aranda

Open Access Research article

Three-dimensional (3D) magnetic resonance volume assessment and loco-regional failure in anal cancer: early evaluation case-control study

Hema Sekhar, Rohit Kochhar, Bernadette Carrington, Thomas Kaye, Damian Tolan, Mark P. Saunders, Matthew Sperrin, David Sebag-Montefiore, Marcel van Herk, Andrew G. Renehan

Open Access Research article

The age threshold of the 8th edition AJCC classification is useful for indicating patients with aggressive papillary thyroid cancer in clinical practice

Krzysztof Kaliszewski, Dorota Diakowska, Łukasz Nowak, Beata Wojtczak, Jerzy Rudnicki

Open Access Research article

A prospective follow-up study of the relationship between high-sensitivity C-reactive protein and primary liver cancer

Sarah Tan Siyin, Tong Liu, Wenqiang Li, Nan Yao, Guoshuai Xu, Jun Qu, Yajun Chen

Open Access Research article

Propensity score-matched analysis of systemic chemotherapy versus salvage hysterectomy for persistent cervical cancer after definitive radiotherapy/concurrent chemoradiotherapy

Munetaka Takekuma, Fumiaki Takahashi, Seiji Mabuchi, Wataru Kudaka, Koji Horie, Mariko Ikeda, Ayumi Shikama, Akira Mitsuhashi, Shoji Nagao, Shiro Suzuki, Mika Mizuno, Shin Nishio, Hideki Tokunaga, Yukinobu Ota, Takahiro Kasamatsu, Ryo Kitagawa, Takafumi Toita, Hiroaki Kobayashi, Mitsuya Ishikawa, Nobuo Yaegashi

Open Access Research article

Spatio-temporal mapping of breast and prostate cancers in South Iran from 2014 to 2017

Mahdieh Montazeri, Benyamin Hoseini, Neda Firouraghi, Fatemeh Kiani, Hosein Raouf-Mobini, Adele Biabangard, Ali Dadashi, Vahideh Zolfaghari, Leila Ahmadian, Saeid Eslami, Robert Bergquist, Nasser Bagheri, Behzad Kiani

Open Access Research article

Eltrombopag inhibits the proliferation of Ewing sarcoma cells via iron chelation and impaired DNA replication

Torin Waters, Kelli L. Goss, Stacia L. Koppenhafer, William W. Terry, David J. Gordon

Open Access Research article

Breast cancer mortality trends in Peruvian women

J. Smith Torres-Roman, Jose Fabian Martinez-Herrera, Greta Carioli, Jorge Ybaseta-Medina, Bryan Valcarcel, Joseph A. Pinto, Alfredo Aguilar, Katherine A. McGlynn, Carlo La Vecchia

Open Access Correction

Correction to: Impact of a combined multimodal-aerobic and multimodal intervention compared to standard aerobic treatment in breast cancer survivors with chronic cancer-related fatigue - results of a three-armed pragmatic trial in a comprehensive cohort design

Matthias Kröz, Marcus Reif, Augustina Glinz, Bettina Berger, Andreas Nikolaou, Roland Zerm, Benno Brinkhaus, Matthias Girke, Arndt Büssing, Christoph Gutenbrunner

Open Access Research article

Immunoproteomics approach revealed elevated autoantibody levels against ANXA1 in early stage gallbladder carcinoma

Javed Akhtar, Ratna Priya, Vaishali Jain, Puja Sakhuja, Anil Kumar Agarwal, Surbhi Goyal, Ravindra Varma Polisetty, Ravi Sirdeshmukh, Sudeshna Kar, Poonam Gautam

Open Access Research article

A genomic-clinicopathologic nomogram for predicting overall survival of hepatocellular carcinoma

Kena Zhou, Qiang Zhou, Congbo Cai

Open Access Case report

Cancer of unknown primary with EGFR mutation successfully treated with targeted therapy directed by clinical next-generation sequencing: a case report

Yosuke Mitani, Masashi Kanai, Tadayuki Kou, Shigeki Kataoka, Keitaro Doi, Junichi Matsubara, Shinya Ohashi, Shigemi Matsumoto, Manabu Muto

Open Access Research article

Bladder cancer-derived interleukin-1 converts the vascular endothelium into a pro-inflammatory and pro-coagulatory surface

A. John, C. Günes, C. Bolenz, S. Vidal-y-Sy, A. T. Bauer, S. W. Schneider, C. Gorzelanny

Open Access Research article

Selective expression of KCNA5 and KCNB1 genes in gastric and colorectal carcinoma

Azer Farah, Maria Kabbage, Salsabil Atafi, Amira Jaballah Gabteni, Mouadh Barbirou, Mouna Madhioub, Lamine Hamzaoui, Mousadak Azzouz Mohamed, Hassen Touinsi, Asma Ouakaa Kchaou, Emna Chelbi, Samir Boubaker, Rahma Ben Abderrazek, Balkiss Bouhaouala-Zahar

Open Access Research article

LAD1 expression is associated with the metastatic potential of colorectal cancer cells

Byul Moon, Suk-Jin Yang, Seong Min Park, Sang-Hyun Lee, Kyu Sang Song, Eun-Jeong Jeong, Mijin Park, Jang-Seong Kim, Young Il Yeom, Jung-Ae Kim

Open Access Research article

Pulmonary cavitation in patients with thyroid cancer receiving antiangiogenic agents

Saumil Datar, Maria Cabanillas, Ramona Dadu, David Ost, Horiana B. Grosu

Open Access Research article

Are tumor-associated micro-angiogenesis and lymphangiogenesis considered as the novel prognostic factors for patients with Xp11.2 translocation renal cell carcinoma?

Wenliang Ma, Jun Yang, Ning Liu, Xiaohong Pu, Feng Qu, Linfeng Xu, Xiaozhi Zhao, Xiaogong Li, Gutian Zhang, Hongqian Guo, Dongmei Li, Weidong Gan

Open Access Research article

Early macrophage infiltrates impair pancreatic cancer cell growth by TNF-α secretion

Cansu Tekin, Hella L. Aberson, Maarten F. Bijlsma, C. Arnold Spek

Open Access Research article

Relationship between surgical R0 resectability and findings of peripancreatic vascular invasion on CT imaging after neoadjuvant S-1 and concurrent radiotherapy in patients with borderline resectable pancreatic cancer

Sho Yasuta, Tatsushi Kobayashi, Hidetoshi Aizawa, Shinichiro Takahashi, Masafumi Ikeda, Masaru Konishi, Motohiro Kojima, Hirofumi Kuno, Katsuhiko Uesaka, Soichiro Morinaga, Atsushi Miyamoto, Hirochika Toyama, Norihisa Takakura, Keishi Sugimachi, Wataru Takayama

Open Access Research article

Epidermal growth factor receptor-mutant non-small cell lung Cancer and Choroidal metastases: long-term outcome and response to epidermal growth factor receptor tyrosine kinase inhibitors

Clémentine Bouchez, Johan Pluvy, Ghassen Soussi, Marina Nguenang, Solenn Brosseau, Morgan Tourne, Mégane Collin, Nathalie Théou-Anton, Alice Guyard, Jamila Ammar, Antoine Khalil, Gérard Zalcman, Valérie Gounant

Open Access Research article

MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway

Chensheng Qiu, Weiliang Su, Nana Shen, Xiaoying Qi, Xiaolin Wu, Kai Wang, Lin Li, Zhu Guo, Hao Tao, Guanrong Wang, Bohua Chen, Hongfei Xiang

Open Access Research article

Liquid biopsy for patients with IBD-associated neoplasia

Hideaki Kinugasa, Sakiko Hiraoka, Kazuhiro Nouso, Shumpei Yamamoto, Mami Hirai, Hiroyuki Terasawa, Eriko Yasutomi, Shohei Oka, Masayasu Ohmori, Yasushi Yamasaki, Toshihiro Inokuchi, Masahiro Takahara, Keita Harada, Takehiro Tanaka, Hiroyuki Okada

Open Access Research article

EZH2 inhibitors reverse resistance to gefitinib in primary EGFR wild-type lung cancer cells

Hao Gong, Yongwen Li, Yin Yuan, Weiting Li, Hongbing Zhang, Zihe Zhang, Ruifeng Shi, Minghui Liu, Chao Liu, Chen Chen, Hongyu Liu, Jun Chen

Open Access Research article

A novel circular RNA hsa_circRNA_103809/miR-377-3p/GOT1 pathway regulates cisplatin-resistance in non-small cell lung cancer (NSCLC)

Xiang Zhu, Jing Han, Huiyin Lan, Qingren Lin, Yuezhen Wang, Xiaojiang Sun

Open Access Research article

A nationally quasi-experimental study to assess the impact of partial organized breast and cervical cancer screening programme on participation and inequalities

Heling Bao, Limin Wang, Matthew Brown, Mei Zhang, Katherine Hunt, Jiangli Di, Zhenping Zhao, Shu Cong, Jing Fan, Liwen Fang, Linhong Wang

Open Access Research article

A single-arm, phase 2 study of adjuvant chemotherapy with oral tegafur-uracil for pathologically lymphovascular invasion positive stage IA non-small cell lung cancer: LOGIK0602 study

Tomoshi Tsuchiya, Ryotaro Kamohara, Masashi Muraoka, Takeshi Nagayasu, Sho Saeki, Mitsuhiro Takenoyama, Makoto Suzuki, Kazuo Inada, Shoji Tokunaga, Tomayoshi Hayashi, Shogo Urabe, Takaomi Koga, Shinji Akamine, Kenji Sugio

Open Access Research article

Radotinib enhances cytarabine (Ara-C)-induced acute myeloid leukemia cell death

Sook-Kyoung Heo, Eui-Kyu Noh, Ho-Min Yu, Do Kyoung Kim, Hye Jin Seo, Yoo Jin Lee, Jaekyung Cheon, Su Jin Koh, Young Joo Min, Yunsuk Choi, Jae-Cheol Jo

Open Access COVID-19 Research article

Cancer patient management strategy in a Cancer Center of Zhejiang, China during the COVID-19 pandemic

Songxiao Xu, Xiangdong Cheng, Zhiwen Pan, Qian Song, Yihong Wang, Juan Xiong, Yongyi Chen, Fan Fan, Jing Zhu, Wanying Wu, Xueying Deng, Yanpin Yu, Xiaohong Xu, Wenhu Chen, Tao Zhu, Yang Yu, Kaizhong Liu, Guoliang Shao, Ming Chen, Enyan Yu

Open Access Research article

O6-methylguanine DNA methyltransferase and glucose transporter 2 in foregut and hindgut gastrointestinal neuroendocrine neoplasms

Hirofumi Watanabe, Yuto Yamazaki, Fumiyoshi Fujishima, Komoto Izumi, Masayuki Imamura, Susumu Hijioka, Kazuhiro Toriyama, Yasushi Yatabe, Atsushi Kudo, Fuyuhiko Motoi, Michiaki Unno, Hironobu Sasano

Open Access Correction

Correction to: Functional and clinical significance of ROR1 in lung adenocarcinoma

Giovanna Schiavone, Samantha Epistolio, Vittoria Martin, Francesca Molinari, Jessica Barizzi, Luca Mazzucchelli, Milo Frattini, Luciano Wannesson

Open Access Study protocol

TRIM study protocol - a prospective randomized multicenter Trial to assess the Role of Imaging during follow-up after radical surgery of stage IIB-C and III cutaneous malignant Melanoma

Ylva Naeser, Hildur Helgadottir, Yvonne Brandberg, Johan Hansson, Roger Olofsson Bagge, Nils O. Elander, Christian Ingvar, Karolin Isaksson, Petra Flygare, Cecilia Nilsson, Frida Jakobsson, Olga del Val Munoz, Antonis Valachis, Malin Jansson, Charlotte Sparring, Lars Ohlsson, Ulf Dyrke, Dimitrios Papantoniou, Anders Sundin, Gustav J. Ullenhag

Open Access Research article

Identification of a four-gene panel predicting overall survival for lung adenocarcinoma

Chunyu Li, Qizhong Long, Danni Zhang, Jun Li, Xianming Zhang

Open Access Research article

Survival impact of extended cycles of second-line chemotherapy in platinum-sensitive relapsed ovarian cancer patients with residual tumor after six cycles

Se Ik Kim, Woo Yeon Hwang, Maria Lee, Hee Seung Kim, Kidong Kim, Hyun Hoon Chung, Jae Hong No, Jae-Weon Kim, Yong Beom Kim, Noh Hyun Park, Yong-Sang Song, Dong Hoon Suh

Open Access Research article

Modified nodal stage of esophageal cancer based on the evaluation of the hazard rate of the negative and positive lymph node

Jinling Zhang, Hongyan Li, Liangjian Zhou, Lianling Yu, Fengyuan Che, Xueyuan Heng

Open Access Research article

Emergence of spatio-temporal variations in chemotherapeutic drug efficacy: in-vitro and in-Silico 3D tumour spheroid studies

M. V. Sheraton, G. G. Y. Chiew, V. Melnikov, E. Y. Tan, K. Q. Luo, N. Verma, P. M. A. Sloot

Open Access Research article

Immune-related protein signature in serum stratify relapsed mantle cell lymphoma patients based on risk

Lavanya Lokhande, Venera Kuci Emruli, Arne Kolstad, Martin Hutchings, Riikka Räty, Mats Jerkeman, Sara Ek

Open Access Research article

Distinct mutation profiles between primary bladder cancer and circulating tumor cells warrant the use of circulating tumors cells as cellular resource for mutation follow-up

Tae-Min Kim, Jin-seon Yoo, Hyong Woo Moon, Kyung Jae Hur, Jin Bong Choi, Sung-Hoo Hong, Ji Youl Lee, U-Syn Ha

Open Access Research article

Prognostic implications of alcohol dehydrogenases in hepatocellular carcinoma

Xiangye Liu, Tingting Li, Delong Kong, Hongjuan You, Fanyun Kong, Renxian Tang

Open Access Research article

Comprehensive analysis of prognostic gene signatures based on immune infiltration of ovarian cancer

Shibai Yan, Juntao Fang, Yongcai Chen, Yong Xie, Siyou Zhang, Xiaohui Zhu, Feng Fang

Open Access Research article

The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma

Fangshi Xu, Yibing Guan, Li Xue, Shanlong Huang, Ke Gao, Zhen Yang, Tie Chong

Open Access Research article

Dynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosis

Ju-Yeon Kim, Eun Jung Jung, Jae-Myung Kim, Han Shin Lee, Seung-Jin Kwag, Ji-Ho Park, Taejin Park, Sang-Ho Jeong, Chi-Young Jeong, Young-Tae Ju

Open Access Research article

Clinicopathological characteristics, treatment and prognosis of head & neck small cell carcinoma: a SEER population-based study

Chen-xi Yu, Feiluore Yibulayin, Lei Feng, Meng Wang, Meng-meng Lu, Yuan Luo, Hui Liu, Zhi-cheng Yang, Alimujiang Wushou

Open Access Research article

Germline variation networks in the PI3K/AKT pathway corresponding to familial high-incidence lung cancer pedigrees

Huan Lin, Gong Zhang, Xu-chao Zhang, Xin-lei Lian, Wen-zhao Zhong, Jian Su, Shi-liang Chen, Yi-long Wu

Open Access Research article

Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease

Dearbhaile Catherine Collins, Raghav Sundar, Anastasia Constantinidou, David Dolling, Timothy Anthony Yap, Sanjay Popat, Mary E. O’Brien, Udai Banerji, Johann Sebastian de Bono, Juanita Suzanne Lopez, Nina Tunariu, Anna Minchom

Open Access Research article

Gene expression analysis of human prostate cell lines with and without tumor metastasis suppressor CD82

Pushpaja Dodla, Vanitha Bhoopalan, Sok Kean Khoo, Cindy Miranti, Suganthi Sridhar

Open Access Research article

Pre-treatment expectations of patients with spinal metastases: what do we know and what can we learn from other disciplines? A systematic review of qualitative studies

R. Gal, D. Oostinga, H. Wessels, J. J. Verlaan, R. Charest-Morin, C. G. Fisher, H. M. Verkooijen, A. L. Versteeg

Open Access Research article

Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas

Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson, Pavan S. Upadhyayula, Brian D. Milligan, Samuel H. Cheshier, Irving L. Weissman, Jann N. Sarkaria, Fredric B. Meyer, John R. Henley

Open Access Research article

A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells

Maria E. Lund, Christopher B. Howard, Kristofer J. Thurecht, Douglas H. Campbell, Stephen M. Mahler, Bradley J. Walsh

Open Access Research article

Inhibitory effects of iron depletion plus eribulin on the breast cancer microenvironment

Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Tamami Morisaki, Katsuyuki Takahashi, Hisakazu Fujita, Masatsune Shibutani, Ryosuke Amano, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa, Masaichi Ohira

Open Access Research article

Pathological responses to low-dose irradiation and Pepleomycin in Oral squamous cell carcinoma are predictive of Locoregional control

Tomohiro Katagiri, Yoshio Ohyama, Hideo Miyamoto, Yuki Egawa, Toshiaki Moriki, Kazuki Hasegawa

Open Access Research article

Intratumoral heterogeneity of second-harmonic generation scattering from tumor collagen and its effects on metastatic risk prediction

Danielle E. Desa, Robert L. Strawderman, Wencheng Wu, Robert L. Hill, Marcel Smid, J. W. M. Martens, Bradley M. Turner, Edward B. Brown

Open Access Research article

Network meta-analysis of targeted therapies for diffuse large B cell lymphoma

Jie Wang, Jun Huang, Qing Zeng

Open Access Research article

Application of Random Forest and data integration identifies three dysregulated genes and enrichment of Central Carbon Metabolism pathway in Oral Cancer

Srija Mukhopadhyay, Sahana Ghosh, Debodipta Das, P. Arun, Bidyut Roy, Nidhan K. Biswas, Arindam Maitra, Partha P. Majumder

Open Access Research article

Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer

Morton Freytag, Martina Kluth, Elena Bady, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Hans Heinzer, Doris Höflmayer, Sören Weidemann, Ria Uhlig, Hartwig Huland, Markus Graefen, Christian Bernreuther, Corinna Wittmer, Maria Christina Tsourlakis, Sarah Minner, David Dum, Andrea Hinsch, Andreas M. Luebke, Ronald Simon, Guido Sauter, Thorsten Schlomm, Katharina Möller

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