Zum Inhalt

Molecular Neurodegeneration

Ausgabe 1/2022

Inhalt (85 Artikel)

Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients

  • Open Access
  • Research article

A. Joseph Bloom, Xianrong Mao, Amy Strickland, Yo Sasaki, Jeffrey Milbrandt, Aaron DiAntonio

Sleep and circadian rhythms in Parkinson’s disease and preclinical models

  • Open Access
  • Review

Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic, Oliver Rawashdeh

Challenge accepted: uncovering the role of rare genetic variants in Alzheimer’s disease

  • Open Access
  • Review

Marzieh Khani, Elizabeth Gibbons, Jose Bras, Rita Guerreiro

The role of inflammasomes in vascular cognitive impairment

  • Open Access
  • Review

Luting Poh, Wei Liang Sim, Dong-Gyu Jo, Quynh Nhu Dinh, Grant R. Drummond, Christopher G. Sobey, Christopher Li-Hsian Chen, Mitchell K. P. Lai, David Y. Fann, Thiruma V. Arumugam

The landscape of human tissue and cell type specific expression and co-regulation of senescence genes

  • Open Access
  • Research article

Peng Xu, Minghui Wang, Won-min Song, Qian Wang, Guo-Cheng Yuan, Peter H. Sudmant, Habil Zare, Zhidong Tu, Miranda E. Orr, Bin Zhang

A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling

  • Open Access
  • Research article

Hong Yang, Feng Xiong, Hai-Bin Qin, Qun-Tao Yu, Jin-Yan Sun, Hai-Wen Zhao, Dong Li, Youtong Zhou, Fu-Kun Zhang, Xiao-Wen Zhu, Tong Wu, Man Jiang, Xiangmin Xu, Youming Lu, Hong-Jie Shen, Wen-Bo Zeng, Fei Zhao, Min-Hua Luo

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

  • Open Access
  • Research article

Enquan Xu, Ravindra Boddu, Hisham A. Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M. Carlisle, Elliot J. Lefkowitz, Ashley S. Harms, Etty N. Benveniste, Talene A. Yacoubian, Laura A. Volpicelli-Daley, David G. Standaert, Andrew B. West

Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells

  • Open Access
  • Research article

Qian Li, Yi Feng, Yingchao Xue, Xiping Zhan, Yi Fu, Gege Gui, Weiqiang Zhou, Jean-Philippe Richard, Arens Taga, Pan Li, Xiaobo Mao, Nicholas J. Maragakis, Mingyao Ying

Dynamic changes of CSF sPDGFRβ during ageing and AD progression and associations with CSF ATN biomarkers

  • Open Access
  • Research article

Jun Wang, Dong-Yu Fan, Hui-Yun Li, Chen-Yang He, Ying-Ying Shen, Gui-Hua Zeng, Dong-Wan Chen, Xu Yi, Ya-Hui Ma, Jin-Tai Yu, Yan-Jiang Wang

Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

  • Open Access
  • Research article

Tarin M. Bigley, Monica Xiong, Muhammad Ali, Yun Chen, Chao Wang, Javier Remolina Serrano, Abdallah Eteleeb, Oscar Harari, Liping Yang, Swapneel J. Patel, Carlos Cruchaga, Wayne M. Yokoyama, David M. Holtzman

Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis

  • Open Access
  • Review

Kim A. Staats, David R. Borchelt, Malú Gámez Tansey, James Wymer

Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer’s disease

  • Open Access
  • Research article

Guoxin Zhang, Lanxia Meng, Zhihao Wang, Qinyu Peng, Guiqin Chen, Jing Xiong, Zhentao Zhang

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

  • Open Access
  • Research article

Thomas E. Mahan, Chao Wang, Xin Bao, Ankit Choudhury, Jason D. Ulrich, David M. Holtzman

Retraction Note: Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4

  • Open Access
  • Retraction Note

Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Carol Miller, Patrick M. Sullivan, Hoau-Yan Wang, Hussein N. Yassine

Differential regulation of progranulin derived granulin peptides

  • Open Access
  • Research article

Tingting Zhang, Huan Du, Mariela Nunez Santos, Xiaochun Wu, Mitchell D. Pagan, Lianne Jillian Trigiani, Nozomi Nishimura, Thomas Reinheckel, Fenghua Hu

Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease

  • Open Access
  • Research article

Waijiao Cai, Pranay Srivastava, Danielle Feng, Yue Lin, Charles R. Vanderburg, Yuehang Xu, Pamela Mclean, Matthew P. Frosch, David E. Fisher, Michael A. Schwarzschild, Xiqun Chen

Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application

  • Open Access
  • Review

Minghui Wang, Won-min Song, Chen Ming, Qian Wang, Xianxiao Zhou, Peng Xu, Azra Krek, Yonejung Yoon, Lap Ho, Miranda E. Orr, Guo-Cheng Yuan, Bin Zhang

Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease

  • Open Access
  • Review

Diane Bairamian, Sha Sha, Nathalie Rolhion, Harry Sokol, Guillaume Dorothée, Cynthia A. Lemere, Slavica Krantic

The route of SARS-CoV-2 to brain infection: have we been barking up the wrong tree?

  • Open Access
  • COVID-19
  • Letter to the Editor

Rafal Butowt, Christopher S. von Bartheld

Does proteopathic tau propagate trans-synaptically in the brain?

  • Open Access
  • Commentary

Wen Hu, Fei Liu, Cheng-Xin Gong, Khalid Iqbal

Solving neurodegeneration: common mechanisms and strategies for new treatments

  • Open Access
  • Review

Lauren K. Wareham, Shane A. Liddelow, Sally Temple, Larry I. Benowitz, Adriana Di Polo, Cheryl Wellington, Jeffrey L. Goldberg, Zhigang He, Xin Duan, Guojun Bu, Albert A. Davis, Karthik Shekhar, Anna La Torre, David C. Chan, M. Valeria Canto-Soler, John G. Flanagan, Preeti Subramanian, Sharyn Rossi, Thomas Brunner, Diane E. Bovenkamp, David J. Calkins

In Memoriam of John T. Trojanowski, MD, PhD 1946-2022

  • Open Access
  • Commentary

Hui Zheng, David M. Holtzman

Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications

  • Open Access
  • Review

Todd McLaughlin, Andy Medina, Jacob Perkins, Maria Yera, Joshua J. Wang, Sarah X. Zhang

Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro

  • Open Access
  • Research article

Mika P. Cadiz, Tanner D. Jensen, Jonathon P. Sens, Kuixi Zhu, Won-Min Song, Bin Zhang, Mark Ebbert, Rui Chang, John D. Fryer

Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease

  • Open Access
  • Research article

Pieter Jelle Visser, Lianne M. Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J. van der Lee, Magda Tsolaki, Frans R. J. Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J. B. Vos, Isabelle Bos, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg, Betty M. Tijms, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg, Betty M. Tijms

Tauopathies: new perspectives and challenges

  • Open Access
  • Review

Yi Zhang, Kai-Min Wu, Liu Yang, Qiang Dong, Jin-Tai Yu

Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration

  • Open Access
  • Research article

Alba Cervantes González, David J. Irwin, Daniel Alcolea, Corey T. McMillan, Alice Chen-Plotkin, David Wolk, Sònia Sirisi, Oriol Dols-Icardo, Marta Querol-Vilaseca, Ignacio Illán-Gala, Miguel Angel Santos-Santos, Juan Fortea, Edward B. Lee, John Q. Trojanowski, Murray Grossman, Alberto Lleó, Olivia Belbin

VCP suppresses proteopathic seeding in neurons

  • Open Access
  • Research article

Jiang Zhu, Sara Pittman, Dhruva Dhavale, Rachel French, Jessica N. Patterson, Mohamed Salman Kaleelurrrahuman, Yuanzi Sun, Jaime Vaquer-Alicea, Gianna Maggiore, Christoph S. Clemen, William J. Buscher, Jan Bieschke, Paul Kotzbauer, Yuna Ayala, Marc I. Diamond, Albert A. Davis, Conrad Weihl

The role of ATP-binding cassette subfamily A in the etiology of Alzheimer’s disease

  • Open Access
  • Review

Liene Bossaerts, Rita Cacace, Christine Van Broeckhoven

Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy

  • Open Access
  • Research article

A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam, Stephen M. Strittmatter

BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia

  • Open Access
  • Research article

Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B. Wood, Jubao Duan, Gopal Thinakaran, Srikant Rangaraju

Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

  • Open Access
  • Review

Martin Zirngibl, Peggy Assinck, Anastasia Sizov, Andrew V. Caprariello, Jason R. Plemel

Correction: Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease

  • Open Access
  • Correction

Pieter Jelle Visser, Lianne M. Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J. van der Lee, Magda Tsolaki, Frans R. J. Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J. B. Vos, Isabelle Bos, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg, Betty M. Tijms, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg, Betty M. Tijms

Prompting endogenous repair of brain injury: science fiction or reality?

  • Open Access
  • Research highlight

Aurelie de Rus Jacquet, Francesca Cicchetti

Imaging tau pathology in Alzheimer’s disease with positron emission tomography: lessons learned from imaging-neuropathology validation studies

  • Open Access
  • Perspective

Alexis Moscoso, Melissa C. Wren, Tammaryn Lashley, Erik Arstad, Melissa E. Murray, Nick C. Fox, Kerstin Sander, Michael Schöll

TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

  • Open Access
  • Review

Rui-Yang Li, Qi Qin, Han-Chen Yang, Ying-Ying Wang, Ying-Xin Mi, Yun-Si Yin, Meng Wang, Chao-Ji Yu, Yi Tang

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

  • Open Access
  • Research article

Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot Thomsen, Jason Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy K. Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Isabel Lopez, Hilda Solanoy, Shababa T. Masoud, Chun-chi Liang, Karin Lin, Giuseppe Astarita, Nathalie Khoury, Joy Yu Zuchero, Robert G. Thorne, Kevin Shen, Stephanie Miller, Jorge J. Palop, Dylan Garceau, Michael Sasner, Jennifer D. Whitesell, Julie A. Harris, Selina Hummel, Johannes Gnörich, Karin Wind, Lea Kunze, Artem Zatcepin, Matthias Brendel, Michael Willem, Christian Haass, Daniel Barnett, Till S. Zimmer, Anna G. Orr, Kimberly Scearce-Levie, Joseph W. Lewcock, Gilbert Di Paolo, Pascal E. Sanchez

Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4

  • Open Access
  • Research article

Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Patrick M. Sullivan, Hussein N. Yassine

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

  • Open Access
  • Review

Emily Connell, Gwenaelle Le Gall, Matthew G. Pontifex, Saber Sami, John F. Cryan, Gerard Clarke, Michael Müller, David Vauzour

LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions

  • Open Access
  • Research article

Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay-Jiguang Zhu, Timothy Y. Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang An

Unraveling protein dynamics to understand the brain – the next molecular frontier

  • Open Access
  • Review

Kyle D. Brewer, Sophia M. Shi, Tony Wyss-Coray

The role of NURR1 in metabolic abnormalities of Parkinson’s disease

  • Open Access
  • Review

Murad Al-Nusaif, Yuting Yang, Song Li, Cheng Cheng, Weidong Le

CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease

  • Open Access
  • Research article

Shweta S. Puntambekar, Miguel Moutinho, Peter Bor-Chian Lin, Vaishnavi Jadhav, Danika Tumbleson-Brink, Ananya Balaji, Martin Alvarado Benito, Guixiang Xu, Adrian Oblak, Cristian A. Lasagna-Reeves, Gary E. Landreth, Bruce T. Lamb

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

  • Open Access
  • Research article

Kathryn R. Bowles, Derian A. Pugh, Yiyuan Liu, Tulsi Patel, Alan E. Renton, Sara Bandres-Ciga, Ziv Gan-Or, Peter Heutink, Ari Siitonen, Sarah Bertelsen, Jonathan D. Cherry, Celeste M. Karch, Steven J. Frucht, Brian H. Kopell, Inga Peter, Y. J. Park, Alexander Charney, Towfique Raj, John F. Crary, A. M. Goate

Combination therapy using GDNF and cell transplant in Parkinson’s disease

  • Open Access
  • Research highlight

Bin Xiao, Su-Chun Zhang, Eng-King Tan

Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson’s disease

  • Open Access
  • Research article

Giulietta Maria Riboldi, Ricardo A. Vialle, Elisa Navarro, Evan Udine, Katia de Paiva Lopes, Jack Humphrey, Amanda Allan, Madison Parks, Brooklyn Henderson, Kelly Astudillo, Charalambos Argyrou, Maojuan Zhuang, Tamjeed Sikder, J. Oriol Narcis, Shilpa Dilip Kumar, William Janssen, Allison Sowa, Giacomo P. Comi, Alessio Di Fonzo, John F. Crary, Steven J. Frucht, Towfique Raj

When the infectious environment meets the AD brain

  • Open Access
  • Review

Tal Ganz, Nina Fainstein, Tamir Ben-Hur

Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice

  • Open Access
  • Research article

Leah K. Cuddy, Alia O. Alia, Miranda A. Salvo, Sidhanth Chandra, Tom N. Grammatopoulos, Craig J. Justman, Peter T. Lansbury Jr, Joseph R. Mazzulli, Robert Vassar

Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2

  • Open Access
  • Review

Jean-Vianney Haure-Mirande, Mickael Audrain, Michelle E. Ehrlich, Sam Gandy

Correction: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy

  • Open Access
  • Correction

A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam, Stephen M. Strittmatter

LRP1 is a neuronal receptor for α-synuclein uptake and spread

  • Open Access
  • Research article

Kai Chen, Yuka A. Martens, Axel Meneses, Daniel H. Ryu, Wenyan Lu, Ana Caroline Raulin, Fuyao Li, Jing Zhao, Yixing Chen, Yunjung Jin, Cynthia Linares, Marshall Goodwin, Yonghe Li, Chia-Chen Liu, Takahisa Kanekiyo, David M. Holtzman, Todd E. Golde, Guojun Bu, Na Zhao

Trem2 deletion enhances tau dispersion and pathology through microglia exosomes

  • Open Access
  • Research article

Bing Zhu, Yan Liu, Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Piña-Crespo, Huaxi Xu, Timothy Y. Huang

CD8+ T cells in neurodegeneration: friend or foe?

  • Open Access
  • Perspective

Dan Hu, Weiming Xia, Howard L. Weiner

RETRACTED ARTICLE: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD

  • Open Access
  • Research article

Michiyo Iba, Ross A. McDevitt, Changyoun Kim, Roshni Roy, Dimitra Sarantopoulou, Ella Tommer, Byron Siegars, Michelle Sallin, Somin Kwon, Jyoti Misra Sen, Ranjan Sen, Eliezer Masliah

Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity

  • Open Access
  • Research article

Yi-Chen Hsieh, Joseph Negri, Amy He, Richard V. Pearse II, Lei Liu, Duc M. Duong, Lori B. Chibnik, David A. Bennett, Nicholas T. Seyfried, Tracy L. Young-Pearse

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

  • Open Access
  • Review

Rosalía Fernández-Calle, Sabine C. Konings, Javier Frontiñán-Rubio, Juan García-Revilla, Lluís Camprubí-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, José Luís Venero, Henrietta M. Nielsen, Gunnar K. Gouras, Tomas Deierborg

Author response to “post-infection cognitive impairments in a cohort of elderly patients with COVID-19”

  • Open Access
  • COVID-19
  • Letter to the Editor

Yu-Hui Liu, Ye-Ran Wang, Qing-Hua Wang, Juan Liu, Yan-Jiang Wang

Liver-ing in your head rent free: peripheral ApoE4 drives CNS pathology

  • Open Access
  • Research highlight

Lesley R. Golden, Lance A. Johnson

Tau interactome and RNA binding proteins in neurodegenerative diseases

  • Open Access
  • Review

Tomas Kavanagh, Aditi Halder, Eleanor Drummond

Correction: Challenge accepted: Uncovering the role of rare genetic variants in Alzheimer’s disease

  • Open Access
  • Correction

Marzieh Khani, Elizabeth Gibbons, Jose Bras, Rita Guerreiro

Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

  • Open Access
  • Correction

Qingyi Ma, Zhen Zhao, Abhay P. Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B. Verghese, Joachim Herz, David M. Holtzman, Berislav V. Zlokovic

ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies

  • Open Access
  • Review

Ana-Caroline Raulin, Sydney V. Doss, Zachary A. Trottier, Tadafumi C. Ikezu, Guojun Bu, Chia-Chen Liu

TREM2 and microglia exosomes: a potential highway for pathological tau

  • Open Access
  • Commentary

Nimansha Jain, Jason D. Ulrich

Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease

  • Open Access
  • Review

Alena Salasova, Giulia Monti, Olav M. Andersen, Anders Nykjaer

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

  • Open Access
  • Research article

Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C. Ikezu, Francis Shue, Sydney V. Doss, Alla Alnobani, Yuka A. Martens, Melissa Wren, Yan W. Asmann, Bin Zhang, Guojun Bu, Chia-Chen Liu

Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer’s disease in Tg2576 mice

  • Open Access
  • Research article

Livia La Barbera, Annalisa Nobili, Emma Cauzzi, Ilaria Paoletti, Mauro Federici, Luana Saba, Cecilia Giacomet, Ramona Marino, Paraskevi Krashia, Marcello Melone, Flavio Keller, Nicola Biagio Mercuri, Maria Teresa Viscomi, Fiorenzo Conti, Marcello D’Amelio

Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad

  • Open Access
  • Review

Kreesan Reddy, Birger Victor Dieriks

LRP1: a novel receptor for the transmission of pathological α-Synuclein

  • Open Access
  • Research highlight

Crystal Pan, Chao Peng

Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy

  • Open Access
  • Research article

Bilal Khalil, Deepak Chhangani, Melissa C. Wren, Courtney L. Smith, Jannifer H. Lee, Xingli Li, Christian Puttinger, Chih-Wei Tsai, Gael Fortin, Dmytro Morderer, Junli Gao, Feilin Liu, Chun Kim Lim, Jingjiao Chen, Ching-Chieh Chou, Cara L. Croft, Amanda M. Gleixner, Christopher J. Donnelly, Todd E. Golde, Leonard Petrucelli, Björn Oskarsson, Dennis W. Dickson, Ke Zhang, James Shorter, Shige H. Yoshimura, Sami J. Barmada, Diego E. Rincon-Limas, Wilfried Rossoll

Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer’s disease continuum

  • Open Access
  • Research article

Johan Gobom, Andréa L. Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A. Pascoal, Thomas K. Karikari, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow

Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance

  • Open Access
  • Research article

Sameera Zia, Brady P. Hammond, Martin Zirngibl, Anastasia Sizov, Charbel S. Baaklini, Sharmistha P. Panda, Madelene F. S. Ho, Kelly V. Lee, Apurba Mainali, Mena K. Burr, Sioned Williams, Andrew V. Caprariello, Christopher Power, Thomas Simmen, Bradley J. Kerr, Jason R. Plemel

Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

  • Open Access
  • Research article

Dong Won Kim, Kevin J. Tu, Alice Wei, Ashley J. Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin Braunstein, Jonathan P. Ling, Juan C. Troncoso, Philip C. Wong, Seth Blackshaw, Ronald L. Schnaar, Tong Li

TREM2 dependent and independent functions of microglia in Alzheimer’s disease

  • Open Access
  • Review

Jinchao Hou, Yun Chen, Gary Grajales-Reyes, Marco Colonna

Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels

  • Open Access
  • Research article

Melissa E. Murray, Christina M. Moloney, Naomi Kouri, Jeremy A. Syrjanen, Billie J. Matchett, Darren M. Rothberg, Jessica F. Tranovich, Tiffany N. Hicks Sirmans, Heather J. Wiste, Baayla D. C. Boon, Aivi T. Nguyen, R. Ross Reichard, Dennis W. Dickson, Val J. Lowe, Jeffrey L. Dage, Ronald C. Petersen, Clifford R. Jack Jr, David S. Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, Michelle M. Mielke

Kompaktes Leitlinien-Wissen Neurologie (Link öffnet in neuem Fenster)

Mit medbee Pocketcards schnell und sicher entscheiden.
Leitlinien-Wissen kostenlos und immer griffbereit auf ihrem Desktop, Handy oder Tablet.

Neu im Fachgebiet Neurologie

Als Kind pummelig, als Erwachsener geistig weniger flexibel

Wer bereits in der Kindheit oder Jugend ein ungünstiges kardiovaskuläres Risikoprofil aufweist, muss im jungen Erwachsenenalter mit kognitiven Nachteilen rechnen.

Gesunder Lebensstil bei Parkinson essenziell

Wie sehr Menschen mit Parkinson von körperlicher Aktivität, mediterraner Ernährung und Entspannungsübungen profitieren, zeigt ein Review im Fachblatt „Lancet“. Betroffene können mit entsprechenden Maßnahmen eine deutlich verbesserte Lebensqualität erreichen.

RNA-basierte CAR-T-Zell-Therapie hält Myasthenie in Schach

Eine gegen BCMA gerichtete Therapie mit CAR-T-Zellen kann eine schwere Myasthenia gravis über ein Jahr hinweg gut kontrollieren. Der RNA-basierte Ansatz verursacht zudem kaum Nebenwirkungen, erfordert aber sechs wöchentliche Infusionen.

Demenzrisiko: Keine Angst vor fettem Käse!

  • 14.01.2026
  • Demenz
  • Nachrichten

Wer sich täglich ein Stück fetten Käse gönnt oder auf fette Sahne schwört, darf sich über ein vermindertes Demenzrisiko freuen. Dass Milchfett vor Demenz schützt, lässt sich daraus allerdings nicht unbedingt schließen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Bildnachweise
Die Leitlinien für Ärztinnen und Ärzte, Untersuchung eines adipösen Kindes/© Colourbox (Symbolbild mit Fotomodell), Senior mit Parkinson hält den Löffel mit zwei Händen/© MarianVejcik / Getty Images / iStock (Symbolbild mit Fotomodell), Störung der Lidhebung bei Myasthenia gravis/© Alessandro Grandini / stock.adobe.com (Symbolbild mit Fotomodell), Person hält ein Glas Milch in beiden Händen/© Africa Studio / stock.adobe.com (Symbolbild mit Fotomodell)