Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are the two most performed techniques in bariatric surgery. The aim of this study is to compare two surgical procedures in terms of weight loss and the development of comorbidities such as type II diabetes mellitus T2D, arterial hypertension, sleep apnea (OSAS), and gastroesophageal reflux disease (GERD).
Methods
Data from the German Bariatric Surgery Registry (GBSR) from 2005 to 2021 were used. 1,392 RYGB and 1,132 SG primary surgery patients were included. Minimum age 18 years; five-year follow-up data available. Tests were performed with a 5% significance level.
Results
Loss of follow-up 95.41% within five years. Five years after surgery, the RYGB showed significant advantages in terms of excess weight loss (%EWL 64.2% vs. 56.9%) and remission rates of the studied comorbidities: hypertension (54.4% vs. 47.8%), OSAS (64.5% vs. 50.1%), and GERD (86.1% vs. 66.9%). Compared to the pre-test, individuals diagnosed with insulin-dependent T2D showed significant improvements with RYGB over a five-year period (remission rate: 75% vs. 63%). In contrast, non-insulin-dependent T2D showed no significant difference between the two approaches (p = 0.125).
Conclusion
Both surgical procedures resulted in significant weight loss and improved comorbidities. However, the improvement in comorbidities was significantly greater in patients who underwent RYGB than in those who underwent SG, suggesting that the RYGB technique is preferable.
Nevertheless, RYGB requires a high degree of surgical skill. Therefore, acquiring expertise in the technical facets of the surgery is essential to achieving favorable outcomes.
Hinweise
Key points
• The primary aim of this study was to ensure the quality of both SG and RYGB through data analysis.
• The incidence of newly developed postoperative reflux within five years was three times higher after SG compared to RYGB.
• The remission of hypertension, IDDM, and GERD was significantly greater after RYGB compared to SG.
• The results of this study suggest that RYGB is the preferred method over SG, as it achieved better results than SG in several areas.
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Introduction
Severe obesity is associated with a variety of chronic conditions that compromise overall health and increase the risk of death in obese individuals [1, 2]. An increase in BMI significantly increases the likelihood of developing obesity-related conditions such as arterial hypertension aHTN, diabetes mellitus type 2 (T2D), and apnea (OSAS) [3, 4]. Most non-surgical treatments have shown limited effectiveness in reducing weight and managing obesity-related comorbidities [5]. Clinical studies have consistently shown that bariatric surgery is an effective method for weight loss and management of obesity-related comorbidities [6]. Bariatric surgery is a growing surgical field focused on the treatment of obesity due to the rapid increase in weight worldwide [7].
Surgical techniques have historically been classified as malabsorptive, restrictive, or mixed. However, the efficacy of different bariatric surgical approaches in terms of weight loss, comorbidity reduction, and perioperative outcomes varies widely. Sleeve gastrectomy (SG) and Roux-Y gastric bypass (RYGB) have long been recognized as standard bariatric surgical procedures [8].
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RYGB and SG each have their own advantages and disadvantages. SG has experienced a rapid rise as a bariatric surgical procedure for patients with obesity due to its technical simplicity [9]. However, when it comes to treating obesity-related conditions, bariatric surgery has shown more favorable results when using techniques like RYGB as opposed to SG [10].
The objectives of this study are to compare the efficacy of SG and RYGB in achieving remission of obesity-related comorbidities, to identify any perioperative complications that may be associated with both procedures, and to provide an update on weight status five years after surgery. By comparing the results of our study with those of international randomized trials, we hope to provide an overview of the current status and outcomes of both procedures in Germany and draw comparisons between the outcomes in Germany and those of international randomized trials.
Material and methods
Data collection and study design
The study was conducted in accordance with the principles specified in the Declaration of Helsinki, which governs biomedical research. All participants completed an informed consent form before data were entered into the registry. Patients were included in the study if they consented to follow-up.
Data were collected online for the purpose of quality assurance research. The research involved entering the relevant data into a specially designed database. StatConsult performed the data analysis using export data from 04/2021, which were reviewed, and plausibility checked by the study director.
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The current retrospective multicenter analysis of the German Bariatric Surgery Registry (GBSR) database, which was compiled prospectively between January 2005 and April 2021, used the following inclusion criteria (Fig. 1):
Minimum age 18 years.
RYGB or SG is acceptable as the primary surgical procedure.
A valid five-year follow-up (1,643–2,008 days after surgery) is required.
Fig. 1
Flow chart of the study's and patients' criteria
×
Selection of the appropriate surgical procedure was influenced by individual patient characteristics and physician indications. Data collected included:
Population statistics, weight data, comorbidities, and ASA classification.
Long-term follow-up data, including weight development, BMI reduction, %EWL, development of T2D, aHTN, OSAS, and GERD.
Patients were considered to be completely cured of reflux at follow-up examinations if the symptoms and medication treatment of reflux were no longer present after surgery. Some clinics added pH monitoring and endoscopy; however, this was not a universal practice and not a standard procedure to rule out reflux disease after bariatric surgery.
The development of DM, aHTN, and OSAS was compared with the original preoperative data based on medication and symptom development after surgery. Different categories were analyzed for all comorbidities compared: Worsening, improvement, new development, no change or complete remission of comorbidities.
Statistical analysis
Statistical analyses were performed using SAS 9.4 at a 5% significance level, with a p-value of less than or equal to 0.05 indicating a statistically significant difference.
Descriptive and univariate/unadjusted analyses:
Analysis included examination of mean, standard deviation, and number of patients for quasi-continuous variables and root-transformed data. The mean values of the original and transformed data differ. Continuous variables are reported as minimum, lower quartile, median, upper quartile, and maximum and a paired t-test is used for comparison.
Unadjusted analyses are used to analyze the effect of a single variable on a target parameter, with a focus on comparing surgical procedures. The chi-squared test is used for categorical outcome variables, and the Satterthwaite robust t-test is used for continuous outcome variables. Significant deviations from the normal distribution require a root function transformation to approximate the distribution.
Results
The study included a total of 73,445 patients. Of these, 54,984 patients underwent either RYGB or SG. Of the 2,524 patients who were followed up for five years, 55.2% (n = 1,392) underwent RYGB, whereas 44.8% (n = 1,132) underwent SG. The majority of both procedures were performed using laparoscopic techniques (> 97%), and SG had a significantly shorter operating time. Postoperative and total hospital stay did not show a significant advantage for either group.
The study found a significant gender distribution among the 2,524 patients, with a higher proportion of females (75.2%) than males (24.8%). Among the SG group, 357 (31.5%) patients were male and 775 (68.5%) were female. In the RYGB cohort, 19.3% were male and 80.7% were female (p < 0.001).
Of the total of 2,339 patients, 92.7% had a documented comorbidity at the time of surgery (Fig. 2). According to the study, there was considerable variation in patients’ comorbidities. Cardiovascular disease and degenerative skeletal disease were more common in SG patients, whereas smoking, varicosis, T2D, insulin-dependent diabetes mellitus (IDDM), GERD, and non-alcoholic steatohepatitis (NASH) were more common in RYGB patients (p < 5% overall). Table 1 and Fig. 2 provide a brief summary of the comorbidities identified preoperatively and assessed during the follow-up period.
Fig. 2
Distribution of comorbidities at the time of surgery. OCVD = other cardiovascular disease, DSD = degenerative skeletal disease, DSPD = degenerative spinal disease, NASH = nonalcoholic steatohepatitis, RID = rheumatoid inflammatory disease, PCOS = polycystic ovary syndrome, CID = chronic inflammatory bowel disease.
Table 1
Demographic distribution of age, height, body weight, BMI, and associated diseases studied in the long-term follow-up
Surgical procedure
p value
SG
RYGB
N
%
Min
Max
Mean ± STD
N
%
Min
Max
Mean ± STD
Age (years)
1132
18
73
44.9 ± 11.5
1392
18
74
45.0 ± 10.8
0.761
Height (cm)
1132
124
201
170.2 ± 9.8
1391
141
204
168.8 ± 9.0
< 0.001
Weight (kg)
1132
77
293
146.4 ± 30.5
1391
77
238
136.8 ± 23.4
< 0.001
BMI (kg/m2)
1132
26.6
103.4
50.4 ± 8.9
1391
32.7
90.5
47.9 ± 6.8
< 0.001
ASA
^
ASA I
45
4.0
40
2.9
< 0.001
ASA II
444
39.3
648
46.6
ASA III
614
54.3
682
49.1
ASA IV
28
2.5
20
1.4
Comorbidities (total)
1056
93.3
1283
92.2
0.284
T2DM
379
37.2
550
41.3
0.044
IDDM
115
11.3
188
14.1
0.043
NIDDM
221
21.7
323
24.2
0.144
aHTN
766
67.7
919
66.0
0.382
OSAS
297
26.2
333
23.9
0.182
GERD
118
10.4
309
22.2
< 0.001
×
The analysis showed no significant difference in age distribution between the SG and RYGB groups. Patients treated with SG had a higher level of morbidity and a higher body mass index (BMI). During the first five years after surgery, the mean BMI decreased from 50.4 kg/m2 to 36.1 kg/m2 (SG) and from 47.9 kg/m2 to 33.6 kg/m2 (RYGB) with no statistically significant difference between the two groups. However, RYGB resulted in a significantly higher %EWL (p < 0.001) (Tables 1 and 2).
Table 2
Overview of weight loss, BMI reduction, and %EWL after 5 years
SG
RYGB
p-value
Min
Max
Mean ± STD
Min
Max
Mean ± STD
Weight loss (kg)
-14
141
41.5 ± 21.7
-19
117
40.7 ± 17.1
0.292
BMI-Reduction (kg/m2)
-6.2
69.0
14.3 ± 7.3
-7
55.7
14.3 ± 5.9
0.968
%EWL
-36.9
273.7
57.9 ± 25.2
-88.7
140.8
64.2 ± 24.0
< 0.001
Five years after surgery, both SG and RYGB showed improvements in the recorded comorbidities with complete and partial remissions. Table 3 shows a summary of the change in comorbidities in each group.
Table 3
Comparison of the development of comorbidities in both groups after 5 years, relative to the time of surgery
SG
RYGB
p-
value
N
%
N
%
IDDM
Yes ➜ No
80
69.6
143
76.1
0.315
Yes ➜ Yes
35
30.4
45
23.9
De-Novo
5
0.49*
13
1.1*
NIDDM
Yes ➜ No
185
83.7
278
86.3
0.698
Yes ➜ Yes
36
16.3
44
13.7
De-Novo
9
1.0*
13
0.84*
aHTN
Yes ➜ No
366
47.8
499
54.4
0.024
Yes ➜ Yes
400
52.2
418
45.6
De-Novo
14
3.8*
19
4.0*
OSAS
Yes ➜ No
149
50.1
214
64.5
0.001
Yes ➜ Yes
148
49.9
118
35.5
De-Novo
12
1.4*
14
1.3*
GERD
Yes ➜ No
79
66.9
266
86.1
< 0.001
Yes ➜ Yes
39
33.1
43
13.9
De-Novo
299
29.5*
108
10.0*
The percentages for the yes—no and yes—yes categories refer to the number of patients with the respective comorbidity at the time of surgery and after 5 years
*The percentages of the de-novo category refer to the patients without the respective comorbidity at the time of surgery and with this comorbidity after 5 years, but the p-value includes all three categories
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When examining the progression of comorbidities from the time of surgery to five years postoperatively, RYGB showed a significant advantage in aHTN, OSAS, and GERD (Table 3). In addition, RYGB showed a significant advantage in IDDM when comparing the situation five years after surgery with the most recent examination (Table 4).
Table 4
Descriptive statistics: change in comorbidities at 5-year follow-up (changes refer to the time point postoperatively and the last previous visit(s) and thus not directly to the baseline value)
Change in comorbidity
Surgical procedure
SG
RYGB
n
%
n
%
p
IDDM
Reduction
6
6.5
23
16.0
0.003
Worsening
2
2.2
0
0
No change
28
30.4
20
13.9
No more therapy required
52
56.5
85
59.0
NIDDM – > IDDM
2
2.2
5
3.5
De-novo
2
2.2
11
7.6
NIDDM
Reduction
11
6.8
11
4.9
0.125
Worsening
3
1.9
4
1.8
No change
28
17.3
26
11.6
No more therapy required
115
71.0
164
73.2
IDDM – > NIDDM
0
0
0
0
De-novo
5
3.1
19
8.5
aHTN
Reduction
108
15.1
138
17.3
0.018
Worsening
11
1.5
9
1.1
No change
253
35.5
224
28.1
No more therapy required
299
41.9
360
45.2
De-novo
42
5.9
66
8.3
OSAS
Reduction
57
20.3
78
26.3
< 0.001
Worsening
102
36.3
53
17.8
No change
0
0
0
0
No more therapy required
121
43.1
165
55.6
De-novo
1
0.4
1
0.3
GERD
Reduction
59
15.6
58
31.9
< 0.001
Worsening
120
31.8
25
13.7
No change
0
0
0
0
No more therapy required
111
29.4
56
30.8
De-novo
87
23.1
43
23.6
Regarding postoperative de-novo of comorbidities, IDDM, NIDDM, aHTN, and OSAS did not differ between the two surgical procedures. However, there was a significant difference in de-novo postoperative GERD, which was almost three times more frequent after SG, but also occurred in 10% after RYGB (Table 4).
Discussion
Bariatric and metabolic surgery has been empirically shown to be more effective in achieving weight loss than non-surgical approaches [18, 19]. Patients who underwent bariatric surgery experienced a significant weight loss, with a mean reduction of 26 kg, according to a meta-analysis [20]. This finding contrasts with the results of non-surgical treatments. However, a comprehensive risk assessment is essential, especially for elderly and critically ill patients [21].
The present analysis analyzes patients who were enrolled in the registry study after undergoing primary SG or RYGB, with a follow-up period of five years.
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The patient’s condition and the surgical center’s expertise together determined the surgical indication and procedure selection.
Particularly in regions such as the Middle East and the United States, where chronic obesity is widespread, the current prevalence of SG is approximately 70% [11]. This pattern is also observed in Germany and Europe [12]. In an international comparison, our data suggest that the indication for surgery in Germany is relatively late and occurs only in the transition from obesity to superobesity (BMI > 50 kg/m2). The mean BMI in this study was 49 kg/m2.
Due to a lack of follow-up, the study was able to evaluate only 2,524 of the 54,984 patients for whom data were available at five years postoperatively. The decrease in follow-up rates (95.41%) over a 5-year period is due to the patients’ commitment to attending follow-up sessions rather than being influenced by the treating clinics. The substantial loss to follow-up rate implies that long-term outcomes may exceed those of the “lost” residual population; therefore, a thorough critical evaluation of the long-term data is imperative.
The analysis yielded notable results due to the variation within each category and the gender disparities in the distribution of bariatric surgery.
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We believe that the consistent use of SG in male patients results in a higher preoperative BMI compared to female patients. Other studies that have examined patients with preoperative elevated BMIs have reached the same conclusion: SG was used at a higher rate compared to RYGB [13, 14].
Regarding the reduction in BMI, the %EWL, and weight loss after both procedures, three studies [15‐17] demonstrated a greater reduction in BMI after RYGB, while two studies [18, 19] found no significant difference (Table 5). Eight studies [15‐22] used %EWL as a measure of weight loss after both procedures. Three studies [15, 16, 20] reported a significantly higher %EWL five years after RYGB (Table 6). Our research findings indicate that RYGB demonstrated a statistically significant superiority in terms of %EWL. However, there were no significant differences seen in weight loss or change in BMI between the two procedures (Tables 2, 5, and 6). Based on the development of BMI, weight and %EWL and the preoperative values, the statement about %EWL development in our study should be viewed skeptically due to the different initial weight of the two groups. Therefore, this progress should not be the only consideration when deciding on surgical procedures; other demographic and patient-specific factors should also be taken into account. In addition, the initial BMI and perioperative conditions of the patients may have influenced the choice of procedure but not the postoperative course. In our opinion, the surgical procedure has a greater impact on weight loss, %EWL, and BMI decrease, as indicated in the literature and our study results, rather than the initial preoperative weight and BMI values, despite statistical significance.
Table 5
Prospective studies with comparative results on development of BMI between SG and RYGB at baseline and 5-year follow-up and comparison with the results of our study
In the current study, more than 90% of patients had preoperative comorbidities. However, the follow-up period was only five years and focused on T2D, aHTN, OSAS, and GERD.
According to the available studies, there were no significant changes between the two groups five years after surgery, even though both surgeries improve T2D [15‐17]. Perrone et al. [22] found a significant difference in T2D remission rate at five years in favor of RYGB. 9,710 patients with T2D were followed for five years in a large American registry study [23]. The study reported first-year remission rates for RYGB (59.2%) and SG (55.7%). There were significant differences between the two groups at the five-year mark: remission rates increased to 86.1% after RYGB and 83.5% after SG. When comparing the preoperative and five-year follow-up status for remission of IDDM and NIDDM, our results did not show a statistically significant difference. There was a significant difference in the remission of IDDM in favor of the RYGB group five years after surgery compared to the previous controls during follow-up (p = 0.003), but not in the remission of NIDDM (p = 0.125). Therefore, the results of the literature and our registry study support the hypothesis that malabsorptive bariatric procedures (RYGB, BPD/DS) are more effective than restrictive procedures (SG, gastric banding) in terms of T2D remission.
In the case of aHTN, Salminen et al. [19] found that the remission rate after RYGB was significantly higher than after SG. Other studies [15‐18, 21, 22] have found only a trend towards a benefit for RYGB compared to SG, but no significant benefit was observed. Our GBSR study showed remarkable remission rates for aHTN five years after the above surgical procedures (Table 7). In contrast to the remission rate of 47.8% for SG, RYGB resulted in a significantly higher remission rate of 54.4% (p = 0.024) when comparing the two surgical procedures.
Table 7
Prospective studies with comparative results on comorbidity remission between SG and RYGB at 5-year follow-up and comparison with the results of our study
Comparing the two surgical groups, slightly more than one fifth of the patients in our study had OSAS (Table 1). Both cohorts had significant remission rates. They were significantly higher after RYGB with 64.5% compared to 50.1% after SG (Table 3). The present study compared four searches [16, 18, 21, 22], all of which examined the progression of OSAS (Table 7). Remission rates were found to be predominantly high for both procedures, with no significant differences. Consistent with the results of the current study and the existing literature, both procedures induce OSAS remission. We believe that the differences between the two procedures do not only depend on the surgical approach, but also on demographic variables, postoperative weight loss, and observation schedule.
It has been observed that GERD is more common after SG than after RYGB [24]. Some surgeons even require preoperative impedance and manometry measurements. If positive results are obtained, RYGB [25] should be performed. Significant determinants associated with the development of gastroesophageal reflux disease (GERD) after SG are fundus resection, suspension apparatus modifications at the gastroesophageal junction, and the high-pressure system of the sleeve stomach [26, 27]. As a result, the incidence of de-novo GERD is high, while the remission rate of pre-existing GERD is minimal [25, 28]. In our study, 10% of cases undergoing RYGB developed de-novo GERD, compared to 29.5% in SG. Peterli et al. [18] observed comparable results in their study of de-novo GERD: 31.6% adherence to SG and 10.7% adherence to RYGB (p = 0.001).
An inherent limitation of our study is the lack of randomization. Randomization of patients is largely discouraged and often outright rejected in Germany due to strict ethical standards.
Furthermore, the study has a 95% follow-up loss rate, which is not subject to variation by the treating clinics and surgeons. Consequently, we can only characterize the outcomes of the two procedures based on the results obtained from the available data. Therefore, the conclusions drawn from the existing body of literature should be taken into account in conjunction with the recommendations of this study, and not in isolation.
Despite these limitations, our aim is to use sophisticated statistical analysis to bring existing registry data up to the standard of a randomized trial. Based on our assessment, the results of our study are comparable to those observed in international randomized trials.
Conclusion
The primary aim of this study was to ensure the quality of bariatric surgery, to evaluate the potential hazards associated with the procedure, and define patient selection criteria for both SG and RYGB through data analysis. The study revealed significant differences in the prevalence of GERD, aHTN, and OSAS among the comorbidities studied. The incidence of newly developed postoperative reflux within five years was three times higher after SG compared to RYGB. Remission of aHTN, OSAS, IDDM, and GERD was significantly greater after RYGB than after SG.
The results of the study indicate that the RYGB procedure has superior performance in several categories, suggesting its superiority over SG.
The literature indicates that SG is a reliable and widely used bariatric surgical technique known for its straightforward technical configuration and impeccable safety record. Therefore, given the advantages of RYGB over SG in the present study, it is imperative to carefully consider the merits of each bariatric procedure in order to achieve the most favorable expected outcomes from bariatric surgery. Therefore, when evaluating the acceptability of the procedure, additional factors such as patient consent, preoperative risk factors, and surgeon expertise should be considered in addition to the outcomes of the two procedures.
In addition to the specific procedure itself, bariatric surgery typically requires a comprehensive multidisciplinary therapeutic approach, including postoperative patient care.
Declarations
Ethical approval
For this type of retrospective study, no formal consent was required. All data were gathered and analyzed in accordance with the privacy and ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Competing interests
The authors declare no competing interests.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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