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Zeitschrift

Molecular Neurodegeneration

Molecular Neurodegeneration 1/2018

Ausgabe 1/2018

Inhaltsverzeichnis ( 68 Artikel )

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

Seung Pil Yun, Donghoon Kim, Sangjune Kim, SangMin Kim, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Saebom Lee, Tae-In Kam, Suhyun Lee, Sangwoo Ham, Jae Hong Park, Valina L. Dawson, Ted M. Dawson, Yunjong Lee, Han Seok Ko

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Molecular and functional signatures in a novel Alzheimer’s disease mouse model assessed by quantitative proteomics

Dong Kyu Kim, Joonho Park, Dohyun Han, Jinhee Yang, Ahbin Kim, Jongmin Woo, Youngsoo Kim, Inhee Mook-Jung

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

Jesús Madero-Pérez, Elena Fdez, Belén Fernández, Antonio J. Lara Ordóñez, Marian Blanca Ramírez, Patricia Gómez-Suaga, Dieter Waschbüsch, Evy Lobbestael, Veerle Baekelandt, Angus C. Nairn, Javier Ruiz-Martínez, Ana Aiastui, Adolfo López de Munain, Pawel Lis, Thomas Comptdaer, Jean-Marc Taymans, Marie-Christine Chartier-Harlin, Alexandria Beilina, Adriano Gonnelli, Mark R. Cookson, Elisa Greggio, Sabine Hilfiker

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Piperine ameliorates SCA17 neuropathology by reducing ER stress

Jifeng Guo, Yiting Cui, Qiong Liu, Yang Yang, Yujing Li, Ling Weng, Beisha Tang, Peng Jin, Xiao-Jiang Li, Su Yang, Shihua Li

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

Sirui Jiang, Priya Nandy, Wenzhang Wang, Xiaopin Ma, Jeffrey Hsia, Chunyu Wang, Zhenlian Wang, Mengyue Niu, Sandra L. Siedlak, Sandy Torres, Hisashi Fujioka, Ying Xu, Hyoung-gon Lee, George Perry, Jun Liu, Xiongwei Zhu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

WonHee Kim, Liang Ma, Selene Lomoio, Rachel Willen, Sylvia Lombardo, Jinghui Dong, Philip G. Haydon, Giuseppina Tesco

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

Laura M. Taylor, Pamela J. McMillan, Nicole F. Liachko, Timothy J. Strovas, Bernardino Ghetti, Thomas D. Bird, C. Dirk Keene, Brian C. Kraemer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

Ga Ram Jeong, Eun-Hae Jang, Jae Ryul Bae, Soyoung Jun, Ho Chul Kang, Chi-Hu Park, Joo-Ho Shin, Yukio Yamamoto, Keiko Tanaka-Yamamoto, Valina L. Dawson, Ted M. Dawson, Eun-Mi Hur, Byoung Dae Lee

01.12.2018 | Short report | Ausgabe 1/2018 Open Access

Extracellular α-synuclein levels are regulated by neuronal activity

Kaoru Yamada, Takeshi Iwatsubo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Genetic ablation of dynactin p150Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice

Jia Yu, Chen Lai, Hoon Shim, Chengsong Xie, Lixin Sun, Cai-Xia Long, Jinhui Ding, Yan Li, Huaibin Cai

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

Justyna Sosna, Stephan Philipp, Ricardo Albay III, Jorge Mauricio Reyes-Ruiz, David Baglietto-Vargas, Frank M. LaFerla, Charles G. Glabe

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Targeting Hif1a rescues cone degeneration and prevents subretinal neovascularization in a model of chronic hypoxia

Maya Barben, Christian Schori, Marijana Samardzija, Christian Grimm

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

Julia E. Gerson, Kathleen M. Farmer, Natalie Henson, Diana L. Castillo-Carranza, Mariana Carretero Murillo, Urmi Sengupta, Alan Barrett, Rakez Kayed

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cognitive impairment in metabolically-obese, normal-weight rats: identification of early biomarkers in peripheral blood mononuclear cells

Margalida Cifre, Andreu Palou, Paula Oliver

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A. Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, Dan Can, Huaxi Xu, Guojun Bu, Xiao-Fen Chen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration

Todd McLaughlin, Marek Falkowski, Jae Whan Park, Stephen Keegan, Michael Elliott, Joshua J. Wang, Sarah X. Zhang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury

Bevan S. Main, Sonia Villapol, Stephanie S. Sloley, David J. Barton, Maia Parsadanian, Chinyere Agbaegbu, Kathryn Stefos, Mondona S. McCann, Patricia M. Washington, Olga C. Rodriguez, Mark P. Burns

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S. Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, Jörg Tatzelt, Paul Saftig, Markus Glatzel, Hermann C. Altmeppen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa

Alonso Sánchez-Cruz, Beatriz Villarejo-Zori, Miguel Marchena, Josefa Zaldivar-Díez, Valle Palomo, Carmen Gil, Ignacio Lizasoain, Pedro de la Villa, Ana Martínez, Enrique J. de la Rosa, Catalina Hernández-Sánchez

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Vibrational spectroscopy: a promising approach to discriminate neurodegenerative disorders

Maria Paraskevaidi, Pierre L. Martin-Hirsch, Francis L. Martin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

Norihito Uemura, Hisashi Yagi, Maiko T. Uemura, Yusuke Hatanaka, Hodaka Yamakado, Ryosuke Takahashi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model

Jane C. Hettinger, Hyo Lee, Guojun Bu, David M. Holtzman, John R. Cirrito

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology

Michael C. Pace, Guilian Xu, Susan Fromholt, John Howard, Benoit I. Giasson, Jada Lewis, David R. Borchelt

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Srikant Rangaraju, Eric B. Dammer, Syed Ali Raza, Priyadharshini Rathakrishnan, Hailian Xiao, Tianwen Gao, Duc M. Duong, Michael W. Pennington, James J. Lah, Nicholas T. Seyfried, Allan I. Levey

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse

Rebecca Kusko, Jennifer Dreymann, Jermaine Ross, Yoonjeong Cha, Renan Escalante-Chong, Marta Garcia-Miralles, Liang Juin Tan, Michael E. Burczynski, Ben Zeskind, Daphna Laifenfeld, Mahmoud Pouladi, Michal Geva, Iris Grossman, Michael R. Hayden

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson’s disease

Charles R. Schutt, Howard E. Gendelman, R. Lee Mosley

01.12.2018 | Review | Ausgabe 1/2018 Open Access

2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling

Eduarda G Z Centeno, Helena Cimarosti, Angela Bithell

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration

Emmanuel Quansah, Wouter Peelaerts, J. William Langston, David K. Simon, Jerry Colca, Patrik Brundin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

Paul J. Cheng-Hathaway, Erin G. Reed-Geaghan, Taylor R. Jay, Brad T. Casali, Shane M. Bemiller, Shweta S. Puntambekar, Victoria E. von Saucken, Roxanne Y. Williams, J. Colleen Karlo, Miguel Moutinho, Guixiang Xu, Richard M. Ransohoff, Bruce T. Lamb, Gary E. Landreth

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis

Tatyana A. Shelkovnikova, Michail S. Kukharsky, Haiyan An, Pasquale Dimasi, Svetlana Alexeeva, Osman Shabir, Paul R. Heath, Vladimir L. Buchman

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Lodewijk J. A. Toonen, Maurice Overzier, Melvin M. Evers, Leticia G. Leon, Sander A. J. van der Zeeuw, Hailiang Mei, Szymon M. Kielbasa, Jelle J. Goeman, Kristina M. Hettne, Olafur Th. Magnusson, Marion Poirel, Alexandre Seyer, Peter A. C. ‘t Hoen, Willeke M. C. van Roon-Mom

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

Andrew E. Arrant, Alexandra M. Nicholson, Xiaolai Zhou, Rosa Rademakers, Erik D. Roberson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

iPSC-derived familial Alzheimer’s PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling

Cesar L. Moreno, Lucio Della Guardia, Valeria Shnyder, Maitane Ortiz-Virumbrales, Ilya Kruglikov, Bin Zhang, Eric E. Schadt, Rudolph E. Tanzi, Scott Noggle, Christoph Buettner, Sam Gandy

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteins

Srikant Rangaraju, Eric B. Dammer, Syed Ali Raza, Tianwen Gao, Hailian Xiao, Ranjita Betarbet, Duc M. Duong, James A. Webster, Chadwick M. Hales, James J. Lah, Allan I. Levey, Nicholas T. Seyfried

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

TMEM106B haplotypes have distinct gene expression patterns in aged brain

Yingxue Ren, Marka van Blitterswijk, Mariet Allen, Minerva M. Carrasquillo, Joseph S. Reddy, Xue Wang, Thomas G. Beach, Dennis W. Dickson, Nilüfer Ertekin-Taner, Yan W. Asmann, Rosa Rademakers

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Clinical spectrum and genetic landscape for hereditary spastic paraplegias in China

En-Lin Dong, Chong Wang, Shuang Wu, Ying-Qian Lu, Xiao-Hong Lin, Hui-Zhen Su, Miao Zhao, Jin He, Li-Xiang Ma, Ning Wang, Wan-Jin Chen, Xiang Lin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci

Monica Y. Sanchez-Contreras, Naomi Kouri, Casey N. Cook, Daniel J. Serie, Michael G. Heckman, NiCole A. Finch, Richard J. Caselli, Ryan J. Uitti, Zbigniew K. Wszolek, Neill Graff-Radford, Leonard Petrucelli, Li-San Wang, Gerard D. Schellenberg, Dennis W. Dickson, Rosa Rademakers, Owen A. Ross

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

Daniel Felsky, Ellis Patrick, Julie A. Schneider, Sara Mostafavi, Chris Gaiteri, Nikolaos Patsopoulos, David A. Bennett, Philip L. De Jager

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

Jens Mayer, Christian Harz, Laura Sanchez, Gavin C. Pereira, Esther Maldener, Sara R. Heras, Lyle W. Ostrow, John Ravits, Ranjan Batra, Eckart Meese, Jose Luis García-Pérez, John L. Goodier

01.12.2018 | Review | Ausgabe 1/2018 Open Access

A new hypothesis for Parkinson’s disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomics

Julia Obergasteiger, Giulia Frapporti, Peter P. Pramstaller, Andrew A. Hicks, Mattia Volta

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases

Jason A. Chen, Zhongbo Chen, Hyejung Won, Alden Y. Huang, Jennifer K. Lowe, Kevin Wojta, Jennifer S. Yokoyama, Gilbert Bensimon, P. Nigel Leigh, Christine Payan, Aleksey Shatunov, Ashley R. Jones, Cathryn M. Lewis, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean-Francois Dartigues, Albert Ludolph, Adam L. Boxer, Jeff M. Bronstein, Ammar Al-Chalabi, Daniel H. Geschwind, Giovanni Coppola

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Counteracting roles of MHCI and CD8+ T cells in the peripheral and central nervous system of ALS SOD1G93A mice

Giovanni Nardo, Maria Chiara Trolese, Mattia Verderio, Alessandro Mariani, Massimiliano de Paola, Nilo Riva, Giorgia Dina, Nicolò Panini, Eugenio Erba, Angelo Quattrini, Caterina Bendotti

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

Changyoun Kim, Brian Spencer, Edward Rockenstein, Hodaka Yamakado, Michael Mante, Anthony Adame, Jerel Adam Fields, Deborah Masliah, Michiyo Iba, He-Jin Lee, Robert A. Rissman, Seung-Jae Lee, Eliezer Masliah

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

Justin Rustenhoven, Amy M. Smith, Leon C. Smyth, Deidre Jansson, Emma L. Scotter, Molly E. V. Swanson, Miranda Aalderink, Natacha Coppieters, Pritika Narayan, Renee Handley, Chris Overall, Thomas I. H. Park, Patrick Schweder, Peter Heppner, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Haihan Jiao, Matt Rutar, Nilisha Fernando, Ted Yednock, Sethu Sankaranarayanan, Riemke Aggio-Bruce, Jan Provis, Riccardo Natoli

01.12.2018 | Methodology | Ausgabe 1/2018 Open Access

Long-read sequencing across the C9orf72 ‘GGGGCC’ repeat expansion: implications for clinical use and genetic discovery efforts in human disease

Mark T. W. Ebbert, Stefan L. Farrugia, Jonathon P. Sens, Karen Jansen-West, Tania F. Gendron, Mercedes Prudencio, Ian J. McLaughlin, Brett Bowman, Matthew Seetin, Mariely DeJesus-Hernandez, Jazmyne Jackson, Patricia H. Brown, Dennis W. Dickson, Marka van Blitterswijk, Rosa Rademakers, Leonard Petrucelli, John D. Fryer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase

Bruno Becker, Faisal Hayat Nazir, Gunnar Brinkmalm, Elena Camporesi, Hlin Kvartsberg, Erik Portelius, Martina Boström, Marie Kalm, Kina Höglund, Maria Olsson, Henrik Zetterberg, Kaj Blennow

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Julia K. Götzl, Alessio-Vittorio Colombo, Katrin Fellerer, Anika Reifschneider, Georg Werner, Sabina Tahirovic, Christian Haass, Anja Capell

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Xianyuan Xiang, Thomas M. Piers, Benedikt Wefers, Kaichuan Zhu, Anna Mallach, Bettina Brunner, Gernot Kleinberger, Wilbur Song, Marco Colonna, Jochen Herms, Wolfgang Wurst, Jennifer M. Pocock, Christian Haass

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Michael Dumbacher, Tom Van Dooren, Katrien Princen, Koen De Witte, Mélissa Farinelli, Sam Lievens, Jan Tavernier, Wim Dehaen, Stefaan Wera, Joris Winderickx, Sara Allasia, Amuri Kilonda, Stéphane Spieser, Arnaud Marchand, Patrick Chaltin, Casper C. Hoogenraad, Gerard Griffioen

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Peripheral immune system in aging and Alzheimer’s disease

Wei Cao, Hui Zheng

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

Erik C. B. Johnson, Eric B. Dammer, Duc M. Duong, Luming Yin, Madhav Thambisetty, Juan C. Troncoso, James J. Lah, Allan I. Levey, Nicholas T. Seyfried

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

Olivia J Conway, Minerva M Carrasquillo, Xue Wang, Jenny M Bredenberg, Joseph S Reddy, Samantha L Strickland, Curtis S Younkin, Jeremy D Burgess, Mariet Allen, Sarah J Lincoln, Thuy Nguyen, Kimberly G Malphrus, Alexandra I Soto, Ronald L Walton, Bradley F Boeve, Ronald C Petersen, John A Lucas, Tanis J Ferman, William P Cheshire, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross, Dennis W Dickson, Neill R Graff-Radford, Nilüfer Ertekin-Taner

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology

Annerieke Sierksma, Ashley Lu, Evgenia Salta, Elke Vanden Eynden, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge, David Blum, Luc Buée, Mark Fiers, Bart De Strooper

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

Sander Beel, Sarah Herdewyn, Raheem Fazal, Mathias De Decker, Matthieu Moisse, Wim Robberecht, Ludo Van Den Bosch, Philip Van Damme

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis

Takae Kiyama, Ching-Kang Chen, Steven W Wang, Ping Pan, Zhenlin Ju, Jing Wang, Shinako Takada, William H Klein, Chai-An Mao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

Qingyi Ma, Zhen Zhao, Abhay P Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B Verghese, Joachim Herz, David M Holtzman, Berislav V Zlokovic

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Peripheral immune system in aging and Alzheimer’s disease

Wei Cao, Hui Zheng

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

Bin Zhang, Yuemang Yao, Anne-Sophie Cornec, Killian Oukoloff, Michael J. James, Pyry Koivula, John Q. Trojanowski, Amos B. Smith III, Virginia M.-Y. Lee, Carlo Ballatore, Kurt R. Brunden

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis

Irene Zubiri, Vittoria Lombardi, Michael Bremang, Vikram Mitra, Giovanni Nardo, Rocco Adiutori, Ching-Hua Lu, Emanuela Leoni, Ping Yip, Ozlem Yildiz, Malcolm Ward, Linda Greensmith, Caterina Bendotti, Ian Pike, Andrea Malaspina

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Functional alterations of myeloid cells during the course of Alzheimer’s disease

Aaron D. Thome, Alireza Faridar, David R. Beers, Jason R. Thonhoff, Weihua Zhao, Shixiang Wen, Belen Pascual, Joseph C. Masdeu, Stanley H. Appel

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

Huazhang Zhu, Weizhen Zhang, Yingying Zhao, Xingsheng Shu, Wencong Wang, Dandan Wang, Yangfan Yang, Zhijun He, Xiaomei Wang, Ying Ying

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Disease-modifying effects of metabolic perturbations in ALS/FTLD

Ali Jawaid, Romesa Khan, Magdalini Polymenidou, Paul E. Schulz

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Advances in developing novel therapeutic strategies for Alzheimer’s disease

Jiqing Cao, Jianwei Hou, Jing Ping, Dongming Cai

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

Hong Wang, Yupeng Li, John W. Ryder, Justin T. Hole, Philip J. Ebert, David C. Airey, Hui-Rong Qian, Benjamin Logsdon, Alice Fisher, Zeshan Ahmed, Tracey K. Murray, Annalisa Cavallini, Suchira Bose, Brian J. Eastwood, David A. Collier, Jeffrey L. Dage, Bradley B. Miller, Kalpana M. Merchant, Michael J. O’Neill, Ronald B. Demattos

01.12.2018 | Review | Ausgabe 1/2018 Open Access

New insights into the role of TREM2 in Alzheimer’s disease

Maud Gratuze, Cheryl E. G. Leyns, David M. Holtzman

01.12.2018 | Methodology | Ausgabe 1/2018 Open Access

Development and validation of a simplified method to generate human microglia from pluripotent stem cells

Amanda McQuade, Morgan Coburn, Christina H. Tu, Jonathan Hasselmann, Hayk Davtyan, Mathew Blurton-Jones

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration

Gregor Bieri, Kurt M. Lucin, Caitlin E. O’Brien, Hui Zhang, Saul A. Villeda, Tony Wyss-Coray

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