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Metabolic Brain Disease

Erschienen in:

01.12.2014 | Research Article

Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro

verfasst von: Arne Schousboe, Helle S. Waagepetersen, Renata Leke, Lasse K. Bak

Erschienen in: Metabolic Brain Disease | Ausgabe 4/2014

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Abstract

The literature related to the effects of elevated plasma ammonia levels on brain energy metabolism is abundant, but heterogeneous in terms of the conclusions. Thus, some studies claim that ammonia has a direct, inhibitory effect on energy metabolism whereas others find no such correlation. In this review, we discuss both recent and older literature related to this controversial topic. We find that it has been consistently reported that hepatic encephalopathy and concomitant hyperammonemia lead to reduced cerebral oxygen consumption. However, this may not be directly linked to an effect of ammonia but related to the fact that hepatic encephalopathy is always associated with reduced brain activity, a condition clearly characterized by a decreased CMRO₂. Whether this may be related to changes in GABAergic function remains to be elucidated.

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Titel: Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro
verfasst von: Arne Schousboe
Helle S. Waagepetersen
Renata Leke
Lasse K. Bak
Publikationsdatum: 01.12.2014
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 4/2014
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-014-9513-8

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