Erschienen in:
01.03.2011 | Editorial
Management of colorectal liver metastases: past, present, and future
verfasst von:
Thomas A. Aloia, Jean-Nicolas Vauthey
Erschienen in:
Updates in Surgery
|
Ausgabe 1/2011
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Excerpt
The decade that began the new century (2000–2010) was marked by reports highlighting major success in the treatment of liver metastases from colorectal cancer. The EORTC (European Organisation for Research and Treatment of Cancer) trial was the first significant randomized trial examining the utility of short course pre- and postoperative chemotherapy with a direct comparison with surgery alone [
1]. Multiple centers indicated improved long-term survivals of more than 50% at 5 years after resection [
2‐
4]. These improved survivals have resulted from a combination of better patient selection, increased efficacy of systemic chemotherapy and improvements in surgical technique including the development of creative solutions to difficult anatomic problems [
5‐
9]. These results have encouraged surgeons to continue to expand the indications for surgery in patients with colorectal liver metastases. …