Effects of transversus abdominis plane block versus quadratus lumborum block on postoperative analgesia: a meta-analysis of randomized controlled trials
Trunk block technique has been used in postoperative analgesia for patients undergoing surgery, specifically, transversus abdominis plane block (TAPB) and quadratus lumborum block (QLB) have been proved effective. The purpose of this meta-analysis is to evaluate the effects of TAPB and QLB in postoperative analgesia.
Methods
Online databases, including MEDLINE, EMBASE, Cochrane Library (&Trail), Web of Science, CNKI, Wanfang and QVIP were applied to collect the randomized controlled trials (RCTs) from inception to Dec. 9th, 2019. Twenty-two studies were finally included containing 777 patients in the TAPB group and 783 cases in QLB group. RCTs comparing TAPB and QLB in postoperative analgesia were included in this meta-analysis. The indicators including total analgesia consumption postoperatively, operative time, duration of anesthesia, visual analogue scale (VAS) score at 24 h postoperatively, duration of postoperative analgesia, the number of patients requiring analgesia postoperatively and adverse reactions were analyzed.
Results
our findings showed that morphine consumption (mg) (WMD = 3.893, 95%CI: 2.053 to 5.733, P < 0.001), fentanyl consumption (μg) (WMD = 23.815, 95%CI: 15.521 to 32.109, P < 0.001), VAS score at 24 h postoperatively (WMD = 0.459, 95%CI: 0.118 to 0.801, P = 0.008), the number of patients requiring analgesia postoperatively (WMD = 3.893, 95%CI: 2.053 to 5.733, P < 0.001), and the incidence of dizziness (WMD = 2.691, 95%CI: 1.653 to 4.382, P < 0.001) in TAPB group were higher than in QLB group.
Conclusions
QLB is superior to TAPB in reducing morphine consumption, fentanyl consumption, VAS score at 24 h postoperatively, the number of patients requiring analgesia postoperatively, and the incidence of dizziness.
Hinweise
Yanqing Wang and Xiaojia Wang contributed equally to this work.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Abkürzungen
TAPB
Transversus abdominis plane block
QLB
Quadratus lumborum block
RCTs
Randomized controlled trials
VAS
Visual analogue scale
RR
Relative risk
WMD
Weighted mean difference
JCAHO
Joint commission on accreditation of medical institutions
Background
Postoperative pain, including acute postoperative pain and persistent chronic postoperative pain, remains a main clinical problem. Without timely and effective treatment, acute postoperative pain can turn into persistent chronic postoperative pain [1]. Previous studies showed that 10–50% of patients undergoing surgery suffered from postoperative pain lasting more than 1 month, and 2–10% of these patients continued to experience moderate to severe chronic pain. Furthermore, inadequate postoperative analgesia continues to occur despite advances in analgesia techniques [2, 3]. Inadequate management of postoperative pain can lead to serious consequences, such as poor immediate postoperative effect, prolonged stay and/or hospital readmission, poor patient satisfaction, increased burden on patients and health systems [3, 4]. Therefore, effective prevention and control of postoperative pain is of great significance.
Multimodal analgesia technique has been widely applied in postoperative analgesia [3, 5]. Truncal block, including transversus abdominis plane block (TAPB), quadratus lumborum block (QLB), rectus sheath block and hernia block, plays important roles in multimodal analgesia [6, 7]. TAPB involves injecting local anesthetic into the plane between the transverse abdominis and the internal oblique, it can block the sensory nerve supply to the anterior abdominal wall by deposition of local anesthetics and has shown promising in managing postoperative pain [8‐10]. QLB, similar to TAPB, was first introduced as a different form of TAPB in 2007 [11]. It is also known as an interfascial plane block because it involves injecting local anesthetics into the thoracolumbar fascia which is different from TAPB. QLB can result in a widespread sensory suppression via a wide distribution of local anesthetics, and has been increasingly used for postoperative analgesia [11‐14].
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In recent years, many randomized controlled trials (RCTs) have been conducted to compare the effects of TAPB and QLB in postoperative analgesia [6, 15‐18]. However, the results of outcomes of postoperative analgesia were inconsistent. In the current study, we aimed to compare the efficacy of TAPB versus QLB in postoperative analgesia based on RCT articles with a meta-analysis. The indicators for this meta-analysis included total analgesia consumption postoperatively, operative time, duration of anesthesia, visual analogue scale (VAS) score at 24 h postoperatively, duration of postoperative analgesia, the number of patients requiring analgesia postoperatively and adverse reactions.
Methods
Search strategy
The literatures were retrieved from MEDLINE, EMBASE, Cochrane Library (&Trail), Web of Science, CNKI, Wanfang and QVIP the deadline for searching documents was Dec. 9th, 2019. The index words for searching literatures as follows: ‘transversus abdominis’ OR ‘transversus abdominis plane block’ OR ‘transverse abdominis’ OR ‘transverse abdominis plane block’ OR ‘TAP’ OR ‘TAP block’ OR ‘TAPB’ AND ‘quadratus lumborum’ OR ‘quadratus lumborum block’ OR ‘quadrate lumborum’ OR ‘quadrate lumborum block’ OR ‘QL’ OR ‘QL block’ OR ‘QLB’.
Inclusion and exclusion criteria
Inclusion criteria: (1) RCTs; (2) comparison of TAPB and QLB in postoperative analgesia; (3) English and Chinese literatures; (4) outcome indicators: total analgesia consumption postoperatively, operative time, duration of anesthesia, VAS score at 24 h postoperatively, duration of postoperative analgesia, the number of patients requiring analgesia postoperatively and adverse reactions.
Exclusion criteria: (1) reviews, meta-analyses, conference articles and letters; (2) animal experiments; (3) repetitive studies; (4) articles that cannot extract the valid data.
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Methodological quality appraisal
The studies were screened independently by two researchers Y Wang and X Wang. In the event of disagreements, a third party (K Zhang) would participate in the discussion. The modified Jadad scale (Table 1) was applied to evaluate the quality of literatures. The scale was divided into 7 points, 1–3 were defined as low quality, and 4–7 were defined as high quality.
Table 1
The modified Jaded Scale
Classification
Score
Description
Randomization
Inappropriate
0
Semi-randomized or quasi-randomized trials
Unclear
1
Randomized trials without describing methods for generating random sequences
Appropriate
2
Random sequences produced by a computer or a random number table
Allocation concealment
Inappropriate
0
Regular grouping
Unclear
1
Only use of a random number table or other random assignment scheme
Appropriate
2
A method for assigning sequences without prediction
Blinding
Inappropriate
0
Use of double blindness without an appropriate method
Unclear
1
Only mention of double blindness
Appropriate
2
A description of the specific and appropriate method of double blindness
Withdrawals or dropouts
No
0
No description of withdrawal or dropouts
Yes
1
A description of withdrawal or dropouts
Statistical analysis
Heterogeneity test was conducted for each indicator and measured by statistics of I2, with I2 > 50% indicating significant heterogeneity. If I2 > 50%, a random effects model was used; if I2 < 50%, the fixed effects model was applied, and the heterogeneity was assessed. The software Stata 15.0 (Stata Corporation, College Station, TX, USA) was used for statistical analysis, effect index relative risk (RR) was used for enumeration data and weighted mean difference (WMD) for measurement data. P < 0.05 was considered statistically significant.
Results
Included studies
According to the search strategy, literature searches via the databases identified 453 articles. Following removing duplicates, screening titles or abstracts, and after assessing the full texts of relevant studies, 22 articles [6, 15‐35] were finally included containing 777 patients in the TAPB group and 783 cases in QLB group (Table 2 and Fig. 1).
Table 2
Characteristics of studies included in meta-analysis
Author
Year
Country
Score
Treatment
TAPB_n (M/F)
TAPB_age# (years)
QLB_n (M/F)
QLB_age# (years)
Quality
Outcomes
Baytar
2019
Turkey
4
TAPB vs QLB
53 (11/42)
48.12 ± 12.42
54 (15/39)
46.42 ± 16.57
HQ
b f g
Yousef
2018
Egypt
5
TAPB vs QLB
30 (0/30)
50.70 ± 6.8
30 (0/30)
56.5 ± 6.97
HQ
a b c d e f
Kumar
2018
India
4
TAPB vs QLB
35 (15/20)
38.34 ± 11.59
35 (15/19)
39.20 ± 11.64
HQ
a b d f
Öksüz
2017
Turkey
3
TAPB vs QLB
25 (21/4)
3.02 ± 1.82
25 (21/4)
3.13 ± 0.20
LQ
e f
Blanco
2016
Arab
3
TAPB vs QLB
38 (0/38)
NA
38 (0/38)
NA
LQ
a
Verma
2019
India
6
TAPB vs QLB
30 (0/30)
28 ± 3
30 (0/30)
30 ± 3
HQ
b d f
Ipek
2019
Turkey
3
TAPB vs QLB
29 (19/10)
4.16 ± 2.55
35 (28/7)
3.89 ± 3.26
LQ
e f g
Shan
2019
China
3
TAPB vs QLB
30 (0/30)
30 ± 3
30 (0/30)
29 ± 6
LQ
c f
Deng
2019
China
6
TAPB vs QLB
34 (12/22)
53.5 ± 10.6
34 (14/20)
51.1 ± 13.8
HQ
b c f
Fu
2019
China
4
TAPB vs QLB
30 (NA)
71.8 ± 5.8
30 (NA)
72.2 ± 6.9
HQ
b f
Han
2017
China
4
TAPB vs QLB
38 (24/14)
27.8 ± 3.9
39 (20/19)
26.3 ± 3.2
HQ
b c f
He
2018
China
2
TAPB vs QLB
36 (20/16)
67.3 ± 2.3
36 (19/17)
67.7 ± 2.1
LQ
e f
Li G
2018
China
5
TAPB vs QLB
40 (0/40)
31 ± 4
40 (0/40)
30 ± 5
HQ
b c f
Li N
2019
China
3
TAPB vs QLB
30 (0/30)
42.10 ± 5.26
30 (0/30)
41.07 ± 4.75
LQ
b e f
Ma
2019
China
3
TAPB vs QLB
30 (17/13)
55. 2 ± 4. 4
30 (16/14)
53.1 ± 4.6
LQ
e
Ren
2018
China
3
TAPB vs QLB
82 (44/38)
45.7 ± 15.2
78 (40/38)
46.3 ± 15.1
LQ
b c
Xia
2018
China
4
TAPB vs QLB
30 (15/15)
48 ± 8
30 (12/18)
46 ± 11
HQ
f
Yang
2019
China
3
TAPB vs QLB
30 (0/30)
NA
30 (0/30)
NA
LQ
a b
Yang
2019
China
5
TAPB vs QLB
30 (0/30)
38.5 ± 14.8
30 (0/30)
43.9 ± 15.04
HQ
b c e f
Ye
2019
China
4
TAPB vs QLB
28 (12/16)
48.9 ± 2.1
30 (14/16)
50.3 ± 2.8
HQ
c f
Zhu
2019
China
3
TAPB vs QLB
39 (20/19)
68.8 ± 3.4
39 (18/21)
69.1 ± 3.2
LQ
e f
Zhu
2018
China
3
TAPB vs QLB
30 (0/30)
52 ± 6
30 (0/30)
51 ± 7
LQ
b e f
#: mean ± standard deviation
TAPB transversus abdominis plane block, QLB quadratus lumborum block, VAS visual analog scale, HQ high-quality, LQ low-quality, NA unavailable
a: morphine consumption; b: VAS score at 24 h postoperatively; c: fentanyl consumption; d: duration of postoperative analgesia; e: the number of patients requiring analgesia postoperatively; f: operative time; g: duration of anesthesia
Fig. 1
Flow chart of the review process
×
Overall meta-analysis
As shown in Table 3, our findings showed that morphine consumption (mg) (WMD = 3.893, 95%CI: 2.053 to 5.733, P < 0.001), fentanyl consumption (μg) (WMD = 23.815, 95%CI: 15.521 to 32.109, P < 0.001), VAS score at 24 h postoperatively (WMD = 0.459, 95%CI: 0.118 to 0.801, P = 0.008), the number of patients requiring analgesia postoperatively (WMD = 3.893, 95%CI: 2.053 to 5.733, P < 0.001), and the incidence of dizziness (RR = 2.691, 95%CI: 1.653 to 4.382, P < 0.001) in TAPB group were higher than in QLB group. No significant differences were observed between the two groups regarding the operative time (min) (P = 0.573), duration of anesthesia (min) (P = 0.733), duration of postoperative analgesia (h) (P = 0.258), and nausea and vomiting (P = 0.141).
Table 3
Overall results of the meta-analysis
Outcomes
WMD/RR (95%CI)
P
I2
Morphine consumption (mg)
Overall
3.893 (2.053, 5.733)
< 0.001
72.7
Operation types
Abdominal surgery
2.400 (1.825, 2.975)
< 0.001
NA
Pelvic surgery
4.731 (2.634, 6.829)
< 0.001
44.5
Quality
High-quality
3.205 (1.283, 5.127)
0.001
76.2
Low-quality
6.443 (0.098, 12.788)
0.047
72.2
Fentanyl consumption (μg)
Overall
23.815 (15.521, 32.109)
< 0.001
96.0
Operation types
Abdominal surgery
14.077 (7.412, 20.742)
< 0.001
92.3
Pelvic surgery
34.808 (14.079, 55.537)
0.001
96.5
Quality
High-quality
26.576 (13.594, 39.558)
< 0.001
96.9
Low-quality
16.264 (7.527, 25.000)
< 0.001
73.3
Operative time
Overall
0.324 (−0.805, 1.454)
0.573
0.0
Duration of anesthesia (min)
Overall
-2.139 (−14.423, 10.146)
0.733
80.8
VAS score at 24 h postoperatively
Overall
0.459 (0.118, 0.801)
0.008
94.8
Operation types
Abdominal surgery
0.224 (−0.033, 0.480)
0.088
80.1
Pelvic surgery
0.671 (0.103, 1.240)
0.021
95.4
Quality
High-quality
0.576 (0.048, 1.104)
0.032
96.3
Low-quality
0.218 (−0.019, 0.455)
0.071
66.1
Duration of postoperative analgesia
Overall
-21.882 (−59.774, 16.010)
0.258
100.0
Operation types
Abdominal surgery
-3.400 (−4.038, −2.762)
< 0.001
NA
Pelvic surgery
−31.125 (−78.851, 16.600)
0.201
100.0
Number of patients requiring analgesia postoperatively
Overall
2.618 (2.040, 3.361)
< 0.001
13.2
Adverse reactions
Dizziness
Overall
2.691 (1.653, 4.382)
< 0.001
0.0
Nausea and vomiting
Overall
1.918 (0.805, 4.571)
0.141
50.9
Quality
High-quality
4.100 (1.932, 8.699)
< 0.001
0.0
Low-quality
0.417 (0.054, 3.239)
0.403
70.9
CI confidence interval, RR, risk ratio, WMD weighted mean difference, VAS visual analog scal, NA unavailable
Total analgesia consumption postoperatively
Total analgesia consumption postoperatively (mg) as an outcome was reported containing 4 studies (n = 266) on morphine consumption (mg) and 8 articles (n = 623) on fentanyl consumption (μg). Patients in TAPB group consumed more morphine than QLB group (WMD = 3.893, 95%CI: 2.053 to 5.733; P < 0.001) (Table 3 and Fig. 2a). Heterogeneity among the included studies was statistically significant (I2 = 72.7%). Subgroup analysis was performed to identify sources of heterogeneity. According to operation types and literature quality, there were significant differences in abdominal surgery (WMD = 2.400, 95%CI: 1.825 to 2.975, P < 0.001), pelvic surgery (WMD: 4.731, 95%CI: 2.634 to 6.829, P < 0.001), high-quality (WMD = 3.205, 95%CI: 1.283 to 5.127, P = 0.001) and low-quality (WMD = 6.443, 95%CI: 0.098 to 12.788, P = 0.047) between the two groups (Fig. 2b and c). The fentanyl consumption in TAPB group was higher than that in QLB group (WMD = 23.815, 95%CI: 15.521 to 32.109, P < 0.001) (Table 3 and Fig. 3a). We also found statistical differences in abdominal surgery (WMD = 14.077, 95%CI: 7.412 to 20.742, P < 0.001), pelvic surgery (WMD: 34.808, 95%CI: 14.079 to 55.537, P < 0.001), high-quality (WMD = 26.576, 95%CI: 13.594 to 39.558, P < 0.001) and low-quality (WMD = 16.264, 95%CI: 7.527 to 25.000, P < 0.001) between the two groups (Fig. 3b and c).
Fig. 2
Forest plot for morphine consumption (a), operation types (b) and literature quality (c)
Fig. 3
Forest plot for of fentanyl consumption (a), operation types (b) and literature quality (c)
×
×
Operative time
Eighteen articles (n = 1204) on operative time (min) were included containing 597 patients in TAPB group and 607 patients in QLB group. The operative time in TAPB group was similar to QLB group, with no significant differences (WMD = 0.324, 95%CI: − 0.805 to 1.454, P = 0.573).
Duration of anesthesia
The data of duration of anesthesia (min) as a clinical outcome was extracted from 2 articles including 171 cases. Duration of anesthesia in TAPB group was near to QLB group, with no significant differences (WMD = -2.139, 95%CI: − 14.423 to10.146, P = 0.733).
VAS score at 24 h postoperatively
Thirteen studies, including 982 patients, reported VAS score at 24 h postoperatively for pain as an outcome (I2 = 94.8%). The VAS score at 24 h postoperatively in TAPB group was higher than that in QLB group (WMD = 0.459, 95% CI: 0.118 to 0.801; P = 0.008) (Fig. 4a). The results of subgroup analysis showed statistical differences in pelvic surgery (WMD = 0.671, 95% CI: 0.103 to 1.240, P = 0.021) and high-quality (WMD = 0.576, 95% CI: 13.594 to 39.558, P < 0.001) (Fig. 4b and c).
Fig. 4
Forest plot for VAS score at 24 h postoperatively (a), operation types (b) and literature quality (c)
×
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Duration of postoperative analgesia
The duration of postoperative analgesia (h) was reported as an outcome in 3 studies (n = 190) (I2 = 100.00%). Duration of postoperative analgesia in TAPB group was shorter than QLB group (WMD = -21.882, 95% CI: − 59.774 to 16.010, P = 0.258) (Fig. 5a). The findings also showed differences in abdominal surgery (WMD = -3.400, 95% CI: − 4.038 to − 2.762, P < 0.001) (Fig. 5b).
Fig. 5
Forest plot for duration of postoperative analgesia (a) and operation types (b)
×
The number of patients requiring analgesia postoperatively
Nine studies (564 patients) on the number of patients requiring analgesia postoperatively were analyzed (I2 = 13.2%). The results founded that the number of patients requiring analgesia after surgery in TAPB group were higher than QLB group (RR = 2.618, 95% CI: 2.040 to 3.361, P < 0.001).
Adverse reactions
The incidence of dizziness in TAPB group from 5 articles was (n = 361) higher than that in QLB group (I2 = 0.0%, RR = 2.691, 95% CI: 1.653 to 4.382, P < 0.001) (Fig. 6). 8 studies (n = 535) on the incidence of nausea and vomiting were no differences between the two groups (I2 = 50.9%, RR = 1.918, 95% CI: 0.805 to 4.571, P = 0.141).
Fig. 6
Forest plot for the incidence of dizziness
×
Publication bias
Publication bias was performed using Begg’ test. There were no distinct publication bias in morphine consumption (Z = 1.36, P = 0.174), operative time (Z = 1.17, P = 0.240), duration of anesthesia (Z = 1.00, P = 0.317), VAS score at 24 h postoperatively (Z = 1.10, P = 0.273), duration of postoperative analgesia (Z = -1.00, P = 0.317), the number of patients requiring analgesia postoperatively (Z = -0.42, P = 0.677), the incidence of dizziness (Z = 0.49, P = 0.624), and nausea and vomiting (Z = -0.12, P = 1.000), except fentanyl consumption (Z = 2.23, P = 0.026).
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Discussion
Twenty-two studies [6, 15‐20] on effects of TAPB vs. QLB in postoperative analgesia were included in this meta-analysis. Overall results showed that QLB showed more effective analgesia than TAPB in regards to morphine consumption, fentanyl consumption, VAS score at 24 h postoperatively, the number of patients requiring analgesia postoperatively, and the incidence of dizziness.
Pain was regarded as the fifth vital sign by the joint commission on accreditation of medical institutions (JCAHO) in 2000, ignoring pain management equals disrespecting human rights [36]. Postoperative pain is a major concern for patients and clinicians. Inadequate management of postoperative pain remains a common clinical problem worldwide [3, 4, 37]. TAPB has been described as a successful adjunct procedure for postoperative analgesia, however with some complications: failure of block, abdominal organ injury, nerve injury, vascular injury and so on [38‐40]. Fortunately, the application of ultrasound can display injection point, the tap plane and the needle. With the guidance of ultrasound, the accuracy of puncture is improved, and the related complications are reduced [13, 41]. However, TAPB only blocks the anterolateral skin, muscles and parietal peritoneal sensory nerve fibers of the abdominal wall, and has no inhibitory effect on visceral pain [42]. QLB, as an effective and reliable option for relieving postoperative pain, is performed exclusively under the guidance of ultrasound, and the passage of the needle and the site of the local anesthetic application are far from the abdominal organs, great vessels and peritoneal cavity [43‐47]. QLB can block the sympathetic nerves distributed between the thoracolumbar fascias. Some scholars suggested that QLB may alleviate the visceral pain to a certain extent [48]. Compared with TAPB, the drug diffusion range of QLB drugs was relatively wide, even reaching the paravertebral space of chests [49].
In this meta-analysis, VAS score at 24 h postoperatively of TAPB group was higher than that of QLB group, which may cause high consumption of analgesics. We also found that morphine and fentanyl consumption postoperatively in TAPB group were higher than QLB group. Similarly, a previous study showed that QLB type 1 significantly reduced morphine consumption up to postoperative 48 h [50]. Salama et al. found that QLB performed after cesarean section provided an ideal effect in reducing total postoperative morphine consumption [44]. The reason why the patients in TAPB group consumed more morphine than QLB group may be that TAPB only provides effective somatic analgesia, however poor effect in visceral analgesia [47]. Yousef reported that patients undergoing hysterectomy bilateral QLB provided more effective intraoperative and postoperative analgesia with less intraoperative fentanyl consumption and less postoperative morphine consumption compared with bilateral TAPB [18]. As we all know, morphine and fentanyl are common analgesic drugs for pain, and excessive use may cause several adverse reactions. Herein, it is significant for postoperative analgesia to explore an adjunct procedure that can reduce analgesia consumption.
The number of patients requiring analgesia postoperatively in QLB group was less than TAPB group. Zhu et al. [51] have studied the rate at patients who receive QLB requested analgesia postoperatively. They performed ultrasound-guided subcostal approach to QLB in an ipsilateral parasagittal oblique plane at the L1-L2 level on patients who underwent laparoscopic nephrectomy, and they reported that QLB was related with reducing rate of patients requiring rescue analgesia postoperatively. There were no significant differences in the operative time, duration of anesthesia, duration of postoperative analgesia, and nausea and vomiting between the two groups. The reasons may be less number of articles and small sample size included in this study. More high-quality studies with large samples are needed to further verify these results.
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Because of representing the high level of evidences, the meta-analysis of RCTs can help patients, doctors and policy-makers to make decisions [52]. This meta-analysis was conducted to compare the effect of TAPB and QLB on postoperative analgesia based on RCT studies. However, several limitations of this study should be noted. First, heterogeneity existed in some measurements, and subgroup analyses failed to change the heterogeneity. Furthermore, there was a publication bias in fentanyl consumption, which may be attributed to the fact that the positive results were easy to publish, and only one English article and 2 low-quality studies were included in this meta-analysis. These factors mentioned above may affect our results. Therefore, the current results should be interpreted with caution.
Conclusions
In summary, compared with TAPB, QLB provided effective intraoperative and postoperative analgesia with less morphine consumption, less fentanyl consumption, lower VAS score at 24 h postoperatively, decreased number of patients requiring analgesia postoperatively, and reduced incidence of dizziness. In addition, QLB is comparable with TAPB as regards to operative time, duration of anesthesia, and the incidence of nausea and vomiting. More researches with well-designed and adequate sample size are required to confirm these findings.
Acknowledgements
Not applicable.
Ethics approval and consent to participate
Not applicable.
Consent for publication
Not applicable.
Competing interests
The authors declare that they have no competing interests.
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Effects of transversus abdominis plane block versus quadratus lumborum block on postoperative analgesia: a meta-analysis of randomized controlled trials
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