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01.11.2013 | Original Article

Impact of cow’s milk allergy on enterocolitis associated with Hirschsprung’s disease

verfasst von: Satoshi Umeda, Hisayoshi Kawahara, Akihiro Yoneda, Yuko Tazuke, Gakuto Tani, Tomohiro Ishii, Taro Goda, Katsuhisa Hirano, Kayo Ikeda, Shinobu Ida, Masahiro Nakayama, Akio Kubota, Masahiro Fukuzawa

Erschienen in: Pediatric Surgery International | Ausgabe 11/2013

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Abstract

Purpose

To investigate the impact of cow’s milk allergy (CMA) on infants with Hirschsprung’s disease (HD).

Methods

Twenty-four patients, who developed gastrointestinal symptoms before the age of 60 days and underwent surgery for HD in the period between January 2003 and December 2012, were enrolled in this study. They were divided into two groups based on CMA-related findings: stimulation index of lymphocyte stimulation test >300 % and the presence of eosinophilic infiltration in the resected colon. Ten patients were determined specimen as not having CMA (Group A), because they did not satisfy any of the criteria. The remaining 14 were determined as having possible CMA (Group B), because they satisfied either or both findings. Patient background characteristics, pre- and postoperative clinical history, and laboratory data were compared between Groups A and B.

Results

Pre- and postoperative enterocolitis did not occur in Group A patients. Postoperative enterocolitis was more frequent in Group B than in Group A (p = 0.04). Other clinical and laboratory data did not show significant difference between the two groups.

Conclusion

CMA is a possible risk factor for postoperative enterocolitis in patients with HD.

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Titel: Impact of cow’s milk allergy on enterocolitis associated with Hirschsprung’s disease
verfasst von: Satoshi Umeda
Hisayoshi Kawahara
Akihiro Yoneda
Yuko Tazuke
Gakuto Tani
Tomohiro Ishii
Taro Goda
Katsuhisa Hirano
Kayo Ikeda
Shinobu Ida
Masahiro Nakayama
Akio Kubota
Masahiro Fukuzawa
Publikationsdatum: 01.11.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Surgery International / Ausgabe 11/2013
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-013-3379-4

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Impact of cow’s milk allergy on enterocolitis associated with Hirschsprung’s disease