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Current Osteoporosis Reports

Erschienen in:

09.06.2018 | Bone and Joint Pain (T King Deeny and S Amin, Section Editors)

New Insights in Understanding and Treating Bone Fracture Pain

verfasst von: Stefanie A. T. Mitchell, Lisa A. Majuta, Patrick W. Mantyh

Erschienen in: Current Osteoporosis Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

This paper describes recent advances in understanding the mechanisms that drive fracture pain and how these findings are helping develop new therapies to treat fracture pain.

Recent Findings

Immediately following fracture, mechanosensitive nerve fibers that innervate bone are mechanically distorted. This results in these nerve fibers rapidly discharging and signaling the initial sharp fracture pain to the brain. Within minutes to hours, a host of neurotransmitters, cytokines, and nerve growth factor are released by cells at the fracture site. These factors stimulate, sensitize, and induce ectopic nerve sprouting of the sensory and sympathetic nerve fibers which drive the sharp pain upon movement and the dull aching pain at rest. If rapid and effective healing of the fracture occurs, these factors return to baseline and the pain subsides, but if not, these factors can drive chronic bone pain.

Summary

New mechanism-based therapies have the potential to fundamentally change the way acute and chronic fracture pain is managed.

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Titel: New Insights in Understanding and Treating Bone Fracture Pain
verfasst von: Stefanie A. T. Mitchell
Lisa A. Majuta
Patrick W. Mantyh
Publikationsdatum: 09.06.2018
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 4/2018
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-018-0446-8

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