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01.05.2014 | Magnetic Resonance

Multi-delay arterial spin labeling perfusion MRI in moyamoya disease–comparison with CT perfusion imaging

verfasst von: Rui Wang, Songlin Yu, Jeffry R. Alger, Zhentao Zuo, Juan Chen, Rong Wang, Jing An, Bo Wang, Jizong Zhao, Rong Xue, Danny J. J. Wang

Erschienen in: European Radiology | Ausgabe 5/2014

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Abstract

Objectives

To present a multi-delay pseudo-continuous ASL (pCASL) protocol that offers simultaneous measurements of cerebral blood flow (CBF) and arterial transit time (ATT), and to study correlations between multi-delay pCASL and CT perfusion in moyamoya disease.

Methods

A 4 post-labeling delay (PLD) pCASL protocol was applied on 17 patients with moyamoya disease who also underwent CT perfusion imaging. ATT was estimated using the multi-delay protocol and included in the calculation of CBF. ASL and CT perfusion images were rated for lesion severity/conspicuity. Pearson correlation coefficients were calculated across voxels between the two modalities in grey and white matter of each subject respectively and between normalized mean values of ASL and CT perfusion measures in major vascular territories.

Results

Significant associations between ASL and CT perfusion were detected using subjective ratings, voxel-wise analysis in grey and white matter and region of interest (ROI)-based analysis of normalized mean perfusion. The correlation between ASL CBF and CT perfusion was improved using the multi-delay pCASL protocol compared to CBF acquired at a single PLD of 2 s (P < 0.05).

Conclusions

There is a correlation between perfusion data from ASL and CT perfusion imaging in patients with moyamoya disease. Multi-delay ASL can improve CBF quantification, which could be a prognostic imaging biomarker in patients with moyamoya disease.

Key Points

• Simultaneous measurements of CBF and ATT can be achieved using multi-delay pCASL.

• Multi-delay ASL was compared with CT perfusion in patients with moyamoya disease.

• Statistical analyses showed significant associations between multi-delay ASL and CT perfusion.

• Multi-delay ASL can improve CBF quantification in moyamoya disease.

Nur mit Berechtigung zugänglich

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Titel: Multi-delay arterial spin labeling perfusion MRI in moyamoya disease–comparison with CT perfusion imaging
verfasst von: Rui Wang
Songlin Yu
Jeffry R. Alger
Zhentao Zuo
Juan Chen
Rong Wang
Jing An
Bo Wang
Jizong Zhao
Rong Xue
Danny J. J. Wang
Publikationsdatum: 01.05.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 5/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3098-9

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Multi-delay arterial spin labeling perfusion MRI in moyamoya disease–comparison with CT perfusion imaging