Ausgabe 1/2022
Inhalt (85 Artikel)
Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients
A. Joseph Bloom, Xianrong Mao, Amy Strickland, Yo Sasaki, Jeffrey Milbrandt, Aaron DiAntonio
Sleep and circadian rhythms in Parkinson’s disease and preclinical models
Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic, Oliver Rawashdeh
Challenge accepted: uncovering the role of rare genetic variants in Alzheimer’s disease
Marzieh Khani, Elizabeth Gibbons, Jose Bras, Rita Guerreiro
The role of inflammasomes in vascular cognitive impairment
Luting Poh, Wei Liang Sim, Dong-Gyu Jo, Quynh Nhu Dinh, Grant R. Drummond, Christopher G. Sobey, Christopher Li-Hsian Chen, Mitchell K. P. Lai, David Y. Fann, Thiruma V. Arumugam
The landscape of human tissue and cell type specific expression and co-regulation of senescence genes
Peng Xu, Minghui Wang, Won-min Song, Qian Wang, Guo-Cheng Yuan, Peter H. Sudmant, Habil Zare, Zhidong Tu, Miranda E. Orr, Bin Zhang
A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling
Hong Yang, Feng Xiong, Hai-Bin Qin, Qun-Tao Yu, Jin-Yan Sun, Hai-Wen Zhao, Dong Li, Youtong Zhou, Fu-Kun Zhang, Xiao-Wen Zhu, Tong Wu, Man Jiang, Xiangmin Xu, Youming Lu, Hong-Jie Shen, Wen-Bo Zeng, Fei Zhao, Min-Hua Luo
Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain
Enquan Xu, Ravindra Boddu, Hisham A. Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M. Carlisle, Elliot J. Lefkowitz, Ashley S. Harms, Etty N. Benveniste, Talene A. Yacoubian, Laura A. Volpicelli-Daley, David G. Standaert, Andrew B. West
Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells
Qian Li, Yi Feng, Yingchao Xue, Xiping Zhan, Yi Fu, Gege Gui, Weiqiang Zhou, Jean-Philippe Richard, Arens Taga, Pan Li, Xiaobo Mao, Nicholas J. Maragakis, Mingyao Ying
Dynamic changes of CSF sPDGFRβ during ageing and AD progression and associations with CSF ATN biomarkers
Jun Wang, Dong-Yu Fan, Hui-Yun Li, Chen-Yang He, Ying-Ying Shen, Gui-Hua Zeng, Dong-Wan Chen, Xu Yi, Ya-Hui Ma, Jin-Tai Yu, Yan-Jiang Wang
Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains
Tarin M. Bigley, Monica Xiong, Muhammad Ali, Yun Chen, Chao Wang, Javier Remolina Serrano, Abdallah Eteleeb, Oscar Harari, Liping Yang, Swapneel J. Patel, Carlos Cruchaga, Wayne M. Yokoyama, David M. Holtzman
Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis
Kim A. Staats, David R. Borchelt, Malú Gámez Tansey, James Wymer
Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer’s disease
Guoxin Zhang, Lanxia Meng, Zhihao Wang, Qinyu Peng, Guiqin Chen, Jing Xiong, Zhentao Zhang
Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis
Thomas E. Mahan, Chao Wang, Xin Bao, Ankit Choudhury, Jason D. Ulrich, David M. Holtzman
Retraction Note: Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4
Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Carol Miller, Patrick M. Sullivan, Hoau-Yan Wang, Hussein N. Yassine
Differential regulation of progranulin derived granulin peptides
Tingting Zhang, Huan Du, Mariela Nunez Santos, Xiaochun Wu, Mitchell D. Pagan, Lianne Jillian Trigiani, Nozomi Nishimura, Thomas Reinheckel, Fenghua Hu
Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease
Waijiao Cai, Pranay Srivastava, Danielle Feng, Yue Lin, Charles R. Vanderburg, Yuehang Xu, Pamela Mclean, Matthew P. Frosch, David E. Fisher, Michael A. Schwarzschild, Xiqun Chen
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application
Minghui Wang, Won-min Song, Chen Ming, Qian Wang, Xianxiao Zhou, Peng Xu, Azra Krek, Yonejung Yoon, Lap Ho, Miranda E. Orr, Guo-Cheng Yuan, Bin Zhang
Alzheimer’s disease – the journey of a healthy brain into organ failure
Todd E. Golde
Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease
Diane Bairamian, Sha Sha, Nathalie Rolhion, Harry Sokol, Guillaume Dorothée, Cynthia A. Lemere, Slavica Krantic
The route of SARS-CoV-2 to brain infection: have we been barking up the wrong tree?
Rafal Butowt, Christopher S. von Bartheld
Does proteopathic tau propagate trans-synaptically in the brain?
Wen Hu, Fei Liu, Cheng-Xin Gong, Khalid Iqbal
The role of inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE-mediated ALS/FTD
Pegah Masrori, Jimmy Beckers, Helena Gossye, Philip Van Damme
Solving neurodegeneration: common mechanisms and strategies for new treatments
Lauren K. Wareham, Shane A. Liddelow, Sally Temple, Larry I. Benowitz, Adriana Di Polo, Cheryl Wellington, Jeffrey L. Goldberg, Zhigang He, Xin Duan, Guojun Bu, Albert A. Davis, Karthik Shekhar, Anna La Torre, David C. Chan, M. Valeria Canto-Soler, John G. Flanagan, Preeti Subramanian, Sharyn Rossi, Thomas Brunner, Diane E. Bovenkamp, David J. Calkins
In Memoriam of John T. Trojanowski, MD, PhD 1946-2022
Hui Zheng, David M. Holtzman
Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications
Todd McLaughlin, Andy Medina, Jacob Perkins, Maria Yera, Joshua J. Wang, Sarah X. Zhang
Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro
Mika P. Cadiz, Tanner D. Jensen, Jonathon P. Sens, Kuixi Zhu, Won-Min Song, Bin Zhang, Mark Ebbert, Rui Chang, John D. Fryer
Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease
Pieter Jelle Visser, Lianne M. Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J. van der Lee, Magda Tsolaki, Frans R. J. Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J. B. Vos, Isabelle Bos, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg, Betty M. Tijms, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg, Betty M. Tijms
Tauopathies: new perspectives and challenges
Yi Zhang, Kai-Min Wu, Liu Yang, Qiang Dong, Jin-Tai Yu
Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration
Alba Cervantes González, David J. Irwin, Daniel Alcolea, Corey T. McMillan, Alice Chen-Plotkin, David Wolk, Sònia Sirisi, Oriol Dols-Icardo, Marta Querol-Vilaseca, Ignacio Illán-Gala, Miguel Angel Santos-Santos, Juan Fortea, Edward B. Lee, John Q. Trojanowski, Murray Grossman, Alberto Lleó, Olivia Belbin
VCP suppresses proteopathic seeding in neurons
Jiang Zhu, Sara Pittman, Dhruva Dhavale, Rachel French, Jessica N. Patterson, Mohamed Salman Kaleelurrrahuman, Yuanzi Sun, Jaime Vaquer-Alicea, Gianna Maggiore, Christoph S. Clemen, William J. Buscher, Jan Bieschke, Paul Kotzbauer, Yuna Ayala, Marc I. Diamond, Albert A. Davis, Conrad Weihl
The role of ATP-binding cassette subfamily A in the etiology of Alzheimer’s disease
Liene Bossaerts, Rita Cacace, Christine Van Broeckhoven
Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam, Stephen M. Strittmatter
BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B. Wood, Jubao Duan, Gopal Thinakaran, Srikant Rangaraju
Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination
Martin Zirngibl, Peggy Assinck, Anastasia Sizov, Andrew V. Caprariello, Jason R. Plemel
Circadian clocks, cognition, and Alzheimer’s disease: synaptic mechanisms, signaling effectors, and chronotherapeutics
Kari R. Hoyt, Karl Obrietan
Microglial lactate metabolism as a potential therapeutic target for Alzheimer’s disease
Yingjun Zhao, Huaxi Xu
Correction: Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease
Pieter Jelle Visser, Lianne M. Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J. van der Lee, Magda Tsolaki, Frans R. J. Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J. B. Vos, Isabelle Bos, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg, Betty M. Tijms, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg, Betty M. Tijms
Prompting endogenous repair of brain injury: science fiction or reality?
Aurelie de Rus Jacquet, Francesca Cicchetti
Imaging tau pathology in Alzheimer’s disease with positron emission tomography: lessons learned from imaging-neuropathology validation studies
Alexis Moscoso, Melissa C. Wren, Tammaryn Lashley, Erik Arstad, Melissa E. Murray, Nick C. Fox, Kerstin Sander, Michael Schöll
TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target
Rui-Yang Li, Qi Qin, Han-Chen Yang, Ying-Ying Wang, Ying-Xin Mi, Yun-Si Yin, Meng Wang, Chao-Ji Yu, Yi Tang
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot Thomsen, Jason Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy K. Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Isabel Lopez, Hilda Solanoy, Shababa T. Masoud, Chun-chi Liang, Karin Lin, Giuseppe Astarita, Nathalie Khoury, Joy Yu Zuchero, Robert G. Thorne, Kevin Shen, Stephanie Miller, Jorge J. Palop, Dylan Garceau, Michael Sasner, Jennifer D. Whitesell, Julie A. Harris, Selina Hummel, Johannes Gnörich, Karin Wind, Lea Kunze, Artem Zatcepin, Matthias Brendel, Michael Willem, Christian Haass, Daniel Barnett, Till S. Zimmer, Anna G. Orr, Kimberly Scearce-Levie, Joseph W. Lewcock, Gilbert Di Paolo, Pascal E. Sanchez
Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4
Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Patrick M. Sullivan, Hussein N. Yassine
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Emily Connell, Gwenaelle Le Gall, Matthew G. Pontifex, Saber Sami, John F. Cryan, Gerard Clarke, Michael Müller, David Vauzour
LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions
Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay-Jiguang Zhu, Timothy Y. Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang An
Unraveling protein dynamics to understand the brain – the next molecular frontier
Kyle D. Brewer, Sophia M. Shi, Tony Wyss-Coray
The role of NURR1 in metabolic abnormalities of Parkinson’s disease
Murad Al-Nusaif, Yuting Yang, Song Li, Cheng Cheng, Weidong Le
CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease
Shweta S. Puntambekar, Miguel Moutinho, Peter Bor-Chian Lin, Vaishnavi Jadhav, Danika Tumbleson-Brink, Ananya Balaji, Martin Alvarado Benito, Guixiang Xu, Adrian Oblak, Cristian A. Lasagna-Reeves, Gary E. Landreth, Bruce T. Lamb
17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes
Kathryn R. Bowles, Derian A. Pugh, Yiyuan Liu, Tulsi Patel, Alan E. Renton, Sara Bandres-Ciga, Ziv Gan-Or, Peter Heutink, Ari Siitonen, Sarah Bertelsen, Jonathan D. Cherry, Celeste M. Karch, Steven J. Frucht, Brian H. Kopell, Inga Peter, Y. J. Park, Alexander Charney, Towfique Raj, John F. Crary, A. M. Goate
Combination therapy using GDNF and cell transplant in Parkinson’s disease
Bin Xiao, Su-Chun Zhang, Eng-King Tan
Crosstalk of organelles in Parkinson’s disease – MiT family transcription factors as central players in signaling pathways connecting mitochondria and lysosomes
Martin Lang, Peter P. Pramstaller, Irene Pichler
APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants
Guojun Bu
Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson’s disease
Giulietta Maria Riboldi, Ricardo A. Vialle, Elisa Navarro, Evan Udine, Katia de Paiva Lopes, Jack Humphrey, Amanda Allan, Madison Parks, Brooklyn Henderson, Kelly Astudillo, Charalambos Argyrou, Maojuan Zhuang, Tamjeed Sikder, J. Oriol Narcis, Shilpa Dilip Kumar, William Janssen, Allison Sowa, Giacomo P. Comi, Alessio Di Fonzo, John F. Crary, Steven J. Frucht, Towfique Raj
When the infectious environment meets the AD brain
Tal Ganz, Nina Fainstein, Tamir Ben-Hur
Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
Leah K. Cuddy, Alia O. Alia, Miranda A. Salvo, Sidhanth Chandra, Tom N. Grammatopoulos, Craig J. Justman, Peter T. Lansbury Jr, Joseph R. Mazzulli, Robert Vassar
Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2
Jean-Vianney Haure-Mirande, Mickael Audrain, Michelle E. Ehrlich, Sam Gandy
Correction: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam, Stephen M. Strittmatter
LRP1 is a neuronal receptor for α-synuclein uptake and spread
Kai Chen, Yuka A. Martens, Axel Meneses, Daniel H. Ryu, Wenyan Lu, Ana Caroline Raulin, Fuyao Li, Jing Zhao, Yixing Chen, Yunjung Jin, Cynthia Linares, Marshall Goodwin, Yonghe Li, Chia-Chen Liu, Takahisa Kanekiyo, David M. Holtzman, Todd E. Golde, Guojun Bu, Na Zhao
Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
Bing Zhu, Yan Liu, Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Piña-Crespo, Huaxi Xu, Timothy Y. Huang
CD8+ T cells in neurodegeneration: friend or foe?
Dan Hu, Weiming Xia, Howard L. Weiner
Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD
Michiyo Iba, Ross A. McDevitt, Changyoun Kim, Roshni Roy, Dimitra Sarantopoulou, Ella Tommer, Byron Siegars, Michelle Sallin, Somin Kwon, Jyoti Misra Sen, Ranjan Sen, Eliezer Masliah
Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity
Yi-Chen Hsieh, Joseph Negri, Amy He, Richard V. Pearse II, Lei Liu, Duc M. Duong, Lori B. Chibnik, David A. Bennett, Nicholas T. Seyfried, Tracy L. Young-Pearse
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
Rosalía Fernández-Calle, Sabine C. Konings, Javier Frontiñán-Rubio, Juan García-Revilla, Lluís Camprubí-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, José Luís Venero, Henrietta M. Nielsen, Gunnar K. Gouras, Tomas Deierborg
To the editor: Response to post-infection cognitive impairments in a cohort of elderly patients with COVID-19, by Wang, Y.J. et al. (2021)
Rahmouni Nesrine, Rosa-Neto Pedro, Brunet Alain
Author response to “post-infection cognitive impairments in a cohort of elderly patients with COVID-19”
Yu-Hui Liu, Ye-Ran Wang, Qing-Hua Wang, Juan Liu, Yan-Jiang Wang
Liver-ing in your head rent free: peripheral ApoE4 drives CNS pathology
Lesley R. Golden, Lance A. Johnson
Tau interactome and RNA binding proteins in neurodegenerative diseases
Tomas Kavanagh, Aditi Halder, Eleanor Drummond
The Golgi apparatus: Site for convergence of COVID-19 brain fog and Alzheimer’s disease?
Yanzhuang Wang, Sam Gandy
Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (Part 1): the 2021 pre-symposium of the 15th international conference on Alzheimer’s and Parkinson’s diseases
Sharyn L. Rossi, Preeti Subramanian, Guojun Bu, Adriana Di Polo, Todd E. Golde, Diane E. Bovenkamp
Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (part 2): the 2021 pre-symposium of the 15th international conference on Alzheimer’s and Parkinson’s diseases
Sharyn L. Rossi, Preeti Subramanian, Guojun Bu, Adriana Di Polo, Todd E. Golde, Diane E. Bovenkamp
Correction: Challenge accepted: Uncovering the role of rare genetic variants in Alzheimer’s disease
Marzieh Khani, Elizabeth Gibbons, Jose Bras, Rita Guerreiro
Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
Qingyi Ma, Zhen Zhao, Abhay P. Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B. Verghese, Joachim Herz, David M. Holtzman, Berislav V. Zlokovic
ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies
Ana-Caroline Raulin, Sydney V. Doss, Zachary A. Trottier, Tadafumi C. Ikezu, Guojun Bu, Chia-Chen Liu
TREM2 and microglia exosomes: a potential highway for pathological tau
Nimansha Jain, Jason D. Ulrich
Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease
Alena Salasova, Giulia Monti, Olav M. Andersen, Anders Nykjaer
Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination
Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C. Ikezu, Francis Shue, Sydney V. Doss, Alla Alnobani, Yuka A. Martens, Melissa Wren, Yan W. Asmann, Bin Zhang, Guojun Bu, Chia-Chen Liu
Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer’s disease in Tg2576 mice
Livia La Barbera, Annalisa Nobili, Emma Cauzzi, Ilaria Paoletti, Mauro Federici, Luana Saba, Cecilia Giacomet, Ramona Marino, Paraskevi Krashia, Marcello Melone, Flavio Keller, Nicola Biagio Mercuri, Maria Teresa Viscomi, Fiorenzo Conti, Marcello D’Amelio
Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad
Kreesan Reddy, Birger Victor Dieriks
Glial interference: impact of type I interferon in neurodegenerative diseases
Ethan Roy, Wei Cao
LRP1: a novel receptor for the transmission of pathological α-Synuclein
Crystal Pan, Chao Peng
Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
Bilal Khalil, Deepak Chhangani, Melissa C. Wren, Courtney L. Smith, Jannifer H. Lee, Xingli Li, Christian Puttinger, Chih-Wei Tsai, Gael Fortin, Dmytro Morderer, Junli Gao, Feilin Liu, Chun Kim Lim, Jingjiao Chen, Ching-Chieh Chou, Cara L. Croft, Amanda M. Gleixner, Christopher J. Donnelly, Todd E. Golde, Leonard Petrucelli, Björn Oskarsson, Dennis W. Dickson, Ke Zhang, James Shorter, Shige H. Yoshimura, Sami J. Barmada, Diego E. Rincon-Limas, Wilfried Rossoll
Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer’s disease continuum
Johan Gobom, Andréa L. Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A. Pascoal, Thomas K. Karikari, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance
Sameera Zia, Brady P. Hammond, Martin Zirngibl, Anastasia Sizov, Charbel S. Baaklini, Sharmistha P. Panda, Madelene F. S. Ho, Kelly V. Lee, Apurba Mainali, Mena K. Burr, Sioned Williams, Andrew V. Caprariello, Christopher Power, Thomas Simmen, Bradley J. Kerr, Jason R. Plemel
Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Dong Won Kim, Kevin J. Tu, Alice Wei, Ashley J. Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin Braunstein, Jonathan P. Ling, Juan C. Troncoso, Philip C. Wong, Seth Blackshaw, Ronald L. Schnaar, Tong Li
TREM2 dependent and independent functions of microglia in Alzheimer’s disease
Jinchao Hou, Yun Chen, Gary Grajales-Reyes, Marco Colonna
Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels
Melissa E. Murray, Christina M. Moloney, Naomi Kouri, Jeremy A. Syrjanen, Billie J. Matchett, Darren M. Rothberg, Jessica F. Tranovich, Tiffany N. Hicks Sirmans, Heather J. Wiste, Baayla D. C. Boon, Aivi T. Nguyen, R. Ross Reichard, Dennis W. Dickson, Val J. Lowe, Jeffrey L. Dage, Ronald C. Petersen, Clifford R. Jack Jr, David S. Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, Michelle M. Mielke