It is unclear how mortality and causes of death vary between patients and surgical procedures and how occurrence of postoperative complications is associated with prognosis. This study describes long-term mortality rates and causes of death in a general surgical population. Furthermore, we explore the effect of postoperative complications on mortality.
Methods
A single-centre analysis of postoperative complications, with mortality as primary endpoint, was conducted in 4479 patients undergoing surgery. We applied univariate and multivariable regression models to analyse the effect of risk factors, including surgical risk and postoperative complications, on mortality. Causes of death were also explored.
Results
75 patients (1.7 %) died within 30 days after surgery and 730 patients (16.3 %) died during a median follow-up of 6.3 years (IQR 5.8–6.8). Significant differences in long-term mortality were observed with worst outcome for patients undergoing high-risk vascular surgery (HR 1.5; 95 % CI 1.2–1.9). When looking at causes of death, high-risk surgery was associated with a twofold higher risk of cardiovascular death (HR 1.9; 95 % CI 1.2–3.1), whereas the intermediate-risk group had a higher risk of dying from cancer-related causes (HR 1.5; 95 % CI 1.1–2.0). Occurrence of complications—particularly of cardiovascular nature— was associated with worse survival (HR 1.9; 95 % CI 1.3–2.7).
Conclusion
High-risk vascular surgery and occurrence of postoperative complications are important predictors of late mortality. Further focus on these groups of patients can contribute to reduced morbidity. Improvement in quality of care should be aimed at preventing postoperative complications and thus a better outcome in a general surgical population.
Introduction
Each year, more than 230 million major surgical procedures are performed worldwide [1]. Risk of mortality after surgery differs greatly in patients and surgical procedures. Also, evidence increasingly suggests that patients experiencing postoperative complications have a reduced quality of life and life expectancy itself [2‐4]. Khuri et al. demonstrated that this adverse effect of complications on late mortality is independent of patients’ preoperative risk factors [2]. However, it is unknown if the causes of death are also effected. Recently, a large cohort study described important variations in postoperative mortality rates between European nations [5]. Both findings highlight room for improvement of perioperative care. In order to adequately inform patients of significant surgery risks, information on surgery-related complications and mortality is important.
The objective of our study is to describe long-term mortality rates and cause of death in a general surgical population. Furthermore, in addition to demographic and disease specific factors, we explored the effect of postoperative complications on long-term mortality.
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Methods
Study sample
This study was performed in the Zuyderland medical centre, a medium-sized regional hospital in the Netherlands. This hospital contains a modern degree of automation and a reliable registration of the electronic medical record. A prospective database is used containing data on all surgical procedures performed [6]. The study complies with the Helsinki statement on research ethics, and the local medical ethical committee gave formal review and approval. Data were collected from patients who underwent elective or urgent non-cardiac surgery. We identified 5373 consecutive patients undergoing surgery from March 2005 to December 2006. Patients younger than 14 years old and patients undergoing surgical procedures under local infiltration were excluded. Because one of our primary endpoints was long-term survival, a patient’s first operation within the enrollment period was considered the index operation, and survival was determined from that moment onward. However, when a patient needed repeated surgery during the same hospital stay, we included the need for a re-operation as a separate outcome measure. A total of 4479 patients were considered suitable for the final study population.
Baseline characteristics
Individual data on the patient’s medical history were obtained by a surgeon or a surgical resident prior to surgery. Data collected included main diagnosis, history of cardiac, pulmonary or cerebrovascular disease, diabetes mellitus, hypertension, ASA classification [7], any malignancy, as well as intoxications, use of medication, and patient’s height and bodyweight. Information from the electronic medical record on baseline characteristics could be completed in 96 up to 100 %, except for information on smoking habits, which could be obtained in 75 % of patients.
Pathological cardiac history was defined as a condition involving coronary artery disease, heart failure, valvular heart disease, arrhythmias or cardiomyopathy. Pulmonary disease was defined as illness of the lungs or respiratory system, such as COPD, asthma, lung cancer, chronic infections or previous embolisms. A previous cerebral thrombosis, embolism or hemorrhage was noted as cerebrovascular disease. Table 1 shows the surgical procedures, classified according to the standardized Dutch classification system [8]. For the purpose of this study, we categorized the main surgical procedures into fifteen generally accepted groups, which were then distributed over three risk categories: low-, intermediate- and high-risk procedures [9]. In this general teaching hospital, trauma patients are physiologically stable and patients undergoing highly complex low-volume surgery are being treated in tertiary university hospitals. Information on whether the patient had surgery requiring hospitalization or day-case surgery was also collected. Finally, we documented the type of anaesthesia, divided into general and/or regional. Validation of the database using a random sampling audit procedure confirmed a high level of accuracy and completeness of data.
Table 1
Surgical Categories according to the standardized Dutch classification system8
Surgical Categories
Low-risk surgery
Breast surgery
Hernia surgerya
Minor surgery of soft tissue
Minor trauma surgery
Perianal surgery
Varicose vein surgery
Intermediate-risk surgery
Appendectomy
Carotid artery surgery
Cholecystectomy
Head and neck surgery
Major abdominal surgeryb
Major trauma surgeryc
Thoracic surgery
High-risk surgery
Ischemic limb amputation
Major vascular surgeryd
aExcept for incisional hernia repair
bI.e. liver, gastric, bowel, spleen, oesophagus and incisional hernia surgery
cI.e. multi trauma or trauma involving the femur or the hip
dI.e. open aortic repair and peripheral bypass surgery
Outcome
All-cause mortality was the primary endpoint of this study. Secondary endpoints were postoperative complications within 30 days after surgery and cause of death. For the evaluation of outcome, a surgical resident followed patients during hospitalization and postoperative visits to the outpatient clinic up to 1 year. We gathered the following data: date of surgery, date of discharge, length of hospital stay, operating time, blood loss and postoperative complications. Complications were defined as any event deviating from a normal postoperative course within 30 days after surgery. We separately documented the following postoperative complications: wound infections, pneumonia, cardiovascular and cerebrovascular events, deep vein thrombosis and/or pulmonary embolisms, ICU-admission, readmission and need for complication surgery. A surgical resident as well as a member of the surgical staff independently scored complications. For an objective interpretation of outcome, we used the earlier proposed Clavien–Dindo classification system as guidance [10]. Complications were subsequently divided into 4 categories: no complication, a self-limiting complication (for example, a small wound dehiscence not needing specific treatment), a non-self-limiting complication (for example, the need for antibiotics in case of pneumonia or wound infection, a re-operation, or a CT-guided drainage of an abscess) and a major complication, which involves complications with residual disability, including organ failure.
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Information on long-term mortality and cause of death were obtained by inquiry of the national public register and Dutch Central Bureau of Statistics. Autopsy was not routinely performed, and the expected cause leading to health deterioration prior to death was considered the underlying cause of death, in parallel to the strategy used for the overall Dutch population. The causes of death were grouped according to the International Classification of Diseases, 10th Revision (ICD-10). For patients who lived abroad, last available follow-up information was used. For better understanding of surgical outcome, we compared our study population with a general age and gender matched Dutch population. Information about the general population was extracted from the Electronic Databank of Central Bureau of Statistics Netherlands [11].
Statistical analysis
Categorical variables are presented as numbers and percentages. Continuous data are presented as mean ± standard deviation (SD) when normally distributed or as median values and corresponding 25th and 75th percentiles when data were skewed. We used Chi-square test for comparison of categorical variables and analysis of variance or Kruskal–Wallis test for continuous variables. Univariate and multivariable Cox regression models were used to evaluate association between surgical risk categories and mortality. Low-risk surgery was used as reference category in the regression analyses. To ensure we give a true estimate of mortality risk, we entered all potential confounders (age, gender, type of anaesthesia, ASA classification, diabetes, hypertension, pulmonary- , cardiac- or cerebrovascular disease, BMI, malignancy) in the multivariable regression models.
Kaplan–Meier survival curves were calculated for each type of surgical category. The predictive value of postoperative complications on cause-specific long-term mortality was assessed in 30-day survivors using Cox regression analysis.
Since it seems predictable that patients undergoing high-risk procedures are more at risk of experiencing postoperative complications and death, we performed an additional sensitivity analysis, excluding this high-risk surgery group.
Results are reported as hazard ratios (HR) with a 95 % confidence interval. Significance was set at a two-sided P value <0.05. Analysis was performed using SPSS software version 20.0.0.
Results
Patient population
4479 patients undergoing general surgery were included in this analysis. There were an equal percentage of men and women in the cohort and mean age was 55.0 ± 17.5 years. Table 2 shows clinical baseline and surgery-related characteristics of the study population. The majority of procedures (85.6 %) were performed under general anaesthesia. Most of the procedures (56.4 %) could be classified as low-risk surgery according to the surgical risk classification system [9]. Intermediate- and high-risk surgery accounted for 38.4 and 5.2 %, respectively.
Table 2
Baseline characteristics
All patients
(N = 4479)
Any complication
(N = 949)
Overall mortality
(N = 730)
Demographics
Age, years (mean ± SD)
55.0 ± 17.5
62.7 ± 16.8#
71.6 ± 12.3##
Male sex (%)
2307 (51.5 %)
495 (52.2 %)
402 (55.1 %)##
ASA classification (%)
#
##
I
1501 (33.5 %)
157 (16.6 %)
19 (2.6 %)
II
1600 (35.7 %)
292 (31.0 %)
149 (20.6 %)
III
1169 (26.1 %)
405 (42.9 %)
428 (59.0 %)
IV
161 (3.6 %)
85 (9.0 %)
125 (17.2 %)
V
4 (0.1 %)
4 (0.4 %)
4 (0.6 %)
Medical history (%)
Diabetes mellitus
402 (9.1 %)
142 (15.1 %)#
160 (22.2 %)##
Hypertension
884 (20.0 %)
261 (27.8 %)#
259 (35.9 %)##
Cerebrovascular disease
313 (7.1 %)
92 (9.8 %)#
132 (18.3 %)##
Malignant disease
1028 (23.2 %)
296 (31.4 %)#
358 (49.4 %)##
Pathological cardiac history
825 (18.6 %)
294 (31.3 %)#
358 (49.7 %)##
Pathological pulmonary history
633 (14.3 %)
186 (19.8 %)#
221 (30.7 %)##
Smoking* (%)
#
##
Current smoking
1075 (32.1 %)
202 (29.2 %)
183 (32.8 %)
History
590 (17.6 %)
143 (20.7 %)
157 (28.1 %)
No smoking
1682 (50.3 %)
346 (50.1 %)
218 (39.1 %)
BMI category (%)
#
##
Normal weight (BMI 18,5-25 kg/m2)
1815 (42.3 %)
339 (37.8 %)
331 (48.2 %)
Underweight (BMI < 18,5 kg/m2)
100 (2.3 %)
28 (3.1 %)
35 (5.1 %)
Overweight (BMI 25-30 kg/m2)
1635 (38.1 %)
345 (38.5 %)
212 (30.9 %)
Obese (BMI > 30 kg/m2)
743 (16.6 %)
185 (20.6 %)
109 (15.9 %)
Surgical categories (%)
#
##
Low-risk surgery
2527 (56.4 %)
302 (31.8 %)
238 (32.6 %)
Breast
382 (8.5 %)
49 (5.2 %)
63 (8.6 %)
Hernia
839 (18.7 %)
88 (9.3 %)
79 (10.8 %)
Minor surgery of soft tissue
408 (9.1 %)
66 (7.0 %)
58 (7.9 %)
Minor trauma
228 (5.1 %)
27 (2.8 %)
12 (1.6 %)
Perianal surgery
278 (6.2 %)
19 (2.0 %)
14 (1.9 %)
Varicose vein surgery
392 (8.8 %)
53 (5.6 %)
12 (1.6 %)
Intermediate-risk surgery
1720 (38.4 %)
534 (56.3 %)
367 (50.3 %)
Appendectomy
251 (5.6 %)
55 (5.8 %)
11 (1.5 %)
Carotid artery
74 (1.7 %)
12 (1.3 %)
15 (2.1 %)
Cholecystectomy
495 (11.1 %)
100 (10.5 %)
30 (4.1 %)
Head and neck
102 (2.3 %)
30 (3.2 %)
8 (1.1 %)
Major abdominal
629 (14.0 %)
295 (31.1 %)
222 (30.4 %)
Major trauma
79 (1.8 %)
27 (2.8 %)
46 (6.3 %)
Thoracic
90 (2.0 %)
15 (1.6 %)
35 (4.8 %)
High risk surgery
232 (5.2 %)
113 (11.9 %)
125 (17.1 %)
Amputation
36 (0.8 %)
18 (1.9 %)
29 (4.0 %)
Major vascular
196 (4.4 %)
95 (10.0 %)
96 (13.2 %)
Surgery characteristics (%)
General anaesthesia
3824 (85.6 %)
866 (91.7 %)#
654 (90.0 %)##
Outpatient surgery
1539 (34.4 %)
139 (14.6 %)#
67 (9.2 %)##
Length of stay, (days) (median + IQR)
2 (1–8)
8 (2–16)
7 (2–15)
Blood Loss, (mL) (median + IQR)
15 (5–50)
50 (20–250)
50 (10–200)
Operation time, (min) (median + IQR)
41 (25–68)
63 (38–110)
61 (35–113)
# Significantly different (p <05) when compared to patients without complications
## Significantly different (p <05) when compared to alive patients
* Data available in 75.7 % of patients
Table 3 shows baseline characteristics according to the main surgical categories. As expected, demographics and proportion of comorbidities varied widely when categorized by different surgical procedures. Patients with trauma of the hip and major vascular patients were of higher age (76.1 ± 17.2 and 69.8 ± 10.7, respectively). In general, patients who underwent vascular surgery had the highest prevalence of comorbid diseases.
Table 3
Baseline characteristics according to main surgical categories
Male (%)
Age, years
Mean ± SD
HT (%)
DM (%)
Cerebrovascular disease (%)
Malignant disease (%)
Pathological cardiac history (%)
Pathological pulmonary history (%)
Current
smoking (%)
Low surgical risk
1408 (55.7 %)
52.2 (± 16.4)
380 (15.2 %)
152 (6.1 %)
94 (3.8 %)
511 (20.5 %)
339 (13.6 %)
287 (11.5 %)
604 (32.6 %)
Breast
19 (5.0 %)
57.3 (± 14.8)
80 (20.9 %)
33 (8.6 %)
14 (3.7 %)
333 (87.2 %)
52 (13.6 %)
41 (10.7 %)
91 (28.2 %)
Hernia
739 (88.1 %)
56.5 (± 15.6)
126 (15.1 %)
47 (5.6 %)
45 (5.4 %)
48 (5.8 %)
152 (18.2 %)
96 (11.5 %)
194 (30.1 %)
Minor surgery of soft tissue
226 (55.4 %)
49.8 (± 16.5)
77 (18.9 %)
37 (9.1 %)
17 (4.2 %)
97 (23.8 %)
59 (14.5 %)
66 (16.2 %)
102 (34.8 %)
Minor trauma
102 (44.7 %)
48.3 (± 18.5)
34 (16.3 %)
13 (6.2 %)
7 (3.3 %)
7 (3.3 %)
21 (10.0 %)
20 (9.6 %)
45 (32.8 %)
Perianal surgery
207 (74.5 %)
40.5 (± 15.7)
21 (7.8 %)
14 (5.2 %)
5 (1.9 %)
9 (3.3 %)
28 (10.4 %)
21 (7.8 %)
98 (50.0 %)
Varicose vein surgery
115 (29.3 %)
50.9 (± 13.0)
42 (10.7 %)
8 (2.0 %)
6 (1.5 %)
17 (4.3 %)
27 (6.9 %)
43 (11.0 %)
74 (28.6 %)
Intermediate surgical risk
739 (43.0 %)
57.0 (± 18.4)
394 (23.1 %)
181 (10.6 %)
174 (10.2 %)
489 (28.6 %)
347 (20.3 %)
288 (16.9 %)
388 (29.6 %)
Appendectomy
126 (50.2 %)
39.6 (± 17.9)
24 (9.7 %)
8 (3.2 %)
4 (1.6 %)
12 (4.9 %)
14 (5.7 %)
8 (3.2 %)
51 (27.7 %)
Carotid artery
53 (71.6 %)
67.4 (± 9.3)
31 (41.9 %)
18 (24.3 %)
60 (81.1 %)
7 (9.5 %)
32 (43.2 %)
10 (13.5 %)
28 (41.2 %)
Cholecystectomy
152 (30.7 %)
54.0 (± 15.2)
97 (19.6 %)
38 (7.7 %)
24 (4.9 %)
36 (7.3 %)
74 (15.0 %)
48 (9.7 %)
123 (31.9 %)
Head and neck
41 (40.2 %)
54.1 (± 15.0)
20 (19.8 %)
9 (8.9 %)
4 (4.0 %)
22 (21.8 %)
7 (6.9 %)
8 (7.8 %)
23 (34.3 %)
Major abdominal
292 (46.4 %)
62.8 (± 16.7)
175 (28.0 %)
84 (13.4 %)
59 (9.4 %)
340 (54.2 %)
154 (24.6 %)
110 (17.6 %)
122 (25.8 %)
Major trauma
22 (27.8 %)
76.1 (± 17.2)
27 (35.5 %)
19 (25.0 %)
14 (18.4 %)
16 (20.8 %)
38 (50.0 %)
23 (30.3)
9 (18.0 %)
Thoracic
53 (58.9 %)
60.0 (± 15.7)
20 (22.2 %)
5 (5.6 %)
9 (10.0 %)
56 (62.2 %)
28 (31.1 %)
81 (90.0 %)
32 (38.1 %)
High surgical risk
160 (69.0 %)
69.7 (± 11.5)
110 (47.8 %)
69 (30.0 %)
45 (19.6 %)
28 (12.2 %)
139 (60.4 %)
58 (25.2 %)
83 (45.4 %)
Amputation
18 (50.0 %)
68.8 (± 15.2)
16 (44.4 %)
19 (52.8 %)
13 (36.1 %)
4 (11.1 %)
21 (58.3 %)
9 (25.0 %)
11 (40.7 %)
Major vascular
142 (72.4 %)
69.8 (± 10.7)
94 (48.5 %)
50 (25.8 %)
32 (16.5 %)
24 (12.4 %)
118 (60.8 %)
49 (25.3 %)
72 (46.2 %)
Postoperative complications
We evaluated the effect of different surgical categories on postoperative outcome (Table 4). Complications occurred in 949 patients (21.0 %). In general, patients who experienced complications were of higher age (62.7 ± 16.8) when compared to all patients and had more comorbidities (Table 2). Amputation of an ischemic limb and major vascular surgery was associated with highest risk of complications (50.0 and 48.5 %). As expected, non-self-limiting complications (32.8 %), major complications (4.7 %) and 30-day mortality (8.6 %) were more often seen in the high-risk group.
Table 4
Postoperative Outcome within 30 Days
No complication (%)
Self-limiting complication
(Grade 1) (%)
Non-self-limiting complication
(Grade 2 + 3) (%)
Major complication
(Grade 4) (%)
Death
(Grade 5) (%)
Low-risk surgery
2225 (88.0)
77 (3.0)
216 (8.5)
1 (0.0)
8 (0.3)
Breast
333 (87.2)
13 (3.4)
36 (9.4)
0 (0.0)
0 (0.0)
Hernia
751 (89.5)
19 (2.3)
65 (7.7)
1 (0.1)
3 (0.4)
Minor surgery of soft tissue
342 (83.8)
18 (4.4)
44 (10.8)
0 (0.0)
4 (1.0)
Minor trauma
201 (88.2)
8 (3.5)
19 (8.3)
0 (0.0)
0 (0.0)
Perianal surgery
259 (93.2)
5 (1.8)
13 (4.7)
0 (0.0)
1 (0.4)
Varicose vein surgery
339 (86.5)
14 (3.6)
39 (9.9)
0 (0.0)
0 (0.0)
Intermediate-risk surgery
1186 (69.0)
99 (5.8)
349 (20.3)
39 (2.3)
47 (2.7)
Appendectomy
196 (78.1)
16 (6.4)
37 (14.7)
1 (0.4)
1 (0.4)
Carotid artery
62 (83.8)
5 (6.8)
2 (2.7)
3 (4.1)
2 (2.7)
Cholecystectomy
395 (79.8)
30 (6.1)
64 (12.9)
3 (0.6)
3 (0.6)
Head and neck
72 (70.6)
11 (10.8)
19 (18.6)
0 (0.0)
0 (0.0)
Major abdominal
334 (53.1)
31 (4.9)
198 (31.5)
29 (4.6)
37 (5.9)
Major trauma
52 (65.8)
2 (2.5)
19 (24.1)
3 (3.8)
3 (3.8)
Thoracic
75 (83.3)
4 (4.4)
10 (11.1)
0 (0.0)
1 (1.0)
High risk surgery
119 (51.3)
6 (2.6)
76 (32.8)
11 (4.7)
20 (8.6)
Amputation
18 (50.0)
2 (5.6)
9 (25.0)
1 (2.8)
6 (16.7)
Major vascular
101 (51.5)
4 (2.0)
67 (34.2)
10 (5.1)
14 (7.1)
All types
3530 (78.8)
182 (4.1)
641 (14.3)
51 (1.1)
75 (1.7)
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All-cause mortality
Overall 30-day mortality rate was 1.7 % (75 patients), with cardiac and cancer-related death accounting for 26.6 and 19.0 %, respectively. Information on long-term mortality and cause of death was available in 96.4 % of patients. For patients who lived abroad or had immigrated (N = 108, 2.4 %), last available follow-up information was used. The primary endpoint of all-cause mortality was observed in 730 patients (16.3 %) during median follow-up of 6.3 years (IQR 5.8–6.8). When comparing risk of mortality associated with types of surgery, confounding factors such as demographics and comorbidities must be taken into account. Table 5 shows important differences in long-term mortality in relation to surgical risk in a multivariable regression model. Patients who underwent intermediate (HR 1.2; 95 % CI 1.0–1.5) or high-risk surgery (HR 1.5; 95 % CI 1.2–1.9) had a significant higher relative mortality risk. Figures 1 and 2 show Kaplan–Meier estimates of long-term survival among different surgical procedures and categories. In order to interpret the effect of surgery on long-term survival, Fig. 2 also shows the survival curve of the age and gender matched general Dutch population.
Table 5
The association between surgery risks and different mortality hazards
Events
Univariate
Multivariable*
N (%)
Hazard Ratio
95 % CI
Hazard Ratio
95 % CI
Overall mortality
Low-risk surgery
238
1
–
1
–
Intermediate-risk surgery
367
2.364
1.998–2.796
1.216
1.017–1.455
High-risk surgery
125
7.512
6.014–9.382
1.507
1.166–1.946
Cardiovascular mortality
Low-risk surgery
57
1
–
1
–
Intermediate-risk surgery
58
1.686
1.170–2.431
0.860
0.574–1.287
High-risk surgery
46
12.747
8.621–18.848
1.923
1.194–3.095
Cancer-related mortality
Low-risk surgery
93
1
–
1
–
Intermediate-risk surgery
192
3.301
2.574–4.233
1.503
1.143–1.977
High-risk surgery
21
3.615
2.270–5.758
1.281
0.762–2.152
aAnalyses were adjusted for age, gender, type of anaesthesia, ASA classification, diabetes, hypertension, pulmonary-, cardiac- or cerebrovascular disease, BMI and the presence of a malignancy
Fig. 1
Kaplan–Meier estimates of long-term survival among different surgical procedures
Fig. 2
Kaplan–Meier estimates of long-term survival among different surgical categories, including a survival curve of the age and gender matched general Dutch population
×
×
Late causes of death
When looking at the cause of late mortality, patients in the high-risk group, i.e., vascular patients, had a twofold higher risk of cardiovascular death (HR 1.9; 95 % CI 1.2–3.1) compared to low-risk patients (Table 5). Patients in the intermediate group, i.e., the group consisting of most patients undergoing cancer surgery (28.6 %), had a higher risk of dying from a cancer-related cause (HR 1.5; 95 % CI 1.1–2.0).
Association between postoperative complications and mortality
We found a significant adverse effect between the presence of postoperative complications and long-term mortality (Table 6). Figure 3 shows a Kaplan–Meier estimate of 30-day survivors, calculated for different types of complications. This survival curve illustrates that survival in the patient group with self-limiting complications is already worse compared to those with no complications, whereas the prognosis in the two patient groups with non-self-limiting and major complications is considerably and increasingly worse. After exclusion of high-risk procedures, this association between complications and mortality still remained significant in low- and intermediate-surgical risk patients (HR 1.2; 95 % CI 1.1–1.5).
Table 6
The association between 30-day complications and different long-term mortality hazards (in 30-day survivors)
Events
Univariate
Multivariable
N (%)
Hazard Ratio
95 % CI
Hazard Ratio
95 % CI
Overall mortality
627
2.393
2.033–2.818
1.197
1.009–1.421
Cardiovascular mortality
140
3.527
2.526–4.924
1.890
1.312–2.721
Cancer-related mortality
291
2.230
1.748–2.845
1.101
0.850–1.426
aAnalyses were adjusted for age, gender, type of anaesthesia, ASA classification, diabetes, hypertension, pulmonary-, cardiac- or cerebrovascular disease, BMI and the presence of a malignancy
Fig. 3
Kaplan–Meier estimates of 30-day survivors, calculated for different types of complications
×
Discussion
Late mortality after surgery might be higher than expected (16 % at 6 years). The 30-day mortality of 1.7 % we found is much similar to the 1.9 % reported in a study performed in the Netherlands in 2010 [12]. Previous studies on outcome following surgery are scarce, mostly retrospective in design and based on administrative databases [12‐14]. Lee et al. demonstrated that clinical chart review had a significantly better accuracy than a comparable administrative database model, probably due to undercoding of comorbidities in the latter [15].
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Instead of focussing on demographic and disease specific factors only, we took variables such as postoperative complications into account, which have been reported to be of clinical importance [2, 3, 16, 17]. To our knowledge, this is the first prospective study to combine all these factors in order to analyse long-term outcome, including cause of late death.
According to this study, special focus on two groups of patients is advised in order to improve postoperative care. As can be expected, the first group associated with an adverse outcome is the group of high-risk vascular patients. Although these were only 5 % of operated patients, they accounted for 27 % of 30-day mortality. The high incidence of postoperative death in this subpopulation is in accordance with previous literature [9, 12, 18]. Taking the surgical procedure itself into account when predicting risk of postoperative complications, rather than patients’ comorbidity only, remains very important.
The second group highly and independently associated with late death has patients who experience postoperative complications. In this study, complications occurred in 21 % of patients, who were mostly of higher age and had more comorbidities. In order to better understand, the relationship between postoperative complications and reduced survival one might ask if a complication is the cause of this reduction, or a sign of a bigger pathological problem. In this study, we demonstrated that the relationship between complications and reduced survival remains valid even after adjusting for potential confounders. Moreover, after exclusion of high-risk surgery in a sensitivity analysis, this relationship still remains significant.
Recent literature shows that frailty is associated with higher morbidity and mortality, independent of other risk factors in a surgical population. Preoperative recognition of this multidimensional vulnerability may be an adjunct in assessment of preoperative risk factors. Also, evidence has shown that the surgical procedure itself elicits a stress response, initiated by tissue injury [19‐22]. Surgical injury profoundly affects the innate and adaptive immune responses, leading to an increased susceptibility to complications [22].
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Cause-specific mortality analysis showed that the high-risk group had a twofold higher risk of dying from a cardiovascular cause. As expected, patients in the intermediate surgery group were more likely to die from a cancer-related cause. In order to appreciate these numbers, the Dutch registration for cause of death needs clarification. The certificate of death filled in by a medical practitioner is based on guidelines of the World Health Organization [23]. Only one cause can be coded as primary cause of death. Primary cause of death is the cause of the initial health deterioration leading to the end of life. For example, if a patient had surgery because of intestinal cancer and died due to postoperative myocardial infarction, cause of death would be cancer-related and the myocardial event noted as a secondary response to his underlying illness [24]. Reliability of cause-of-death coding in the Netherlands turns out to be high (>90 %) for major causes of death, such as cancer- and cardiovascular-related causes [24, 25].
We recognize that our study has potential limitations. It is conducted in a single centre with a potential bias in referral pattern. However, at the time of enrolment, only patients needing total pelvic exenteration or patients with severe comorbidity were referred to tertiary centres. All other major abdominal surgery, such as liver, gastric, bowel, spleen, oesophagus and incisional hernia surgery, was performed in this regional hospital. Our data contain quite a large number of intermediate- and high-risk procedures and procedures with a long operation time.
Second, we only included patients who underwent surgery. There might have been high-risk patients screened for surgery, but denied because of the risk of potential adverse outcome. For patients with malignancy, type and stage of their disease is known to influence life expectancy. We entered the presence of a malignancy as a potential confounder in all multivariable models; however, we did not specifically assess severity of malignant disease in this general surgical population.
Finally, due to the observational character, this study is inherent to unmeasured confounding.
Surgical outcome is influenced by the patients’ preoperative status, severity of disease or surgical procedure and quality of care [26]. In the Netherlands, a high-resource country, accessibility and quality of care are considered equal for all inhabitants. Also, the wide implementation of modern perioperative programmes such as fast-track surgery or goal-directed therapy seems to contribute to a reduced postoperative morbidity. [27, 28].
In conclusion, high-risk vascular surgery and the occurrence of postoperative complications are important prognostic factors of late mortality. Further focus on these groups of patients can contribute to a reduced postoperative morbidity. Improvement in quality of surgical care should be aimed at preventing postoperative complications and thus a better outcome in a general surgical population.
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Conflicts of interest
None.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.
Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.
Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.
Bei schwerer Aortenstenose und obstruktiver KHK empfehlen die Leitlinien derzeit eine chirurgische Kombi-Behandlung aus Klappenersatz plus Bypass-OP. Diese Empfehlung wird allerdings jetzt durch eine aktuelle Studie infrage gestellt – mit überraschender Deutlichkeit.
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Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.
Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.
