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Erschienen in:

06.04.2022 | Neuropathic Pain (A Abd-Elsayed, Section Editor)

Small Fiber Neuropathy

verfasst von: N. Strand, C. Wie, J. Peck, M. Maita, N. Singh, J. Dumbroff, V. Tieppo Francio, M. Murphy, K. Chang, D. M. Dickerson, J. Maloney

Erschienen in: Current Pain and Headache Reports | Ausgabe 6/2022

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Abstract

Purpose of Review

This narrative review aims to summarize advances in the field of small fiber neuropathy made over the last decade, with emphasis on novel research highlighting the distinctive features of SFN.

Recent Findings

While the management of SFNs is ideally aimed at treating the underlying cause, most patients will require pain control via multiple, concurrent therapies. Herein, we highlight the most up-to-date information for diagnosis, medication management, interventional management, and novel therapies on the horizon.

Summary

Despite the prevalence of small fiber neuropathies, there is no clear consensus on guidelines specific for the treatment of SFN. Despite the lack of specific guidelines for SFN treatment, the most recent general neuropathic pain guidelines are based on Cochrane studies and randomized controlled trials (RCTs) which have individually examined therapies used for the more commonly studied SFNs, such as painful diabetic neuropathy and HIV neuropathy. The recommendations from current guidelines are based on variables such as number needed to treat (NNT), safety, ease of use, and effect on quality of life.

Tavee J, Zhou L. Small fiber neuropathy: a burning problem. Cleve Clin J Med. 2009;76(5):297–305. https://doi.org/10.3949/ccjm.76a.08070.CrossRefPubMed

Kelley MA, Hackshaw KV. Intraepidermal nerve fiber density as measured by skin punch biopsy as a marker for small fiber neuropathy: application in patients with fibromyalgia. Diagnostics (Basel). 2021;11(3). https://doi.org/10.3390/diagnostics11030536.

Egenolf N, Zu Altenschildesche CM, Kress L, Eggermann K, Namer B, Gross F, et al. Diagnosing small fiber neuropathy in clinical practice: a deep phenotyping study. Ther Adv Neurol Disord. 2021;14:17562864211004318. https://doi.org/10.1177/17562864211004318.CrossRefPubMedPubMedCentral

Li C, Wang W, Ni W, Jin Y, Guo S, Jin J, et al. Better islet function and cardiovascular autonomic function in Chinese type 2 diabetic patients with pure small fiber neuropathy than with mixed neuropathy. Diabetes Ther. 2021;12(9):2423–36. https://doi.org/10.1007/s13300-021-01111-0.CrossRefPubMedPubMedCentral

Levine TD. Small fiber neuropathy: disease classification beyond pain and burning. J Cent Nerv Syst Dis. 2018;10:1179573518771703. https://doi.org/10.1177/1179573518771703.CrossRefPubMedPubMedCentral

Hovaguimian A, Gibbons CH. Diagnosis and treatment of pain in small-fiber neuropathy. Curr Pain Headache Rep. 2011;15(3):193–200. https://doi.org/10.1007/s11916-011-0181-7.CrossRefPubMedPubMedCentral

• Terkelsen AJ, Karlsson P, Lauria G, Freeman R, Finnerup NB, Jensen TS. The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol. 2017;16(11):934–44. https://doi.org/10.1016/S1474-4422(17)30329-0. This manuscript reviews the clinical presentation of small fiber neuropathy and offers a comprehensive view of evaluation of this condition that would be useful for the pain medine.

Khoshnoodi MA, Truelove S, Burakgazi A, Hoke A, Mammen AL, Polydefkis M. Longitudinal assessment of small fiber neuropathy: evidence of a non-length-dependent distal axonopathy. JAMA Neurol. 2016;73(6):684–90. https://doi.org/10.1001/jamaneurol.2016.0057.CrossRefPubMed

Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, et al. Diabetic neuropathy: a position statement by the American Diabetes Association. Diabetes Care. 2017;40(1):136–54. https://doi.org/10.2337/dc16-2042.CrossRefPubMed

10.

Gemignani F, Bellanova MF, Saccani E, Pavesi G. Non-length-dependent small fiber neuropathy: not a matter of stockings and gloves. Muscle Nerve. 2022;65(1):10–28. https://doi.org/10.1002/mus.27379.CrossRefPubMed

11.

Kaur D, Tiwana H, Stino A, Sandroni P. Autonomic neuropathies. Muscle Nerve. 2021;63(1):10–21. https://doi.org/10.1002/mus.27048.CrossRefPubMed

12.

Zhou L. Small fiber neuropathy in the elderly. Clin Geriatr Med. 2021;37(2):279–88. https://doi.org/10.1016/j.cger.2021.01.002.CrossRefPubMed

13.

Lauria G, Hsieh ST, Johansson O, Kennedy WR, Leger JM, Mellgren SI, et al. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. Eur J Neurol. 2010;17(7):903–12, e44–9. https://doi.org/10.1111/j.1468-1331.2010.03023.x.

14.

Freeman R, Gewandter JS, Faber CG, Gibbons C, Haroutounian S, Lauria G, et al. Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria. Neurology. 2020;95(22):1005–14. https://doi.org/10.1212/WNL.0000000000010988.CrossRefPubMedPubMedCentral

15.

Backonja MM, Attal N, Baron R, Bouhassira D, Drangholt M, Dyck PJ, et al. Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus. Pain. 2013;154(9):1807–19. https://doi.org/10.1016/j.pain.2013.05.047.CrossRefPubMed

16.

Di Stefano G, La Cesa S, Leone C, Pepe A, Galosi E, Fiorelli M, et al. Diagnostic accuracy of laser-evoked potentials in diabetic neuropathy. Pain. 2017;158(6):1100–7. https://doi.org/10.1097/j.pain.0000000000000889.CrossRefPubMed

17.

Inui K, Kakigi R. Pain perception in humans: use of intraepidermal electrical stimulation. J Neurol Neurosurg Psychiatry. 2012;83(5):551–6. https://doi.org/10.1136/jnnp-2011-301484.CrossRefPubMed

18.

Thaisetthawatkul P, Fernandes Filho JA, Herrmann DN. Contribution of QSART to the diagnosis of small fiber neuropathy. Muscle Nerve. 2013;48(6):883–8. https://doi.org/10.1002/mus.23891.CrossRefPubMed

19.

Tavakoli M, Petropoulos IN, Malik RA. Corneal confocal microscopy to assess diabetic neuropathy: an eye on the foot. J Diabetes Sci Technol. 2013;7(5):1179–89. https://doi.org/10.1177/193229681300700509.CrossRefPubMedPubMedCentral

20.

Ziegler D, Papanas N, Zhivov A, Allgeier S, Winter K, Ziegler I, et al. Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes. Diabetes. 2014;63(7):2454–63. https://doi.org/10.2337/db13-1819.CrossRefPubMed

21.

Hoeijmakers JG, Faber CG, Lauria G, Merkies IS, Waxman SG. Small-fibre neuropathies–advances in diagnosis, pathophysiology and management. Nat Rev Neurol. 2012;8(7):369–79. https://doi.org/10.1038/nrneurol.2012.97.CrossRefPubMed

22.

Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010;33(10):2285–93. https://doi.org/10.2337/dc10-1303.CrossRefPubMedPubMedCentral

23.

Devigili G, Tugnoli V, Penza P, Camozzi F, Lombardi R, Melli G, et al. The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain. 2008;131(Pt 7):1912–25. https://doi.org/10.1093/brain/awn093.CrossRefPubMedPubMedCentral

24.

Gorson KC, Herrmann DN, Thiagarajan R, Brannagan TH, Chin RL, Kinsella LJ, et al. Non-length dependent small fibre neuropathy/ganglionopathy. J Neurol Neurosurg Psychiatry. 2008;79(2):163–9. https://doi.org/10.1136/jnnp.2007.128801.CrossRefPubMed

25.

Gemignani F, Giovanelli M, Vitetta F, Santilli D, Bellanova MF, Brindani F, et al. Non-length dependent small fiber neuropathy. a prospective case series. J Peripher Nerv Syst. 2010;15(1):57–62. https://doi.org/10.1111/j.1529-8027.2010.00252.x.

26.

Khan S, Zhou L. Characterization of non-length-dependent small-fiber sensory neuropathy. Muscle Nerve. 2012;45(1):86–91. https://doi.org/10.1002/mus.22255.CrossRefPubMed

27.

Cazzato D, Lauria G. Small fibre neuropathy. Curr Opin Neurol. 2017;30(5):490–9. https://doi.org/10.1097/WCO.0000000000000472.CrossRefPubMed

28.

Hammi C, Yeung B. Neuropathy [Updated 2021 Aug 2]. StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; 2021. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542220/. Accessed 11 Nov 2021.

29.

Peripheral Neuropathy Fact Sheet. In: NINDS, editor. NIH Publication No. 18-NS-48532018 August.

30.

Heij L, Dahan A, Hoitsma E. Sarcoidosis and pain caused by small-fiber neuropathy. Pain Res Treat. 2012;2012: 256024. https://doi.org/10.1155/2012/256024.CrossRefPubMedPubMedCentral

31.

Zhou L, Shin S. Small fiber neuropathy. Available at: https://practicalneurology.com/articles/2021-july-aug/small-fiber-neuropathy/pdf. Accessed 11 Nov 2021.

32.

Devigili G, Cazzato D, Lauria G. Clinical diagnosis and management of small fiber neuropathy: an update on best practice. Expert Rev Neurother. 2020;20(9):967–80. https://doi.org/10.1080/14737175.2020.1794825.CrossRefPubMed

33.

Sene D. Small fiber neuropathy: diagnosis, causes, and treatment. Joint Bone Spine. 2018;85(5):553–9. https://doi.org/10.1016/j.jbspin.2017.11.002.CrossRefPubMed

34.

Zhou L. Small fiber neuropathy. Semin Neurol. 2019;39(5):570–7. https://doi.org/10.1055/s-0039-1688977.CrossRefPubMed

35.

Bouhassira D, Attal N, Alchaar H, Boureau F, Brochet B, Bruxelle J, et al. Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain. 2005;114(1–2):29–36. https://doi.org/10.1016/j.pain.2004.12.010.CrossRefPubMed

36.

Saperstein DS. Small fiber neuropathy. Neurol Clin. 2020;38(3):607–18. https://doi.org/10.1016/j.ncl.2020.04.001.CrossRefPubMed

37.

de Greef BTA, Hoeijmakers JGJ, Gorissen-Brouwers CML, Geerts M, Faber CG, Merkies ISJ. Associated conditions in small fiber neuropathy - a large cohort study and review of the literature. Eur J Neurol. 2018;25(2):348–55. https://doi.org/10.1111/ene.13508.CrossRefPubMed

38.

Sommer C, Lauria G. Skin biopsy in the management of peripheral neuropathy. Lancet Neurol. 2007;6(7):632–42. https://doi.org/10.1016/S1474-4422(07)70172-2.CrossRefPubMed

39.

Smith AG, Howard JR, Kroll R, Ramachandran P, Hauer P, Singleton JR, et al. The reliability of skin biopsy with measurement of intraepidermal nerve fiber density. J Neurol Sci. 2005;228(1):65–9. https://doi.org/10.1016/j.jns.2004.09.032.CrossRefPubMed

40.

Provitera V, Gibbons CH, Wendelschafer-Crabb G, Donadio V, Vitale DF, Loavenbruck A, et al. The role of skin biopsy in differentiating small-fiber neuropathy from ganglionopathy. Eur J Neurol. 2018;25(6):848–53. https://doi.org/10.1111/ene.13608.CrossRefPubMed

41.

Lefaucheur JP. Painful neuropathies and small fiber involvement. Rev Neurol (Paris). 2014;170(12):825–36. https://doi.org/10.1016/j.neurol.2014.10.008.CrossRef

42.

Lefaucheur JP, Wahab A, Plante-Bordeneuve V, Sene D, Menard-Lefaucheur I, Rouie D, et al. Diagnosis of small fiber neuropathy: a comparative study of five neurophysiological tests. Neurophysiol Clin. 2015;45(6):445–55. https://doi.org/10.1016/j.neucli.2015.09.012.CrossRefPubMed

43.

Hansson P, Backonja M, Bouhassira D. Usefulness and limitations of quantitative sensory testing: clinical and research application in neuropathic pain states. Pain. 2007;129(3):256–9. https://doi.org/10.1016/j.pain.2007.03.030.CrossRefPubMed

44.

Tavee JO, Karwa K, Ahmed Z, Thompson N, Parambil J, Culver DA. Sarcoidosis-associated small fiber neuropathy in a large cohort: clinical aspects and response to IVIG and anti-TNF alpha treatment. Respir Med. 2017;126:135–8. https://doi.org/10.1016/j.rmed.2017.03.011.CrossRefPubMed

45.

Attal N, Cruccu G, Baron R, Haanpaa M, Hansson P, Jensen TS, et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol. 2010;17(9):1113-e88. https://doi.org/10.1111/j.1468-1331.2010.02999.x.CrossRefPubMed

46.

Dworkin RH, O’Connor AB, Audette J, Baron R, Gourlay GK, Haanpaa ML, et al. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc. 2010;85(3 Suppl):S3-14. https://doi.org/10.4065/mcp.2009.0649.CrossRefPubMedPubMedCentral

47.

Moulin D, Boulanger A, Clark AJ, Clarke H, Dao T, Finley GA, et al. Pharmacological management of chronic neuropathic pain: revised consensus statement from the Canadian Pain Society. Pain Res Manag. 2014;19(6):328–35. https://doi.org/10.1155/2014/754693.CrossRefPubMedPubMedCentral

48.

Chetty S, Baalbergen E, Bhigjee AI, Kamerman P, Ouma J, Raath R, et al. Clinical practice guidelines for management of neuropathic pain: expert panel recommendations for South Africa. Available online: . South African Family Practice. 2014;55(2):143–56. https://doi.org/10.1080/20786204.2013.10874323.

49.

Acevedo JC, Amaya A, Casasola Ode L, Chinchilla N, De Giorgis M, Florez S, et al. Guidelines for the diagnosis and management of neuropathic pain: consensus of a group of Latin American experts. J Pain Palliat Care Pharmacother. 2009;23(3):261–81. https://doi.org/10.1080/15360280903098572.CrossRefPubMed

50.

Turk DC, Audette J, Levy RM, Mackey SC, Stanos S. Assessment and treatment of psychosocial comorbidities in patients with neuropathic pain. Mayo Clin Proc. 2010;85(3 Suppl):S42-50. https://doi.org/10.4065/mcp.2009.0648.CrossRefPubMedPubMedCentral

51.

Morley S, Eccleston C, Williams A. Systematic review and meta-analysis of randomized controlled trials of cognitive behaviour therapy and behaviour therapy for chronic pain in adults, excluding headache. Pain. 1999;80(1–2):1–13. https://doi.org/10.1016/s0304-3959(98)00255-3.CrossRefPubMed

52.

Kioskli K, Scott W, Winkley K, Kylakos S, McCracken LM. Psychosocial factors in painful diabetic neuropathy: a systematic review of treatment trials and survey studies. Pain Med. 2019;20(9):1756–73. https://doi.org/10.1093/pm/pnz071.CrossRefPubMed

53.

Davies B, Cramp F, Gauntlett-Gilbert J, Wynick D, McCabe CS. The role of physical activity and psychological coping strategies in the management of painful diabetic neuropathy–a systematic review of the literature. Physiotherapy. 2015;101(4):319–26. https://doi.org/10.1016/j.physio.2015.04.003.CrossRefPubMed

54.

Ahn S, Song R. Effects of Tai Chi Exercise on glucose control, neuropathy scores, balance, and quality of life in patients with type 2 diabetes and neuropathy. J Altern Complement Med. 2012;18(12):1172–8. https://doi.org/10.1089/acm.2011.0690.CrossRefPubMedPubMedCentral

55.

• Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, et al. Interventional management of neuropathic pain: NeuPSIG recommendations. Pain. 2013;154(11):2249–61. https://doi.org/10.1016/j.pain.2013.06.004. A nice review of interventional treatments for neuropathic pain.

56.

Gupta M, Knezevic NN, Abd-Elsayed A, Ray M, Patel K, Chowdhury B. Treatment of painful diabetic neuropathy-a narrative review of pharmacological and interventional approaches. Biomedicines. 2021;9(5):573. https://doi.org/10.3390/biomedicines9050573.CrossRefPubMedPubMedCentral

57.

Mokhtari T, Ren Q, Li N, Wang F, Bi Y, Hu L. Transcutaneous electrical nerve stimulation in relieving neuropathic pain: basic mechanisms and clinical applications. Curr Pain Headache Rep. 2020;24(4):14. https://doi.org/10.1007/s11916-020-0846-1.CrossRefPubMed

58.

Jin DM, Xu Y, Geng DF, Yan TB. Effect of transcutaneous electrical nerve stimulation on symptomatic diabetic peripheral neuropathy: a meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. 2010;89(1):10–5. https://doi.org/10.1016/j.diabres.2010.03.021.CrossRefPubMed

59.

Pieber K, Herceg M, Paternostro-Sluga T. Electrotherapy for the treatment of painful diabetic peripheral neuropathy: a review. J Rehabil Med. 2010;42(4):289–95. https://doi.org/10.2340/16501977-0554.CrossRefPubMed

60.

Dubinsky RM, Miyasaki J. Assessment: efficacy of transcutaneous electric nerve stimulation in the treatment of pain in neurologic disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2010;74(2):173–6. https://doi.org/10.1212/WNL.0b013e3181c918fc.CrossRefPubMed

61.

Tesfaye S, Watt J, Benbow SJ, Pang KA, Miles J, MacFarlane IA. Electrical spinal-cord stimulation for painful diabetic peripheral neuropathy. Lancet. 1996;348(9043):1698–701. https://doi.org/10.1016/S0140-6736(96)02467-1.CrossRefPubMed

62.

Daousi C, Benbow SJ, MacFarlane IA. Electrical spinal cord stimulation in the long-term treatment of chronic painful diabetic neuropathy. Diabet Med. 2005;22(4):393–8. https://doi.org/10.1111/j.1464-5491.2004.01410.x.CrossRefPubMed

63.

de Vos CC, Meier K, Zaalberg PB, Nijhuis HJ, Duyvendak W, Vesper J, et al. Spinal cord stimulation in patients with painful diabetic neuropathy: a multicentre randomized clinical trial. Pain. 2014;155(11):2426–31. https://doi.org/10.1016/j.pain.2014.08.031.CrossRefPubMed

64.

Slangen R, Schaper NC, Faber CG, Joosten EA, Dirksen CD, van Dongen RT, et al. Spinal cord stimulation and pain relief in painful diabetic peripheral neuropathy: a prospective two-center randomized controlled trial. Diabetes Care. 2014;37(11):3016–24. https://doi.org/10.2337/dc14-0684.CrossRefPubMed

65.

van Beek M, Slangen R, Schaper NC, Faber CG, Joosten EA, Dirksen CD, et al. Sustained treatment effect of spinal cord stimulation in painful diabetic peripheral neuropathy: 24-month follow-up of a prospective two-center randomized controlled trial. Diabetes Care. 2015;38(9):e132-4. https://doi.org/10.2337/dc15-0740.CrossRefPubMed

66.

Pluijms WA, Slangen R, Bakkers M, Faber CG, Merkies IS, Kessels AG, et al. Pain relief and quality-of-life improvement after spinal cord stimulation in painful diabetic polyneuropathy: a pilot study. Br J Anaesth. 2012;109(4):623–9. https://doi.org/10.1093/bja/aes251.CrossRefPubMed

67.

van Beek M, Geurts JW, Slangen R, Schaper NC, Faber CG, Joosten EA, et al. Severity of neuropathy is associated with long-term spinal cord stimulation outcome in painful diabetic peripheral neuropathy: five-year follow-up of a prospective two-center clinical trial. Diabetes Care. 2018;41(1):32–8. https://doi.org/10.2337/dc17-0983.CrossRefPubMed

68.

Galan V, Scowcroft J, Chang P, Li S, Staats P, Subbaroyan J, et al. Ten kHz spinal cord stimulation for the treatment of chronic peripheral polyneuropathy: 12-Month results from prospective open-label pilot study. Pain Pract. 2021;21(8):898–906. https://doi.org/10.1111/papr.13059.CrossRefPubMed

69.

Galan V, Scowcroft J, Chang P, Li S, Staats P, Rotte A, et al. 10-kHz spinal cord stimulation treatment for painful diabetic neuropathy: results from post-hoc analysis of the SENZA-PPN study. Pain Manag. 2020;10(5):291–300. https://doi.org/10.2217/pmt-2020-0033.CrossRefPubMed

70.

Mekhail NA, Argoff CE, Taylor RS, Nasr C, Caraway DL, Gliner BE, et al. High-frequency spinal cord stimulation at 10 kHz for the treatment of painful diabetic neuropathy: design of a multicenter, randomized controlled trial (SENZA-PDN). Trials. 2020;21(1):87. https://doi.org/10.1186/s13063-019-4007-y.CrossRefPubMedPubMedCentral

71.

Petersen EA, Stauss TG, Scowcroft JA, Brooks ES, White JL, Sills SM, et al. Effect of high-frequency (10-kHz) spinal cord stimulation in patients with painful diabetic neuropathy: a randomized clinical trial. JAMA Neurol. 2021;78(6):687–98. https://doi.org/10.1001/jamaneurol.2021.0538.CrossRefPubMedPubMedCentral

72.

Chang CH, Chang YS, Hsieh YL. Transient receptor potential vanilloid subtype 1 depletion mediates mechanical allodynia through cellular signal alterations in small-fiber neuropathy. Pain Rep. 2021;6(1): e922. https://doi.org/10.1097/PR9.0000000000000922.CrossRefPubMedPubMedCentral

73.

Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science. 2000;288(5464):306–13. https://doi.org/10.1126/science.288.5464.306.CrossRefPubMed

74.

Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997;389(6653):816–24. https://doi.org/10.1038/39807.CrossRefPubMed

75.

Julius D. TRP channels and pain. Annu Rev Cell Dev Biol. 2013;29:355–84. https://doi.org/10.1146/annurev-cellbio-101011-155833.CrossRefPubMed

76.

Liao HY, Hsieh CL, Huang CP, Lin YW. Electroacupuncture attenuates CFA-induced inflammatory pain by suppressing Nav1.8 through S100B, TRPV1, opioid, and adenosine pathways in mice. Sci Rep. 2017;7:42531. https://doi.org/10.1038/srep42531.

77.

Ruehle BS, Handwerker HO, Lennerz JK, Ringler R, Forster C. Brain activation during input from mechanoinsensitive versus polymodal C-nociceptors. J Neurosci. 2006;26(20):5492–9. https://doi.org/10.1523/JNEUROSCI.2059-05.2006.CrossRefPubMedPubMedCentral

78.

Obreja O, Ringkamp M, Turnquist B, Hirth M, Forsch E, Rukwied R, et al. Nerve growth factor selectively decreases activity-dependent conduction slowing in mechano-insensitive C-nociceptors. Pain. 2011;152(9):2138–46. https://doi.org/10.1016/j.pain.2011.05.021.CrossRefPubMed

79.

Obreja O, Rukwied R, Nagler L, Schmidt M, Schmelz M, Namer B. Nerve growth factor locally sensitizes nociceptors in human skin. Pain. 2018;159(3):416–26. https://doi.org/10.1097/j.pain.0000000000001108.CrossRefPubMed

80.

Schnakenberg M, Thomas C, Schmelz M, Rukwied R. Nerve growth factor sensitizes nociceptors to C-fibre selective supra-threshold electrical stimuli in human skin. Eur J Pain. 2021;25(2):385–97. https://doi.org/10.1002/ejp.1678.CrossRefPubMed

81.

Schmelz M, Schmid R, Handwerker HO, Torebjork HE. Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres. Brain. 2000;123(Pt 3):560–71. https://doi.org/10.1093/brain/123.3.560.CrossRefPubMed

82.

Anand P, Bley K. Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. Br J Anaesth. 2011;107(4):490–502. https://doi.org/10.1093/bja/aer260.CrossRefPubMedPubMedCentral

83.

Abrams RMC, Pedowitz EJ, Simpson DM. A critical review of the capsaicin 8% patch for the treatment of neuropathic pain associated with diabetic peripheral neuropathy of the feet in adults. Expert Rev Neurother. 2021;21(3):259–66. https://doi.org/10.1080/14737175.2021.1874920.CrossRefPubMed

84.

Backonja M, Wallace MS, Blonsky ER, Cutler BJ, Malan P Jr, Rauck R, et al. NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. Lancet Neurol. 2008;7(12):1106–12. https://doi.org/10.1016/S1474-4422(08)70228-X.CrossRefPubMed

85.

Wallace M, Pappagallo M. Qutenza(R): a capsaicin 8% patch for the management of postherpetic neuralgia. Expert Rev Neurother. 2011;11(1):15–27. https://doi.org/10.1586/ern.10.182.CrossRefPubMed

86.

Eijkenboom I, Sopacua M, Hoeijmakers JGJ, de Greef BTA, Lindsey P, Almomani R, et al. Yield of peripheral sodium channels gene screening in pure small fibre neuropathy. J Neurol Neurosurg Psychiatry. 2019;90(3):342–52. https://doi.org/10.1136/jnnp-2018-319042.CrossRefPubMed

87.

Bennett DL, Clark AJ, Huang J, Waxman SG, Dib-Hajj SD. The role of voltage-gated sodium channels in pain signaling. Physiol Rev. 2019;99(2):1079–151. https://doi.org/10.1152/physrev.00052.2017.CrossRefPubMed

88.

Dib-Hajj SD, Waxman SG. Sodium channels in human pain disorders: genetics and pharmacogenomics. Annu Rev Neurosci. 2019;42:87–106. https://doi.org/10.1146/annurev-neuro-070918-050144.CrossRefPubMed

89.

Beydoun A, D’Souza J, Hebert D, Doty P. Lacosamide: pharmacology, mechanisms of action and pooled efficacy and safety data in partial-onset seizures. Expert Rev Neurother. 2009;9(1):33–42. https://doi.org/10.1586/14737175.9.1.33.CrossRefPubMed

90.

de Greef BTA, Hoeijmakers JGJ, Geerts M, Oakes M, Church TJE, Waxman SG, et al. Lacosamide in patients with Nav1.7 mutations-related small fibre neuropathy: a randomized controlled trial. Brain. 2019;142(2):263–75. https://doi.org/10.1093/brain/awy329.

91.

Namer B, Schmidt D, Eberhardt E, Maroni M, Dorfmeister E, Kleggetveit IP, et al. Pain relief in a neuropathy patient by lacosamide: proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors. EBioMedicine. 2019;39:401–8. https://doi.org/10.1016/j.ebiom.2018.11.042.CrossRefPubMed

92.

Labau JIR, Estacion M, Tanaka BS, de Greef BTA, Hoeijmakers JGJ, Geerts M, et al. Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy. Brain. 2020;143(3):771–82. https://doi.org/10.1093/brain/awaa016.

93.

Pereira PR, Viala K, Maisonobe T, Haroche J, Mathian A, Hie M, et al. Sjogren sensory neuronopathy (Sjogren ganglionopathy): long-term outcome and treatment response in a series of 13 cases. Medicine (Baltimore). 2016;95(19): e3632. https://doi.org/10.1097/MD.0000000000003632.CrossRef

94.

Gaillet A, Champion K, Lefaucheur JP, Trout H, Bergmann JF, Sene D. Intravenous immunoglobulin efficacy for primary Sjogren’s syndrome associated small fiber neuropathy. Autoimmun Rev. 2019;18(11): 102387. https://doi.org/10.1016/j.autrev.2019.102387.CrossRefPubMed

95.

Yuki N, Chan AC, Wong AHY, Inoue T, Yokai M, Kurihara T, et al. Acute painful autoimmune neuropathy: a variant of Guillain-Barre syndrome. Muscle Nerve. 2018;57(2):320–4. https://doi.org/10.1002/mus.25738.CrossRefPubMed

96.

Geerts M, de Greef BTA, Sopacua M, van Kuijk SMJ, Hoeijmakers JGJ, Faber CG, et al. Intravenous immunoglobulin therapy in patients with painful idiopathic small fiber neuropathy. Neurology. 2021;96(20):e2534–45. https://doi.org/10.1212/WNL.0000000000011919.CrossRefPubMedPubMedCentral

97.

Maino P, Koetsier E, Kaelin-Lang A, Gobbi C, Perez R. Efficacious dorsal root ganglion stimulation for painful small fiber neuropathy: a case report. Pain Physician. 2017;20(3):E459–63.PubMed

98.

Walega DR, Smith C, Epstein JB. Bilateral stellate ganglion blockade for recalcitrant oral pain from burning mouth syndrome: a case report. J Oral Facial Pain Headache. 2014;28(2):171–5. https://doi.org/10.11607/ofph.1165.CrossRefPubMed

99.

van Velzen M, Heij L, Niesters M, Cerami A, Dunne A, Dahan A, et al. ARA 290 for treatment of small fiber neuropathy in sarcoidosis. Expert Opin Investig Drugs. 2014;23(4):541–50. https://doi.org/10.1517/13543784.2014.892072.CrossRefPubMed

100.

Uyesugi B, Lippincott B, Dave S. Treatment of a painful keloid with botulinum toxin type A. Am J Phys Med Rehabil. 2010;89(2):153–5. https://doi.org/10.1097/PHM.0b013e3181c1ec11.CrossRefPubMed

Titel: Small Fiber Neuropathy
verfasst von: N. Strand
C. Wie
J. Peck
M. Maita
N. Singh
J. Dumbroff
V. Tieppo Francio
M. Murphy
K. Chang
D. M. Dickerson
J. Maloney
Publikationsdatum: 06.04.2022
Verlag: Springer US
Erschienen in: Current Pain and Headache Reports / Ausgabe 6/2022
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI: https://doi.org/10.1007/s11916-022-01044-8

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Purpose of Review

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