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Erschienen in: Intensive Care Medicine 11/2016

11.08.2016 | Focus Editorial

Focus on optimization of early antimicrobial therapy in ICU-acquired infections

Erschienen in: Intensive Care Medicine | Ausgabe 11/2016

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Excerpt

The purpose of a new empirical antimicrobial therapy is to deliver adequate treatment early while limiting antibiotic selection pressure and antibiotic resistance. The choice of molecules will be guided by the guidelines and the knowledge of previous multiresistant bacteria (MRB) carriers, secondarily adapted according to microbiological data. Finally, early optimal pharmacokinetics/pharmacodynamics (PK/PD) of empirical therapy is a necessary and safe starting point from where de-escalation can take place. The antimicrobial chosen for de-escalation should be used according to antibiotic susceptibility testing, and using proper doses to ensure appropriate PK during targeted therapy. …
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Metadaten
Titel
Focus on optimization of early antimicrobial therapy in ICU-acquired infections
Publikationsdatum
11.08.2016
Erschienen in
Intensive Care Medicine / Ausgabe 11/2016
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-016-4485-2

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