Background
Biogenesis, function, and study approaches of circRNAs
Biogenesis of circRNAs
Functions of circRNAs
Approaches for circRNA studies
Research on and discovery of circRNAs in BCa
CircRNA expression profiles in BCa
Sample | Special treatment | Detection Method | GEO database | Data source | total circRNA | Number of circRNA differently expressed (fold change ≥2) | circRNAs validated by qRT-PCR | Ref./PMID |
---|---|---|---|---|---|---|---|---|
4 paird BCa and BCN tissues | RNAse R | CircRNA microarray | GSE92675 | CircRNA microarray | 3243 | 469 (285 upregulated, 184 downregulated) | 6 | 27484176 |
3 paird BCa and BCN tissues | rRNA-depleted and RNase R | RNA-seq | GSE97239 | RNA-seq | 16,353 (6154) | 571 (47 upregulated, 524 downregulated) | circ_HIPK3 | 28794202 |
1 paird BCa and BCN tissues | rRNA-depleted | RNA-seq | GSE77661 | RNA-seq | 67,358(27296) | / | circ_HIPK3 | 27050392 |
4 paird BC and BCN tissues | / | RNA-seq | / | RNA-seq | / | 59(7 upregulated, 52 downregulated) | hsa circ 0018069 | 30984788 |
2 paird BCa and BCN tissues | RNAse R | RNA-seq | / | RNA-seq | 6834 | 567 | 40 | 30745833 |
5 paird BCa and BCN tissues | rRNA and linear RNA-depleted | RNA-seq | / | RNA-seq | 88,732(62,788) | 56 (14 upregulated, 42 downregulated) | 2 | 29151929 |
4 paird BCa and BCN tissues | rRNA-depleted | RNA-seq | / | RNA-seq | / | 118 (34 upregulated, 84 downregulated) | 3 | 30025927 |
9 different grades of BCa and BCN tissues | / | RNA-seq | / | RNA-seq | / | 244 (H vs L), 316 (H vs N), 42 circRNAs overlapped | 7 | 31545480 |
BCa 5637, T24 and SV-HUC-1 cell lines | / | CircRNA microarray | / | CircRNA microarray | / | / | circ_CASC15 | 31072448 |
10 paird BCa and HC urine samples | Rnase R | CircRNA microarray | / | CircRNA microarray | / | 86 (53 upregulated, 33 downregulated) | circ_0137439 | 31777254 |
3 pairs of BCSCs and BCNSCs samples | / | CircRNA microarray | / | CircRNA microarray | 4451 | 127 (113 upregulated, 14 downregulated) | circ_103809 | 32065779 |
3 paird BCa and BCN tissues | / | CircRNA microarray | / | CircRNA microarray | / | 734 (478 upregulated, 256 downregulated) | 8 | 30983072 |
3 paird BCa and BCN tissues | Rnase R | CircRNA microarray | GSE112719 | CircRNA microarray | / | 80 (37 upregulated, 43 downregulated) | circ_101320 | 30305293 |
3 paird BCa and BCN tissues | / | CircRNA microarray | / | CircRNA microarray | 1038 | / | 7 | 29558461 |
457 NMIBC samples | / | RNA-Seq | / | Bioinformatics analysis | 15,223 | / | 13 | 29263845 |
4 paird BCa and BCN tissues | / | CircRNA microarray | GSE92675 | Bioinformatics analysis | / | 469 (285 upregulated, 184 downregulated) | circ_MYLK | 28687357 |
3 paird BCa and BCN tissues | / | / | GSE97239, GSE92675 | Bioinformatics analysis | / | 18 (5 upregulated, 13 downregulated) | 3 | 31169020 |
4 paird BCa and BCN tissues | / | CircRNA microarray | GSE92675 | Bioinformatics analysis | / | 200 | hsa_circ_0000144 | 30098434 |
4 paird BCa and BCN tissues | / | CircRNA microarray | GSE92675 | Bioinformatics analysis | / | 408 | circ_0058063 | 30362519 |
4 paird BCa and BCN tissues | / | CircRNA microarray | GSE92675 | Bioinformatics analysis | / | 89 (66 upregulated, 23 downregulated) | circ_0001429 | 30909190 |
4 paird BCa and BCN tissues | / | CircRNA microarray | GSE92675 | Bioinformatics analysis | / | 433 (264 upregulated, 169 downregulated) | circ_CEP128 | 30134837 |
4 paird BCa and BCN tissues | / | CircRNA microarray | GSE92675 | Bioinformatics analysis | 3423 | 433 (264 upregulated, 169 downregulated) | circ_CEP128 | 30939216 |
4 paird BCa and BCN tissues | / | CircRNA microarray | GSE92675 | Bioinformatics analysis | / | 312 (195 upregulated, 117 downregulated) | circ_0058063 | 32181485 |
4 paird BCa and BCN tissues | / | CircRNA microarray | GSE92675 | Bioinformatics analysis | / | / | circ_VANGL1 | 30146736 |
4 paird BCa and BCN tissues | / | CircRNA microarray | GSE92675 | Bioinformatics analysis | 3243 | 469 (285 upregulated, 184 downregulated) | / | 27363013 |
4 paird BCa and BCN tissues | / | CircRNA microarray | GSE92675 | Bioinformatics analysis | / | 428 (261 upregulated, 167 downregulated) | hsa_circ_0011385 | 32015691 |
Biological functions and molecular mechanisms of circRNAs in BCa
CircRNAs regulate the hallmarks of cancer
Name | CircBase ID | Sponge target | Gene | Function | Types of BCa tissues and BCa cell lines | Ref./PMID |
---|---|---|---|---|---|---|
upregulated | ||||||
circ_0058063 | hsa_circ_0058063 | miR-486-3p | FOXP4 | promoted cell proliferation, invasion, and inhibited apoptosis | 94 cases of BCa and the non-cancerous normal tissues; 5637, BIU-87 and RT-112 cell lines | 32181485 |
circ_0058063 | hsa_circ_0058063 | miR-145-5p | CDK6 | promoted cell proliferation and migration, inhibited cell apoptosis, and decreased cell cycle arrest | 25 pairs of BCa tissues and adjacent normal tissues; T24 and J82 cell lines | 30362519 |
circ_0017247 | hsa_circ_0017247 | / | Wnt/β-catenin | promoted cell proliferation and tumor formation, inhibited apoptosis, and decreased cell cycle arrest | 50 BCa tissues and adjacent tissues; UM-UC3, SW780, BIU and J82 cell lines | 32096177 |
circ_103809 | hsa_circ_0072088 | miR-511 | / | promoted the self-renewal, migration and invasion | 3 pairs of BCa tissues and adjacent normal bladder tissues; T24 and EJ cell lines | 32065779 |
circ_FNTA | hsa_circ_0084171 | miR-370-3p | FNTA | promoted invasion and decreased chemosensitivity to cisplatin | 41 BCa tissues and adjacent normal bladder tissues; T24, J82, 5637, and UMUC3 cell lines | 32052578 |
circ_PDSS1 | hsa_circ_0093398 | miR-16 | / | promoted cell proliferation, invasion and migration | 72 BCa and adjacent healthy tissues; HT-1197 and UMUC3 cells | 31868205 |
circ_403658 | hsa_circ_0004383 | / | LDHA | promoted cell growth and invasion | 123 BCa tissues and the matched adjacent tissues; SW780, 5637, T24, J82 and RT4 cell lines | 31814891 |
circ_0137439 | hsa_circ_0137439 | miR-142-5p | MTDH | promoted cell proliferation, migration, and metastasis | 116 bladder cancer urine samples and 30 normal samples; T24 and 5637 cell lines | 31777254 |
circ_VANGL1 | hsa_circ_0002623 | miR-605-3p | VANGL1 | promoted cell proliferation, migration, and invasion | 87 BCa tissues and 37 normal adjacent tissues; T24 and EJ cells | 30146736 |
circ_VANGL1 | hsa_circ_0002623 | miR-1184 | IGFBP2 | promoted cell proliferation, migration, and invasion | 60 BCa and corresponding paracancerous tissue; J82, T24, EJ, RT-4, UM-UC-3, and TCC cell lines | 31758655 |
circ_ZFR | hsa_circ_0072088 | miR-377 | ZEB2 | promoted cell growth, migration and invasion, and decreased cell cycle arrest and apoptosis | 104 pairs of BCa tissues and adjacent normal tissues; UMUC3, T24, J82, 5637, SW780, EJ and BIU87 cell lines | 31746333 |
circ_0001361 | hsa_circ_0001361 | miR-491-5p | MMP9 | promoted cell invasion and metastasis | 69 pairs of BCa tissues and matched adjacent normal bladder epithelial tissues; SV-HUC-1, EJ, UMUC3, RT4, and 5637 cell lines | 31705065 |
circ_UVRAG | hsa_circ_0023642 | miR-223 | FGFR2 | promoted proliferation, migration, tumor formation, and metastasis | T24, EJ, J82, UM-UC-3, TCC, and RT-4 cell lines | 30387298 |
circ_0023642 | hsa_circ_0023642 | miR-490-5p | EGFR | promoted cell invasion and metastasis | J82 and UMUC3 cell lines | 31455760 |
circ_CASC15 | hsa_circ_0075828 | miR-1224-5p | CREB1 | promoteed cell proliferation | 67 pair BCa tissues and matched para-carcinoma tissues; 5637, and T24 cell lines | 31072448 |
circ_0068871 | hsa_circ_0068871 | miR-181a-5p | FGFR3 | promoted cell proliferation and migration | 32 BCa and adjacent normal tissue; T24, UMUC3, EJ, and J82 cell lines | 30999937 |
circ_DOCK1 | hsa_circ_0020394 | miR-132-3p | Sox5 | promoted cell proliferation, migration, and tumour growth | 23 BC tissue specimens and 32 normal bladder tissues; BIU-87, EJ-m3, T24 and 5673 cell lines | 30983072 |
circ_CEP128 | hsa_circ_0102722 | miR-145-5p | SOX11 | promoted cell proliferation, and decreased cell apoptosis and cell cycle arrest | 10 pairs of BCa tissues and adjacent bladder tissues; RT-112, 5637, BIU-87, TCCSUP and HEK293T cell lines | 30134837 |
circ_CEP128 | hsa_circ_0102722 | miR-145-5p | Myd88 | promoted cell proliferation and migration, and decreased cell apoptosis and cell cycle arrest | 40 BCa specimens and blood samples; 293T, J82 and T24 cell lines | 30939216 |
circ_0001429 | hsa_circ_0001429 | miR-205-5p | VEGFA | enhanced cell propagation and metastasis, reduced cell apoptosis, and promoted tumor growth and lung metastasis | 20 pairs of BCa tissues and paired adjacent normal bladder tissues; T24 cells and 5637 cells | 30909190 |
circ_TFRC | has_circ_0001445 | miR-107 | TFRC | promoted the invasion, proliferation and tumor growth, contributed to an EMT phenotype | 57 BCa patients tissues compared with adjacent normal patients tissues, EJ, T24, 5637, UMUC3, BIU87, J82, and SW780 cell lines | 30782157 |
circ_ELP3 | hsa_circ_0001785 | / | / | promoted cell proliferation, and reduced apoptosis and chemosensitivity to cisplatin | 18 pairs of tissue samples and 30 bladder cancer samples; T24 and 5647 cells | 30745833 |
circ_PRMT5 | hsa_circ_0031250 | miR-30c | SNAIL1/E-cadherin | promoted cell EMT | 119 UCB tissues with matched adjacent normal bladder tissues; T24, TCC-SUP, 5637, and UM-UC-3 cell lines | 30305293 |
circ_BPTF | hsa_circ_0000799 | miR-31-5p | RAB27A | promoted cell migration and invasive, and tumor growth | 72 pairs of specimens of BCa tissues and adjacent noncancerous tissues; UM-UC-3 and T24 cell lines | 30103209 |
circ_0000144 | hsa_circ_0000144 | miR-217 | RUNX2 | promoted cell proliferation and invasion | 21 pairs of BCa tissues and adjacent normal tissues; T24, EJ, UMUC3, RT4 and 253J cell lines | 30098434 |
circ_PTK2 | hsa_circ_0003221 | / | / | promoted the proliferation and migration | 40 pairs of BCa tissue and blood samples. T24 and 5637 cell lines | 29125888 |
circ_MYLK | hsa_circ_0002768 | miR-29a | VEGFA/VEGFR2 | accelerated cell proliferation, migration, tube formation, and promoted EMT | 32 pairs bladder carcinomas and matched para-carcinomas; EJ, T24, 5673 and BIU-87 cell lines | 28687357 |
circ_TCF25 | hsa_circ_0041103 | miR-103a-3p/miR-107 | CDK6 | promoted proliferation and migration | 40 pairs bladder carcinoma tissue and matched para-carcinoma tissues; T24 and EJ cell lines | 27484176 |
downregulated | ||||||
circ_FUT8 | hsa_circ_0003028 | miR-570-3p | KLF10 | inhibited migration, invasion, and metastasis | 145 BCa tissues and 50 matched adjacent normal bladder tissues; T24, SV-HUC-1, and UM-UC-3 cell lines | 32072011 |
circ_RIP2 | hsa_circ_0005777 | miR-1305 | Tgf-β2/smad3 | promoted migration, invasion, clone formation and EMT | 45 paired BCa and the adjacent normal tissues, 58 bladder cancer tissues, 5637 and UM-UC-3 cell lines | 32019579 |
circ_FAM114A2 | hsa_circ_0001546 | miR-762 | ΔNP63/TP63 | inhibited migration, invasion and proliferation | 31 BCa tissues and paired adjacent noncancer tissues; T24, J82, 5637, and 293T cell lines | 31969560 |
circ_0091017 | hsa_circ_0091017 | miR-589-5p | / | inhibited cell proliferation, migration and invasiveness | 40 pairs of BCa tissues and normal adjacent tissues; 5637, EJ, T24, UMUC-3, and RT4 cell lines | 31957821 |
ciRs_6 | hsa_circ_0006260 | miR-653 | March1 | suppressed cell growth and increased cell cycle arrest | 45 paired bladder cancer and the adjacent normal tissues, 58 bladder cancer tissues; 5637 and UM-UC-3 cell lines | 31819015 |
circ_5912 | hsa_circ_0005912 | / | TGF-β signaling | suppressesed cell proliferation, invasion and migration | 58 BCa tissues and the matched adjacent tissues; T24 and SW780 cell lines | 31808751 |
circ_PTPRA | hsa_circ_0006117 | miR-636 | KLF9 | inhibited cell proliferation and tumor growth | 104 BCa specimens, 64 matched BC and adjacent normal specimens; T24 and UM-UC-3 cell lines | 31821171 |
circ_Foxo3 | hsa_circ_0006404 | miR-191-5p | / | promoted cell apoptosis | 30 BCa tissues and adjacent normal bladder tissues; T24, UM-UC-3 and J82 cell lines | 31802888 |
circ_0071662 | hsa_circ_0071662 | miR-146b-3p | HPGD/NF2 | suppressed cell proliferation and invasion | 97 BCa tissues and matched adjacent normal tissues; BIU-87, T-24, EJ-28 and J82 cell lines | 31757227 |
circ_PICALM | hsa_circ_0023919 | miR-1265 | STEAP4 | inhibited cell invasion and metastasis | 168 BCa samples and 40 corresponding adjacent normal tissue samples; T24, UM-UC-3, J82, RT-4, and HEK-293T cell lines | 31648990 |
circ_0137606 | hsa_circ_0137606 | miR-1231 | PHLPP2 | suppressed cell proliferation and metastasis | 13 high-grade BCa, low-grade BCa and a normal controlpatients tissues; T24 and SV-HUC-1 cell lines | 31545480 |
circ-ZKSCAN1 | hsa_circ_0001727 | miR-1178-3p | p21 | inhibited cell proliferation, migration, invasion and metastasis | 68 BCa tissues and the matched normal tissues; T24, UM-UC-3, 5637, and EJ cell lines | 31481066 |
circ_NR3C1 | hsa_circ_0001543 | miR-27a-3p | cyclin D1 | inhibited cell proliferation, cell cycle progression, and tumor growth | 42 pairs of BCa tissues and adjacent normal bladder tissues; T24, EJ, UMUC3, J82, and 5637 cell lines | 31255724 |
circ_SLC8A1 | hsa_circ_0000994 | miR-130b/miR-494 | PTEN | inhibited cell migration, invasion and proliferation | 70 pairs of human bladder cancer tissues compared with their adjacent normal tissues; 5637, T24, J82, EJ, UMUC, and RT4 cell lines | 31228937 |
circ_Cdr1as | hsa_circ_0001946 | miR-1270 | APAF1 | induced cell apoptosis and enhanced chemosensitivity to cisplatin | 160 BCa tissues; TCCSUP, 5367, T24 and EJ cell lines | 31131537 |
circ_Cdr1as | hsa_circ_0001946 | miR-135a | / | inhibited cell proliferation, invasion and migration, and tumour growth | 94 pairs of BCa tissues and adjacent normal tissues; EJ and T24 cell lines | 29694981 |
circ_ACVR2A | hsa_circ_0001073 | miR-626 | EYA4 | suppressed cell proliferation and metastasis | 50BC tissues and matched adjacent normal epithelial tissues; T24, UM-UC-3, RT4, J82, 5637, HT-1376, and TCCSUP cell lines | 31101108 |
circ_0002024 | hsa_circ_0002024 | miR-197-3p | / | suppressed cell proliferation, migration, and invasion | 20 BCa and normal samples; EJ, 5637, T24, and UMUC-2 cell lines | 30972190 |
circ_CDYL | hsa_circ_0008285 | / | C-MYC | inhibited cell growth and migration | 30 pairs of BCa tissues and paired surrounding normal bladder tissues; EJ and T24T cells | 30968727 |
circ_LPAR1 | hsa_circ_0087960 | miR-762 | / | inhibited cell invasion and metastasis | 125 BCa tissues and 68 paired cancer tissues and adjacent non-tumorous tissues; 5637 and T24 cell lines | 30867795 |
circ_MTO1 | hsa_circ_0007874 | miR-221 | / | inhibited cell EMT and metastasis | 117 bladder cancer tissues and the matched adjacent tissues; UMUC3, SVHUC1, T24, J82 and 5637 cell lines | 30551873 |
circ_FNDC3B | hsa_circ_0006156 | miR-1178-3p | G3BP2 | inhibited cell proliferation, migration, invasion, tumorigenesis and metastasis | 82 BCa tissues and 56 pairs of BCa tissues and adjacent noncancerous tissues; T24 and UM-UC-3 cell lines | 30458784 |
circ_UBXN7 | hsa_circ_0001380 | miR-1247-3p | B4GALT3 | inhibited cell proliferation, migration, invasion, and tumor growth | 84 cases of BCa tissues including 30 paired BC tissues and adjacent nontumor tissues; SV-HUC-1, T24 and UM-UC-3 cell lines | 30312173 |
circ_HIPK3 | hsa_circ_0000284 | miR-558 | HPSE | inhibited cell migration, invasion, and angiogenesis, tumor growth, and metastasis | 44 pairs of bladder cancer tissues and paired adjacent normal bladder tissues; UMUC3, and T24 cell lines | 28794202 |
circ_BCRC3 | hsa_circ_0001110 | miR-182-5p | p27 | inhibited cell proliferation, and impairs tumor growth, and increased cell cycle arrest | 47 BCa tissues and their adjacent normal bladder tissues; EJ,T24, and SV-HUC-1 cell lines | 30285878 |
circ_BCRC4 | hsa_circ_0001577 | miR-101 | EZH2 | promoted cell apoptosis and inhibited cell viability | 24 pairs of fresh bladder cancer tissues and surrounding normal adjacent bladder tissues; UMUC3 and T24 cell lines | 29270748 |
circ_ITCH | hsa_circ_0001141 | miR-17, miR-224 | p21, PTEN | inhibited cell proliferation, migration, invasion and metastasis, induced cell cycle arrest and cell apoptosis | 72 pairs of BCa tumor and normal tissues; UMUC3, T24, J82, 353J, 5637, TCC, EJ and RT4 cell lines | 29386015 |
Cell proliferation
Apoptosis
Invasion, migration and metastasis
Angiogenesis
Cisplatin chemoresistance
Molecular mechanisms of circRNAs in BCa
Clinical significance of circRNAs in BCa
circRNA name | circBase ID | Cilinical Sample | Utility | Ref./PMID | ||
---|---|---|---|---|---|---|
Diagnostic | Prognostic | Predictive | ||||
circRNA-MYLK | hsa_circ_0002768 | tissue | √ | 28687357 | ||
Circ_0058063 | hsa_circ_0058063 | tissue | √ | 32181485 | ||
hsa_circ_0076704 | hsa_circ_0076704 | tissue | √ | 31169020 | ||
hsa_circ_0000144 | hsa_circ_0000144 | tissue | √ | 30098434 | ||
circUVRAG | hsa_circ_0023642 | tissue | √ | 30387298 | ||
circ_0071662 | hsa_circ_0071662 | tissue | √ | 31757227 | ||
circ-ITCH | hsa_circ_0001141 | tissue | √ | 29386015 | ||
circLPAR1 | hsa_circ_0087960 | tissue | √ | 30867795 | ||
circPTPRA | hsa_circ_0006117 | tissue | √ | 31821171 | ||
circUBXN7 | hsa_circ_0001380 | tissue | √ | 30312173 | ||
ciRs-6 | hsa_circ_0006260 | tissue | √ | 31819015 | ||
circ_FAM114A2 | hsa_circ_0001546 | tissue | √ | 31969560 | ||
circ_SLC8A1 | hsa_circ_0000994 | tissue | √ | 31228937 | ||
circ_0068871 | hsa_circ_0068871 | tissue | √ | 30999937 | ||
CEP128 | hsa_circ_0102722 | tissue | √ | 30134837 | ||
circPTK2 | hsa_circ_0003221 | tissue and blood | √ | 29125888 | ||
circCDYL | hsa_circ_0008285 | tissue | √ | √ | 29263845, 30968727 | |
circHIPK3 | hsa_circ_0000284 | tissue | √ | √ | 29263845, 28794202 | |
circFUT8 | hsa_circ_0003028 | tissue | √ | √ | 32072011 | |
circRNA_403658 | hsa_circ_0004383 | tissue | √ | √ | 31814891 | |
circRNA_000285 | hsa_circ_0000285 | tissue and serum | √ | √ | 30509102 | |
circPICALM | hsa_circ_0023919 | tissue | √ | √ | 31648990 | |
circ0001361 | hsa_circ_0001361 | tissue | √ | √ | 31705065 | |
circRIP2 | hsa_circ_0005777 | tissue | √ | √ | 32019579 | |
cTFRC | has-circ-0001445 | tissue | √ | √ | 30782157 | |
circ-VANGL1 | hsa_circ_0002623 | tissue | √ | √ | 30146736 | |
circ5912 | hsa_circ_0005912 | tissue | √ | √ | 31808751 | |
circFNDC3B | hsa_circ_0006156 | tissue | √ | √ | 30458784 | |
circ-ZKSCAN1 | hsa_circ_0001727 | tissue | √ | √ | 31481066 | |
circMTO1 | hsa_circ_0007874 | tissue | √ | √ | 30551873 | |
circCASC15 | hsa_circ_0075828 | tissue | √ | √ | 31072448 | |
Circ-BPTF | hsa_circ_0000799 | tissue | √ | √ | 30103209 | |
circPRMT5 | hsa_circ_0031250 | tissue, serum and urine | √ | √ | 30305293 | |
hsa circ 0018069 | hsa circ_0018069 | tissue | √ | √ | 30984788 | |
circZFR | hsa_circ_0072088 | tissue | √ | √ | √ | 31746333 |
circASXL1 | hsa_circ_0001136 | tissue | √ | √ | √ | 31966702 |
circ_0137439 | hsa_circ_0137439 | urine | √ | √ | √ | 31777254 |
Relationships between circRNA levels and clinicopathologic characteristics in BCa
Study | circRNA Name | CircBase ID | Host gene | Position | Cilinical Sample | Detection method | Cut-off value | Reference gene | Dysregulation | Number of patients | Gender | Age | Tumor size | Grade | DF | Stage | LMN | Number of tumors | DM | Invasion | Recurrence | Potential function | AUC | Sensitivity and specifcity | OS | DFS/RFS | PFS | Ref./PMID |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Li et al. | circ_0018069 | hsa circ_0018069 | KIAA1462 | chr10:30315031–30318795 | tissues | qPCR | 0.0007 | β-actin | downregulated | 41 | No | No | No | Yes | – | Yes | No | – | – | Yes | – | Diagnosis | 0.709 | 97.6, 46.3% | – | – | – | 30984788 |
Song et al. | circ_0137439 | hsa_circ_0137439 | MTDH | chr8:98673299–98708521 | urine | qPCR | 1.36 | GAPDH | upregulated | 116 | No | No | – | Yes | – | Yes | Yes | – | – | Yes | – | Diagnosis | 0.89 | 87.93, 80.06% | Yes | Yes | – | 31777254 |
Tang et al. | circ_ASXL1 | hsa_circ_0001136 | ASXL1 | chr20:30954186–30956926 | tissues | qPCR | – | U6 | upregulated | 61 | No | No | No | Yes | – | Yes | Yes | No | Yes | No | – | Diagnosis | 0.77 | 68.6, 76.9% | Yes | – | – | 31966702 |
Zhang et al. | circ_ZFR | hsa_circ_0072088 | ZFR | chr5:32379220–32388780 | tissues | qPCR | MEL | GAPDH | upregulated | 104 | No | No | No | Yes | – | Yes | Yes | – | – | No | Yes | Diagnosis | 0.8216 | – | Yes | – | Yes | 31746333 |
Huang et al. | circ_0000144 | hsa_circ_0000144 | SLAMF6 | chr1:160472466–160472794 | tissues | qPCR | – | U6 | upregulated | 69 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | Yes | – | – | 30098434 |
Chi et al. | circ_000285 | hsa_circ_0000285 | HIPK3 | chr11:33362513–33363232 | tissues, serum | qPCR | MV | β-actin | downregulated | 197 | No | No | Yes | – | Yes | Yes | Yes | – | Yes | – | – | – | – | – | Yes | – | – | 30509102 |
Liu et al. | circ_0001361 | hsa_circ_0001361 | FNDC3B | chr3:171830241–171851336 | tissues | qPCR | – | GAPDH | upregulated | 69 | No | No | No | Yes | – | Yes | No | – | – | Yes | – | – | – | – | Yes | – | – | 31705065 |
Mao et al. | circ_0068871 | hsa_circ_0068871 | FGFR3 | chr4:1801473–1804791 | tissues | qPCR | – | GAPDH | upregulated | 32 | No | No | No | – | – | Yes | – | – | No | – | – | – | – | – | – | – | – | 30999937 |
Abulizi et al. | circ_0071662 | hsa_circ_0071662 | TPPP | chr5:659976–693510 | tissues | qPCR | – | – | downregulated | 158 | No | No | Yes | – | – | Yes | – | – | – | – | – | – | – | – | Yes | – | – | 31757227 |
Zhuang et al. | circ_CASC15 | hsa_circ_0075828 | CASC15 | chr6:22020567–22020771 | tissues | qPCR | – | GAPDH | upregulated | 67 | No | No | No | – | – | Yes | No | – | – | – | – | – | – | – | Yes | Yes | – | 31072448 |
Su et al. | circ_5912 | hsa_circ_0005912 | FIP1L1 | chr4:54265896–54294350 | tissues | qPCR | – | GAPDH | downregulated | 58 | No | No | – | Yes | – | Yes | Yes | No | – | – | – | – | – | Yes | – | – | 31808751 | |
Bi et al. | circ_BPTF | hsa_circ_0000799 | BPTF | chr17:65941524–65972074 | tissues | qPCR | MEL | – | upregulated | 72 | No | No | No | Yes | – | No | No | – | Yes | Yes | – | – | – | Yes | – | – | 30103209 | |
Sun et al. | circ_CDYL | hsa_circ_0008285 | CDYL | chr6:4891946–4892613 | tissues | qPCR | – | GAPDH | downregulated | 30 | No | No | – | No | – | Yes | No | – | No | – | – | – | – | – | – | 30968727 | ||
Okholm et al. | circ_CDYL | hsa_circ_0008285 | CDYL | chr6:4891946–4892613 | tissues | qPCR | MEL | – | downregulated | 457 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | Yes | 29263845 |
Wu et al. | circ_CEP128 | hsa_circ_0102722 | CEP128 | chr14:81209418–81304622 | tissues | qPCR | – | GAPDH | upregulated | 10 | No | No | Yes | – | – | Yes | Yes | – | – | – | – | – | – | – | – | – | 30134837 | |
Liu et al. | circ_FAM114A2 | hsa_circ_0001546 | FAM114A2 | chr5:153413351–153414527 | tissues | qPCR | NAT | GAPDH | downregulated | 31 | No | No | No | Yes | – | Yes | No | – | – | – | – | – | – | – | – | – | 31969560 | |
Liu et al. | circ_FNDC3B | hsa_circ_0006156 | FNDC3B | chr3:171965322–171969331 | tissues | qPCR | – | GAPDH | downregulated | 82 | No | No | No | Yes | – | Yes | Yes | – | – | No | No | – | – | – | Yes | – | – | 30458784 |
He et al. | circ_FUT8 | hsa_circ_0003028 | FUT8 | chr14:66028054–66028484 | tissues | qPCR | – | GAPDH | downregulated | 145 | No | No | No | Yes | – | No | Yes | No | – | – | – | – | – | – | Yes | – | – | 32072011 |
Li et al. | circ_HIPK3 | hsa_circ_0000284 | HIPK3 | chr11:33307958–33309057 | tissues | qPCR | – | GAPDH | downregulated | 44 | No | No | – | Yes | – | Yes | Yes | – | – | Yes | – | – | – | – | – | – | – | 28794202 |
Okholm et al. | circ_HIPK3 | hsa_circ_0000284 | HIPK3 | chr11:33307958–33309057 | tissues | qPCR | MEL | – | downregulated | 457 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | Yes | 29263845 |
Yang et al. | circ_ITCH | hsa_circ_0001141 | ITCH | chr20:33001547–33037285 | tissues | qPCR | – | β-actin | downregulated | 70 | No | No | No | Yes | – | No | – | – | – | – | – | – | – | – | Yes | – | – | 29386015 |
Lin et al. | circ_LPAR1 | hsa_circ_0087960 | LPAR1 | chr9:113734352–113735838 | tissues | qPCR | – | β-actin | upregulated | 125 | No | No | No | No | – | No | – | No | – | – | No | – | – | – | – | – | – | 30867795 |
Li et al. | circ_MTO1 | hsa_circ_0007874 | MTO1 | chr6:74175931–74176329 | tissues | qPCR | – | β-actin | downregulated | 117 | – | – | – | – | – | – | Yes | – | – | – | – | – | – | – | Yes | Yes | – | 30551873 |
Yan et al. | circ_PICALM | hsa_circ_0023919 | PICALM | chr11:85707868–85714494 | tissues | qPCR | – | GAPDH | downregulated | 168 | No | No | No | Yes | – | Yes | Yes | – | – | – | – | – | – | – | Yes | – | – | 31648990 |
Chen et al. | circ_PRMT5 | hsa_circ_0031250 | PRMT5 | chr14:23395341–23396023 | tissues | qPCR | – | GAPDH | upregulated | 119 | No | No | – | No | – | Yes | – | – | – | – | – | – | – | – | – | Yes | – | 30305293 |
Xu et al. | circ_PTK2 | hsa_circ_0003221 | PTK2 | chr8:141856358–141900868 | tissue, blood | qPCR | – | GAPDH | upregulated | 40 | – | – | – | – | Yes | Yes | Yes | – | – | – | – | – | – | – | – | – | – | 29125888 |
He et al. | circ_PTPRA | hsa_circ_0006117 | PTPRA | chr20:2944917–2945848 | tissues | qPCR | – | GAPDH | downregulated | 104 | No | No | Yes | No | – | Yes | No | No | – | – | – | – | – | – | Yes | – | – | 31821171 |
Su et al. | circ_RIP2 | hsa_circ_0005777 | RGNEF | chr5:73136304–73136585 | tissues | qPCR | – | GAPDH | downregulated | 58 | No | No | – | Yes | – | Yes | Yes | No | – | – | – | – | – | – | Yes | – | – | 32019579 |
Liang et al. | circ_0058063 | hsa_circ_0058063 | ATIC | chr2:216177220–216213972 | tissues | qPCR | – | GAPDH | upregulated | 94 | No | No | – | Yes | – | Yes | – | No | – | – | – | – | – | – | Yes | – | – | 32181485 |
Wei et al. | circ_403658 | hsa_circ_0004383 | ZNF292 | chr6:87920168–87928449 | tissues | qPCR | – | GAPDH | upregulated | 123 | No | No | Yes | – | – | Yes | No | – | Yes | – | – | – | – | – | Yes | – | – | 31814891 |
Lu et al. | circ_SLC8A1 | hsa_circ_0000994 | SLC8A1 | chr2:40655612–40657444 | tissues | qPCR | – | GAPDH | downregulated | 70 | No | No | – | Yes | – | Yes | No | – | – | – | – | – | – | – | – | – | – | 31228937 |
Su et al. | circ_TFRC | has_circ_0001445 | TFRC | chr3:195785154–195,787,118 | tissues | qPCR | – | GAPDH | upregulated | 220 | No | No | – | Yes | – | Yes | Yes | No | – | – | – | – | – | – | Yes | – | – | 30782157 |
Liu et al. | circ_UBXN7 | hsa_circ_0001380 | UBXN7 | chr3:196118683–196129890 | tissues | qPCR | – | GAPDH | downregulated | 84 | No | No | No | Yes | – | Yes | No | – | – | No | – | – | – | – | Yes | – | – | 30312173 |
Zeng et al. | circ_VANGL1 | hsa_circ_0002623 | VANGL1 | chr1:116202261–116206889 | tissues | qPCR | – | GAPDH | upregulated | 43 | No | No | – | Yes | – | Yes | Yes | – | – | – | – | – | – | – | Yes | – | – | 30146736 |
Bi et al. | circ_ZKSCAN1 | hsa_circ_0001727 | ZKSCAN1 | chr7:99621041–99621930 | tissues | qPCR | – | GAPDH | downregulated | 137 | No | No | No | Yes | – | Yes | Yes | – | – | – | Yes | – | – | – | Yes | Yes | – | 31481066 |
Su et al. | ciRs_6 | hsa_circ_0006260 | SLC41A2 | chr12:105321750–105322472 | tissues | qPCR | – | GAPDH | downregulated | 58 | No | No | – | Yes | – | Yes | No | No | – | – | – | – | – | – | Yes | – | – | 31819015 |
Liu et al. | circ_0076704 | hsa_circ_0076704 | CD2AP | chr6:47471015–47522502 | tissues | qPCR | – | β-actin | upregulated | 70 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | Yes | – | – | 31169020 |
Yang et al. | circ_UVRAG | hsa_circ_0023642 | UVRAG | chr11:75727858–75728024 | tissues | qPCR | – | – | upregulated | 402 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | NO | – | – | 30387298 |
Zhong et al. | circ_MYLK | hsa_circ_0002768 | MYLK | chr3:123471177–123512691 | tissues | qPCR | – | – | upregulated | 32 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | Yes | – | 28687357 |