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International Journal of Colorectal Disease

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01.12.2023 | RESEARCH

Do colorectal cancer patients with a postoperative stoma have sexual problems? A pooling up analysis of 2566 patients

verfasst von: Xu-Rui Liu, Yue Tong, Zi-Wei Li, Fei Liu, Xiao-Yu Liu, Wei Zhang, Dong Peng

Erschienen in: International Journal of Colorectal Disease | Ausgabe 1/2023

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Abstract

Purpose

This study aimed to evaluate the effect of the stoma on sexual function in colorectal cancer patients.

Methods

Search strategy was conducted in four databases including PubMed, Embase, the Cochrane Library, and Medline on Nov 20, 2022. After that, the quality of eligible studies was assessed by the Newcastle Ottawa Scale (NOS) and the Agency for Healthcare Research Quality (AHRQ). In order to evaluate the sexual function between the stoma group and the non-stoma group, mean values and standard deviation were pooled for scores in questionnaires, and odds ratio and 95% confidence intervals were pooled for self-designed problems. Results were shown in forest plots; Egger’s test and the trim and fill analysis were used for assessing the publication bias. All the data analyses above were performed by STATA 16.0 software.

Results

Six cohort studies and three cross-sectional studies were included for this pooling up analysis. As for the European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ-C38), male patients with stomas had more sexual problems (mean differences = 0.32, 95% confidence intervals = 0.01 to 0.63, I² = 67.80%, P = 0.05); however, other indicators including sexual functioning, sexual enjoyment, and female sexual problems had little difference between the two groups. As for other questionnaires and problems, stoma did not have an impact on sexual function.

Conclusion

The stoma after surgery was not significantly associated with the sexual function of female patients with colorectal cancer and was associated with worse scores on only sexual problems for males.

Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660CrossRefPubMed

Liu XY, Kang B, Cheng YX et al (2022) The short-term and oncologic outcomes of younger VS older colorectal cancer patients undergoing primary surgery: a propensity score matching analysis. BMC Cancer 22(1):153. Published 2022 Feb 8. https://doi.org/10.1186/s12885-022-09246-4

Salibasic M, Pusina S, Bicakcic E et al (2019) Colorectal cancer surgical treatment, our experience. Med Arch 73(6):412–414. https://doi.org/10.5455/medarh.2019.73.412-414CrossRefPubMedPubMedCentral

Cheng YX, Tao W, Liu XY et al (2022) Hypertension remission after colorectal cancer surgery: a single-center retrospective study. Nutr Cancer 74(8):2789–2795. https://doi.org/10.1080/01635581.2021.2025256CrossRefPubMed

Ambe PC, Kurz NR, Nitschke C et al (2018) Intestinal ostomy. Dtsch Arztebl Int 115(11):182–187. https://doi.org/10.3238/arztebl.2018.0182CrossRefPubMed

Banaszkiewicz Z, Woda ŁP, Zwoliński T et al (2015) Intestinal stoma in patients with colorectal cancer from the perspective of 20-year period of clinical observation. Prz Gastroenterol 10(1):23–27. https://doi.org/10.5114/pg.2015.49107CrossRefPubMedPubMedCentral

Correa-Marinez A, Grenabo J, Bock D et al (2018) The type of stoma matters-morbidity in patients with obstructing colorectal cancer. Int J Colorectal Dis 33(12):1773–1780. https://doi.org/10.1007/s00384-018-3164-xCrossRefPubMed

Fok CYJ, Fung TLD, Kwok KH (2021) Predictors of morbidity related to stoma closure after colorectal cancer surgery. Langenbecks Arch Surg 406(2):349–356. https://doi.org/10.1007/s00423-020-02054-zCrossRefPubMed

Peng D, Yu DL, Liu XY et al (2022) Does temporary ileostomy via specimen extraction site affect the short outcomes and complications after laparoscopic low anterior resection in rectal cancer patients? A propensity score matching analysis. BMC Surg 22(1):263. Published 2022 Jul 7. https://doi.org/10.1186/s12893-022-01715-8

10.

Szpilewska K, Juzwiszyn J, Bolanowska Z et al (2018) Acceptance of disease and the quality of life in patients with enteric stoma. Pol Przegl Chir 90(1):13–17. https://doi.org/10.5604/01.3001.0011.5954CrossRefPubMed

11.

Cheng Y, Cheng YX, Liu XY et al (2022) The effect of type 2 diabetes mellitus on the short-term outcomes and prognosis of stage I-III colorectal cancer: a propensity score matching analysis. Cancer Manag Res 14:205–214. Published 2022 Jan 13. https://doi.org/10.2147/CMAR.S347242

12.

Alenezi A, McGrath I, Kimpton A, Livesay K (2021) Quality of life among ostomy patients: a narrative literature review. J Clin Nurs 30(21–22):3111–3123. https://doi.org/10.1111/jocn.15840CrossRefPubMed

13.

Liu XY, Kang B, Cheng YX et al (2022) Higher body mass index was associated with better prognosis in diabetic patients with stage II colorectal cancer. BMC Cancer 22(1):596. Published 2022 Jun 1. https://doi.org/10.1186/s12885-022-09691-1

14.

Kristensen HØ, Thyø A, Emmertsen KJ et al (2022) Surviving rectal cancer at the cost of a colostomy: global survey of long-term health-related quality of life in 10 countries. BJS Open. 6(6):zrac085. https://doi.org/10.1093/bjsopen/zrac085CrossRefPubMedPubMedCentral

15.

Bottomley A, Reijneveld JC, Koller M et al (2019) Current state of quality of life and patient-reported outcomes research. Eur J Cancer 121:55–63. https://doi.org/10.1016/j.ejca.2019.08.016CrossRefPubMed

16.

Schover LR (2019) Sexual quality of life in men and women after cancer. Climacteric 22(6):553–557. https://doi.org/10.1080/13697137.2018.1526893CrossRefPubMed

17.

Basson R (2015) Human sexual response. Handb Clin Neurol 130:11–18. https://doi.org/10.1016/B978-0-444-63247-0.00002-XCrossRefPubMed

18.

Wong CK, Chen J, Yu CL, Sham M, Lam CL (2015) Systematic review recommends the European Organization for Research and Treatment of Cancer colorectal cancer-specific module for measuring quality of life in colorectal cancer patients. J Clin Epidemiol 68(3):266–278. https://doi.org/10.1016/j.jclinepi.2014.09.021CrossRefPubMed

19.

Neijenhuijs KI, Holtmaat K, Aaronson NK et al (2019) The International Index of Erectile Function (IIEF)-a systematic review of measurement properties. J Sex Med 16(7):1078–1091. https://doi.org/10.1016/j.jsxm.2019.04.010CrossRefPubMed

20.

Neijenhuijs KI, Hooghiemstra N, Holtmaat K et al (2019) The Female Sexual Function Index (FSFI)-a systematic review of measurement properties. J Sex Med 16(5):640–660. https://doi.org/10.1016/j.jsxm.2019.03.001CrossRefPubMed

21.

Irfan M, Hussain NHN, Noor NM et al (2020) Epidemiology of male sexual dysfunction in Asian and European regions: a systematic review. Am J Mens Health 14(4):1557988320937200. https://doi.org/10.1177/1557988320937200CrossRefPubMedPubMedCentral

22.

Hidalgo DA, Dewitte M (2021) Individual, relational, and sociocultural determinants of sexual function and sexual satisfaction in Ecuador. Sex Med 9(2):100307. https://doi.org/10.1016/j.esxm.2020.100307CrossRefPubMedPubMedCentral

23.

Cöl C, Hasdemir O, Yalçin E et al (2006) Sexual dysfunction after curative radical resection of rectal cancer in men: the role of extended systematic lymph-node dissection. Med Sci Monit 12(2):CR70-4PubMed

24.

Du P, Wang SY, Zheng PF et al (2019) Comparison of overall survival and quality of life between patients undergoing anal reconstruction and patients undergoing traditional lower abdominal stoma after radical resection. Clin Transl Oncol 21(10):1390–1397. https://doi.org/10.1007/s12094-019-02106-xCrossRefPubMed

25.

Fucini C, Gattai R, Urena C et al (2008) Quality of life among five-year survivors after treatment for very low rectal cancer with or without a permanent abdominal stoma. Ann Surg Oncol 15(4):1099–1106. https://doi.org/10.1245/s10434-007-9748-2CrossRefPubMed

26.

Orsini RG, Thong MS, van de Poll-Franse LV et al (2013) Quality of life of older rectal cancer patients is not impaired by a permanent stoma. Eur J Surg Oncol 39(2):164–170. https://doi.org/10.1016/j.ejso.2012.10.005CrossRefPubMed

27.

Reese JB, Finan PH, Haythornthwaite JA et al (2014) Gastrointestinal ostomies and sexual outcomes: a comparison of colorectal cancer patients by ostomy status. Support Care Cancer 22(2):461–468. https://doi.org/10.1007/s00520-013-1998-xCrossRefPubMed

28.

Thyø A, Elfeki H, Laurberg S, Emmertsen KJ (2019) Female sexual problems after treatment for colorectal cancer - a population-based study. Colorectal Dis 21(10):1130–1139. https://doi.org/10.1111/codi.14710CrossRefPubMed

29.

Digennaro R, Tondo M, Cuccia F et al (2013) Coloanal anastomosis or abdominoperineal resection for very low rectal cancer: what will benefit, the surgeon’s pride or the patient’s quality of life? Int J Colorectal Dis 28(7):949–957. https://doi.org/10.1007/s00384-012-1629-xCrossRefPubMed

30.

Näsvall P, Dahlstrand U, Löwenmark T et al (2017) Quality of life in patients with a permanent stoma after rectal cancer surgery. Qual Life Res 26(1):55–64. https://doi.org/10.1007/s11136-016-1367-6CrossRefPubMed

31.

Pappou EP, Temple LK, Patil S et al (2022) Quality of life and function after rectal cancer surgery with and without sphincter preservation. Front Oncol 12:944843. https://doi.org/10.3389/fonc.2022.944843CrossRefPubMedPubMedCentral

32.

Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. J Clin Epidemiol 134:178–189. https://doi.org/10.1016/j.jclinepi.2021.03.001CrossRefPubMed

33.

Maasoumi R, Rahimi F, Naghizadeh S (2022) Translation and validation of Persian version of sexual function: vaginal changes questionnaire (SVQ) for women with gynecologic cancers. BMC Womens Health 22(1):283. https://doi.org/10.1186/s12905-022-01863-2CrossRefPubMedPubMedCentral

34.

Thyø A, Emmertsen KJ, Laurberg S (2018) The rectal cancer female sexuality score: development and validation of a scoring system for female sexual function after rectal cancer surgery. Dis Colon Rectum 61(6):656–666. https://doi.org/10.1097/DCR.0000000000001064CrossRefPubMed

35.

Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25(9):603–605. https://doi.org/10.1007/s10654-010-9491-zCrossRefPubMed

36.

Fournier AK, Wasserman MR, Jones CF et al (2021) Developing AHRQ’s feasibility assessment criteria for wide-scale implementation of patient-centered outcomes research findings. J Gen Intern Med 36(2):374–382. https://doi.org/10.1007/s11606-020-06247-6CrossRefPubMed

37.

Ioannidis JP (2008) Interpretation of tests of heterogeneity and bias in meta-analysis. J Eval Clin Pract 14(5):951–957. https://doi.org/10.1111/j.1365-2753.2008.00986.xCrossRefPubMed

38.

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560. https://doi.org/10.1136/bmj.327.7414.557CrossRefPubMedPubMedCentral

39.

Duval S, Tweedie R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56(2):455–463. https://doi.org/10.1111/j.0006-341x.2000.00455.xCrossRefPubMed

40.

Dulskas A, Samalavicius NE (2016) A prospective study of sexual and urinary function before and after total mesorectal excision. Int J Colorectal Dis 31(6):1125–1130. https://doi.org/10.1007/s00384-016-2549-yCrossRefPubMed

41.

Hungr C, Sanchez-Varela V, Bober SL (2017) Self-image and sexuality issues among young women with breast cancer: practical recommendations. Rev Invest Clin 69(2):114–122. https://doi.org/10.24875/ric.17002200

42.

Ye S, Yang J, Cao D, Lang J, Shen K (2014) A systematic review of quality of life and sexual function of patients with cervical cancer after treatment. Int J Gynecol Cancer 24(7):1146–1157. https://doi.org/10.1097/IGC.0000000000000207CrossRefPubMed

43.

Walker LM, Santos-Iglesias P (2020) On the relationship between erectile function and sexual distress in men with prostate cancer. Arch Sex Behav 49(5):1575–1588. https://doi.org/10.1007/s10508-019-01603-yCrossRefPubMed

44.

Vonk-Klaassen SM, de Vocht HM, den Ouden ME et al (2016) Ostomy-related problems and their impact on quality of life of colorectal cancer ostomates: a systematic review. Qual Life Res 25(1):125–133. https://doi.org/10.1007/s11136-015-1050-3CrossRefPubMed

45.

Towe M, Huynh LM, El-Khatib F et al (2019) A review of male and female sexual function following colorectal surgery. Sex Med Rev 7(3):422–429. https://doi.org/10.1016/j.sxmr.2019.04.001CrossRefPubMed

46.

Clayton AH, Valladares Juarez EM (2019) Female sexual dysfunction. Med Clin North Am 103(4):681–698. https://doi.org/10.1016/j.mcna.2019.02.008CrossRefPubMed

47.

Rew KT (2021) Men’s health: male sexual dysfunction. FP Essent 503:28–33PubMed

48.

Peleg Nesher S, Luria M, Shachar E et al (2022) Sexual dysfunction among adolescent and young adult cancer patients: diagnostic and therapeutic approach. Curr Opin Support Palliat Care 16(2):83–91. https://doi.org/10.1097/SPC.0000000000000595CrossRefPubMed

49.

Velten J, Margraf J (2017) Satisfaction guaranteed? How individual, partner, and relationship factors impact sexual satisfaction within partnerships. PLoS ONE 12(2):e0172855. https://doi.org/10.1371/journal.pone.0172855CrossRefPubMedPubMedCentral

50.

Melisko ME, Narus JB (2016) Sexual function in cancer survivors: updates to the NCCN guidelines for survivorship. J Natl Compr Canc Netw 14(5 Suppl):685–689. https://doi.org/10.6004/jnccn.2016.0193CrossRefPubMed

Titel: Do colorectal cancer patients with a postoperative stoma have sexual problems? A pooling up analysis of 2566 patients
verfasst von: Xu-Rui Liu
Yue Tong
Zi-Wei Li
Fei Liu
Xiao-Yu Liu
Wei Zhang
Dong Peng
Publikationsdatum: 01.12.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: International Journal of Colorectal Disease / Ausgabe 1/2023
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-023-04372-2

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Do colorectal cancer patients with a postoperative stoma have sexual problems? A pooling up analysis of 2566 patients

Abstract

Purpose

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Results

Conclusion

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