Erschienen in:
01.08.2013 | Poster presentation
Epigenetic profile in lipopolysaccharide-stimulated macrophages
verfasst von:
Ester Correia Sarmento Rios, Thais Martins Lima Salgado, Francisco Garcia Soriano
Erschienen in:
Critical Care
|
Sonderheft 4/2013
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Excerpt
Sepsis remains a clinical challenge for the ICUs. However, it is known that the tolerance mechanism using low doses of lipopolysaccharide (LPS) reduces the expression of proinflammatory genes and involves epigenetic regulation. The chromatin openness is regulated by histone acetyltransferases (HATs) and these enzymes could be modulated by nitric oxide (NO) interaction. In the present work, we demonstrate the pathway of tolerance to LPS from HAT activity and level of histone openness to production of cytokines as well as the influence of NO inhibition. …