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28.08.2021 | Chest

Improving the accuracy of prognosis for clinical stage I solid lung adenocarcinoma by radiomics models covering tumor per se and peritumoral changes on CT

verfasst von: Kunfeng Liu, Kunwei Li, Tingfan Wu, Mingzhu Liang, Yinghua Zhong, Xiangyang Yu, Xin Li, Chuanmiao Xie, Lanjun Zhang, Xueguo Liu

Erschienen in: European Radiology | Ausgabe 2/2022

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Abstract

Objectives

To assess methods to improve the accuracy of prognosis for clinical stage I solid lung adenocarcinoma using radiomics based on different volumes of interests (VOIs).

Methods

This retrospective study included patients with postoperative clinical stage I solid lung adenocarcinoma from two hospitals, center 1 and center 2. Three databases were generated: dataset A (training set from center 1), dataset B (internal test set from center 1), and dataset C (external validation test from center 2). Disease-free survival (DFS) data were collected. CT radiomics models were constructed based on four VOIs: gross tumor volume (GTV), 3 mm external to the tumor border (peritumoral volume [PTV]_0~+3), 6 mm crossing tumor border (PTV_−3~+3), and 6 mm external to the tumor border (PTV_0~+6). The area under the receiver operating characteristic curve (AUC) was used to compare the model accuracies.

Results

A total of 334 patients were included (204 and 130 from centers 1 and 2). The model using PTV_−3~+3 (AUC 0.81 [95% confidence interval {CI}: 0.75, 0.94], 0.81 [0.63, 0.90] for datasets B and C) outperformed the other three models, GTV (0.73 [0.58, 0.81], 0.73 [0.58, 0.83]), PTV_0~+3 (0.76 [0.52, 0.87], 0.75 [0.60, 0.83]), and PTV_0~+6 (0.72 [0.60, 0.81], 0.69 [0.59, 0.81]), in datasets B and C, all p < 0.05.

Conclusions

A radiomics model based on a VOI of 6 mm crossing tumor border more accurately predicts prognosis of clinical stage I solid lung adenocarcinoma than that based on VOIs including overall tumor or external rims of 3 mm and 6 mm.

Key Points

• Radiomics is a useful approach to improve the accuracy of prognosis for stage I solid adenocarcinoma.

• The radiomics model based on VOIs that includes 3 mm within and external to the tumor border (peritumoral volume [PTV] _−3~+3 ) outperformed models that included either only the tumor itself or those that only included the peritumoral volume.

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Titel: Improving the accuracy of prognosis for clinical stage I solid lung adenocarcinoma by radiomics models covering tumor per se and peritumoral changes on CT
verfasst von: Kunfeng Liu
Kunwei Li
Tingfan Wu
Mingzhu Liang
Yinghua Zhong
Xiangyang Yu
Xin Li
Chuanmiao Xie
Lanjun Zhang
Xueguo Liu
Publikationsdatum: 28.08.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 2/2022
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-021-08194-0

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Improving the accuracy of prognosis for clinical stage I solid lung adenocarcinoma by radiomics models covering tumor per se and peritumoral changes on CT