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17.06.2020 | Cardiac

Characteristics of the left ventricular three-dimensional maximum principal strain using cardiac computed tomography: reference values from subjects with normal cardiac function

verfasst von: Kazuki Yoshida, Yuki Tanabe, Teruhito Kido, Akira Kurata, Daichi Uraoka, Masaki Kinoshita, Teruyoshi Uetani, Kazuhisa Nishimura, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi, Teruhito Mochizuki

Erschienen in: European Radiology | Ausgabe 11/2020

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Abstract

Objectives

This study evaluated the characteristics of left ventricular maximum principal strain (LV-MPS) using cardiac CT in subjects with normal LV function.

Methods

Of 973 subjects who underwent retrospective electrocardiogram-gated cardiac CT using a third-generation dual-source CT without beta-blocker administration, 31 subjects with preserved LV ejection fraction ≥ 55% assessed by echocardiography without coronary artery stenosis and cardiac pathology were retrospectively identified. CT images were reconstructed every 5% (0–95%) of the RR interval. LV-MPS and the time to peak (TTP) were analyzed using the 16-segment model and compared among three levels (base, mid, and apex) and among four regions (anterior, septum, inferior, and lateral) using the Steel–Dwass test. The intra- and inter-observer reproducibilities for LV-MPS were calculated using intraclass correlation coefficients (ICCs).

Results

The intra- and inter-observer ICCs (95% confidence interval) for peak LV-MPS were 0.96 (0.94–0.97) and 0.94 (0.92–0.96), respectively. The global peak LV-MPS (median, inter-quantile range) was 0.59 (0.55–0.72). The regional LV-MPS significantly increased in the order of the basal (0.54, 0.49–0.59), mid-LV (0.57, 0.53–0.65), and apex (0.68, 0.60–0.84) (p < 0.05, in each), and was significantly higher in the lateral wall (0.66, 0.60–0.77), while that in the septal region (0.47, 0.44–0.54) was the lowest among the four LV regions (all p < 0.05). No significant difference in TTP was seen among the myocardial levels and regions.

Conclusion

CT-derived LV-MPS is reproducible and quantitatively represents synchronized myocardial contraction with heterogeneous values in subjects with normal LV function.

Key Points

• CT-derived left ventricular maximum principal strain analysis allows highly reproducible quantitative assessments of left ventricular myocardial contraction.

• In subjects with normal cardiac function, the peak value of CT-derived left ventricular maximum principal strain is the highest in the apical level and in the lateral wall and the lowest in the septum.

• The regional peak left ventricular maximum principal strain shows intra-ventricular heterogeneity on a per-patient basis, but myocardial contraction is globally synchronized in subjects with normal cardiac function seen on cardiac CT.

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Titel: Characteristics of the left ventricular three-dimensional maximum principal strain using cardiac computed tomography: reference values from subjects with normal cardiac function
verfasst von: Kazuki Yoshida
Yuki Tanabe
Teruhito Kido
Akira Kurata
Daichi Uraoka
Masaki Kinoshita
Teruyoshi Uetani
Kazuhisa Nishimura
Katsuji Inoue
Shuntaro Ikeda
Osamu Yamaguchi
Teruhito Mochizuki
Publikationsdatum: 17.06.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 11/2020
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-020-07001-6

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Characteristics of the left ventricular three-dimensional maximum principal strain using cardiac computed tomography: reference values from subjects with normal cardiac function