Erschienen in:
Open Access
01.12.2015 | Poster presentation
Levels of N-terminal pro-brain natriuretic peptide in brain injury patients
verfasst von:
L Tsentsiper, E Kondratyeva, S Kondratyev, N Dryagina
Erschienen in:
Critical Care
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Sonderheft 1/2015
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Excerpt
Currently, the most common way to predict the outcome of acute brain damage is to study the level of protein S-100 in the serum. This method lacks specificity as the concentration of protein S-100 significantly increases with age, more for men than women, and there are no data on prognostically significant changes in the level of S-100 after removal of the tumor and cerebral hemorrhages. Endothelins, vasopressin, some cytokines, excess sodium or calcium in serum, activation of the sympathoadrenal system, and tachycardia are the stimulants of brain natriuretic peptide production. The rise of the natriuretic peptide level in cases of acute brain damage has a functionally adaptive nature, based on vasodilation, diuretic action peptide and ability to reduce sympathoadrenal system activity. Thus, we can suppose that the more severe the damage, the higher the stimulation of natriuretic peptide. In this study we investigate the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with severe brain damage and find correlation between the level of peptide and outcome. …
