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30.04.2021 | Review Article

The current status of CZT SPECT myocardial blood flow and reserve assessment: Tips and tricks

verfasst von: Konstantin V. Zavadovsky, Andrew V. Mochula, Alina N. Maltseva, Vladimir V. Shipulin, Svetlana I. Sazonova, Marina O. Gulya, Ricardo Liga, Alessia Gimelli

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 6/2022

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Abstract

Cardiac PET-derived measurements of myocardial blood flow (MBF) and myocardial flow reserve (MFR) are proven robust indexes of the severity of coronary artery disease (CAD). They facilitate the diagnosis of diffuse epicardial and microvascular disease and are also of prognostic significance. However, low availability and high cost have limited their wide clinical implementation. Over the last 15 years, cadmium zinc telluride (CZT)-based detectors have been implemented into SPECT imaging devices. Myocardial perfusion scintigraphy can be performed faster and with less radiation exposure as compared with standard gamma cameras. Rapid dynamic SPECT studies with higher count rates can be performed. This technological breakthrough has renewed the interest in SPECT MBF assessment in patients with CAD. Currently, two cardiac-centered CZT gamma cameras are available commercially—Discovery NM530c and D-SPECT. They differ in parameters such as collimator design, number of detectors, sensitivity, spatial resolution and image reconstruction. A number of publications have focused on the feasibility of dynamic CZT SPECT and on the correlation with cardiac PET and invasive coronary angiography measurements of fractional flow reserve. Current study reviews the present status of MBF and MFR assessment with CZT SPECT. It also aims to provide an overview of specific issues related to acquisition, processing and interpretation of quantitative studies in patients with CAD.

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Titel: The current status of CZT SPECT myocardial blood flow and reserve assessment: Tips and tricks
verfasst von: Konstantin V. Zavadovsky
Andrew V. Mochula
Alina N. Maltseva
Vladimir V. Shipulin
Svetlana I. Sazonova
Marina O. Gulya
Ricardo Liga
Alessia Gimelli
Publikationsdatum: 30.04.2021
Verlag: Springer International Publishing
Erschienen in: Journal of Nuclear Cardiology / Ausgabe 6/2022
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-021-02620-y

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The current status of CZT SPECT myocardial blood flow and reserve assessment: Tips and tricks

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